$335+ Cheap flights from Panama to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Oct 4 — Oct 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to Chicago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama to ChicagoExplore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:30 am -
1 stop19h 00m
Thu 11/510:30 pm -
1 stop17h 45m
Deal found 8/31![Avianca logo]()
$553
This flugladen.de deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flugladen.de is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:10 pm -
1 stop30h 10m
Fri 10/3011:30 pm -
1 stop17h 45m
Deal found 8/30![Avianca logo]()
$563
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:05 am -
1 stop11h 25m
Sat 11/710:30 pm -
1 stop15h 45m
Deal found 8/31![Avianca logo]()
$596
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:02 pm -
1 stop10h 36m
Mon 10/267:29 pm -
1 stop17h 33m
Deal found 9/1![American Airlines logo]()
$613
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:51 pm -
1 stop17h 52m
Tue 1/55:21 am -
2 stops9h 12m
Deal found 9/3![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:02 pm -
1 stop10h 36m
Fri 10/305:05 am -
1 stop7h 57m
Deal found 8/30![American Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:13 pm -
1 stop9h 43m
Sat 11/77:50 pm -
1 stop17h 23m
Deal found 9/1![American Airlines logo]()
$653
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:00 am -
1 stop13h 44m
Tue 10/66:25 am -
1 stop14h 06m
Deal found 9/1![Multiple Airlines logo]()
$800
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:31 pm -
2 stops21h 16m
Sat 11/77:25 am -
1 stop12h 06m
Deal found 9/1![Multiple Airlines logo]()
$836
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
1 stop9h 19m
Tue 1/56:00 am -
1 stop6h 55m
Deal found 8/30![Delta logo]()
$847
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/31![Delta logo]()
$849
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:23 pm -
1 stop8h 21m
Wed 10/76:04 am -
1 stop6h 55m
Deal found 9/2![Delta logo]()
$863
Best flights from Panama to ChicagoDiscover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:28 pm -
Nonstop5h 43m
Tue 1/52:13 pm -
Nonstop5h 25m
Deal found 8/30![Copa Airlines logo]()
$720
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
1 stop9h 19m
Tue 1/56:00 am -
1 stop6h 55m
Deal found 9/3![Delta logo]()
$847
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/288:55 am -
1 stop18h 40m
Fri 12/47:54 pm -
1 stop23h 08m
Deal found 8/30![United Airlines logo]()
$847
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:25 am -
2 stops13h 19m
Tue 10/66:25 am -
1 stop14h 06m
Deal found 9/1![Multiple Airlines logo]()
$885
This Kissandfly.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:24 pm -
1 stop8h 09m
Fri 10/306:04 am -
1 stop6h 55m
Deal found 8/30![KLM logo]()
$902
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:06 am -
Nonstop5h 40m
Mon 12/72:13 pm -
Nonstop5h 24m
Deal found 9/2![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/203:20 pm -
1 stop7h 50m
Wed 1/276:00 am -
1 stop6h 55m
Deal found 9/1![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:28 pm -
Nonstop5h 43m
Tue 1/52:13 pm -
Nonstop5h 25m
Deal found 8/31![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/273:20 pm -
1 stop7h 50m
Wed 2/36:00 am -
1 stop6h 55m
Deal found 9/1![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:57 am -
Nonstop5h 49m
Thu 11/52:13 pm -
Nonstop5h 24m
Deal found 9/1![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:23 pm -
1 stop8h 21m
Sat 10/176:04 am -
1 stop6h 55m
Deal found 8/31![Delta logo]()
$880
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:57 am -
Nonstop5h 49m
Sat 11/72:13 pm -
Nonstop5h 24m
Deal found 9/3![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:23 pm -
1 stop8h 21m
Sun 9/276:05 am -
1 stop6h 53m
Deal found 8/31![Delta logo]()
$916
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:05 am -
Nonstop5h 41m
Mon 11/307:35 am -
Nonstop5h 26m
Deal found 9/1![Copa Airlines logo]()
$844
This Copa Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:20 pm -
Nonstop5h 37m
Thu 11/57:35 am -
Nonstop5h 26m
Deal found 8/30![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:23 pm -
2 stops18h 44m
Tue 9/226:05 am -
1 stop6h 53m
Deal found 8/31![Delta logo]()
$958
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:28 pm -
Nonstop5h 43m
Tue 12/87:35 am -
Nonstop5h 25m
Deal found 9/3![Copa Airlines logo]()
$844
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:20 pm -
Nonstop5h 37m
Mon 11/232:13 pm -
Nonstop5h 24m
Deal found 8/31![Copa Airlines logo]()
$875
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:25 pm -
Nonstop5h 37m
Tue 10/68:01 am -
Nonstop5h 21m
Deal found 9/1![Copa Airlines logo]()
$907
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:25 pm -
Nonstop5h 37m
Sun 9/273:20 pm -
Nonstop5h 21m
Deal found 9/1![Copa Airlines logo]()
$942
Last-minute flights from Panama to ChicagoDiscover last-minute flight deals from Panama to Chicago. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Chicago. Data last updated September 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:00 am -
1 stop13h 44m
Tue 10/66:25 am -
1 stop14h 06m
Deal found 9/1![Multiple Airlines logo]()
$800
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2710:00 am -
1 stop13h 44m
Sun 10/46:46 pm -
1 stop25h 45m
Deal found 8/30![Multiple Airlines logo]()
$910
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:23 pm -
1 stop8h 21m
Wed 10/76:04 am -
1 stop6h 55m
Deal found 9/2![Delta logo]()
$863
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:23 pm -
1 stop8h 21m
Sat 10/176:04 am -
1 stop6h 55m
Deal found 9/2![Delta logo]()
$880
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:02 pm -
1 stop17h 45m
Tue 10/207:29 pm -
1 stop17h 33m
Deal found 8/30![American Airlines logo]()
$662
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:02 pm -
1 stop10h 36m
Mon 10/267:29 pm -
1 stop17h 33m
Deal found 9/1![American Airlines logo]()
$613
