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$294+ Cheap flights from Panama City (PTY) to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Panama City to Charleston

Cheapest flights from Panama City to Charleston
Explore the most affordable flight options available from Panama City to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:53 pmPTY - CHS
2 stops17h 42mAmerican Airlines
Sun 12/288:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 11/6$546
This Mytrip deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:25 amPTY - CHS
2 stops9h 58mMultiple Airlines
Sun 12/2810:18 pmCHS - PTY
3 stops26h 22mMultiple Airlines
Deal found 11/6$889

Cheap flight deals from Panama City to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$396
(United Airlines)

One-way from

$294
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$530
Provider with most accurate pricing for Panama City Tocumen Intl-Charleston flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Charleston flights.
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From Panama City Tocumen Intl to Charleston
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One-way flight from Panama City Tocumen Intl to Charleston
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($174 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Panama City to Charleston that are best for you.

Fly from

Panama City

Fly to

Charleston

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 1/24

4:41 pm-4:10 pm

1 stop23h 29m

Charleston

Tue 1/27

6:30 am-7:38 pm

1 stop13h 08m

$396

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 1/21

2:27 pm-11:34 am

2 stops21h 07m

Charleston

Sun 1/25

9:27 am-3:38 pm

1 stop6h 11m

$409

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 1/24

2:27 pm-11:55 pm

1 stop9h 28m

Charleston

Tue 1/27

4:35 pm-1:27 pm

2 stops20h 52m

$419

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 1/1

2:53 pm-8:47 am

1 stop17h 54m

Charleston

Sat 1/31

6:23 pm-3:38 pm

1 stop21h 15m

$632

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 1/21

7:50 pm-4:10 pm

2 stops20h 20m

Charleston

Sun 1/25

6:31 pm-6:55 pm

3 stops24h 24m

$715

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 11/25

4:41 pm-9:59 pm

1 stop29h 18m

$294

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 11/25

2:43 pm-8:29 am

2 stops17h 46m

$309

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 11/25

10:28 pm-10:05 pm

3 stops47h 37m

$391

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Compare providers for flights from Panama City to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Charleston in November.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Charleston

What is the cheapest time of day to fly from PTY to CHS?

Find hourly flight availability from Panama City to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 15% on flights from Panama City to Charleston by exploring options for tickets in the evening.

How much does it cost to fly round-trip from Panama City to Charleston?

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated November 6, 2025.
Read through reviews of airlines operating flights from Panama City to Charleston, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,042 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.
American Airlines
7.2
Good
11,042 reviews
American Airlines
7.2
Good
11,042 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Charleston?

    For as low as $409, United Airlines can have you in Charleston from Panama City in 21h 07m. Airlines will cover a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Panama City to Charleston round-trip?

    Currently priced at $397, American Airlines will fly you from Panama City to Charleston and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Users have found that American Airlines is 24% cheaper than the other options available to this destination.

  • Can I find deals for flights from Panama City to Charleston that include hotel bookings?

    Yes. In addition to deals on Panama City to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Charleston.

  • Can I find deals for business class flights from Panama City to Charleston?

    Yes. Cheapflights offers flight deals from Panama City to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Santee
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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Alternative routes for Panama City to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Charlotte flights
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Panama City to Florence flights

Top airline flying from Panama City to Charleston

Discover the top airline that operate flights from Panama City to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$546FlexibilityNo cancel feeOn-time71%

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