$119+ Cheap flights from St. Louis to Charleston (STL - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 21 — Apr 281
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Charleston are usually found in August or November, booked 52 days in advance, depart on a Sunday or Monday and return on a Thursday
Cheap flight deals from St. Louis to Charleston
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to CharlestonExplore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
Explore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:55 pm
STL
- CHS
1 stop4h 10m
Southwest
Tue 5/123:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/18![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1212:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 5/164:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/18![Southwest logo]()
$228
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:30 pm
STL
- CHS
1 stop4h 30m
Southwest
Wed 5/137:15 am
CHS
- STL
1 stop5h 15m
Southwest
Deal found 3/18![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 4/1812:40 pm
CHS
- STL
1 stop7h 55m
Southwest
Deal found 3/17![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 5/112:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 3/20![Southwest logo]()
$239
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Thu 4/162:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 3/18![Southwest logo]()
$245
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 am
STL
- CHS
2 stops7h 23m
United Airlines
Tue 4/142:58 pm
CHS
- STL
2 stops7h 15m
United Airlines
Deal found 3/17![United Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Sat 4/187:35 am
CHS
- STL
1 stop7h 45m
Southwest
Deal found 3/18![Southwest logo]()
$248
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:43 pm
STL
- CHS
1 stop6h 37m
American Airlines
Tue 4/144:25 pm
CHS
- STL
1 stop4h 05m
American Airlines
Deal found 3/17![American Airlines logo]()
$251
Best flights from St. Louis to CharlestonDiscover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
Discover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 4/188:00 am
CHS
- STL
1 stop7h 00m
Southwest
Deal found 3/19![Southwest logo]()
$238
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:15 pm
STL
- CHS
1 stop4h 41m
Delta
Sat 6/65:15 am
CHS
- STL
1 stop4h 04m
Delta
Deal found 3/18![Delta logo]()
$331
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Wed 5/139:40 am
CHS
- STL
1 stop7h 59m
United Airlines
Deal found 3/19![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:45 pm
STL
- CHS
1 stop6h 05m
Southwest
Wed 6/101:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 3/18![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Thu 4/166:00 am
CHS
- STL
2 stops7h 50m
Southwest
Deal found 3/18![Southwest logo]()
$260
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:35 am
STL
- CHS
1 stop9h 45m
Southwest
Mon 6/17:00 pm
CHS
- STL
1 stop5h 25m
Southwest
Deal found 3/20![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Tue 4/143:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/17![Southwest logo]()
$334
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1112:40 pm
STL
- CHS
1 stop9h 10m
Southwest
Wed 6/174:15 pm
CHS
- STL
1 stop6h 45m
Southwest
Deal found 3/19![Southwest logo]()
$342
Last-minute flights from St. Louis to CharlestonDiscover last-minute flight deals from St. Louis to Charleston. Data last updated March 22, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Charleston. Data last updated March 22, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 am
STL
- CHS
2 stops7h 23m
United Airlines
Tue 4/145:00 pm
CHS
- STL
1 stop5h 13m
United Airlines
Deal found 3/17![United Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:43 pm
STL
- CHS
1 stop6h 37m
American Airlines
Tue 4/144:25 pm
CHS
- STL
1 stop4h 05m
American Airlines
Deal found 3/17![American Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 4/162:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 3/18![Southwest logo]()
$239
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 4/1812:40 pm
CHS
- STL
1 stop7h 55m
Southwest
Deal found 3/17![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:10 am
STL
- CHS
2 stops8h 49m
United Airlines
Sat 4/185:00 pm
CHS
- STL
1 stop5h 13m
United Airlines
Deal found 3/17![United Airlines logo]()
$253
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Sat 4/187:35 am
CHS
- STL
1 stop7h 45m
Southwest
Deal found 3/18![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 4/277:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 3/18![Southwest logo]()
$249
One-way flights from St. Louis to CharlestonSearch for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
Search for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:24 pm
STL
- CHS
1 stop5h 22m
American Airlines
Deal found 3/20![American Airlines logo]()
$119
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 3/19![Southwest logo]()
$120
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Deal found 3/20![Southwest logo]()
$125
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:30 am
