HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$159+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — DSM
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Fort Myers to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Fort Myers to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$285
(Delta)

One-way from

$159
(American Airlines)

Popular in

October

Cheapest in

February

Average price

$495
Provider with most accurate pricing for Fort Myers SW Florida Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Des Moines flights.
Search Deals
From Fort Myers SW Florida Intl to Des Moines
Search Deals
One-way flight from Fort Myers SW Florida Intl to Des Moines
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($99 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/57:00 amRSW - DSM
1 stop7h 39mDelta
Tue 8/122:53 pmDSM - RSW
1 stop7h 02mDelta
Deal found 4/29$285
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/54:07 pmRSW - DSM
2 stops8h 37mAmerican Airlines
Tue 8/127:29 amDSM - RSW
1 stop6h 16mAmerican Airlines
Deal found 4/29$290
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/297:30 amRSW - DSM
1 stop4h 50mSouthwest
Fri 5/305:30 pmDSM - RSW
1 stop4h 20mSouthwest
Deal found 4/29$314
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/224:33 pmRSW - DSM
1 stop5h 49mUnited Airlines
Mon 5/266:25 amDSM - RSW
1 stop7h 32mUnited Airlines
Deal found 4/29$319
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/229:48 amRSW - DSM
2 stops30h 02mMultiple Airlines
Mon 5/268:35 amDSM - RSW
3 stops33h 36mMultiple Airlines
Deal found 4/29$545

Cheapflights Fare Finder

Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fort Myers

Fly to

Des Moines

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 8/5

7:00 am-1:39 pm

1 stop7h 39m

Des Moines

Tue 8/12

2:53 pm-10:55 pm

1 stop7h 02m

$285

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 8/5

4:07 pm-11:44 pm

2 stops8h 37m

Des Moines

Tue 8/12

7:29 am-2:45 pm

1 stop6h 16m

$290

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/29

7:30 am-11:20 am

1 stop4h 50m

Des Moines

Fri 5/30

5:30 pm-10:50 pm

1 stop4h 20m

$314

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/22

4:33 pm-9:22 pm

1 stop5h 49m

Des Moines

Mon 5/26

6:25 am-2:57 pm

1 stop7h 32m

$319

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/22

9:48 am-2:50 pm

2 stops30h 02m

Des Moines

Mon 5/26

8:35 am-7:11 pm

3 stops33h 36m

$545

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/29

5:21 pm-11:58 pm

1 stop7h 37m

$159

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 5/26

5:10 am-11:20 am

2 stops7h 10m

$239

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/29

12:14 pm-11:54 pm

3 stops36h 40m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Compare providers for flights from Fort Myers to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $336). Flying from Fort Myers to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to DSM?

Find hourly flight availability from Fort Myers to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

One of the essential ways to save on airfare from Fort Myers to Des Moines is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 20% on airfare.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2025.
To help decide which airline to fly from Fort Myers to Des Moines, see what other customers have to say about Southwest, Delta and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Overall

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,295 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Overall

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,929 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Overall

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Overall

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Food

7.1

Crew

8.6

Overall

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

    Delta, at $285, was found to be the cheapest airline from Fort Myers to Des Moines.Alternate airlines to your destination round-trip include American Airlines and Southwest. You may be able to fly from Fort Myers to Des Moines for 38% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Fort Myers to Des Moines one-way?

    $159 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Southwest and United Airlines, with prices starting from $239 and $393, respectively.

  • Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.

  • Can I find deals for business class flights from Fort Myers to Des Moines?

    Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $336). Flying from Fort Myers to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Fort Myers to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Omaha flights
Miami to Omaha flights
Tampa to Omaha flights
Orlando to Cedar Rapids flights
Fort Lauderdale to Omaha flights
Orlando to Des Moines flights
Jacksonville to Omaha flights
Tampa to Moline flights
Orlando to Mason City flights
West Palm Beach to Omaha flights
Orlando to Moline flights
Fort Lauderdale to Des Moines flights
Pensacola to Omaha flights
Jacksonville to Moline flights
Pensacola to Des Moines flights
Jacksonville to Des Moines flights
Tampa to Des Moines flights
Valparaiso to Omaha flights
Tampa to Cedar Rapids flights
Sarasota to Omaha flights
Miami to Des Moines flights
Sarasota to Cedar Rapids flights
Key West to Moline flights
Fort Lauderdale to Moline flights
Fort Myers to Omaha flights
Sarasota to Moline flights
Tallahassee to Des Moines flights
West Palm Beach to Des Moines flights
Jacksonville to Cedar Rapids flights
Panama City to Moline flights
Fort Lauderdale to Cedar Rapids flights
Fort Myers to Moline flights
Panama City to Omaha flights
Sarasota to Des Moines flights
Miami to Cedar Rapids flights
Fort Myers to Cedar Rapids flights
Miami to Moline flights
Gainesville to Des Moines flights
Melbourne to Cedar Rapids flights
Orlando to La Crosse flights
West Palm Beach to Moline flights
Valparaiso to Des Moines flights
Valparaiso to Cedar Rapids flights
Jacksonville to Dubuque flights
Melbourne to Omaha flights
Pensacola to Sioux City flights
Gainesville to Moline flights
Melbourne to Des Moines flights
West Palm Beach to Cedar Rapids flights

Top 3 airlines flying from Fort Myers to Des Moines

Discover the top 3 airlines that operate flights from Fort Myers to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$286Average$351FlexibilityNo cancel feeOn-time71%
DeltaCheapest$288Average$521FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$366Average$446FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.