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$266+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Touko 18 — Touko 251
ma 5/18
ma 5/25
1 adult, Economy
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Cheap flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on huhtikuu 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
la 5/212:23 pm
PTY
-
ORD
1 stop11h 36m
Multiple Airlines
su 5/109:20 am
ORD
-
PTY
2 stops23h 55m
Multiple Airlines
Deal found 4/17$507
This Mytrip deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ke 4/2210:10 am
PTY
-
ORD
2 stops26h 55m
Multiple Airlines
ma 4/277:50 am
ORD
-
PTY
2 stops30h 25m
Multiple Airlines
Deal found 4/13$527
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to 5/73:41 pm
PTY
-
ORD
1 stop8h 15m
Multiple Airlines
su 5/109:20 am
ORD
-
PTY
2 stops23h 55m
Multiple Airlines
Deal found 4/15$528
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma 6/13:41 pm
PTY
-
ORD
1 stop8h 15m
Multiple Airlines
ma 6/89:20 am
ORD
-
PTY
1 stop10h 00m
Multiple Airlines
Deal found 4/17$532
This Trip.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
la 5/24:25 am
PTY
-
MDW
3 stops17h 49m
Multiple Airlines
ti 5/56:00 am
MDW
-
PTY
3 stops27h 15m
Multiple Airlines
Deal found 4/13$610
This Trip.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ke 5/134:25 am
PTY
-
MDW
3 stops17h 37m
Multiple Airlines
ke 5/206:00 am
MDW
-
PTY
3 stops28h 30m
Multiple Airlines
Deal found 4/15$678
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma 6/110:26 am
PTY
-
MDW
1 stop11h 36m
Multiple Airlines
ti 6/96:00 am
MDW
-
PTY
2 stops13h 20m
Multiple Airlines
Deal found 4/13$692
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
la 5/3010:26 am
PTY
-
MDW
1 stop11h 36m
Multiple Airlines
la 6/611:59 am
MDW
-
PTY
2 stops20h 07m
Multiple Airlines
Deal found 4/14$693
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma 6/19:33 pm
PTY
-
MDW
2 stops37h 36m
Multiple Airlines
ma 6/86:00 am
MDW
-
PTY
1 stop14h 34m
Multiple Airlines
Deal found 4/17$698
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma 6/19:33 pm
PTY
-
MDW
2 stops24h 29m
Multiple Airlines
to 6/46:00 am
MDW
-
PTY
1 stop14h 34m
Multiple Airlines
Deal found 4/17$701
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma 12/218:00 am
PTY
-
MDW
1 stop9h 25m
Delta
ti 1/56:00 am
MDW
-
PTY
1 stop6h 55m
Delta
Deal found 4/18$719
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ke 6/310:26 am
PTY
-
MDW
1 stop11h 36m
Multiple Airlines
ke 6/1712:04 pm
MDW
-
PTY
2 stops32h 33m
Multiple Airlines
Deal found 4/16$735

Find flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated huhtikuu 18, 2026.

Round-trip from

$507
(Kiwi.com)

One-way from

$266
(Kiwi.com)

Popular in

May

Cheapest in

July

Average price

$479

Good round-trip deal

$649 or less

Good one-way deal

$392 or less
From Panama to Chicago (CHI)
Search Deals
One-way flight from Panama to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($43 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Panama to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Panama to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated huhtikuu 18, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

ma 6/1

9:33 pm-11:09 am

2 stops37h 36m

Chicago Midway

ma 6/8

6:00 am-8:34 pm

1 stop14h 34m

$698

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

ma 6/1

9:33 pm-10:02 pm

2 stops24h 29m

Chicago Midway

to 6/4

6:00 am-8:34 pm

1 stop14h 34m

$701
Quickest round-trip

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

ke 9/9

7:25 pm-1:02 am

Nonstop5h 37m

Chicago O'Hare Intl

ke 9/16

3:20 pm-8:41 pm

Nonstop5h 21m

$713

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

su 6/14

10:10 pm-4:00 am

Nonstop5h 50m

Chicago O'Hare Intl

la 7/4

8:02 am-1:22 pm

Nonstop5h 20m

$715

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

to 10/8

2:21 pm-11:50 pm

1 stop9h 29m

Chicago O'Hare Intl

ma 10/12

5:30 am-12:56 pm

1 stop7h 26m

$719

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

pe 10/9

3:20 pm-12:10 am

1 stop8h 50m

Chicago O'Hare Intl

to 10/15

5:30 am-2:14 pm

1 stop8h 44m

$719

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

pe 10/9

2:21 pm-11:50 pm

1 stop9h 29m

Chicago O'Hare Intl

ma 10/12

5:30 am-12:56 pm

1 stop7h 26m

$719

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

pe 10/9

3:20 pm-11:27 am

1 stop20h 07m

Chicago O'Hare Intl

ma 10/12

9:30 pm-2:14 pm

1 stop16h 44m

$719

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

ke 6/17

3:30 pm-12:45 am

1 stop9h 15m

Chicago O'Hare Intl

ke 7/8

4:40 pm-4:04 am

1 stop11h 24m

$721

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

pe 7/3

10:00 am-8:05 pm

1 stop10h 05m

Chicago O'Hare Intl

ma 7/13

7:35 am-4:12 pm

1 stop8h 37m

$721

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 47 resultsSorted by cheapest first
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, May is the cheapest month in which you can book a flight from Panama to Chicago (average of $201). Flying from Panama to Chicago in September is currently the most expensive (average of $417). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated huhtikuu 18, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.

Weekly flight availability from Panama to Chicago

Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated huhtikuu 18, 2026.

The most flights from PA0 to CHI are scheduled on a Thursday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated huhtikuu 18, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,576 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,576 reviews
Copa Airlines
7.5
Good
1,576 reviews

Boarding

7.8

Comfort

7.4

Crew

8.1

Entertainment

6.8

Overall

7.5

Food

6.8

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 5h 37m. Fly via Copa Airlines, Delta, or United Airlines to get the fastest option. Panama and Chicago are separated by a distance of 2330 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing Copa Airlines (88%), EVA Air (85%) or United Airlines (83%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $392. On average you can expect to pay $737. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $606.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, May is the cheapest month in which you can book a flight from Panama to Chicago (average of $201). Flying from Panama to Chicago in September is currently the most expensive (average of $417). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Benton Harbor
Lansing
Merrillville
Hammond
Porter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Panama to Chicago

Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated huhtikuu 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$405Average$649FlexibilityNo cancel feeOn-time70%

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