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$240+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:33 pm
PTY
-
ORD
2 stops17h 03m
Multiple Airlines
Fri 5/811:20 pm
ORD
-
PTY
1 stop9h 55m
Multiple Airlines
Deal found 2/17$417
This Trip.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:45 am
PTY
-
ORD
2 stops22h 40m
Multiple Airlines
Tue 3/3110:55 am
ORD
-
PTY
3 stops15h 00m
Multiple Airlines
Deal found 2/15$435
This Mytrip deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:30 am
PTY
-
ORD
3 stops24h 22m
Multiple Airlines
Sun 5/1011:20 pm
ORD
-
PTY
1 stop14h 55m
Multiple Airlines
Deal found 2/17$448
This Trip.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:10 am
PTY
-
ORD
1 stop11h 10m
Avianca
Sun 5/1011:20 pm
ORD
-
PTY
1 stop14h 55m
Avianca
Deal found 2/17$451
This Mytrip deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:45 am
PTY
-
ORD
2 stops24h 54m
Multiple Airlines
Mon 3/29:18 am
ORD
-
PTY
2 stops27h 42m
Multiple Airlines
Deal found 2/17$472
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:10 pm
PTY
-
ORD
2 stops18h 40m
Multiple Airlines
Tue 4/74:51 pm
ORD
-
PTY
1 stop15h 39m
Multiple Airlines
Deal found 2/14$492
This Mytrip deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:50 pm
PTY
-
ORD
2 stops16h 49m
Multiple Airlines
Thu 3/57:23 pm
ORD
-
PTY
2 stops12h 27m
Multiple Airlines
Deal found 2/16$499
This Mytrip deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:10 pm
PTY
-
ORD
2 stops19h 40m
Multiple Airlines
Tue 5/1911:20 pm
ORD
-
PTY
1 stop14h 55m
Multiple Airlines
Deal found 2/17$509
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:26 am
PTY
-
MDW
1 stop10h 28m
Multiple Airlines
Tue 4/76:00 am
MDW
-
PTY
1 stop14h 34m
Multiple Airlines
Deal found 2/14$651
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:10 am
PTY
-
MDW
2 stops23h 46m
Multiple Airlines
Sat 4/116:30 am
MDW
-
PTY
1 stop12h 50m
Multiple Airlines
Deal found 2/17$668
This KAYAK deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/293:30 pm
PTY
-
MDW
1 stop25h 55m
LATAM Airlines
Sun 12/61:05 pm
MDW
-
PTY
1 stop24h 00m
LATAM Airlines
Deal found 2/17$731
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/210:26 am
PTY
-
MDW
1 stop11h 55m
Multiple Airlines
Thu 4/96:00 am
MDW
-
PTY
1 stop14h 34m
Multiple Airlines
Deal found 2/16$813

Find flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated February 18, 2026.

Round-trip from

$417
(Kiwi.com)

One-way from

$240
(Trip.com)

Popular in

January

Cheapest in

July

Average price

$580

Good round-trip deal

$887 or less

Good one-way deal

$596 or less
From Panama to Chicago (CHI)
Search Deals
One-way flight from Panama to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Panama to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Panama to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 3/15

9:45 am-8:25 am

2 stops22h 40m

Chicago O'Hare Intl

Tue 3/31

10:55 am-1:55 am

3 stops15h 00m

$435

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 5/8

10:10 am-9:20 pm

1 stop11h 10m

Chicago O'Hare Intl

Tue 5/19

11:20 pm-2:15 pm

1 stop14h 55m

$451

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 5/7

3:25 am-5:52 am

3 stops26h 27m

Chicago O'Hare Intl

Tue 5/19

11:20 pm-9:15 am

1 stop9h 55m

$472

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 3/2

5:50 pm-9:39 am

2 stops16h 49m

Chicago O'Hare Intl

Thu 3/5

7:23 pm-8:50 am

2 stops12h 27m

$499

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 3/2

5:50 pm-9:39 am

2 stops16h 49m

Chicago O'Hare Intl

Thu 4/2

4:51 pm-5:00 pm

2 stops24h 09m

$523

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 3/31

9:33 pm-9:50 am

1 stop12h 17m

Chicago O'Hare Intl

Tue 4/7

4:51 pm-8:06 am

1 stop15h 15m

$537

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 5/19

3:25 am-9:17 pm

2 stops17h 52m

Chicago O'Hare Intl

Wed 5/27

11:20 pm-9:15 am

1 stop9h 55m

$563

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 5/20

7:25 pm-1:15 am

Nonstop5h 50m

Chicago O'Hare Intl

Wed 5/27

8:02 am-1:22 pm

Nonstop5h 20m

$576

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 5/20

10:10 am-9:20 pm

1 stop11h 10m

Chicago O'Hare Intl

Sun 5/24

11:20 pm-5:00 pm

1 stop17h 40m

$580

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 3/31

10:26 am-8:54 pm

1 stop10h 28m

Chicago Midway

Tue 4/7

6:00 am-8:34 pm

1 stop14h 34m

$651

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 31 results
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in May is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 18, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.

Weekly flight availability from Panama to Chicago

Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 18, 2026.

The most flights from PA0 to CHI are scheduled on a Monday (5 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated February 18, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,556 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Food

6.8

Overall

7.5

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,556 reviews
Copa Airlines
7.5
Good
1,556 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Food

6.8

Overall

7.5

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 11h 10m. Fly via Avianca to get the fastest option. Panama and Chicago are separated by a distance of 2330 mi.

  • What are the cheapest airlines to fly from Panama to Chicago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $223. Copa Airlines flights start at $255 while deals on United Airlines start at $444 one-way.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing Copa Airlines (86%), United Airlines (83%) or EVA Air (78%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $525. On average you can expect to pay $769. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $417.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in May is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Merrillville
Hammond
Porter
Benton Harbor

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama to Chicago

Discover the top 2 airlines that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$405Average$581FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$423Average$485FlexibilityNo cancel feeOn-time69%

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