How long is the flight from Des Moines to Buffalo?

A quick flight from Des Moines to Buffalo can take about 5h 18m. American Airlines provides one of the quickest options available for as low as $330. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What is the cheapest airline to fly from Des Moines to Buffalo round-trip?

American Airlines, at $284, was found to be the cheapest airline from Des Moines to Buffalo.. This flight start at 39% lower than the current average price 3 months from now.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What is the cheapest time of day to fly from DSM to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Buffalo as you normally would.

Most accurate provider : When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

Can I find deals for business class flights from Des Moines to Buffalo?

Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$174+ Cheap Flights from Des Moines to Buffalo

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Cheap flight deals from Des Moines to Buffalo

Cheapest

Best

Last-minute

One-way

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.

Wed 12/96:09 am -

1 stop4h 15m

Wed 12/166:10 am -

1 stop4h 40m

Deal found 11/5

$325

Wed 12/95:24 am -

1 stop5h 18m

Wed 12/164:21 pm -

2 stops9h 12m

Deal found 11/5

$330

Mon 12/141:23 pm -

1 stop8h 34m

Wed 12/161:53 pm -

1 stop4h 21m

Deal found 11/4

$425

Thu 11/265:10 am -

1 stop4h 15m

Mon 11/307:25 pm -

1 stop5h 10m

Deal found 11/4

$426

Last-minute flights from Des Moines to Buffalo
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated November 10, 2026 and is based on user searches.

Thu 11/265:10 am -

1 stop4h 15m

Mon 11/307:25 pm -

1 stop5h 10m

Deal found 11/4

$426

Wed 12/96:09 am -

1 stop4h 15m

Wed 12/166:10 am -

1 stop4h 40m

Deal found 11/5

$325

Wed 12/95:24 am -

1 stop5h 18m

Wed 12/164:21 pm -

2 stops9h 12m

Deal found 11/5

$330

Mon 12/141:23 pm -

1 stop8h 34m

Wed 12/161:53 pm -

1 stop4h 21m

Deal found 11/4

$425

One-way flights from Des Moines to Buffalo
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.

Sat 12/196:11 pm -

1 stop4h 50m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/7

$174

Fri 12/256:15 am -

1 stop4h 12m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/8

$199

Fri 12/259:32 am -

2 stops8h 33m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/8

$204

Tue 3/165:40 am -

1 stop4h 00m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/9

$224

Tue 3/162:02 pm -

2 stops8h 56m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/9

$229

Sat 12/194:15 pm -

1 stop4h 30m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/7

$234

Tue 3/166:15 am -

3 stops11h 11m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/9

$398

Sat 12/1912:39 pm -

3 stops27h 46m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/7

$463

Find flight deals from Des Moines to Buffalo

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$325 (Delta)
One-way from	$174 (Delta)
Popular in	March
Cheapest in	August

Provider with most accurate pricing for Des Moines-Buffalo flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.

Search Deals

From Des Moines to Buffalo

Search Deals

One-way flight from Des Moines to Buffalo

Search Deals

Highest demand for flights based on searches. 2% potential increase in price ($11 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($30 potential savings vs. average RT price).

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 12/19

6:11 pm-12:01 am

1 stop4h 50m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$174

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Fri 12/25

6:15 am-11:27 am

1 stop4h 12m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$199

Quickest round-trip

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Tue 3/16

5:40 am-10:40 am

1 stop4h 00m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$224

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Tue 3/16

2:02 pm-11:58 pm

2 stops8h 56m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$229

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 12/19

4:15 pm-9:45 pm

1 stop4h 30m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$234

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

5:24 am-11:42 am

1 stop5h 18m

Buffalo

Wed 12/16

4:21 pm-12:33 am

2 stops9h 12m

$330

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Tue 3/16

6:15 am-6:26 pm

3 stops11h 11m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$398

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Mon 12/14

1:23 pm-10:57 pm

1 stop8h 34m

Buffalo

Wed 12/16

6:30 am-12:39 pm

1 stop7h 09m

$425

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Tue 3/16

5:40 am-10:40 am

1 stop4h 00m

Buffalo

Sun 3/21

1:25 pm-11:15 pm

1 stop10h 50m

$519

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Fri 12/25

8:00 am-11:09 pm

3 stops14h 09m

Buffalo

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$550

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/7

Sorted by cheapest first

Compare providers for flights from Des Moines to Buffalo

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

DSM-BUF

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.0

Good

12,228 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Jul 2023

DFW - JFK

I liked nothing. My flight from DFW was canceled and my luggage was lost for 3 days. No more crappy American Airlines for me.

American Airlines

7.0

Good

12,228 reviews

American Airlines

7.0

Good

12,228 reviews

Reviews

1 / 20

2.0

Mediocre

Anonymous,Jul 2023

DFW - JFK

I liked nothing. My flight from DFW was canceled and my luggage was lost for 3 days. No more crappy American Airlines for me.

Related info for your journey

How long is the flight from Des Moines to Buffalo?
A quick flight from Des Moines to Buffalo can take about 5h 18m. American Airlines provides one of the quickest options available for as low as $330. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What is the cheapest airline to fly from Des Moines to Buffalo round-trip?
American Airlines, at $284, was found to be the cheapest airline from Des Moines to Buffalo.. This flight start at 39% lower than the current average price 3 months from now.
Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?
Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.
Can I find deals for business class flights from Des Moines to Buffalo?
Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Cheektowaga

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Amherst

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Orchard Park

Eden

Bowmansville

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Popular flights

Alternative routes for Des Moines to Buffalo

Top airline flying from Des Moines to Buffalo

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$284	Average$406	FlexibilityNo cancel fee	On-time71%

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$174+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Buffalo with Cheapflights

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2. Select your favorite providers

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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.

Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.

Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.

Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.

Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated November 10, 2026 and is based on user searches.

Discover last-minute flight deals from Des Moines to Buffalo. Data last updated November 10, 2026 and is based on user searches.

One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.

Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.

Find flight deals from Des Moines to Buffalo

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Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in November.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

How long is the flight from Des Moines to Buffalo?

What is the cheapest airline to fly from Des Moines to Buffalo round-trip?

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

How can I find direct flights from Des Moines to Buffalo?

Can I find deals for business class flights from Des Moines to Buffalo?

Traveling to a place near Buffalo?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.

Other flights to Buffalo

Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 10, 2026.

Complete your trip

Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Des Moines to Buffalo by cabin class

Find flights from Des Moines to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Des Moines and Buffalo flights

Browse other Des Moines and Buffalo flight options. Last updated on November 10, 2026.

Other flights from Des Moines

Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on November 10, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Top airline flying from Des Moines to Buffalo

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Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.

Best flights from Des Moines to Buffalo
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.

Last-minute flights from Des Moines to Buffalo
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated November 10, 2026 and is based on user searches.

One-way flights from Des Moines to Buffalo
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.