$316+ Cheap flights from Panama to Chicago (CHI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Sep 5 — Sep 121
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama to Chicago
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Cheapest flights from Panama to ChicagoExplore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
This Avianca deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:25 am -
1 stop16h 55m
Sun 9/611:20 pm -
1 stop14h 55m
Deal found 8/2![Avianca logo]()
$687
This Avianca deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:30 am -
1 stop10h 25m
Sat 9/511:20 pm -
1 stop14h 55m
Deal found 8/1![Avianca logo]()
$688
This Avianca deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/194:25 am -
1 stop16h 55m
Sun 8/2311:20 pm -
1 stop14h 55m
Deal found 8/4![Avianca logo]()
$708
This oojo deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:55 pm -
1 stop27h 25m
Fri 10/2311:20 pm -
1 stop14h 55m
Deal found 8/3![Avianca logo]()
$712
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
3 stops24h 22m
Sat 9/51:40 am -
3 stops24h 15m
Deal found 8/4![Multiple Airlines logo]()
$723
This Mytrip deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:55 pm -
3 stops35h 57m
Sat 9/51:40 am -
3 stops24h 15m
Deal found 8/5![Multiple Airlines logo]()
$727
This Mytrip deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:55 pm -
3 stops35h 57m
Sun 9/61:40 am -
3 stops24h 15m
Deal found 8/1![Multiple Airlines logo]()
$728
This Avianca deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:55 am -
1 stop18h 25m
Mon 12/1410:20 pm -
1 stop17h 35m
Deal found 8/5![Avianca logo]()
$729
This Avianca deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:55 pm -
1 stop27h 25m
Mon 9/711:20 pm -
1 stop25h 15m
Deal found 8/3![Avianca logo]()
$738
This Mytrip deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
3 stops24h 22m
Mon 9/71:40 am -
3 stops32h 50m
Deal found 8/2![Multiple Airlines logo]()
$740
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/4![Delta logo]()
$805
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/4![Delta logo]()
$807
Best flights from Panama to ChicagoDiscover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
Discover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:06 am -
Nonstop5h 40m
Mon 12/72:13 pm -
Nonstop5h 24m
Deal found 8/3![Copa Airlines logo]()
$799
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/4![Delta logo]()
$805
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:41 pm -
1 stop17h 44m
Thu 12/3110:30 am -
1 stop8h 32m
Deal found 8/1![United Airlines logo]()
$805
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/189:33 pm -
2 stops14h 34m
Thu 10/2212:03 pm -
1 stop8h 28m
Deal found 8/5![Multiple Airlines logo]()
$859
This Copa Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:20 pm -
Nonstop5h 37m
Mon 10/128:01 am -
Nonstop5h 21m
Deal found 8/1![Copa Airlines logo]()
$801
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
1 stop15h 10m
Sat 1/26:00 am -
1 stop13h 00m
Deal found 8/2![Delta logo]()
$805
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:30 pm -
1 stop16h 25m
Mon 10/125:00 am -
1 stop14h 31m
Deal found 8/4![United Airlines logo]()
$807
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:30 pm -
1 stop8h 26m
Mon 12/76:00 am -
1 stop7h 05m
Deal found 8/3![Delta logo]()
$805
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:30 pm -
1 stop19h 46m
Thu 10/156:29 pm -
1 stop19h 45m
Deal found 8/3![United Airlines logo]()
$807
This Copa Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/218:08 am -
Nonstop5h 38m
Wed 2/107:35 am -
Nonstop5h 24m
Deal found 8/3![Copa Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:00 am -
2 stops13h 24m
Tue 1/55:30 am -
1 stop7h 25m
Deal found 8/2![Delta logo]()
$805
This Copa Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:05 am -
Nonstop5h 41m
Thu 11/57:35 am -
Nonstop5h 26m
Deal found 8/4![Copa Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:30 pm -
2 stops17h 16m
Thu 12/317:10 am -
1 stop11h 50m
Deal found 8/1![Delta logo]()
$805
This Copa Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:20 pm -
Nonstop5h 37m
Sat 10/178:01 am -
Nonstop5h 21m
Deal found 8/5![Copa Airlines logo]()
$822
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:24 pm -
1 stop8h 09m
Tue 10/206:04 am -
1 stop6h 55m
Deal found 8/1![Delta logo]()
