$106+ Cheap flights from St. Louis to Charleston (STL - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
May 8 — May 151
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to Charleston are usually found in August or November, booked 51 days in advance, depart on a Tuesday or Monday and return on a Thursday
Cheap flight deals from St. Louis to Charleston
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to CharlestonExplore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
Explore the most affordable flight options available from St. Louis to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:59 pm
STL
- CHS
1 stop7h 03m
Delta
Sat 6/66:03 pm
CHS
- STL
1 stop4h 35m
Delta
Deal found 4/7![Delta logo]()
$201
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
STL
- CHS
1 stop7h 47m
Delta
Tue 5/196:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:35 am
STL
- CHS
2 stops7h 35m
Southwest
Sat 6/67:15 pm
CHS
- STL
1 stop5h 15m
Southwest
Deal found 4/7![Southwest logo]()
$216
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Wed 5/133:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/5![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 4/302:45 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/5![Southwest logo]()
$228
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:06 am
STL
- CHS
1 stop7h 31m
American Airlines
Tue 5/195:11 am
CHS
- STL
1 stop5h 14m
American Airlines
Deal found 4/4![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Mon 5/182:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/7![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 5/72:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/5![Southwest logo]()
$239
Best flights from St. Louis to CharlestonDiscover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
Discover carefully curated flight deals from St. Louis to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:20 pm
STL
- CHS
1 stop4h 36m
Delta
Sat 6/66:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:25 pm
STL
- CHS
1 stop3h 45m
Southwest
Tue 6/23:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/3![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/261:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
Tue 6/3011:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Deal found 4/6![United Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:15 am
STL
- CHS
2 stops8h 45m
Southwest
Sat 6/67:15 pm
CHS
- STL
1 stop5h 15m
Southwest
Deal found 4/7![Southwest logo]()
$253
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Wed 5/65:08 pm
CHS
- STL
1 stop5h 05m
United Airlines
Deal found 4/5![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:35 pm
STL
- CHS
1 stop6h 15m
Southwest
Mon 6/84:45 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 4/5![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:40 pm
STL
- CHS
1 stop4h 09m
Delta
Wed 7/227:20 am
CHS
- STL
1 stop5h 57m
Delta
Deal found 4/3![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:13 pm
STL
- CHS
1 stop7h 38m
United Airlines
Wed 6/33:08 pm
CHS
- STL
1 stop7h 08m
United Airlines
Deal found 4/3![United Airlines logo]()
$317
Last-minute flights from St. Louis to CharlestonDiscover last-minute flight deals from St. Louis to Charleston. Data last updated April 8, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Charleston. Data last updated April 8, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 4/302:45 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/5![Southwest logo]()
$228
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 5/72:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/5![Southwest logo]()
$239
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Wed 5/133:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/5![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Mon 5/182:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/7![Southwest logo]()
$238
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
STL
- CHS
1 stop7h 47m
Delta
Tue 5/196:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:06 am
STL
- CHS
1 stop7h 31m
American Airlines
Tue 5/195:11 am
CHS
- STL
1 stop5h 14m
American Airlines
Deal found 4/4![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:35 am
STL
- CHS
2 stops7h 35m
Southwest
Sat 6/67:15 pm
CHS
- STL
1 stop5h 15m
Southwest
Deal found 4/7![Southwest logo]()
$216
One-way flights from St. Louis to CharlestonSearch for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
Search for one-way flight options from St. Louis to Charleston. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:42 am
STL
- CHS
1 stop5h 56m
Delta
Deal found 4/6![Delta logo]()
$106
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 4/6![Southwest logo]()
$109
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Deal found 4/6![United Airlines logo]()
$114
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:25 am
STL
- CHS
2 stops9h 00m
Southwest
Deal found 4/6![Southwest logo]()
$119
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 4/3![Southwest logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- CHS
2 stops19h 02m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$124
