HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Chicago

$207+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Chicago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated September 17, 2025.

Round-trip from

$404
(Kiwi.com)

One-way from

$207
(Mytrip)

Popular in

March

Cheapest in

July

Average price

$531

Good round-trip deal

$433 or less

Good one-way deal

$722 or less
From Panama to Chicago (CHI)
Search Deals
One-way flight from Panama to Chicago (CHI)
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Panama to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Panama to Chicago (CHI).
Search Deals

Find flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:55 pmPTY - ORD
2 stops18h 27mMultiple Airlines
Thu 11/610:20 pmORD - PTY
1 stop9h 30mMultiple Airlines
Deal found 9/15$404
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Wed 11/56:56 amORD - PTY
Nonstop5h 26mCopa Airlines
Deal found 9/16$418
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:35 pmPTY - ORD
2 stops18h 47mMultiple Airlines
Wed 11/58:50 pmORD - PTY
3 stops27h 10mMultiple Airlines
Deal found 9/16$420
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:10 pmPTY - MDW
2 stops18h 30mDelta
Tue 10/76:00 amMDW - PTY
1 stop6h 56mDelta
Deal found 9/16$423
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:00 amPTY - ORD
1 stop12h 37mUnited Airlines
Mon 10/277:55 pmORD - PTY
1 stop22h 43mUnited Airlines
Deal found 9/15$423
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/292:55 amPTY - ORD
1 stop18h 25mAvianca
Thu 11/610:20 pmORD - PTY
1 stop17h 35mAvianca
Deal found 9/15$427
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1510:05 pmPTY - ORD
2 stops35h 17mMultiple Airlines
Wed 10/222:35 pmORD - PTY
1 stop10h 10mMultiple Airlines
Deal found 9/17$432
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:43 pmPTY - ORD
1 stop22h 21mAmerican Airlines
Sun 12/75:00 amORD - PTY
1 stop7h 47mAmerican Airlines
Deal found 9/16$434
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:31 pmPTY - ORD
1 stop17h 09mAmerican Airlines
Sun 10/55:00 amORD - PTY
1 stop9h 31mAmerican Airlines
Deal found 9/15$436
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/163:15 pmPTY - ORD
1 stop8h 43mAmerican Airlines
Mon 10/208:44 pmORD - PTY
2 stops17h 19mAmerican Airlines
Deal found 9/14$437
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/169:33 pmPTY - MDW
1 stop12h 00mMultiple Airlines
Mon 10/2010:33 amMDW - PTY
1 stop8h 56mMultiple Airlines
Deal found 9/14$462
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:21 pmPTY - MDW
1 stop7h 53mDelta
Wed 11/56:00 amMDW - PTY
1 stop6h 56mDelta
Deal found 9/17$523

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 11/1

7:20 pm-1:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Thu 11/6

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 10/16

6:45 pm-12:21 am

Nonstop5h 36m

Chicago O'Hare Intl

Mon 10/20

3:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 11/1

7:20 pm-1:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Wed 11/5

6:56 am-1:22 pm

Nonstop5h 26m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 10/25

6:45 pm-12:21 am

Nonstop5h 36m

Chicago O'Hare Intl

Tue 11/11

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 11/21

7:20 pm-12:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Sun 12/7

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 10/27

7:20 pm-12:56 am

Nonstop5h 36m

Chicago O'Hare Intl

Fri 10/31

3:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 10/24

6:45 pm-12:21 am

Nonstop5h 36m

Chicago O'Hare Intl

Tue 11/11

6:56 am-1:22 pm

Nonstop5h 26m

$418

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/3

2:10 pm-8:40 am

2 stops18h 30m

Chicago Midway

Tue 10/7

6:00 am-12:56 pm

1 stop6h 56m

$423

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 10/16

9:33 pm-9:33 am

1 stop12h 00m

Chicago Midway

Mon 10/20

10:33 am-7:29 pm

1 stop8h 56m

$462

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 10/31

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Wed 11/5

6:00 am-1:56 pm

1 stop6h 56m

$523

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 26 results
1
2
3

Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, August is the cheapest month in which you can book a flight from Panama to Chicago (average of $245). Flying from Panama to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 38% on flights from Panama to Chicago by exploring options for tickets at noon.

Weekly flight availability from Panama to Chicago

Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 17, 2025.

The most flights from PA0 to CHI are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Entertainment

6.8

Food

6.8

Comfort

7.4

Overall

7.6

Boarding

7.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 5h 45m. Fly via Copa Airlines or Delta to get the fastest option. Panama and Chicago are separated by a distance of 2330 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing Copa Airlines (93%), United Airlines (89%) or EVA Air (85%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $311. On average you can expect to pay $703. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $418.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Panama to Chicago (average of $245). Flying from Panama to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Lansing
Hammond
Benton Harbor
Porter
Chesterton

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
Guatemala City to O'Hare Intl flights
San José to O'Hare Intl flights
Guatemala City to Midway flights
Panama City to O'Hare Intl flights
San José to Midway flights
San Salvador to O'Hare Intl flights
San Pedro Sula to O'Hare Intl flights
San Pedro Sula to Midway flights
San José to St. Louis flights
Managua to O'Hare Intl flights
Philip S.W.Goldson to O'Hare Intl flights
San Pedro Sula to St. Louis flights
Liberia to O'Hare Intl flights
Panama City to St. Louis flights
Philip S.W.Goldson to Midway flights
Guatemala City to St. Louis flights
Managua to Midway flights
Tegucigalpa to St. Louis flights
Managua to St. Louis flights
Tegucigalpa to O'Hare Intl flights
Coxen Hole to O'Hare Intl flights
Tegucigalpa to Midway flights

Top 2 airlines flying from Panama to Chicago

Discover the top 2 airlines that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$415Average$558FlexibilityNo cancel feeOn-time70%
DeltaCheapest$598Average$673FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.