$356+ Cheap flights from Panama to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Nov 3 — Nov 101
Round-trip
1 adult, Economy
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Find cheap flights from Panama to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to Chicago
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Cheapest flights from Panama to ChicagoExplore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 4, 2026.
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 4, 2026.
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:34 pm -
1 stop18h 56m
Sun 11/296:00 am -
1 stop7h 34m
Deal found 10/2![American Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/273:34 pm -
1 stop10h 13m
Fri 12/49:11 pm -
2 stops16h 02m
Deal found 9/29![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/214:33 pm -
1 stop24h 06m
Tue 1/56:59 am -
1 stop7h 34m
Deal found 9/30![American Airlines logo]()
$710
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:34 pm -
1 stop20h 32m
Mon 11/307:50 pm -
1 stop17h 44m
Deal found 9/30![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:41 pm -
1 stop9h 56m
Tue 12/294:40 pm -
1 stop21h 53m
Deal found 9/29![American Airlines logo]()
$719
This BusinessClass deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:13 pm -
1 stop17h 47m
Sun 12/65:00 am -
1 stop8h 13m
Deal found 9/29![GOL logo]()
$720
This Copa Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:57 pm -
1 stop17h 49m
Fri 10/303:13 pm -
1 stop16h 32m
Deal found 10/2![Copa Airlines logo]()
$1,157
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:50 am -
2 stops25h 27m
Fri 10/305:30 am -
2 stops27h 27m
Deal found 10/2![United Airlines logo]()
$1,217
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
1 stop15h 20m
Sat 10/318:00 am -
2 stops24h 50m
Deal found 10/2![Multiple Airlines logo]()
$1,372
This KAYAK deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:45 am -
2 stops15h 00m
Sat 10/315:30 am -
2 stops13h 44m
Deal found 10/2![Copa Airlines logo]()
$1,375
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
1 stop15h 20m
Fri 10/308:00 am -
2 stops35h 14m
Deal found 10/2![Multiple Airlines logo]()
$1,413
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:26 am -
2 stops15h 58m
Fri 10/303:13 pm -
1 stop16h 32m
Deal found 10/2![Multiple Airlines logo]()
$1,544
Best flights from Panama to ChicagoDiscover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
Discover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:57 am -
Nonstop5h 49m
Sat 11/142:13 pm -
Nonstop5h 24m
Deal found 10/1![Copa Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:00 am -
1 stop25h 48m
Thu 11/59:35 pm -
1 stop16h 10m
Deal found 9/30![United Airlines logo]()
$741
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:29 pm -
2 stops25h 49m
Sat 11/285:05 pm -
2 stops19h 57m
Deal found 10/1![Delta logo]()
$742
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
1 stop15h 20m
Fri 10/308:00 am -
2 stops35h 14m
Deal found 10/2![Multiple Airlines logo]()
$1,413
This Copa Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:28 pm -
Nonstop5h 43m
Mon 11/307:35 am -
Nonstop5h 26m
Deal found 9/30![Copa Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:41 pm -
1 stop18h 29m
Sat 11/79:25 am -
1 stop9h 13m
Deal found 10/1![United Airlines logo]()
$742
This Copa Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:20 pm -
Nonstop5h 37m
Wed 10/288:35 am -
Nonstop5h 21m
Deal found 9/29![Copa Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:00 am -
1 stop24h 45m
Wed 11/259:21 am -
1 stop9h 17m
Deal found 10/3![United Airlines logo]()
$742
This Copa Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:28 pm -
Nonstop5h 43m
Mon 11/232:13 pm -
Nonstop5h 24m
Deal found 10/4![Copa Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:41 pm -
1 stop18h 30m
Mon 11/2310:34 am -
1 stop8h 04m
Deal found 10/4![United Airlines logo]()
$742
This Copa Airlines deal was found by Cheapflights users on 10/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:20 pm -
Nonstop5h 37m
Thu 11/57:35 am -
Nonstop5h 26m
Deal found 10/3![Copa Airlines logo]()
$736
This Copa Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:28 pm -
Nonstop5h 43m
Sun 11/292:13 pm -
Nonstop5h 24m
Deal found 10/2![Copa Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:50 am -
2 stops25h 27m
Fri 10/305:30 am -
2 stops27h 27m
Deal found 10/2![United Airlines logo]()
$1,217
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
2 stops15h 00m
Fri 10/305:30 pm -
2 stops39h 20m
Deal found 10/2![United Airlines logo]()
$1,217
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:50 am -
2 stops25h 27m
Sat 10/316:59 am -
2 stops25h 51m
Deal found 10/2![United Airlines logo]()
$1,217
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:45 am -
1 stop15h 20m
Sat 10/313:13 pm -
1 stop17h 37m
Deal found 10/2![United Airlines logo]()
$2,367
Last-minute flights from Panama to ChicagoDiscover last-minute flight deals from Panama to Chicago. Data last updated October 4, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Chicago. Data last updated October 4, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:50 am -
2 stops25h 27m
Fri 10/305:30 am -
2 stops27h 27m
Deal found 10/2![United Airlines logo]()
$1,217
This Copa Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:57 pm -
1 stop17h 49m
Fri 10/303:13 pm -
1 stop16h 32m
Deal found 10/2![Copa Airlines logo]()
$1,157
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
1 stop15h 20m
Sat 10/318:00 am -
2 stops24h 50m
Deal found 10/2![Multiple Airlines logo]()
$1,372
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/259:45 am -
1 stop15h 20m
Fri 10/308:00 am -
2 stops35h 14m
Deal found 10/2![Multiple Airlines logo]()
$1,413
This KAYAK deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:45 am -
2 stops15h 00m
Sat 10/315:30 am -
2 stops13h 44m
Deal found 10/2![Copa Airlines logo]()