STL
- CHS
1 stop6h 25m
United Airlines
Deal found 3/19![United Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
STL
- CHS
1 stop4h 20m
Delta
Deal found 3/19![Delta logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:21 pm
STL
- CHS
2 stops16h 17m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:23 pm
STL
- CHS
2 stops35h 20m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 pm
STL
- CHS
2 stops36h 53m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:33 pm
STL
- CHS
2 stops37h 05m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/184:19 pm
STL
- CHS
1 stop15h 19m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$146
Find flight deals from St. Louis to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (Southwest) |
One-way from | $119 (American Airlines) |
Popular in | May |
Cheapest in | August |
Average price | $430 |
Good round-trip deal | $393 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from St. Louis to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 4/14
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Sat 4/18
8:00 am-2:00 pm
1 stop7h 00m
$238
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Thu 6/4
3:45 pm-10:50 pm
1 stop6h 05m
Charleston
Wed 6/10
1:50 pm-3:00 pm
Nonstop2h 10m
$238
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 4/13
4:00 pm-9:30 pm
1 stop4h 30m
Charleston
Thu 4/16
6:00 am-12:50 pm
2 stops7h 50m
$260
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Thu 5/28
7:35 am-6:20 pm
1 stop9h 45m
Charleston
Mon 6/1
7:00 pm-11:25 pm
1 stop5h 25m
$314
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 6/1
5:15 pm-10:56 pm
1 stop4h 41m
Charleston
Sat 6/6
5:15 am-8:19 am
1 stop4h 04m
$331
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 4/8
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Tue 4/14
3:40 pm-5:00 pm
Nonstop2h 20m
$334
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Thu 6/11
12:40 pm-10:50 pm
1 stop9h 10m
Charleston
Wed 6/17
4:15 pm-10:00 pm
1 stop6h 45m
$342
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/12
7:45 am-1:51 pm
1 stop5h 06m
Charleston
Wed 5/13
9:40 am-4:39 pm
1 stop7h 59m
$347
Cheapest one-way
Quickest one-way
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 4/25
5:20 pm-8:15 pm
Nonstop1h 55m
$120
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 5/18
2:10 pm-5:05 pm
Nonstop1h 55m
$120
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Charleston in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from St. Louis with our price prediction graph.
STL-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Charleston
Prices
More
How far ahead should I book a flight from St. Louis to Charleston?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Charleston. Price data was last updated on March 13, 2026.
The price you pay for your flight from St. Louis to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 51 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from St. Louis to Charleston?
Currently, July is the cheapest month in which you can book a flight from St. Louis to Charleston (average of $89). Flying from St. Louis to Charleston in May is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to CHS?
Find hourly flight availability from St. Louis to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 22, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from St. Louis to Charleston as you normally would.
What’s the top layover airport for flights from St. Louis to Charleston?
Share of 1-stop round-trip flights from St. Louis to Charleston chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 33% of 1-stop itineraries from St. Louis to Charleston on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Charleston?
Average round-trip fare for 1-stop flights from St. Louis to Charleston, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $326.
What’s the fastest layover option from St. Louis to Charleston?
Shortest average travel time for 1-stop one-way flights from St. Louis to Charleston, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 3h 42m.
Which airport typically offers the quickest layover for flights from St. Louis to Charleston?
Average layover duration for 1-stop one-way flights from St. Louis to Charleston, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 0h 55m.
The best insider tips for St. Louis to Charleston flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your St. Louis to Charleston trip
Our travel experts
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated March 22, 2026.
Read through reviews of airlines operating flights from St. Louis to Charleston, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Walterboro
Summerville
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Top 3 airlines flying from St. Louis to Charleston
Discover the top 3 airlines that operate flights from St. Louis to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$345 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$374 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$403 | FlexibilityNo cancel fee | On-time63% |