$391+ Cheap flights from Panama to Chicago (CHI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Panama to ChicagoExplore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This Avianca deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:55 am -
1 stop18h 25m
Sat 11/710:20 pm -
1 stop14h 40m
Deal found 8/17![Avianca logo]()
$419
This Expedia deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:45 am -
1 stop11h 35m
Sun 11/810:20 pm -
1 stop9h 30m
Deal found 8/19![Avianca logo]()
$456
This Avianca deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:25 am -
1 stop16h 55m
Thu 11/510:20 pm -
1 stop9h 30m
Deal found 8/17![Avianca logo]()
$553
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:55 pm -
1 stop30h 25m
Thu 11/1910:20 pm -
1 stop25h 20m
Deal found 8/18![Avianca logo]()
$579
This Avianca deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:55 pm -
1 stop30h 25m
Tue 11/1710:20 pm -
1 stop17h 35m
Deal found 8/18![Avianca logo]()
$604
This Faresmojo deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:45 am -
1 stop11h 35m
Sat 12/510:20 pm -
1 stop9h 30m
Deal found 8/17![Avianca logo]()
$681
This Avianca deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:55 am -
1 stop18h 25m
Thu 11/2610:20 pm -
1 stop9h 30m
Deal found 8/17![Avianca logo]()
$687
This Avianca deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:25 am -
1 stop16h 55m
Sat 9/2611:20 pm -
1 stop9h 55m
Deal found 8/16![Avianca logo]()
$708
This Expedia deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:10 am -
2 stops37h 34m
Wed 10/2811:20 pm -
1 stop14h 40m
Deal found 8/17![Multiple Airlines logo]()
$714
This Faresmojo deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:24 pm -
1 stop9h 28m
Thu 10/155:27 am -
1 stop7h 32m
Deal found 8/16![JetBlue logo]()
$725
This Avianca deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:10 am -
1 stop11h 10m
Fri 9/1811:20 pm -
1 stop9h 55m
Deal found 8/18![Avianca logo]()
$729
This Faresmojo deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:23 pm -
1 stop8h 21m
Sat 10/176:04 am -
1 stop6h 55m
Deal found 8/17![JetBlue logo]()
$750
Best flights from Panama to ChicagoDiscover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from Panama to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:28 pm -
Nonstop5h 43m
Wed 2/177:35 am -
Nonstop5h 24m
Deal found 8/20![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:30 pm -
1 stop8h 26m
Thu 12/106:00 am -
1 stop7h 05m
Deal found 8/17![Delta logo]()
$847
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/284:41 pm -
1 stop10h 54m
Fri 12/45:00 am -
1 stop14h 02m
Deal found 8/19![United Airlines logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:28 pm -
Nonstop5h 43m
Wed 12/22:13 pm -
Nonstop5h 24m
Deal found 8/16![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:30 pm -
1 stop8h 26m
Sun 11/296:00 am -
1 stop7h 05m
Deal found 8/18![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:28 pm -
Nonstop5h 43m
Sat 12/57:35 am -
Nonstop5h 25m
Deal found 8/20![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:00 am -
1 stop9h 25m
Sat 1/96:00 am -
1 stop6h 55m
Deal found 8/16![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/87:28 pm -
Nonstop5h 43m
Mon 2/157:35 am -
Nonstop5h 24m
Deal found 8/19![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/263:25 pm -
1 stop7h 45m
Wed 12/3010:35 am -
1 stop8h 25m
Deal found 8/20![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/288:05 am -
Nonstop5h 41m
Fri 12/42:13 pm -
Nonstop5h 24m
Deal found 8/19![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:30 pm -
1 stop8h 26m
Wed 12/96:00 am -
1 stop7h 05m
Deal found 8/20![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:05 am -
Nonstop5h 41m
Thu 11/267:35 am -
Nonstop5h 26m
Deal found 8/20![Copa Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/93:20 pm -
1 stop7h 50m
Wed 2/176:00 am -
1 stop6h 55m
Deal found 8/17![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:20 pm -
Nonstop5h 37m
Thu 10/158:01 am -
Nonstop5h 21m
Deal found 8/16![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:30 pm -
1 stop8h 26m
Thu 11/266:00 am -
1 stop7h 05m
Deal found 8/18![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:57 am -
Nonstop5h 49m
Sat 11/72:13 pm -
Nonstop5h 24m
Deal found 8/20![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
2 stops13h 24m
Sat 1/25:30 am -
1 stop13h 30m
Deal found 8/17![Delta logo]()
