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$184+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$297
(Delta)

One-way from

$184
(Delta)

Popular in

December

Cheapest in

November

Average price

$366
From Des Moines to Buffalo
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One-way flight from Des Moines to Buffalo
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Highest demand for flights based on searches. 16% potential increase in price ($82 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/3010:59 amDSM - BUF
1 stop6h 45mDelta
Fri 7/45:10 pmBUF - DSM
1 stop6h 53mDelta
Deal found 6/10$297
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/265:26 pmDSM - BUF
1 stop6h 06mAmerican Airlines
Sat 8/25:05 amBUF - DSM
1 stop5h 19mAmerican Airlines
Deal found 6/11$298
This Booking.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/78:41 pmDSM - BUF
1 stop15h 02mFrontier
Fri 9/121:39 pmBUF - DSM
1 stop7h 17mFrontier
Deal found 6/11$322
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:25 pmDSM - BUF
2 stops5h 05mSouthwest
Fri 9/127:50 amBUF - DSM
1 stop6h 10mSouthwest
Deal found 6/11$374
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/73:25 pmDSM - BUF
1 stop4h 51mUnited Airlines
Fri 9/125:54 pmBUF - DSM
1 stop4h 51mUnited Airlines
Deal found 6/11$421
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/257:30 amDSM - BUF
2 stops26h 20mMultiple Airlines
Sun 6/2911:47 amBUF - DSM
2 stops11h 50mMultiple Airlines
Deal found 6/10$661

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Des Moines

Fly to

Buffalo

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 6/30

10:59 am-6:44 pm

1 stop6h 45m

Buffalo

Fri 7/4

5:10 pm-11:03 pm

1 stop6h 53m

$297

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 7/26

5:26 pm-12:32 am

1 stop6h 06m

Buffalo

Sat 8/2

5:05 am-9:24 am

1 stop5h 19m

$298

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 9/7

8:41 pm-12:43 pm

1 stop15h 02m

Buffalo

Fri 9/12

1:39 pm-7:56 pm

1 stop7h 17m

$322

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 9/7

5:25 pm-11:30 pm

2 stops5h 05m

Buffalo

Fri 9/12

7:50 am-1:00 pm

1 stop6h 10m

$374

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 9/7

3:25 pm-9:16 pm

1 stop4h 51m

Buffalo

Fri 9/12

5:54 pm-9:45 pm

1 stop4h 51m

$421

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 6/25

7:30 am-10:50 am

2 stops26h 20m

Buffalo

Sun 6/29

11:47 am-10:37 pm

2 stops11h 50m

$661

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/25

3:39 pm-11:19 pm

1 stop6h 40m

$184

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 7/7

6:30 am-2:22 pm

1 stop6h 52m

$194

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/25

2:00 pm-10:44 am

3 stops43h 44m

$219

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/25

7:33 pm-12:11 pm

2 stops15h 38m

$246

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Buffalo by month

Plan your trip to Buffalo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

Temperature in Buffalo by month

Plan your trip to Buffalo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated June 12, 2025.
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,946 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Frontier
6.0
Okay
3,295 reviews
Southwest
8.0
Very good
4,287 reviews

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Overall

8.0

Food

7.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    Delta, at $297, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and Frontier. These flights start at 31% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $184. However, be on the lookout for offers from American Airlines and Frontier, as they are both options that can get you from Des Moines to Buffalo for a low price.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Williamsville
Amherst
Orchard Park
Batavia
Eden
Cheektowaga
West Seneca

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Alternative routes for Des Moines to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$276Average$351FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$366Average$465FlexibilityNo cancel feeOn-time69%

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