$194+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Mar 14 — Mar 211
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:34 am
DSM
- BUF
1 stop3h 40m
Delta
Wed 5/132:47 pm
BUF
- DSM
1 stop5h 47m
Delta
Deal found 2/11![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:34 am
DSM
- BUF
1 stop5h 33m
Delta
Wed 5/134:55 pm
BUF
- DSM
1 stop6h 37m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:49 am
DSM
- BUF
1 stop5h 37m
Delta
Thu 5/1412:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:20 pm
DSM
- BUF
1 stop4h 10m
Southwest
Tue 5/126:55 pm
BUF
- DSM
1 stop4h 15m
Southwest
Deal found 2/11![Southwest logo]()
$352
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:45 am
DSM
- BUF
1 stop6h 40m
American Airlines
Wed 4/15:00 pm
BUF
- DSM
2 stops7h 48m
American Airlines
Deal found 2/10![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:56 am
DSM
- BUF
1 stop4h 25m
American Airlines
Mon 5/186:00 am
BUF
- DSM
1 stop5h 26m
American Airlines
Deal found 2/9![American Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:24 pm
DSM
- BUF
1 stop4h 38m
United Airlines
Thu 6/115:47 pm
BUF
- DSM
1 stop6h 04m
United Airlines
Deal found 2/9![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
DSM
- BUF
2 stops9h 42m
American Airlines
Wed 5/136:00 pm
BUF
- DSM
1 stop6h 49m
American Airlines
Deal found 2/11![American Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:23 am
DSM
- BUF
1 stop23h 26m
Multiple Airlines
Wed 5/131:08 pm
BUF
- DSM
2 stops27h 07m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$394
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:34 am
DSM
- BUF
1 stop3h 40m
Delta
Sat 5/96:20 am
BUF
- DSM
1 stop5h 43m
Delta
Deal found 2/11![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
DSM
- BUF
1 stop4h 09m
Delta
Sat 5/94:55 pm
BUF
- DSM
1 stop6h 37m
Delta
Deal found 2/11![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:44 pm
DSM
- BUF
1 stop7h 51m
Delta
Tue 5/126:20 am
BUF
- DSM
1 stop5h 43m
Delta
Deal found 2/11![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:34 am
DSM
- BUF
1 stop5h 33m
Delta
Wed 5/134:55 pm
BUF
- DSM
1 stop6h 37m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:34 am
DSM
- BUF
1 stop5h 33m
Delta
Tue 5/1212:04 pm
BUF
- DSM
1 stop5h 39m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:34 am
DSM
- BUF
1 stop3h 40m
Delta
Thu 5/1412:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
DSM
- BUF
1 stop4h 09m
Delta
Mon 5/1112:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:57 pm
DSM
- BUF
1 stop5h 02m
Delta
Tue 5/124:55 pm
BUF
- DSM
1 stop6h 37m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
DSM
- BUF
1 stop4h 09m
Delta
Thu 5/1412:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:49 am
DSM
- BUF
1 stop5h 37m
Delta
Sat 5/96:20 am
BUF
- DSM
1 stop5h 43m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:45 pm
DSM
- BUF
1 stop3h 54m
Delta
Thu 5/1412:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:57 pm
DSM
- BUF
1 stop5h 02m
Delta
Thu 5/1412:10 pm
BUF
- DSM
1 stop6h 43m
Delta
Deal found 2/11![Delta logo]()
$341
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated February 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:24 pm
DSM
- BUF
1 stop4h 27m
United Airlines
Tue 3/38:25 am
BUF
- DSM
1 stop8h 57m
United Airlines
Deal found 2/10![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:10 am
DSM
- BUF
1 stop9h 05m
Southwest
Tue 3/31:20 pm
BUF
- DSM
2 stops8h 50m
Southwest
Deal found 2/10![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2611:26 am
DSM
- BUF
1 stop4h 16m
United Airlines
Thu 4/26:09 am
BUF
- DSM
2 stops7h 20m
United Airlines
Deal found 2/9![United Airlines logo]()
$416
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:45 am
DSM
- BUF
1 stop6h 40m
American Airlines
Wed 4/15:59 pm
BUF
- DSM
1 stop6h 49m
American Airlines
Deal found 2/9![American Airlines logo]()
$352
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2710:04 am
DSM
- BUF
1 stop6h 25m
American Airlines
Deal found 2/10![American Airlines logo]()
$194
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:15 pm
DSM
- BUF
2 stops11h 35m
Southwest
Deal found 2/10![Southwest logo]()
$199
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:20 am
DSM
- BUF
1 stop4h 20m
Delta
Deal found 2/10![Delta logo]()
$259
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:50 am
DSM
- BUF
2 stops9h 50m
United Airlines
Deal found 2/10![United Airlines logo]()
$723
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $317 (Delta) |
One-way from | $194 (American Airlines) |
Popular in | February |
Cheapest in | October |
Average price | $646 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Des Moines
Fly to
Buffalo
Route
Depart
Return
Price
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 5/5
10:34 am-3:14 pm
1 stop3h 40m
Buffalo
Sat 5/9
6:20 am-11:03 am
1 stop5h 43m
$317
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 5/9
6:15 am-11:24 am
1 stop4h 09m
Buffalo
Sat 5/9
4:55 pm-10:32 pm
1 stop6h 37m
$317
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 5/5
2:44 pm-11:35 pm
1 stop7h 51m
Buffalo
Tue 5/12
6:20 am-11:03 am
1 stop5h 43m
$317
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 5/7
7:34 am-2:07 pm
1 stop5h 33m
Buffalo
Wed 5/13
4:55 pm-10:32 pm
1 stop6h 37m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 5/7
7:34 am-2:07 pm
1 stop5h 33m
Buffalo
Tue 5/12
12:04 pm-4:43 pm
1 stop5h 39m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 5/5
10:34 am-3:14 pm
1 stop3h 40m
Buffalo
Thu 5/14
12:10 pm-5:53 pm
1 stop6h 43m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 5/9
6:15 am-11:24 am
1 stop4h 09m
Buffalo
Mon 5/11
12:10 pm-5:53 pm
1 stop6h 43m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Mon 5/11
5:57 pm-11:59 pm
1 stop5h 02m
Buffalo
Tue 5/12
4:55 pm-10:32 pm
1 stop6h 37m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 5/9
6:15 am-11:24 am
1 stop4h 09m
Buffalo
Thu 5/14
12:10 pm-5:53 pm
1 stop6h 43m
$329
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 5/7
11:49 am-6:26 pm
1 stop5h 37m
Buffalo
Sat 5/9
6:20 am-11:03 am
1 stop5h 43m
$329
Showing 1-10 of 16 results
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated February 12, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.9
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.9
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.9
Overall
7.9
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 12, 2026.
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on February 12, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on February 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Buffalo
Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$148 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$317 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$463 | FlexibilityNo cancel fee | On-time69% |