This flugladen.de deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flugladen.de is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:10 pm -
1 stop30h 10m
Fri 10/3011:30 pm -
1 stop17h 45m
Deal found 8/30![Avianca logo]()
$563
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:02 pm -
1 stop10h 36m
Fri 10/305:05 am -
1 stop7h 57m
Deal found 8/30![American Airlines logo]()
$646
This Kissandfly.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:24 pm -
1 stop8h 09m
Fri 10/306:04 am -
1 stop6h 55m
Deal found 8/30![KLM logo]()
$902
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/31![Delta logo]()
$849
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:02 pm -
1 stop21h 08m
Thu 11/54:43 pm -
1 stop20h 30m
Deal found 8/31![American Airlines logo]()
$670
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:05 am -
1 stop11h 25m
Sat 11/710:30 pm -
1 stop15h 45m
Deal found 8/31![Avianca logo]()
$596
One-way flights from Panama to ChicagoSearch for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
Search for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:05 am -
Nonstop5h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Copa Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:13 pm -
1 stop10h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![American Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:35 pm -
3 stops35h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:35 pm -
3 stops35h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:35 pm -
3 stops35h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:24 am -
2 stops22h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:35 pm -
3 stops35h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:24 am -
2 stops22h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$378
This Trip.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:00 am -
1 stop13h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:34 am -
3 stops49h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$468
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:28 pm -
3 stops34h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:00 am -
1 stop13h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$498
Find flight deals from Panama to Chicago
Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated September 4, 2026.
Round-trip from | $553 (Avianca) |
|---|---|
One-way from | $335 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $738 |
Good round-trip deal | $843 or less |
Good one-way deal | $473 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Thu 11/12
8:05 am-12:46 pm
Nonstop5h 41m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$335
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Thu 11/12
3:13 pm-12:44 am
1 stop10h 31m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$340
Quickest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 10/26
7:28 pm-1:05 am
Nonstop5h 37m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$356
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Thu 10/15
10:00 am-11:43 pm
1 stop13h 43m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$416
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sat 9/12
9:45 pm-5:52 am
2 stops32h 07m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$430
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 10/26
2:02 pm-7:47 am
1 stop17h 45m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$449
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Thu 10/15
3:05 pm-11:00 am
1 stop19h 55m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$459
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Thu 9/10
10:00 am-11:44 pm
1 stop13h 44m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$487
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Thu 9/10
8:11 am-5:52 am
2 stops21h 41m
Chicago O'Hare Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$535
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Fri 10/9
12:03 pm-11:43 pm
2 stops35h 40m
Chicago Midway
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$551
Showing 1-10 of 42 resultsSorted by cheapest first
Best time to book a flight from Panama to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
PTY-ORD
PTY-MDW
PAC-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Chicago
PA0-CHI
PTY-ORD
PTY-MDW
PAC-ORD
What is the cheapest month to book a flight from Panama to Chicago?
Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $556). Flying from Panama to Chicago in July is currently the most expensive (average of $825). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to CHI?
Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 4, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.
Weekly flight availability from Panama to Chicago
Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 4, 2026.
The most flights from PA0 to CHI are scheduled on a Wednesday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How far ahead should I book a flight from Panama to Chicago?
The price you pay for your flight from Panama to Chicago may vary depending on when you book. For the best chance of a lower fare, look to book 46 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated September 4, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Food
6.9
Entertainment
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Crew
8.1
Food
6.9
Entertainment
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Chicago flight routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Alternative routes for Panama to Chicago
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to Chicago by cabin class
Find flights from Panama to Chicago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and Chicago flights
Browse other Panama and Chicago flight options. Last updated on September 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama to Chicago
Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$417 | Average$761 | FlexibilityNo cancel fee | On-time70% |