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$253+ Cheap flights from Panama City (PTY) to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Panama City to Charleston

Cheapest flights from Panama City to Charleston
Explore the most affordable flight options available from Panama City to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:00 am
PTY
-
CHS
1 stop11h 15m
United Airlines
Wed 6/311:18 am
CHS
-
PTY
1 stop9h 13m
United Airlines
Deal found 2/16$410
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:40 pm
PTY
-
CHS
1 stop6h 25m
American Airlines
Mon 10/198:08 pm
CHS
-
PTY
1 stop18h 52m
American Airlines
Deal found 2/15$424
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:14 pm
PTY
-
CHS
2 stops19h 53m
American Airlines
Wed 6/36:42 pm
CHS
-
PTY
2 stops18h 32m
American Airlines
Deal found 2/14$429
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm
PTY
-
CHS
2 stops21h 35m
American Airlines
Sat 9/127:39 am
CHS
-
PTY
1 stop7h 31m
American Airlines
Deal found 2/15$442
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm
PTY
-
CHS
1 stop17h 49m
American Airlines
Sun 9/137:39 am
CHS
-
PTY
1 stop7h 31m
American Airlines
Deal found 2/15$446
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/181:40 pm
PTY
-
CHS
1 stop9h 19m
American Airlines
Wed 4/18:08 pm
CHS
-
PTY
1 stop19h 53m
American Airlines
Deal found 2/17$448
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:14 pm
PTY
-
CHS
2 stops22h 53m
American Airlines
Tue 6/161:00 pm
CHS
-
PTY
2 stops24h 14m
American Airlines
Deal found 2/17$451

Find flight deals from Panama City to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$410
(United Airlines)

One-way from

$253
(American Airlines)

Popular in

March

Cheapest in

December

Average price

$435
Provider with most accurate pricing for Panama City Tocumen Intl-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Charleston flights.
Search Deals
From Panama City Tocumen Intl to Charleston
Search Deals
One-way flight from Panama City Tocumen Intl to Charleston
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($203 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($64 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Panama City to Charleston that are best for you.

Fly from

Panama City

Fly to

Charleston

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

7:55 am-10:15 pm

1 stop13h 20m

Charleston

Tue 6/16

6:50 am-2:14 pm

1 stop8h 24m

$410

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

7:55 am-10:15 pm

1 stop13h 20m

Charleston

Wed 6/3

11:18 am-7:31 pm

1 stop9h 13m

$410

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

1:14 pm-10:07 am

2 stops19h 53m

Charleston

Wed 6/3

6:42 pm-12:14 pm

2 stops18h 32m

$429

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 4/7

1:49 pm-12:26 pm

2 stops21h 37m

$253

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 4/24

3:30 pm-9:59 pm

1 stop29h 29m

$257

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 4/3

3:51 pm-10:19 am

1 stop17h 28m

$262

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 4/24

1:49 pm-11:49 am

2 stops21h 00m

$277

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 4/7

10:55 pm-11:59 pm

1 stop24h 04m

$292

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 4/7

9:33 pm-10:13 pm

3 stops23h 40m

$339

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 4/3

5:55 pm-10:13 pm

3 stops27h 18m

$375

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 11 results
1
2
  • Most accurate provider: When it comes to deals on Panama City-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Charleston

What is the cheapest month to book a flight from Panama City to Charleston?

Currently, December is the cheapest month in which you can book a flight from Panama City to Charleston (average of $148). Flying from Panama City to Charleston in March is currently the most expensive (average of $726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to Charleston?

Related info for your journey

Find useful and relevant information for your journey from Panama City to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Charleston?

    For as low as $410, United Airlines can have you in Charleston from Panama City in 13h 20m. Airlines will cover a distance of 1645 mi.

  • Can I find deals for flights from Panama City to Charleston that include hotel bookings?

    Yes. In addition to deals on Panama City to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Charleston.

  • Can I find deals for business class flights from Panama City to Charleston?

    Yes. Cheapflights offers flight deals from Panama City to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Charleston?

    Currently, December is the cheapest month in which you can book a flight from Panama City to Charleston (average of $148). Flying from Panama City to Charleston in March is currently the most expensive (average of $726). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

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Alternative routes for Panama City to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
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