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Deal found 4/5![United Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:27 pm
STL
- CHS
2 stops23h 08m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
STL
- CHS
2 stops40h 21m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:33 pm
STL
- CHS
2 stops37h 05m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$129
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:42 am
STL
- CHS
1 stop6h 10m
Delta
Deal found 4/6![Delta logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:27 pm
STL
- CHS
2 stops28h 20m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$131
Find flight deals from St. Louis to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $201 (Delta) |
One-way from | $106 (Delta) |
Popular in | July |
Cheapest in | August |
Average price | $403 |
Good round-trip deal | $315 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from St. Louis to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 6/1
5:20 pm-10:56 pm
1 stop4h 36m
Charleston
Sat 6/6
6:03 pm-11:59 pm
1 stop6h 56m
$211
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 5/30
2:25 pm-7:10 pm
1 stop3h 45m
Charleston
Tue 6/2
3:40 pm-5:00 pm
Nonstop2h 20m
$238
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 6/2
10:15 am-8:00 pm
2 stops8h 45m
Charleston
Sat 6/6
7:15 pm-11:30 pm
1 stop5h 15m
$253
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 6/26
1:13 pm-9:48 pm
1 stop7h 35m
Charleston
Tue 6/30
11:31 am-3:46 pm
1 stop5h 15m
$287
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 6/5
3:35 pm-10:50 pm
1 stop6h 15m
Charleston
Mon 6/8
4:45 pm-5:50 pm
Nonstop2h 05m
$288
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/5
7:45 am-1:51 pm
1 stop5h 06m
Charleston
Wed 5/6
5:08 pm-9:13 pm
1 stop5h 05m
$312
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 6/2
1:13 pm-9:51 pm
1 stop7h 38m
Charleston
Wed 6/3
3:08 pm-9:16 pm
1 stop7h 08m
$317
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 7/17
3:40 pm-8:49 pm
1 stop4h 09m
Charleston
Wed 7/22
7:20 am-12:17 pm
1 stop5h 57m
$337
Cheapest one-way
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 5/6
6:50 pm-11:50 pm
1 stop4h 00m
$106
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 5/9
10:19 am-5:53 pm
1 stop6h 34m
$106
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Charleston in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from St. Louis with our price prediction graph.
STL-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Charleston
Prices
More
How far ahead should I book a flight from St. Louis to Charleston?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Charleston. Price data was last updated on April 3, 2026.
The price you pay for your flight from St. Louis to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 51 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from St. Louis to Charleston?
Currently, July is the cheapest month in which you can book a flight from St. Louis to Charleston (average of $89). Flying from St. Louis to Charleston in January is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to CHS?
Find hourly flight availability from St. Louis to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 8, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from St. Louis to Charleston as you normally would.
What’s the top layover airport for flights from St. Louis to Charleston?
Share of 1-stop round-trip flights from St. Louis to Charleston chosen by Cheapflights users in the past 12 months, using the same layover each way.
Chicago (ORD) – chosen by Cheapflights users on 50% of 1-stop itineraries from St. Louis to Charleston on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Charleston?
Average round-trip fare for 1-stop flights from St. Louis to Charleston, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Charlotte (CLT) is the most affordable 1-stop option, with an average round-trip price of $335.
What’s the fastest layover option from St. Louis to Charleston?
Shortest average travel time for 1-stop one-way flights from St. Louis to Charleston, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Charlotte (CLT) have the shortest average one-way travel time for 1-stop routes: 3h 42m.
Which airport typically offers the quickest layover for flights from St. Louis to Charleston?
Average layover duration for 1-stop one-way flights from St. Louis to Charleston, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 0h 55m.
The best insider tips for St. Louis to Charleston flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your St. Louis to Charleston trip
Our travel experts
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated April 8, 2026.
Read through reviews of airlines operating flights from St. Louis to Charleston, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Top 3 airlines flying from St. Louis to Charleston
Discover the top 3 airlines that operate flights from St. Louis to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$342 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$243 | Average$374 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$267 | Average$402 | FlexibilityNo cancel fee | On-time63% |