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$271+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Dec 14 — Dec 211
Sun 12/14
Sun 12/21
1 adult, Economy
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Find flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:50 pmPTY - ORD
2 stops31h 19mMultiple Airlines
Wed 12/105:00 amORD - PTY
2 stops26h 50mMultiple Airlines
Deal found 11/12$549
This Cheapflightsfares deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:55 amPTY - ORD
1 stop18h 25mAvianca
Mon 12/110:20 pmORD - PTY
1 stop14h 40mAvianca
Deal found 11/14$555
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:25 amPTY - ORD
2 stops35h 23mMultiple Airlines
Tue 12/97:41 pmORD - PTY
1 stop11h 25mMultiple Airlines
Deal found 11/13$557
This Cheapflightsfares deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:55 amPTY - ORD
1 stop18h 25mAvianca
Fri 1/910:20 pmORD - PTY
1 stop17h 35mAvianca
Deal found 11/12$579
This Cheapflightsfares deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:45 amPTY - ORD
1 stop11h 35mAvianca
Sun 12/710:20 pmORD - PTY
1 stop14h 40mAvianca
Deal found 11/12$580
This Cheapflightsfares deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:55 amPTY - ORD
1 stop18h 25mAvianca
Sat 1/104:10 pmORD - PTY
1 stop17h 20mAvianca
Deal found 11/14$590
This Mytrip deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:25 amPTY - ORD
2 stops18h 11mMultiple Airlines
Mon 12/14:58 pmORD - PTY
2 stops20h 57mMultiple Airlines
Deal found 11/14$595
This Delta deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amPTY - MDW
1 stop9h 20mDelta
Sun 1/49:50 amMDW - PTY
1 stop9h 10mDelta
Deal found 11/13$623
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:00 amPTY - MDW
1 stop9h 20mDelta
Thu 1/296:00 amMDW - PTY
1 stop6h 55mDelta
Deal found 11/12$642
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/139:45 amPTY - MDW
2 stops13h 45mMultiple Airlines
Mon 12/226:15 amMDW - PTY
1 stop25h 25mMultiple Airlines
Deal found 11/12$662
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:37 pmPTY - MDW
1 stop9h 03mDelta
Mon 12/86:00 amMDW - PTY
1 stop7h 21mDelta
Deal found 11/12$707
This Delta deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:37 pmPTY - MDW
1 stop9h 03mDelta
Mon 12/16:00 amMDW - PTY
1 stop7h 12mDelta
Deal found 11/14$745

Cheap flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated November 14, 2025.

Round-trip from

$517
(Kiwi.com)

One-way from

$271
(Mytrip)

Popular in

March

Cheapest in

July

Average price

$514

Good round-trip deal

$533 or less

Good one-way deal

$574 or less
From Panama to Chicago (CHI)
Search Deals
One-way flight from Panama to Chicago (CHI)
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High demand for flights, 1% potential price rise
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Panama to Chicago (CHI).
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 11/27

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Mon 12/1

10:20 pm-2:00 pm

1 stop14h 40m

$555

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 11/27

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Mon 12/8

10:20 pm-2:00 pm

1 stop14h 40m

$555

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 12/27

2:55 am-8:20 pm

1 stop18h 25m

Chicago O'Hare Intl

Fri 1/9

10:20 pm-4:55 pm

1 stop17h 35m

$579

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 5/2

5:25 pm-1:15 pm

1 stop19h 50m

Chicago O'Hare Intl

Sun 5/10

2:35 pm-10:10 am

1 stop19h 35m

$579

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 2/1

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Fri 2/6

10:20 pm-8:50 am

1 stop9h 30m

$579

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 3/7

7:20 pm-12:04 am

Nonstop5h 44m

Chicago O'Hare Intl

Tue 3/10

3:22 pm-8:35 pm

Nonstop5h 13m

$580

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 3/1

7:20 pm-12:04 am

Nonstop5h 44m

Chicago O'Hare Intl

Thu 4/30

3:13 pm-8:35 pm

Nonstop5h 22m

$580

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 2/14

7:20 pm-12:04 am

Nonstop5h 44m

Chicago O'Hare Intl

Sun 2/22

2:22 pm-8:35 pm

Nonstop5h 13m

$580

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 4/2

8:10 am-1:46 pm

Nonstop5h 36m

Chicago O'Hare Intl

Sun 4/5

3:13 pm-8:35 pm

Nonstop5h 22m

$580

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 2/2

7:55 am-12:31 pm

Nonstop5h 36m

Chicago O'Hare Intl

Tue 2/10

7:34 am-2:00 pm

Nonstop5h 26m

$582

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 26 results
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 14, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 11% on flights from Panama to Chicago by exploring options for tickets in the evening.

Weekly flight availability from Panama to Chicago

Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 14, 2025.

The most flights from PA0 to CHI are scheduled on a Wednesday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated November 14, 2025.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,565 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,565 reviews
Copa Airlines
7.6
Good
1,565 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,479 reviews
Copa Airlines
7.6
Good
1,565 reviews

Boarding

7.8

Crew

8.1

Comfort

7.4

Entertainment

6.8

Overall

7.6

Food

6.9

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 11h 35m. Fly via Avianca or Delta to get the fastest option. Panama and Chicago are separated by a distance of 2330 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing EVA Air (91%), Copa Airlines (91%) or United Airlines (91%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $371. On average you can expect to pay $797. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $528.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Hammond
Porter
Benton Harbor
Merrillville

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Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
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San José to Midway flights
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Managua to Midway flights
Tegucigalpa to St. Louis flights
Tegucigalpa to Midway flights

Top airline flying from Panama to Chicago

Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$415Average$586FlexibilityNo cancel feeOn-time70%

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