What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

United Airlines, at $285, was found to be the cheapest airline from Fort Myers to Des Moines.Alternate airlines to your destination round-trip include American Airlines and Southwest. You may be able to fly from Fort Myers to Des Moines for 38% less than the average price by searching for these airlines.

What is the cheapest day to fly from Fort Myers to Des Moines?

Travelers seeking maximum savings on their Fort Myers to Des Moines flight should consider departing on Friday afternoons when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Fort Myers to Des Moines?

American Airlines, Delta and Southwest are the most popular airlines when flying from Fort Myers to Des Moines.

What is the cheapest day to fly round-trip from Fort Myers to Des Moines?

Sunday flights are generally found to be more expensive for flights from Fort Myers to Des Moines. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Des Moines.

What is the cheapest month to fly from Fort Myers to Des Moines?

Flights from Fort Myers to Des Moines lean towards being more expensive in October. Prices are generally better when you fly from Fort Myers to Des Moines in February, with the cheapest ticket starting at $351.

Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Fort Myers to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.

Can I find deals for business class flights from Fort Myers to Des Moines?

Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$159+ Flights from Fort Myers to Des Moines

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Cheap flight deals from Fort Myers to Des Moines

Round-trip from	$285 (United Airlines)
One-way from	$159 (American Airlines)
Popular in	October
Cheapest in	February
Average price	$446

From Fort Myers SW Florida Intl to Des Moines

Search Deals

One-way flight from Fort Myers SW Florida Intl to Des Moines

Search Deals

Highest demand for flights based on searches. 18% potential increase in price ($101 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Thu 8/77:15 amRSW - DSM

1 stop8h 26mUnited Airlines

Thu 8/142:57 pmDSM - RSW

1 stop6h 03mUnited Airlines

Deal found 6/10

$285

Thu 8/74:14 pmRSW - DSM

2 stops8h 13mAmerican Airlines

Thu 8/145:12 amDSM - RSW

1 stop7h 30mAmerican Airlines

Deal found 6/10

$290

Wed 7/98:17 pmRSW - DSM

2 stops27h 19mMultiple Airlines

Wed 7/1611:00 amDSM - RSW

2 stops30h 25mMultiple Airlines

Deal found 6/11

$348

Thu 6/267:05 amRSW - DSM

1 stop4h 25mSouthwest

Sun 7/66:40 pmDSM - RSW

1 stop4h 40mSouthwest

Deal found 6/11

$427

Best flights from Fort Myers to Des Moines
Discover carefully curated flight deals from Fort Myers to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Thu 8/77:15 amRSW - DSM

1 stop8h 26mUnited Airlines

Thu 8/142:57 pmDSM - RSW

1 stop6h 03mUnited Airlines

Deal found 6/10

$285

Thu 8/77:52 pmRSW - DSM

1 stop4h 53mAmerican Airlines

Mon 8/115:00 amDSM - RSW

2 stops9h 43mAmerican Airlines

Deal found 6/12

$290

Wed 7/98:17 pmRSW - DSM

2 stops27h 19mMultiple Airlines

Wed 7/1611:00 amDSM - RSW

2 stops30h 25mMultiple Airlines

Deal found 6/11

$348

Thu 6/267:05 amRSW - DSM

1 stop4h 25mSouthwest

Sun 7/66:40 pmDSM - RSW

1 stop4h 40mSouthwest

Deal found 6/11

$427

Last-minute flights from Fort Myers to Des Moines
Discover last-minute flight deals from Fort Myers to Des Moines. Data last updated June 12, 2025 and is based on user searches.

Sun 6/228:09 pmRSW - DSM

2 stops17h 37mMultiple Airlines

Tue 7/12:23 pmDSM - RSW

3 stops20h 30mMultiple Airlines

Deal found 6/9

$565

Sun 6/2212:14 pmRSW - DSM

1 stop6h 32mUnited Airlines

Tue 7/12:57 pmDSM - RSW

1 stop6h 03mUnited Airlines

Deal found 6/9

$572

Thu 6/267:05 amRSW - DSM

1 stop4h 25mSouthwest

Sun 7/66:40 pmDSM - RSW

1 stop4h 40mSouthwest

Deal found 6/11

$427

Wed 7/98:17 pmRSW - DSM

2 stops27h 19mMultiple Airlines

Wed 7/1611:00 amDSM - RSW

2 stops30h 25mMultiple Airlines

Deal found 6/11

$348

Wed 7/97:15 amRSW - DSM

1 stop8h 26mUnited Airlines

Wed 7/1611:25 amDSM - RSW

1 stop8h 02mUnited Airlines

Deal found 6/11

$353

Fri 7/114:07 pmRSW - DSM

2 stops8h 37mAmerican Airlines

Fri 8/15:00 amDSM - RSW

2 stops9h 17mAmerican Airlines

Deal found 6/9

$397

One-way flights from Fort Myers to Des Moines
Search for one-way flight options from Fort Myers to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Sat 11/87:00 amRSW - DSM

1 stop8h 33mAmerican Airlines

Deal found 6/11

$159

Thu 7/107:00 amRSW - DSM

2 stops36h 06mMultiple Airlines

Deal found 6/10

$191

Fri 7/257:15 amRSW - DSM

2 stops14h 00mUnited Airlines

Deal found 6/12

$239

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 8/7

7:15 am-2:41 pm

1 stop8h 26m

Des Moines

Thu 8/14

2:57 pm-10:00 pm

1 stop6h 03m

$285

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 8/7

4:14 pm-11:27 pm

2 stops8h 13m

Des Moines

Thu 8/14

5:12 am-1:42 pm

1 stop7h 30m

$290

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 7/9

8:17 pm-10:36 pm

2 stops27h 19m

Des Moines

Wed 7/16

11:00 am-6:25 pm

2 stops30h 25m

$348

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 6/26

7:05 am-10:30 am

1 stop4h 25m

Des Moines

Sun 7/6

6:40 pm-12:20 am

1 stop4h 40m

$427

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 11/8

7:00 am-2:33 pm

1 stop8h 33m

$159

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 7/10

7:00 am-6:06 pm

2 stops36h 06m

$191

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 7/25

7:15 am-8:15 pm

2 stops14h 00m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $336). Flying from Fort Myers to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to DSM?

One of the essential ways to save on airfare from Fort Myers to Des Moines is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 20% on airfare.

Rainfall in Des Moines by month

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?
United Airlines, at $285, was found to be the cheapest airline from Fort Myers to Des Moines.Alternate airlines to your destination round-trip include American Airlines and Southwest. You may be able to fly from Fort Myers to Des Moines for 38% less than the average price by searching for these airlines.
Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?
Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Fort Myers to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.
Can I find deals for business class flights from Fort Myers to Des Moines?
Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Fort Myers to Des Moines?
Currently, August is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $336). Flying from Fort Myers to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Altoona

Ames

Johnston

Boone

West Des Moines

Ankeny

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Other flights to Des Moines

Top 3 airlines flying from Fort Myers to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$276	Average$422	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$286	Average$351	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$366	Average$446	FlexibilityNo cancel fee	On-time63%

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$159+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Fort Myers to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Fort Myers to Des Moines

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des MoinesExplore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

What is the cheapest time of day to fly from RSW to DSM?

Find hourly flight availability from Fort Myers to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

Reviews of airlines servicing Des Moines

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

How can I find direct flights from Fort Myers to Des Moines?

Can I find deals for business class flights from Fort Myers to Des Moines?

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Traveling to a place near Fort Myers?

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Alternative routes for Fort Myers to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Fort Myers to Des Moines

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Travel Smart

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.