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$176+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Mar 3 — Mar 101
Tue 3/3
Tue 3/10
1 adult, Economy
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Cheap flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 1, 2026.

This Priceline deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:55 am
PTY
-
ORD
1 stop18h 25m
Avianca
Wed 3/410:20 pm
ORD
-
PTY
1 stop17h 35m
Avianca
Deal found 1/31$289
This Avianca deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/29:45 am
PTY
-
ORD
1 stop11h 35m
Avianca
Thu 2/510:20 pm
ORD
-
PTY
1 stop9h 30m
Avianca
Deal found 1/31$291
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/99:45 am
PTY
-
ORD
1 stop11h 35m
Avianca
Tue 2/1710:20 pm
ORD
-
PTY
1 stop9h 30m
Avianca
Deal found 1/31$303
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/109:45 am
PTY
-
ORD
1 stop11h 35m
Avianca
Tue 2/1710:20 pm
ORD
-
PTY
1 stop9h 30m
Avianca
Deal found 1/31$307
This Avianca deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/19:45 am
PTY
-
ORD
1 stop11h 35m
Avianca
Fri 2/610:20 pm
ORD
-
PTY
1 stop17h 35m
Avianca
Deal found 1/31$350
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:45 am
PTY
-
ORD
1 stop11h 35m
Multiple Airlines
Wed 3/47:23 pm
ORD
-
PTY
2 stops12h 27m
Multiple Airlines
Deal found 1/31$368
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/179:45 am
PTY
-
ORD
1 stop11h 35m
Multiple Airlines
Tue 3/244:51 pm
ORD
-
PTY
2 stops15h 59m
Multiple Airlines
Deal found 1/31$378
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/162:55 pm
PTY
-
ORD
2 stops27h 36m
Multiple Airlines
Mon 3/2311:20 pm
ORD
-
PTY
1 stop9h 30m
Multiple Airlines
Deal found 1/30$380
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:50 pm
PTY
-
ORD
2 stops16h 49m
Multiple Airlines
Tue 2/1710:20 pm
ORD
-
PTY
1 stop9h 30m
Multiple Airlines
Deal found 1/31$402
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1210:26 am
PTY
-
MDW
1 stop13h 08m
Multiple Airlines
Tue 2/176:00 am
MDW
-
PTY
1 stop13h 34m
Multiple Airlines
Deal found 1/31$552
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:27 pm
PTY
-
MDW
1 stop8h 01m
Delta
Sat 5/96:00 am
MDW
-
PTY
1 stop6h 55m
Delta
Deal found 1/30$660
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/912:03 pm
PTY
-
MDW
2 stops11h 16m
Multiple Airlines
Tue 2/176:00 am
MDW
-
PTY
1 stop13h 34m
Multiple Airlines
Deal found 1/31$674

Find flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated February 1, 2026.

Round-trip from

$289
(Priceline)

One-way from

$176
(Priceline)

Popular in

January

Cheapest in

July

Average price

$516

Good round-trip deal

$887 or less

Good one-way deal

$485 or less
From Panama to Chicago (CHI)
Search Deals
One-way flight from Panama to Chicago (CHI)
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Panama to Chicago (CHI).
Search Deals
Price to beat on a one-way flight from Panama to Chicago (CHI).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 1, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 2/12

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Tue 2/17

10:20 pm-8:50 am

1 stop9h 30m

$291

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 3/16

2:55 pm-6:31 pm

2 stops27h 36m

Chicago O'Hare Intl

Mon 3/23

11:20 pm-8:50 am

1 stop9h 30m

$380

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 2/15

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Tue 2/17

10:20 pm-8:50 am

1 stop9h 30m

$463

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 2/28

11:25 am-10:39 pm

2 stops12h 14m

Chicago O'Hare Intl

Sat 3/7

10:20 pm-8:50 am

1 stop9h 30m

$474

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 3/15

5:50 pm-9:20 pm

1 stop27h 30m

Chicago O'Hare Intl

Tue 3/31

11:20 pm-9:15 am

1 stop9h 55m

$478

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 5/9

5:30 am-6:15 pm

2 stops12h 45m

Chicago O'Hare Intl

Thu 5/14

10:17 am-5:00 pm

2 stops30h 43m

$499

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 3/31

3:25 am-6:26 pm

2 stops15h 01m

Chicago O'Hare Intl

Tue 4/28

5:15 am-2:15 pm

2 stops33h 00m

$500

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 3/29

3:05 am-9:50 am

2 stops30h 45m

Chicago O'Hare Intl

Mon 4/13

4:51 pm-9:15 am

2 stops16h 24m

$506

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 5/6

5:30 am-6:15 pm

3 stops12h 45m

Chicago O'Hare Intl

Sat 5/9

7:41 am-2:15 pm

3 stops30h 34m

$524

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 3/30

9:33 pm-9:50 am

1 stop12h 17m

Chicago O'Hare Intl

Tue 4/14

4:51 pm-8:06 am

1 stop15h 15m

$525

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 38 results
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $243). Flying from Panama to Chicago in May is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 1, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.

Weekly flight availability from Panama to Chicago

Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 1, 2026.

The most flights from PA0 to CHI are scheduled on a Thursday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated February 1, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Food

6.8

Comfort

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Overall

7.6

Boarding

7.8

Entertainment

6.8

Food

6.8

Comfort

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 8h 01m. Fly via Avianca or Delta to get the fastest option. Panama and Chicago are separated by a distance of 2316 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama to Chicago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $244. Copa Airlines flights start at $255 while deals on United Airlines start at $444 one-way.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing United Airlines (87%), EVA Air (86%) or Copa Airlines (84%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $408. On average you can expect to pay $861. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $352.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $243). Flying from Panama to Chicago in May is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Merrillville
Hammond
Porter
Benton Harbor

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
San José to O'Hare Intl flights
Guatemala City to O'Hare Intl flights
Panama City to O'Hare Intl flights
Guatemala City to Midway flights
San José to Midway flights
San Pedro Sula to O'Hare Intl flights
San Salvador to O'Hare Intl flights
San Pedro Sula to Midway flights
San José to St. Louis flights
Guatemala City to St. Louis flights
Philip S.W.Goldson to O'Hare Intl flights
Managua to O'Hare Intl flights
Panama City to St. Louis flights
Philip S.W.Goldson to Midway flights
San Pedro Sula to St. Louis flights
Managua to St. Louis flights
Liberia to O'Hare Intl flights
Coxen Hole to O'Hare Intl flights
Tegucigalpa to St. Louis flights
Tegucigalpa to O'Hare Intl flights
Tegucigalpa to Midway flights
Managua to Midway flights

Top 2 airlines flying from Panama to Chicago

Discover the top 2 airlines that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$405Average$581FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$423Average$485FlexibilityNo cancel feeOn-time69%

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