$847
This Copa Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:10 am -
Nonstop5h 49m
Fri 11/137:35 am -
Nonstop5h 26m
Deal found 8/18![Copa Airlines logo]()
$844
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 am -
2 stops13h 24m
Sun 1/35:30 am -
1 stop7h 30m
Deal found 8/16![Delta logo]()
$847
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:24 pm -
1 stop8h 09m
Thu 11/56:04 am -
1 stop6h 55m
Deal found 8/20![Delta logo]()
$849
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:24 pm -
1 stop8h 09m
Mon 10/126:04 am -
1 stop6h 55m
Deal found 8/16![Delta logo]()
$849
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/163:20 pm -
1 stop7h 50m
Tue 2/236:00 am -
1 stop6h 55m
Deal found 8/20![Delta logo]()
$864
Last-minute flights from Panama to ChicagoDiscover last-minute flight deals from Panama to Chicago. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to Chicago. Data last updated August 21, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:55 pm -
3 stops35h 57m
Tue 9/81:40 am -
3 stops22h 55m
Deal found 8/16![Multiple Airlines logo]()
$773
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:30 pm -
1 stop8h 06m
Fri 9/116:05 am -
1 stop6h 53m
Deal found 8/18![Delta logo]()
$958
This Mytrip deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:55 pm -
3 stops35h 57m
Sat 9/261:40 am -
3 stops24h 15m
Deal found 8/17![Multiple Airlines logo]()
$780
This Faresmojo deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/82:23 pm -
1 stop9h 36m
Wed 9/165:30 am -
1 stop7h 28m
Deal found 8/17![JetBlue logo]()
$779
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:23 pm -
1 stop8h 21m
Fri 9/186:05 am -
1 stop6h 53m
Deal found 8/18![Delta logo]()
$916
This Avianca deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:10 am -
1 stop11h 10m
Fri 9/1811:20 pm -
1 stop9h 55m
Deal found 8/18![Avianca logo]()
$729
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:12 pm -
1 stop12h 48m
Tue 9/227:35 am -
1 stop10h 19m
Deal found 8/16![Multiple Airlines logo]()
$766
This Avianca deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:25 am -
1 stop16h 55m
Sat 9/2611:20 pm -
1 stop9h 55m
Deal found 8/16![Avianca logo]()
$708
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:55 pm -
1 stop14h 57m
Tue 9/221:40 am -
1 stop12h 20m
Deal found 8/19![Multiple Airlines logo]()
$746
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:23 pm -
1 stop8h 21m
Sat 9/266:05 am -
1 stop6h 53m
Deal found 8/19![Delta logo]()
$880
This Mytrip deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:30 am -
3 stops24h 22m
Sat 9/261:40 am -
3 stops24h 15m
Deal found 8/19![Multiple Airlines logo]()
$782
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:12 pm -
1 stop10h 40m
Sat 10/37:35 am -
1 stop10h 19m
Deal found 8/16![Multiple Airlines logo]()
$778
One-way flights from Panama to ChicagoSearch for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
Search for one-way flight options from Panama to Chicago. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:45 pm -
2 stops32h 07m
Deal found 8/19![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:31 pm -
2 stops14h 31m
Deal found 8/18![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:25 am -
2 stops19h 18m
Deal found 8/16![Multiple Airlines logo]()
$409
This Mytrip deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 am -
3 stops24h 22m
Deal found 8/20![Multiple Airlines logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:31 pm -
2 stops16h 20m
Deal found 8/18![Multiple Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:24 am -
2 stops22h 28m
Deal found 8/20![Multiple Airlines logo]()
$426
This Mytrip deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:55 am -
3 stops26h 48m
Deal found 8/18![Multiple Airlines logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:03 pm -
1 stop27h 34m
Deal found 8/19![Multiple Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:30 pm -
2 stops23h 17m
Deal found 8/18![Multiple Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:25 am -
2 stops13h 22m
Deal found 8/19![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:00 am -
3 stops35h 47m
Deal found 8/18![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:45 pm -
3 stops45h 19m
Deal found 8/19![Multiple Airlines logo]()
$543
Find flight deals from Panama to Chicago
Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated August 21, 2026.
