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$220+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
may. 4 — may. 111
dom. 5/4
dom. 5/11
1 adult, Economy
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Cheap flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated abril 29, 2025.

Round-trip from

$393
(Priceline)

One-way from

$220
(Trip.com)

Popular in

July

Cheapest in

April

Average price

$479

Good round-trip deal

$479 or less

Good one-way deal

$553 or less
From Panama to Chicago (CHI)
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One-way flight from Panama to Chicago (CHI)
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Highest demand for flights based on searches. 4% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Panama to Chicago (CHI).
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Price to beat on a one-way flight from Panama to Chicago (CHI).
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Find flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 29, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/268:10 pmPTY - ORD
2 stops18h 15mAvianca
mié. 10/292:35 pmORD - PTY
1 stop9h 45mAvianca
Deal found 4/29$399
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/288:01 amPTY - ORD
1 stop9h 40mMultiple Airlines
dom. 6/18:17 amORD - PTY
1 stop11h 12mMultiple Airlines
Deal found 4/29$423
This Copa Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/287:55 amPTY - ORD
Nonstop5h 52mCopa Airlines
dom. 6/13:07 pmORD - PTY
Nonstop5h 28mCopa Airlines
Deal found 4/29$480
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/82:23 pmPTY - MDW
2 stops22h 06mDelta
vie. 7/256:00 amMDW - PTY
1 stop7h 03mDelta
Deal found 4/29$485
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/282:13 pmPTY - ORD
1 stop9h 45mDelta
jue. 6/125:05 pmORD - PTY
2 stops26h 25mDelta
Deal found 4/29$485
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/273:30 pmPTY - ORD
1 stop18h 51mUnited Airlines
mar. 7/157:10 amORD - PTY
1 stop9h 02mUnited Airlines
Deal found 4/29$494
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/151:50 pmPTY - ORD
2 stops17h 33mAmerican Airlines
lun. 10/208:37 pmORD - PTY
2 stops15h 48mAmerican Airlines
Deal found 4/29$587
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/289:22 amPTY - MDW
1 stop10h 21mMultiple Airlines
dom. 6/110:18 amMDW - PTY
1 stop9h 15mMultiple Airlines
Deal found 4/29$879
This eDestinos deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/73:22 pmPTY - ORD
1 stop22h 53mAeromexico
dom. 8/102:00 amORD - PTY
1 stop11h 47mAeromexico
Deal found 4/29$933

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 29, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

jue. 6/26

8:10 pm-2:25 pm

2 stops18h 15m

Chicago O'Hare Intl

mié. 10/29

2:35 pm-12:20 am

1 stop9h 45m

$399

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

mié. 5/28

8:01 am-5:41 pm

1 stop9h 40m

Chicago O'Hare Intl

dom. 6/1

8:17 am-7:29 pm

1 stop11h 12m

$423

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

mié. 5/28

7:55 am-1:47 pm

Nonstop5h 52m

Chicago O'Hare Intl

dom. 6/1

3:07 pm-8:35 pm

Nonstop5h 28m

$480

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

mar. 7/8

2:23 pm-12:29 pm

2 stops22h 06m

Chicago Midway

vie. 7/25

6:00 am-1:03 pm

1 stop7h 03m

$485

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

mié. 5/28

2:13 pm-11:58 pm

1 stop9h 45m

Chicago O'Hare Intl

jue. 6/12

5:05 pm-7:30 pm

2 stops26h 25m

$485

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

vie. 6/27

3:30 pm-10:21 am

1 stop18h 51m

Chicago O'Hare Intl

mar. 7/15

7:10 am-4:12 pm

1 stop9h 02m

$494

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

mié. 10/15

1:50 pm-7:23 am

2 stops17h 33m

Chicago O'Hare Intl

lun. 10/20

8:37 pm-12:25 pm

2 stops15h 48m

$587

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

mié. 5/28

9:22 am-7:43 pm

1 stop10h 21m

Chicago Midway

dom. 6/1

10:18 am-7:33 pm

1 stop9h 15m

$879

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

jue. 8/7

3:22 pm-2:15 pm

1 stop22h 53m

Chicago O'Hare Intl

dom. 8/10

2:00 am-1:47 pm

1 stop11h 47m

$933

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

sáb. 5/24

3:20 am-10:41 pm

2 stops19h 21m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 15 results
1
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, August is the cheapest month in which you can book a flight from Panama to Chicago (average of $245). Flying from Panama to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated abril 29, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 25% on flights from Panama to Chicago by exploring options for tickets at noon.

Rainfall in Chicago by month

Plan your trip to Chicago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Chicago ranges from 1.7 - 4.9 inches per month. August is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Chicago when rainfall is around 1.7 in.

Temperature in Chicago by month

Plan your trip to Chicago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Chicago, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated abril 29, 2025.
To help decide which airline to fly from Panama to Chicago, see what other customers have to say about Delta, Copa Airlines and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.5
Good
1,411 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,929 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Panama to Chicago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $269. United Airlines flights start at $440 while deals on Copa Airlines start at $547 one-way.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing EVA Air (89%), Copa Airlines (82%) or United Airlines (82%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $280. On average you can expect to pay $1,632. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $408.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Panama to Chicago (average of $245). Flying from Panama to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama?

Book flights to Panama if you plan to visit one of these locations
Merrillville
Hammond
Benton Harbor
Porter
Lansing
Valparaiso
Chesterton

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Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
San José to O'Hare Intl flights
Guatemala City to O'Hare Intl flights
Guatemala City to Midway flights
Panama City to O'Hare Intl flights
San Salvador to O'Hare Intl flights
San José to Midway flights
San José to St. Louis flights
San Pedro Sula to O'Hare Intl flights
Philip S.W.Goldson to O'Hare Intl flights
Panama City to St. Louis flights
Managua to O'Hare Intl flights
Philip S.W.Goldson to Midway flights
San Pedro Sula to Midway flights
San Pedro Sula to St. Louis flights
Managua to St. Louis flights
Liberia to O'Hare Intl flights
Tegucigalpa to O'Hare Intl flights
Guatemala City to St. Louis flights
Tegucigalpa to St. Louis flights
Coxen Hole to O'Hare Intl flights
Tegucigalpa to Midway flights
Managua to Midway flights

Top 3 airlines flying from Panama to Chicago

Discover the top 3 airlines that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$450Average$559FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$485Average$692FlexibilityNo cancel feeOn-time69%
DeltaCheapest$492Average$671FlexibilityNo cancel feeOn-timeN/A

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