$1,375
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:26 am -
2 stops15h 58m
Fri 10/303:13 pm -
1 stop16h 32m
Deal found 10/2![Multiple Airlines logo]()
$1,544
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:26 am -
2 stops15h 58m
Sat 10/318:35 am -
1 stop10h 39m
Deal found 10/2![Multiple Airlines logo]()
$1,609
This Ovago deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:45 am -
2 stops15h 00m
Fri 10/305:30 am -
2 stops13h 44m
Deal found 10/2![Copa Airlines logo]()
$1,691
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:34 pm -
1 stop18h 56m
Sun 11/296:00 am -
1 stop7h 34m
Deal found 10/2![American Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:34 pm -
1 stop20h 32m
Mon 11/307:50 pm -
1 stop17h 44m
Deal found 9/30![American Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:34 pm -
1 stop18h 56m
Fri 12/47:50 pm -
1 stop17h 23m
Deal found 10/2![American Airlines logo]()
$722
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/273:34 pm -
1 stop10h 13m
Fri 12/49:11 pm -
2 stops16h 02m
Deal found 9/29![American Airlines logo]()
$702
One-way flights from Panama to ChicagoSearch for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
Search for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated October 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:34 pm -
1 stop10h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:30 pm -
2 stops24h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:45 pm -
2 stops25h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:45 pm -
2 stops25h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:34 pm -
1 stop18h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![American Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:34 pm -
1 stop25h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:00 am -
1 stop8h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:03 pm -
2 stops24h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:00 am -
1 stop26h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$448
Find flight deals from Panama to Chicago
Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated October 4, 2026.
Round-trip from | $646 (American Airlines) |
|---|---|
One-way from | $356 (American Airlines) |
Popular in | July |
Cheapest in | November |
Average price | $743 |
Good round-trip deal | $694 or less |
Good one-way deal | $596 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 4, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Tue 10/20
12:03 pm-11:32 am
2 stops23h 29m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$509
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 10/19
12:03 pm-3:30 pm
1 stop27h 27m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$544
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Wed 10/21
2:02 pm-11:33 pm
1 stop9h 31m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$567
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Thu 11/19
5:30 am-10:40 pm
3 stops18h 10m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$591
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sat 12/19
4:33 pm-9:23 am
1 stop17h 50m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$613
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/9
12:03 pm-3:30 pm
1 stop27h 27m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$624
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Wed 10/7
4:25 am-5:52 am
3 stops25h 27m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$631
Quickest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/16
7:20 pm-12:57 am
Nonstop5h 37m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$707
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Tue 12/22
4:33 pm-8:20 am
2 stops16h 47m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$707
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 10/19
8:10 am-1:59 pm
Nonstop5h 49m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$710
Showing 1-10 of 27 resultsSorted by cheapest first
Best time to book a flight from Panama to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
PTY-ORD
DAV-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Chicago
PA0-CHI
PTY-ORD
DAV-ORD
What is the cheapest month to book a flight from Panama to Chicago?
Currently, April is the cheapest month in which you can book a flight from Panama to Chicago (average of $586). Flying from Panama to Chicago in March is currently the most expensive (average of $808). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to CHI?
Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 4, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.
Weekly flight availability from Panama to Chicago
Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated October 4, 2026.
The most flights from PA0 to CHI are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).
How far ahead should I book a flight from Panama to Chicago?
The price you pay for your flight from Panama to Chicago may vary depending on when you book. For the best chance of a lower fare, look to book 72 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated October 4, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Food
6.9
Comfort
7.4
Boarding
7.8
Entertainment
6.9
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Food
6.9
Comfort
7.4
Boarding
7.8
Entertainment
6.9
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Panama to Chicago
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 4, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to Chicago by cabin class
Find flights from Panama to Chicago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and Chicago flights
Browse other Panama and Chicago flight options. Last updated on October 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama to Chicago
Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$574 | Average$801 | FlexibilityNo cancel fee | On-time70% |