What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

American Airlines, at $266, was found to be the cheapest airline from Fort Myers to Des Moines. An alternate airline flying to your destination would be Southwest. You may be able to fly from Fort Myers to Des Moines for 36% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular airlines that fly from Fort Myers to Des Moines?

Southwest, American Airlines and Delta are the most popular airlines when flying from Fort Myers to Des Moines.

Most accurate provider : When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Fort Myers to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.

Can I find deals for business class flights from Fort Myers to Des Moines?

Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$75+ Cheap Flights from Fort Myers to Des Moines

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Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Thu 12/411:38 amRSW - DSM

3 stops32h 25mMultiple Airlines

Mon 12/82:00 pmDSM - RSW

Nonstop3h 04mMultiple Airlines

Deal found 10/25

$176

Wed 11/266:50 pmRSW - DSM

Nonstop3h 19mMultiple Airlines

Mon 12/16:53 pmDSM - RSW

2 stops24h 49mMultiple Airlines

Deal found 10/26

$229

Thu 11/137:45 pmRSW - DSM

1 stop4h 50mSouthwest

Sat 11/156:25 amDSM - RSW

1 stop6h 45mSouthwest

Deal found 10/25

$352

Thu 11/136:13 amRSW - DSM

2 stops8h 03mAmerican Airlines

Sat 11/152:19 pmDSM - RSW

2 stops9h 08mAmerican Airlines

Deal found 10/25

$362

Thu 11/135:05 pmRSW - DSM

2 stops22h 53mMultiple Airlines

Fri 11/145:58 pmDSM - RSW

2 stops19h 20mMultiple Airlines

Deal found 10/25

$451

Thu 11/137:30 amRSW - DSM

1 stop4h 30mSouthwest

Fri 11/145:45 amDSM - RSW

1 stop4h 40mSouthwest

Deal found 10/25

$467

Best flights from Fort Myers to Des Moines
Discover carefully curated flight deals from Fort Myers to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 27, 2025.

Thu 12/48:29 pmRSW - DSM

2 stops17h 26mMultiple Airlines

Mon 12/82:00 pmDSM - RSW

Nonstop3h 04mMultiple Airlines

Deal found 10/25

$185

Thu 11/137:45 pmRSW - DSM

1 stop4h 50mSouthwest

Sat 11/156:25 amDSM - RSW

1 stop6h 45mSouthwest

Deal found 10/25

$352

Thu 11/136:13 amRSW - DSM

2 stops8h 03mAmerican Airlines

Sat 11/152:19 pmDSM - RSW

2 stops9h 08mAmerican Airlines

Deal found 10/25

$362

Wed 11/266:50 pmRSW - DSM

Nonstop3h 19mMultiple Airlines

Mon 12/16:53 pmDSM - RSW

2 stops24h 49mMultiple Airlines

Deal found 10/26

$229

Thu 11/137:30 amRSW - DSM

1 stop4h 30mSouthwest

Fri 11/145:45 amDSM - RSW

1 stop4h 40mSouthwest

Deal found 10/25

$467

Thu 11/135:05 pmRSW - DSM

2 stops22h 53mMultiple Airlines

Fri 11/145:58 pmDSM - RSW

2 stops19h 20mMultiple Airlines

Deal found 10/25

$451

Last-minute flights from Fort Myers to Des Moines
Discover last-minute flight deals from Fort Myers to Des Moines. Data last updated October 27, 2025 and is based on user searches.

Tue 11/1112:42 pmRSW - DSM

1 stop5h 43mUnited Airlines

Sat 11/159:01 amDSM - RSW

2 stops11h 50mUnited Airlines

Deal found 10/27

$552

Thu 11/137:45 pmRSW - DSM

1 stop4h 50mSouthwest

Sat 11/156:25 amDSM - RSW

1 stop6h 45mSouthwest

Deal found 10/25

$352

Thu 11/136:13 amRSW - DSM

2 stops8h 03mAmerican Airlines

Sat 11/152:19 pmDSM - RSW

2 stops9h 08mAmerican Airlines

Deal found 10/25

$362

Thu 11/135:05 pmRSW - DSM

2 stops22h 53mMultiple Airlines

Fri 11/145:58 pmDSM - RSW

2 stops19h 20mMultiple Airlines

Deal found 10/25

$451

Thu 11/137:30 amRSW - DSM

1 stop4h 30mSouthwest

Fri 11/145:45 amDSM - RSW

1 stop4h 40mSouthwest

Deal found 10/25

$467

Wed 11/266:50 pmRSW - DSM

Nonstop3h 19mMultiple Airlines

Mon 12/16:53 pmDSM - RSW

2 stops24h 49mMultiple Airlines

Deal found 10/26

$229

One-way flights from Fort Myers to Des Moines
Search for one-way flight options from Fort Myers to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 27, 2025.

