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Des Moines

$116+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/4. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — DSM
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:31 pm
RSW
-
DSM
2 stops23h 17m
Multiple Airlines
Mon 2/166:00 am
DSM
-
RSW
Nonstop3h 04m
Multiple Airlines
Deal found 1/24$210
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/261:58 pm
RSW
-
DSM
1 stop8h 53m
American Airlines
Thu 3/52:02 pm
DSM
-
RSW
1 stop5h 40m
American Airlines
Deal found 1/26$310
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/97:02 pm
RSW
-
DSM
Nonstop3h 19m
Multiple Airlines
Fri 2/137:17 pm
DSM
-
RSW
3 stops38h 22m
Multiple Airlines
Deal found 1/25$378
This Delta deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:00 pm
RSW
-
DSM
1 stop5h 42m
Delta
Mon 7/62:35 pm
DSM
-
RSW
1 stop7h 19m
Delta
Deal found 1/24$407
This United Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:00 am
RSW
-
DSM
1 stop8h 24m
United Airlines
Sat 3/212:04 pm
DSM
-
RSW
2 stops8h 50m
United Airlines
Deal found 1/23$412
This United Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:30 pm
RSW
-
DSM
1 stop8h 11m
United Airlines
Wed 2/183:24 pm
DSM
-
RSW
1 stop5h 45m
United Airlines
Deal found 1/23$417
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:35 am
RSW
-
DSM
1 stop5h 26m
Delta
Mon 2/165:15 pm
DSM
-
RSW
1 stop5h 02m
Delta
Deal found 1/25$423

Find flight deals from Fort Myers to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$210
(Kiwi.com)

One-way from

$116
(Kiwi.com)

Popular in

May

Cheapest in

December

Average price

$200
Provider with most accurate pricing for Fort Myers SW Florida Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Des Moines flights.
Search Deals
From Fort Myers SW Florida Intl to Des Moines
Search Deals
One-way flight from Fort Myers SW Florida Intl to Des Moines
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($115 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fort Myers

Fly to

Des Moines

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 2/26

4:19 pm-9:59 pm

1 stop6h 40m

Des Moines

Thu 3/5

2:02 pm-8:42 pm

1 stop5h 40m

$310

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 2/9

7:02 pm-9:21 pm

Nonstop3h 19m

Des Moines

Fri 2/13

7:17 pm-10:39 am

3 stops38h 22m

$378

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 3/14

7:00 am-2:24 pm

1 stop8h 24m

Des Moines

Sat 3/21

2:04 pm-11:54 pm

2 stops8h 50m

$412

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 2/14

2:30 pm-9:41 pm

1 stop8h 11m

Des Moines

Wed 2/18

3:24 pm-10:09 pm

1 stop5h 45m

$417

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 4/1

7:24 pm-1:46 pm

1 stop19h 22m

$126

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 4/3

10:54 am-1:13 pm

Nonstop3h 19m

$139

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 2/28

7:20 am-10:55 am

1 stop4h 35m

$169

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 3/25

6:45 am-4:07 pm

2 stops10h 22m

$181

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sun 2/8

7:36 pm-10:19 am

3 stops15h 43m

$186

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 2/28

6:00 am-2:18 pm

3 stops33h 18m

$195

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 14 results
1
2

Compare providers for flights from Fort Myers to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Currently, December is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $64). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to DSM?

Find hourly flight availability from Fort Myers to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 26, 2026.

When flying from Fort Myers to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated January 26, 2026.
Peruse reviews from past customers who have flown with Southwest and American Airlines from Fort Myers to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,268 reviews

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,268 reviews
Southwest
8.0
Very good
4,268 reviews

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,189 reviews
Southwest
8.0
Very good
4,268 reviews

Comfort

8.0

Entertainment

7.5

Crew

8.6

Food

7.0

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Des Moines?

    There are many flights that can get you from Fort Myers to Des Moines in 6h 40m. Fly via American Airlines to get the fastest option. The distance between Fort Myers and Des Moines is about 1237 mi.

  • What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

    American Airlines, at $236, was found to be the cheapest airline from Fort Myers to Des Moines. An alternate airline flying to your destination would be Southwest. You may be able to fly from Fort Myers to Des Moines for 34% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Fort Myers to Des Moines one-way?

    $53 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $118 and $125, respectively.

  • What are the cheapest flights from Fort Myers to Des Moines?

    While on average a flight from Fort Myers to Des Moines is generally $208, our data shows the cheapest flight currently is $125. When looking at the most popular route, (Fort Myers SW Florida Intl - Des Moines), you can expect to pay $359 for that flight.

  • Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.

  • Can I find deals for business class flights from Fort Myers to Des Moines?

    Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Des Moines?

    Currently, December is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $64). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 2 airlines flying from Fort Myers to Des Moines

Discover the top 2 airlines that operate flights from Fort Myers to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$343FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$346Average$388FlexibilityNo cancel feeOn-time63%

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