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$255+ Cheap flights from Panama City (PTY) to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Panama City to Charleston

Cheapest flights from Panama City to Charleston
Explore the most affordable flight options available from Panama City to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:41 pmPTY - CHS
1 stop29h 16mUnited Airlines
Wed 12/316:30 amCHS - PTY
1 stop13h 08mUnited Airlines
Deal found 12/3$449
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:55 pmPTY - CHS
2 stops17h 42mAmerican Airlines
Wed 12/315:30 amCHS - PTY
1 stop10h 24mAmerican Airlines
Deal found 12/3$463
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/154:43 pmPTY - CHS
1 stop16h 02mAmerican Airlines
Mon 12/298:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 12/2$484
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:55 pmPTY - CHS
1 stop15h 52mAmerican Airlines
Mon 12/298:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 12/3$536
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:41 pmPTY - CHS
1 stop29h 18mUnited Airlines
Thu 12/116:30 amCHS - PTY
1 stop13h 08mUnited Airlines
Deal found 12/3$558
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:43 pmPTY - CHS
1 stop8h 03mAmerican Airlines
Thu 12/116:31 pmCHS - PTY
2 stops19h 16mAmerican Airlines
Deal found 12/3$572
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:50 pmPTY - CHS
1 stop28h 33mAmerican Airlines
Thu 12/186:30 pmCHS - PTY
2 stops19h 23mAmerican Airlines
Deal found 12/2$635

Find flight deals from Panama City to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$377
(United Airlines)

One-way from

$255
(American Airlines)

Popular in

March

Cheapest in

August

Average price

$488
Provider with most accurate pricing for Panama City Tocumen Intl-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Charleston flights.
Search Deals
From Panama City Tocumen Intl to Charleston
Search Deals
One-way flight from Panama City Tocumen Intl to Charleston
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($176 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Panama City to Charleston that are best for you.

Fly from

Panama City

Fly to

Charleston

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 1/21

4:41 pm-3:59 pm

1 stop23h 18m

Charleston

Wed 1/28

4:55 pm-2:45 pm

1 stop21h 50m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sun 1/18

2:27 pm-11:39 am

2 stops21h 12m

Charleston

Sun 1/25

6:00 am-3:38 pm

1 stop9h 38m

$434

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 12/18

4:41 pm-9:57 pm

1 stop29h 16m

Charleston

Wed 12/31

6:30 am-7:38 pm

1 stop13h 08m

$449

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 12/18

4:55 pm-10:37 am

2 stops17h 42m

Charleston

Wed 12/31

5:30 am-3:54 pm

1 stop10h 24m

$463

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 12/15

4:43 pm-12:03 pm

2 stops19h 20m

Charleston

Mon 12/29

8:08 pm-3:54 pm

2 stops19h 46m

$484

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 2/18

2:50 pm-2:52 pm

2 stops24h 02m

Charleston

Sun 2/22

3:45 pm-1:22 pm

2 stops21h 37m

$507

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 12/26

4:55 pm-8:47 am

1 stop15h 52m

Charleston

Mon 12/29

8:08 pm-3:54 pm

2 stops19h 46m

$536

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 3/7

2:50 pm-11:42 am

2 stops20h 52m

$255

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sun 3/8

3:13 pm-10:26 am

1 stop18h 13m

$259

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sun 3/8

5:50 pm-4:05 pm

3 stops45h 15m

$270

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 11 results
1
2

Compare providers for flights from Panama City to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Charleston in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Charleston

What is the cheapest time of day to fly from PTY to CHS?

Find hourly flight availability from Panama City to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 15% on flights from Panama City to Charleston by exploring options for tickets in the evening.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Charleston?

    For as low as $434, United Airlines can have you in Charleston from Panama City in 21h 12m. Airlines will cover a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama City to Charleston that include hotel bookings?

    Yes. In addition to deals on Panama City to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Charleston.

  • Can I find deals for business class flights from Panama City to Charleston?

    Yes. Cheapflights offers flight deals from Panama City to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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