$204+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Jul 13 — Jul 201
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:22 pm
DSM
- BUF
1 stop7h 34m
American Airlines
Tue 7/78:08 am
BUF
- DSM
1 stop5h 57m
American Airlines
Deal found 6/12![American Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Tue 8/45:20 am
BUF
- DSM
1 stop8h 14m
American Airlines
Deal found 6/12![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:35 pm
DSM
- BUF
1 stop8h 02m
United Airlines
Wed 9/210:30 am
BUF
- DSM
1 stop4h 46m
United Airlines
Deal found 6/11![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am
DSM
- BUF
1 stop5h 42m
American Airlines
Sun 9/205:44 pm
BUF
- DSM
1 stop6h 57m
American Airlines
Deal found 6/9![American Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
DSM
- BUF
1 stop6h 53m
American Airlines
Mon 9/145:18 pm
BUF
- DSM
1 stop5h 29m
American Airlines
Deal found 6/11![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Mon 9/145:40 am
BUF
- DSM
2 stops9h 05m
Southwest
Deal found 6/11![Southwest logo]()
$350
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
DSM
- BUF
1 stop4h 22m
Delta
Wed 7/156:29 am
BUF
- DSM
1 stop4h 16m
Delta
Deal found 6/10![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:23 am
DSM
- BUF
2 stops11h 36m
United Airlines
Wed 7/156:04 pm
BUF
- DSM
1 stop4h 18m
United Airlines
Deal found 6/10![United Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Thu 7/238:08 am
BUF
- DSM
1 stop5h 57m
American Airlines
Deal found 6/13![American Airlines logo]()
$362
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:22 pm
DSM
- BUF
1 stop7h 34m
American Airlines
Tue 7/78:08 am
BUF
- DSM
1 stop5h 57m
American Airlines
Deal found 6/12![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Mon 9/145:40 am
BUF
- DSM
2 stops9h 05m
Southwest
Deal found 6/11![Southwest logo]()
$350
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:45 am
DSM
- BUF
2 stops10h 11m
United Airlines
Wed 9/210:30 am
BUF
- DSM
2 stops10h 56m
United Airlines
Deal found 6/11![United Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:55 pm
DSM
- BUF
2 stops23h 00m
Multiple Airlines
Sun 8/308:57 pm
BUF
- DSM
1 stop20h 41m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:34 pm
DSM
- BUF
1 stop4h 11m
Delta
Wed 7/16:29 am
BUF
- DSM
1 stop4h 15m
Delta
Deal found 6/9![Delta logo]()
$421
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:20 am
DSM
- BUF
2 stops5h 50m
Southwest
Tue 8/46:00 am
BUF
- DSM
2 stops6h 50m
Southwest
Deal found 6/12![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/211:23 am
DSM
- BUF
1 stop4h 18m
United Airlines
Fri 7/310:57 am
BUF
- DSM
2 stops10h 33m
United Airlines
Deal found 6/8![United Airlines logo]()
$432
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:23 am
DSM
- BUF
2 stops11h 36m
United Airlines
Tue 7/710:34 am
BUF
- DSM
3 stops11h 48m
United Airlines
Deal found 6/12![United Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- BUF
2 stops8h 00m
Southwest
Sat 8/12:40 pm
BUF
- DSM
2 stops9h 15m
Southwest
Deal found 6/10![Southwest logo]()
$432
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:24 pm
DSM
- BUF
2 stops7h 35m
United Airlines
Wed 7/156:04 pm
BUF
- DSM
1 stop4h 18m
United Airlines
Deal found 6/10![United Airlines logo]()
$440
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated June 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated June 13, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:06 pm
DSM
- BUF
1 stop25h 06m
Multiple Airlines
Wed 7/12:50 pm
BUF
- DSM
2 stops31h 37m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:22 pm
DSM
- BUF
1 stop7h 34m
American Airlines
Tue 7/78:08 am
BUF
- DSM
1 stop5h 57m
American Airlines
Deal found 6/12![American Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:54 am
DSM
- BUF
1 stop6h 30m
Delta
Wed 7/156:29 am
BUF
- DSM
1 stop4h 16m
Delta
Deal found 6/10![Delta logo]()
$355
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:23 am
DSM
- BUF
2 stops11h 36m
United Airlines
Wed 7/156:04 pm
BUF
- DSM
1 stop4h 18m
United Airlines
Deal found 6/10![United Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Thu 7/238:08 am
BUF
- DSM
1 stop5h 57m
American Airlines
Deal found 6/13![American Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Sat 8/18:08 am
BUF
- DSM
1 stop5h 55m
American Airlines
Deal found 6/10![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Tue 8/45:20 am
BUF
- DSM
1 stop8h 14m
American Airlines
Deal found 6/12![American Airlines logo]()
$337
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:32 pm
DSM
- BUF
1 stop5h 26m
Delta
Deal found 6/10![Delta logo]()
$204
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- BUF
2 stops6h 35m
Southwest
Deal found 6/10![Southwest logo]()
$219
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:55 am
DSM
- BUF
1 stop4h 59m
American Airlines
Deal found 6/10![American Airlines logo]()
$244
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- BUF
2 stops8h 00m
Southwest
Deal found 6/10![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:00 am
DSM
- BUF
1 stop6h 13m
United Airlines
Deal found 6/8![United Airlines logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:40 pm
DSM
- BUF
3 stops18h 49m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:00 am
DSM
- BUF
1 stop6h 13m
United Airlines
Deal found 6/8![United Airlines logo]()
$568
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $336 (American Airlines) |
One-way from | $204 (Delta) |
Popular in | March |
Cheapest in | October |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 6/30
3:22 pm-11:56 pm
1 stop7h 34m
Buffalo
Tue 7/7
8:08 am-1:05 pm
1 stop5h 57m
$336
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 9/11
5:40 am-10:45 am
1 stop4h 05m
Buffalo
Mon 9/14
5:40 am-1:45 pm
2 stops9h 05m
$350
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 9/1
5:45 am-4:56 pm
2 stops10h 11m
Buffalo
Wed 9/2
10:30 am-8:26 pm
2 stops10h 56m
$380
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 8/27
1:55 pm-1:55 pm
2 stops23h 00m
Buffalo
Sun 8/30
8:57 pm-4:38 pm
1 stop20h 41m
$395
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 7/28
5:20 am-12:10 pm
2 stops5h 50m
Buffalo
Tue 8/4
6:00 am-11:50 am
2 stops6h 50m
$407
Quickest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 6/27
5:34 pm-10:45 pm
1 stop4h 11m
Buffalo
Wed 7/1
6:29 am-9:44 am
1 stop4h 15m
$421
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 7/2
11:23 am-4:41 pm
1 stop4h 18m
Buffalo
Fri 7/3
10:57 am-8:30 pm
2 stops10h 33m
$432
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 6/30
11:23 am-11:59 pm
2 stops11h 36m
Buffalo
Tue 7/7
10:34 am-9:22 pm
3 stops11h 48m
$432
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 7/22
5:20 am-2:20 pm
2 stops8h 00m
Buffalo
Sat 8/1
2:40 pm-10:55 pm
2 stops9h 15m
$432
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 7/14
3:24 pm-11:59 pm
2 stops7h 35m
Buffalo
Wed 7/15
6:04 pm-9:22 pm
1 stop4h 18m
$440
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 13, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Overall
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Overall
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Overall
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Overall
7.9
Entertainment
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Batavia
Williamsville
Orchard Park
Eden
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 13, 2026.
Complete your trip
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on June 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Buffalo
Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$362 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$430 | FlexibilityNo cancel fee | On-time69% |