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$282+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Jan 31 — Feb 71
Sat 1/31
Sat 2/7
1 adult, Economy
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Cheap flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 1, 2026.

This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3011:55 pmPTY - ORD
1 stop10h 15mUnited Airlines
Thu 1/297:50 pmORD - PTY
1 stop20h 17mUnited Airlines
Deal found 12/30$757
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:55 pmPTY - ORD
2 stops17h 26mAmerican Airlines
Thu 1/295:00 amORD - PTY
1 stop9h 38mAmerican Airlines
Deal found 12/30$1,008
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3011:55 pmPTY - ORD
1 stop10h 59mUnited Airlines
Fri 1/99:05 pmORD - PTY
1 stop16h 40mUnited Airlines
Deal found 12/30$1,048
This Air Canada deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:40 pmPTY - ORD
2 stops26h 30mMultiple Airlines
Fri 1/912:50 pmORD - PTY
2 stops18h 24mMultiple Airlines
Deal found 12/30$1,367
This Copa Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Thu 1/297:35 amORD - PTY
Nonstop5h 25mCopa Airlines
Deal found 12/30$1,540

Find flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated January 1, 2026.

Round-trip from

$392
(Mytrip)

One-way from

$282
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$497

Good round-trip deal

$633 or less

Good one-way deal

$552 or less
From Panama to Chicago (CHI)
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One-way flight from Panama to Chicago (CHI)
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Price to beat on a round-trip flight from Panama to Chicago (CHI).
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Price to beat on a one-way flight from Panama to Chicago (CHI).
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 1, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 1/29

2:55 am-9:03 pm

2 stops19h 08m

Chicago O'Hare Intl

Fri 2/6

5:15 am-12:40 am

2 stops18h 25m

$451

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 2/12

5:50 pm-11:03 pm

2 stops30h 13m

Chicago O'Hare Intl

Tue 2/17

9:18 am-8:40 am

1 stop22h 22m

$473

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 1/29

10:25 am-6:16 pm

1 stop8h 51m

Chicago O'Hare Intl

Thu 2/5

6:57 pm-8:50 am

2 stops12h 53m

$565

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 1/26

6:34 pm-8:18 am

1 stop14h 44m

Chicago O'Hare Intl

Mon 2/2

9:23 am-7:20 pm

1 stop8h 57m

$569

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 5/8

3:25 am-1:15 pm

1 stop9h 50m

Chicago O'Hare Intl

Fri 5/29

2:35 pm-12:45 am

1 stop10h 10m

$571

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 1/22

11:25 am-6:16 pm

3 stops31h 51m

Chicago O'Hare Intl

Sun 1/25

9:23 am-8:50 am

3 stops46h 27m

$576

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 1/20

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Sat 1/24

10:20 pm-8:50 am

1 stop9h 30m

$577

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 1/25

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Sat 5/16

2:35 pm-12:10 am

1 stop9h 35m

$579

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 1/29

10:26 am-10:19 pm

1 stop12h 53m

Chicago Midway

Thu 2/5

6:20 am-8:34 pm

1 stop13h 14m

$640

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Thu 2/12

10:26 am-10:34 pm

1 stop13h 08m

Chicago Midway

Tue 2/17

6:00 am-8:34 pm

1 stop13h 34m

$645

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/30

Showing 1-10 of 29 results
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 1, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated January 1, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,566 reviews

Food

6.8

Overall

7.6

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.6
Good
1,566 reviews
Copa Airlines
7.6
Good
1,566 reviews

Food

6.8

Overall

7.6

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Panama to Chicago one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $234. Copa Airlines flights start at $255 while deals on United Airlines start at $444 one-way.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing EVA Air (93%), Copa Airlines (90%) or United Airlines (90%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $316. On average you can expect to pay $651. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $392.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, October is the cheapest month in which you can book a flight from Panama to Chicago (average of $239). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Lansing
Merrillville
Hammond
Porter
Benton Harbor

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Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
San José to O'Hare Intl flights
Guatemala City to O'Hare Intl flights
Panama City to O'Hare Intl flights
San José to Midway flights
Guatemala City to Midway flights
San Salvador to O'Hare Intl flights
San Pedro Sula to O'Hare Intl flights
San José to St. Louis flights
San Pedro Sula to Midway flights
Philip S.W.Goldson to O'Hare Intl flights
Guatemala City to St. Louis flights
Liberia to O'Hare Intl flights
Managua to O'Hare Intl flights
Philip S.W.Goldson to Midway flights
Panama City to St. Louis flights
San Pedro Sula to St. Louis flights
Coxen Hole to O'Hare Intl flights
Managua to Midway flights
Managua to St. Louis flights
Tegucigalpa to St. Louis flights
Tegucigalpa to O'Hare Intl flights
Tegucigalpa to Midway flights

Top 2 airlines flying from Panama to Chicago

Discover the top 2 airlines that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$405Average$608FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$423Average$485FlexibilityNo cancel feeOn-time69%

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