Fri 12/56:50 pmRSW - DSM

Nonstop3h 19mAllegiant Air

Deal found 10/24

$75

Wed 12/38:00 amRSW - DSM

1 stop6h 31mDelta

Deal found 10/24

$119

Sat 12/68:29 pmRSW - DSM

2 stops47h 34mMultiple Airlines

Deal found 10/24

$137

Thu 12/41:15 pmRSW - DSM

2 stops30h 48mMultiple Airlines

Deal found 10/24

$144

Wed 12/39:02 pmRSW - DSM

2 stops40h 53mMultiple Airlines

Deal found 10/24

$145

Sun 12/71:15 pmRSW - DSM

2 stops30h 48mMultiple Airlines

Deal found 10/24

$148

Mon 12/227:41 pmRSW - DSM

1 stop5h 56mAmerican Airlines

Deal found 10/25

$164

Sat 1/106:50 amRSW - DSM

1 stop6h 27mDelta

Deal found 10/27

$169

Sat 1/101:12 pmRSW - DSM

2 stops9h 59mAmerican Airlines

Deal found 10/26

$174

Fri 12/56:00 amRSW - DSM

2 stops9h 58mMultiple Airlines

Deal found 10/24

$188

Cheap flight deals from Fort Myers to Des Moines

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$176 (Kiwi.com)
One-way from	$75 (Kiwi.com)
Popular in	October
Cheapest in	August
Average price	$680

Provider with most accurate pricing for Fort Myers SW Florida Intl-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Des Moines flights.

Search Deals

From Fort Myers SW Florida Intl to Des Moines

Search Deals

One-way flight from Fort Myers SW Florida Intl to Des Moines

Search Deals

Highest demand for flights based on searches. 11% potential increase in price ($54 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 12/4

8:29 pm-12:55 pm

2 stops17h 26m

Des Moines

Mon 12/8

2:00 pm-6:04 pm

Nonstop3h 04m

$185

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 11/26

6:50 pm-9:09 pm

Nonstop3h 19m

Des Moines

Mon 12/1

6:53 pm-8:42 pm

2 stops24h 49m

$229

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/13

7:45 pm-11:35 pm

1 stop4h 50m

Des Moines

Sat 11/15

6:25 am-2:10 pm

1 stop6h 45m

$352

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/13

6:13 am-1:16 pm

2 stops8h 03m

Des Moines

Sat 11/15

2:19 pm-12:27 am

2 stops9h 08m

$362

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/13

5:05 pm-2:58 pm

2 stops22h 53m

Des Moines

Fri 11/14

5:58 pm-2:18 pm

2 stops19h 20m

$451

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/13

7:30 am-11:00 am

1 stop4h 30m

Des Moines

Fri 11/14

5:45 am-11:25 am

1 stop4h 40m

$467

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 12/5

6:50 pm-9:09 pm

Nonstop3h 19m

$75

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 12/6

4:12 pm-10:34 pm

1 stop7h 22m

$119

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 12/3

8:00 am-1:31 pm

1 stop6h 31m

$119

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 12/4

1:15 pm-7:03 pm

2 stops30h 48m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/24

Showing 1-10 of 15 results

Compare providers for flights from Fort Myers to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Fort Myers-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Fort Myers-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Fort Myers-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Fort Myers-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Currently, November is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $93). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to DSM?

One of the essential ways to save on airfare from Fort Myers to Des Moines is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 67% on airfare.

Reviews of airlines servicing Des Moines

Peruse reviews from past customers who have flown with Southwest and American Airlines from Fort Myers to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,236 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

American Airlines

7.2

Good

11,033 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?
American Airlines, at $266, was found to be the cheapest airline from Fort Myers to Des Moines. An alternate airline flying to your destination would be Southwest. You may be able to fly from Fort Myers to Des Moines for 36% less than the average price by searching for these airlines.
Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?
Yes. In addition to deals on Fort Myers to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Fort Myers to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Des Moines.
Can I find deals for business class flights from Fort Myers to Des Moines?
Yes. Cheapflights offers flight deals from Fort Myers to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Fort Myers to Des Moines?
Currently, November is the cheapest month in which you can book a flight from Fort Myers to Des Moines (average of $93). Flying from Fort Myers to Des Moines in May is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Johnston

Altoona

Boone

Ames

West Des Moines

Ankeny

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Other flights to Des Moines

Top 2 airlines flying from Fort Myers to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$266	Average$343	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$366	Average$416	FlexibilityNo cancel fee	On-time63%

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$75+ Cheap flights from Fort Myers to Des Moines (RSW - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Fort Myers to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Fort Myers to Des Moines

Cheapest flights from Fort Myers to Des MoinesExplore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Cheap flight deals from Fort Myers to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Compare providers for flights from Fort Myers to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Des Moines in October.

Best time to book a flight from Fort Myers to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Fort Myers with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Des Moines

What is the cheapest month to book a flight from Fort Myers to Des Moines?

What is the cheapest time of day to fly from RSW to DSM?

Reviews of airlines servicing Des Moines

Peruse reviews from past customers who have flown with Southwest and American Airlines from Fort Myers to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Fort Myers to Des Moines round-trip?

Can I find deals for flights from Fort Myers to Des Moines that include hotel bookings?

How can I find direct flights from Fort Myers to Des Moines?

Can I find deals for business class flights from Fort Myers to Des Moines?

What is the cheapest month to book a flight from Fort Myers to Des Moines?

Traveling to a place near Des Moines?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Fort Myers to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Fort Myers to Des Moines

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Cheapest flights from Fort Myers to Des Moines
Explore the most affordable flight options available from Fort Myers to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.