$807
This Copa Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:20 pm -
Nonstop5h 37m
Sat 10/173:20 pm -
Nonstop5h 21m
Deal found 8/4![Copa Airlines logo]()
$822
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/1![Delta logo]()
$807
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:24 pm -
1 stop8h 09m
Mon 10/126:04 am -
1 stop6h 55m
Deal found 8/5![Delta logo]()
$828
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:24 pm -
1 stop8h 09m
Sat 11/76:04 am -
1 stop6h 55m
Deal found 8/5![Delta logo]()
$828
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:23 pm -
1 stop8h 21m
Fri 9/186:05 am -
1 stop6h 53m
Deal found 8/2![Delta logo]()
$856
Last-minute flights from Panama to ChicagoDiscover last-minute flight deals from Panama to Chicago. Data last updated August 6, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Chicago. Data last updated August 6, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/194:25 am -
1 stop16h 55m
Sun 8/2311:20 pm -
1 stop14h 55m
Deal found 8/4![Avianca logo]()
$708
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:20 pm -
1 stop8h 16m
Sat 8/296:11 am -
1 stop6h 54m
Deal found 8/4![Delta logo]()
$873
This Avianca deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:30 am -
1 stop10h 25m
Sat 9/511:20 pm -
1 stop14h 55m
Deal found 8/1![Avianca logo]()
$688
This Mytrip deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:30 am -
3 stops24h 22m
Fri 9/41:40 am -
3 stops32h 50m
Deal found 8/1![Multiple Airlines logo]()
$750
This Mytrip deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:55 pm -
3 stops35h 57m
Sat 9/51:40 am -
3 stops24h 15m
Deal found 8/5![Multiple Airlines logo]()
$727
This Avianca deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:25 am -
1 stop16h 55m
Sun 9/611:20 pm -
1 stop14h 55m
Deal found 8/2![Avianca logo]()
$687
This Mytrip deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
3 stops24h 22m
Sat 9/51:40 am -
3 stops24h 15m
Deal found 8/4![Multiple Airlines logo]()
$723
This Mytrip deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
3 stops24h 22m
Mon 9/71:40 am -
3 stops32h 50m
Deal found 8/2![Multiple Airlines logo]()
$740
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/12:20 pm -
1 stop8h 16m
Sun 9/66:05 am -
1 stop6h 50m
Deal found 8/4![Delta logo]()
$859
This Mytrip deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:55 pm -
3 stops35h 57m
Sun 9/61:40 am -
3 stops24h 15m
Deal found 8/1![Multiple Airlines logo]()
$728
This Avianca deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:55 pm -
1 stop27h 25m
Mon 9/711:20 pm -
1 stop25h 15m
Deal found 8/3![Avianca logo]()
$738
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:23 pm -
1 stop8h 21m
Fri 9/186:05 am -
1 stop6h 53m
Deal found 8/3![Delta logo]()
$838
One-way flights from Panama to ChicagoSearch for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
Search for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:25 am -
3 stops25h 27m
Deal found 8/3![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:45 pm -
2 stops32h 07m
Deal found 8/3![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:25 am -
2 stops19h 27m
Deal found 8/5![Multiple Airlines logo]()
$369
This Mytrip deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:30 am -
3 stops24h 22m
Deal found 8/3![Multiple Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:25 am -
2 stops19h 27m
Deal found 8/5![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:11 am -
2 stops21h 41m
Deal found 8/4![Multiple Airlines logo]()
$381
This Mytrip deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:25 am -
2 stops24h 43m
Deal found 8/5![Multiple Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:25 am -
2 stops24h 33m
Deal found 8/4![Multiple Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:33 pm -
2 stops44h 18m
Deal found 8/5![Multiple Airlines logo]()
$478
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:03 pm -
2 stops34h 44m
Deal found 8/3![Multiple Airlines logo]()
$498
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:25 am -
2 stops12h 22m
Deal found 8/5![Multiple Airlines logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2810:00 am -
1 stop22h 01m
Deal found 8/1![Multiple Airlines logo]()
$550
Find flight deals from Panama to Chicago
Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated August 6, 2026.
