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$290+ Cheap flights from Panama to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHI
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Panama to Chicago

Cheapest flights from Panama to Chicago
Explore the most affordable flight options available from Panama to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Sat 1/1711:51 pmORD - PTY
Nonstop5h 22mCopa Airlines
Deal found 10/29$418
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:37 pmPTY - MDW
1 stop9h 03mDelta
Mon 12/86:00 amMDW - PTY
1 stop7h 21mDelta
Deal found 10/30$424
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amPTY - ORD
1 stop8h 13mDelta
Fri 1/27:00 amORD - PTY
2 stops12h 00mDelta
Deal found 10/30$424
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:43 pmPTY - ORD
1 stop21h 24mAmerican Airlines
Sun 12/74:45 pmORD - PTY
1 stop20h 02mAmerican Airlines
Deal found 10/29$432
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/64:43 pmPTY - ORD
1 stop8h 54mAmerican Airlines
Wed 12/105:00 amORD - PTY
1 stop9h 42mAmerican Airlines
Deal found 10/29$433
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:20 pmPTY - ORD
Nonstop5h 45mCopa Airlines
Sun 11/306:56 amORD - PTY
Nonstop5h 26mCopa Airlines
Deal found 10/29$434
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:43 pmPTY - ORD
1 stop10h 54mAmerican Airlines
Wed 12/34:45 pmORD - PTY
1 stop20h 02mAmerican Airlines
Deal found 10/29$440
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/64:43 pmPTY - ORD
2 stops15h 57mAmerican Airlines
Sat 1/249:10 pmORD - PTY
2 stops15h 17mAmerican Airlines
Deal found 10/29$444
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:43 pmPTY - ORD
1 stop19h 22mAmerican Airlines
Sun 11/307:17 pmORD - PTY
1 stop17h 26mAmerican Airlines
Deal found 10/29$449
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:50 amPTY - ORD
Nonstop5h 56mCopa Airlines
Sun 12/77:33 amORD - PTY
Nonstop5h 27mCopa Airlines
Deal found 10/29$450
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2311:25 amPTY - ORD
2 stops12h 48mMultiple Airlines
Sun 11/3010:20 pmORD - PTY
1 stop17h 35mMultiple Airlines
Deal found 10/29$480
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:43 pmPTY - ORD
1 stop10h 54mAmerican Airlines
Mon 11/245:00 amORD - PTY
1 stop7h 43mAmerican Airlines
Deal found 10/29$494

Cheap flight deals from Panama to Chicago

Keep the following information in mind while searching for Panama to Chicago flight deals. Data was last updated October 30, 2025.

Round-trip from

$418
(Copa Airlines)

One-way from

$290
(Mytrip)

Popular in

March

Cheapest in

July

Average price

$561

Good round-trip deal

$436 or less

Good one-way deal

$574 or less
From Panama to Chicago (CHI)
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One-way flight from Panama to Chicago (CHI)
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama to Chicago (CHI).
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Price to beat on a one-way flight from Panama to Chicago (CHI).
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Panama

Fly to

Chicago

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 11/14

7:20 pm-12:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Sat 11/15

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 12/22

7:56 am-12:52 pm

Nonstop5h 56m

Chicago O'Hare Intl

Mon 12/29

11:51 pm-6:13 am

Nonstop5h 22m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 12/20

7:20 pm-12:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Sun 1/11

2:13 pm-8:35 pm

Nonstop5h 22m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 1/14

8:10 am-12:46 pm

Nonstop5h 36m

Chicago O'Hare Intl

Sun 1/25

2:13 pm-8:35 pm

Nonstop5h 22m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 12/20

5:37 pm-10:21 pm

Nonstop5h 44m

Chicago O'Hare Intl

Mon 1/5

2:13 pm-8:35 pm

Nonstop5h 22m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 11/20

7:50 am-12:46 pm

Nonstop5h 56m

Chicago O'Hare Intl

Mon 11/24

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 11/27

7:50 am-12:46 pm

Nonstop5h 56m

Chicago O'Hare Intl

Mon 12/8

7:33 am-2:00 pm

Nonstop5h 27m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 11/26

7:50 am-12:46 pm

Nonstop5h 56m

Chicago O'Hare Intl

Wed 12/3

2:07 pm-8:35 pm

Nonstop5h 28m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 12/27

7:20 pm-12:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Sat 1/10

2:13 pm-8:35 pm

Nonstop5h 22m

$418

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 12/20

7:20 pm-12:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Sat 1/17

11:51 pm-6:13 am

Nonstop5h 22m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 30 results
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Best time to book a flight from Panama to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Chicago

What is the cheapest month to book a flight from Panama to Chicago?

Currently, March is the cheapest month in which you can book a flight from Panama to Chicago (average of $242). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to CHI?

Find hourly flight availability from Panama to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 11% on flights from Panama to Chicago by exploring options for tickets in the evening.

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Panama to Chicago, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Food

6.9

Entertainment

6.8

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Food

6.9

Entertainment

6.8

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Food

6.9

Entertainment

6.8

Boarding

7.8

Overall

7.6

Crew

8.1

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Chicago?

    There are many flights that can get you from Panama to Chicago in 5h 45m. Fly via Copa Airlines or Delta to get the fastest option. Panama and Chicago are separated by a distance of 2330 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama to Chicago?

    The most popular flight routes from Panama to Chicago are Panama City Tocumen Intl - Chicago O'Hare Intl, Panama City Tocumen Intl - Chicago Midway and Panama City Marcos A. Gelabert Intl - Chicago O'Hare Intl.

  • What are the most reliable airlines from Panama to Chicago?

    No one likes to see their flight delayed. When booking a flight from Panama to Chicago consider choosing Copa Airlines (93%), EVA Air (90%) or United Airlines (89%) as they are the most reliable in getting you off to your destination on time.

  • What are the cheapest flights from Panama to Chicago?

    The cheapest flight price from Panama to Chicago is $417. On average you can expect to pay $782. The most popular route, (Panama City Tocumen Intl - Chicago O'Hare Intl), can usually be booked for $418.

  • Can I find deals for flights from Panama to Chicago that include hotel bookings?

    Yes. In addition to deals on Panama to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Chicago.

  • Can I find deals for business class flights from Panama to Chicago?

    Yes. Cheapflights offers flight deals from Panama to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Chicago?

    Currently, March is the cheapest month in which you can book a flight from Panama to Chicago (average of $242). Flying from Panama to Chicago in April is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
Lansing
Hammond
Porter
Benton Harbor

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Alternative routes for Panama to Chicago

See prices for flight routes from nearby airports that may be better suited for you.
Guatemala City to O'Hare Intl flights
San José to O'Hare Intl flights
Panama City to O'Hare Intl flights
San José to Midway flights
Guatemala City to Midway flights
San Salvador to O'Hare Intl flights
San Pedro Sula to O'Hare Intl flights
San José to St. Louis flights
Philip S.W.Goldson to O'Hare Intl flights
San Pedro Sula to Midway flights
San Pedro Sula to St. Louis flights
Managua to O'Hare Intl flights
Philip S.W.Goldson to Midway flights
Guatemala City to St. Louis flights
Panama City to St. Louis flights
Managua to Midway flights
Liberia to O'Hare Intl flights
Tegucigalpa to O'Hare Intl flights
Managua to St. Louis flights
Tegucigalpa to St. Louis flights
Coxen Hole to O'Hare Intl flights
Tegucigalpa to Midway flights

Top airline flying from Panama to Chicago

Discover the top airline that operate flights from Panama to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$415Average$583FlexibilityNo cancel feeOn-time70%

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