Round-trip from | $419 (Avianca) |
|---|---|
One-way from | $391 (Kiwi.com) |
Popular in | July |
Cheapest in | November |
Average price | $774 |
Good round-trip deal | $810 or less |
Good one-way deal | $473 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 2/1
7:28 pm-12:11 am
Nonstop5h 43m
Chicago O'Hare Intl
Wed 2/17
7:35 am-1:59 pm
Nonstop5h 24m
$842
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Wed 11/25
7:28 pm-12:11 am
Nonstop5h 43m
Chicago O'Hare Intl
Wed 12/2
2:13 pm-8:37 pm
Nonstop5h 24m
$842
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sun 11/22
7:28 pm-12:11 am
Nonstop5h 43m
Chicago O'Hare Intl
Sat 12/5
7:35 am-2:00 pm
Nonstop5h 25m
$842
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Mon 2/8
7:28 pm-12:11 am
Nonstop5h 43m
Chicago O'Hare Intl
Mon 2/15
7:35 am-1:59 pm
Nonstop5h 24m
$842
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sat 11/28
8:05 am-12:46 pm
Nonstop5h 41m
Chicago O'Hare Intl
Fri 12/4
2:13 pm-8:37 pm
Nonstop5h 24m
$842
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sat 11/21
8:05 am-12:46 pm
Nonstop5h 41m
Chicago O'Hare Intl
Thu 11/26
7:35 am-2:01 pm
Nonstop5h 26m
$842
Quickest round-trip
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/9
7:20 pm-12:57 am
Nonstop5h 37m
Chicago O'Hare Intl
Thu 10/15
8:01 am-1:22 pm
Nonstop5h 21m
$844
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Sat 10/31
7:57 am-1:46 pm
Nonstop5h 49m
Chicago O'Hare Intl
Sat 11/7
2:13 pm-8:37 pm
Nonstop5h 24m
$844
Panama CityChicago
PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl
PTYORD
Panama City Tocumen Intl
Fri 10/23
8:10 am-1:59 pm
Nonstop5h 49m
Chicago O'Hare Intl
Fri 11/13
7:35 am-2:01 pm
Nonstop5h 26m
$844
Panama CityChicago
PTY Panama City Tocumen Intl - MDW Chicago Midway
PTYMDW
Panama City Tocumen Intl
Mon 11/23
3:30 pm-10:56 pm
1 stop8h 26m
Chicago Midway
Thu 12/10
6:00 am-2:05 pm
1 stop7h 05m
$847
Showing 1-10 of 48 resultsSorted by cheapest first
Best time to book a flight from Panama to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
PTY-ORD
PTY-MDW
PAC-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to Chicago
PA0-CHI
PTY-ORD
PTY-MDW
PAC-ORD
What is the cheapest month to book a flight from Panama to Chicago?
Currently, November is the cheapest month in which you can book a flight from Panama to Chicago (average of $544). Flying from Panama to Chicago in August is currently the most expensive (average of $830). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PA to CHI?
Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 21, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Chicago as you normally would.
Weekly flight availability from Panama to Chicago
Explore weekly flight availability from Panama to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 21, 2026.
The most flights from PA0 to CHI are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (2 on average).
How far ahead should I book a flight from Panama to Chicago?
The price you pay for your flight from Panama to Chicago may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated August 21, 2026.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.4
Food
6.9
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Comfort
7.4
Food
6.9
Entertainment
6.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
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Alternative routes for Panama to Chicago
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Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 21, 2026.
Complete your trip
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Panama and Chicago flights
Browse other Panama and Chicago flight options. Last updated on August 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama to Chicago
Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$417 | Average$757 | FlexibilityNo cancel fee | On-time70% |