Round-trip from | $687 (Avianca) |
|---|---|
One-way from | $316 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $709 |
Good round-trip deal | $810 or less |
Good one-way deal | $721 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Wed 12/2
8:06 am-12:46 pm
Nonstop5h 40m
Chicago O'Hare Intl
Mon 12/7
2:13 pm-8:37 pm
Nonstop5h 24m
$799
Quickest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/9
7:20 pm-12:57 am
Nonstop5h 37m
Chicago O'Hare Intl
Mon 10/12
8:01 am-1:22 pm
Nonstop5h 21m
$801
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Tue 11/3
3:24 pm-10:33 pm
1 stop8h 09m
Chicago Midway
Thu 11/5
6:04 am-1:59 pm
1 stop6h 55m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Tue 12/1
4:41 pm-9:25 am
1 stop17h 44m
Chicago O'Hare Intl
Thu 12/31
10:30 am-8:02 pm
1 stop8h 32m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Wed 12/23
8:00 am-10:10 pm
1 stop15h 10m
Chicago Midway
Sat 1/2
6:00 am-8:00 pm
1 stop13h 00m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Wed 12/2
3:30 pm-10:56 pm
1 stop8h 26m
Chicago Midway
Mon 12/7
6:00 am-2:05 pm
1 stop7h 05m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 12/21
8:00 am-8:24 pm
2 stops13h 24m
Chicago O'Hare Intl
Tue 1/5
5:30 am-1:55 pm
1 stop7h 25m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Tue 12/1
3:30 pm-7:46 am
2 stops17h 16m
Chicago O'Hare Intl
Thu 12/31
7:10 am-8:00 pm
1 stop11h 50m
$805
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/9
3:30 pm-7:55 am
1 stop16h 25m
Chicago O'Hare Intl
Mon 10/12
5:00 am-7:31 pm
1 stop14h 31m
$807
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/9
3:30 pm-11:16 am
1 stop19h 46m
Chicago O'Hare Intl
Thu 10/15
6:29 pm-2:14 pm
1 stop19h 45m
$807
Showing 1-10 of 50 resultsSorted by cheapest first
Best time to book a flight from Panama to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
PTY-ORD
PTY-MDW
PAC-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Chicago
PA0-CHI
PTY-ORD
PTY-MDW
PAC-ORD
What is the cheapest month to book a flight from Panama to Chicago?
Currently, November is the cheapest month in which you can book a flight from Panama to Chicago (average of $550). Flying from Panama to Chicago in July is currently the most expensive (average of $825). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to CHI?
Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 6, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.
How far ahead should I book a flight from Panama to Chicago?
The price you pay for your flight from Panama to Chicago may vary depending on when you book. For the best chance of a lower fare, look to book 49 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated August 6, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Comfort
7.4
Entertainment
6.8
Food
6.9
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Comfort
7.4
Entertainment
6.8
Food
6.9
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Chicago flight routes
Complete your trip
Flights by cabin class
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Popular flights
Alternative routes for Panama to Chicago
See prices for flight routes from nearby airports that may be better suited for you.
Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 6, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to Chicago by cabin class
Find flights from Panama to Chicago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and Chicago flights
Browse other Panama and Chicago flight options. Last updated on August 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama to Chicago
Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$417 | Average$733 | FlexibilityNo cancel fee | On-time70% |