$163+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Oct 4 — Oct 111
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:58 pm -
1 stop6h 48m
Mon 11/237:52 am -
1 stop6h 36m
Deal found 9/1![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:10 am -
1 stop4h 15m
Mon 10/267:35 pm -
1 stop4h 40m
Deal found 9/4![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:35 pm -
1 stop5h 18m
Thu 9/246:20 am -
1 stop4h 18m
Deal found 8/30![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:05 am -
1 stop7h 22m
Sat 10/177:00 am -
2 stops7h 30m
Deal found 8/31![American Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
2 stops8h 45m
Sat 10/173:40 pm -
2 stops6h 10m
Deal found 8/31![Southwest logo]()
$401
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:11 pm -
1 stop4h 36m
Sun 10/187:00 am -
1 stop4h 30m
Deal found 8/31![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:27 pm -
1 stop8h 06m
Fri 11/276:01 pm -
1 stop4h 54m
Deal found 9/1![United Airlines logo]()
$424
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:58 pm -
1 stop6h 48m
Mon 11/237:52 am -
1 stop6h 36m
Deal found 9/1![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:10 am -
1 stop4h 15m
Mon 10/262:50 pm -
2 stops9h 25m
Deal found 9/4![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:11 pm -
1 stop4h 36m
Sun 10/187:00 am -
1 stop4h 30m
Deal found 8/31![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:35 pm -
1 stop5h 18m
Sun 9/206:20 am -
1 stop4h 18m
Deal found 9/1![Delta logo]()
$497
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
2 stops8h 45m
Sat 10/173:40 pm -
2 stops6h 10m
Deal found 8/31![Southwest logo]()
$401
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:27 pm -
1 stop8h 06m
Fri 11/276:01 pm -
1 stop4h 54m
Deal found 9/1![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:30 pm -
1 stop7h 17m
Mon 9/284:55 pm -
2 stops7h 46m
Deal found 8/31![American Airlines logo]()
$462
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
1 stop3h 50m
Sun 10/185:50 am -
2 stops8h 45m
Deal found 8/31![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:24 am -
2 stops6h 54m
Tue 9/225:57 pm -
1 stop4h 31m
Deal found 9/3![United Airlines logo]()
$502
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated September 4, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:35 pm -
1 stop5h 18m
Sun 9/206:20 am -
1 stop4h 18m
Deal found 9/1![Delta logo]()
$497
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:35 pm -
1 stop5h 18m
Thu 9/246:20 am -
1 stop4h 18m
Deal found 8/30![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:00 am -
2 stops8h 21m
Thu 9/247:59 am -
1 stop7h 00m
Deal found 8/30![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:30 pm -
1 stop7h 17m
Mon 9/284:55 pm -
2 stops7h 46m
Deal found 8/31![American Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:05 am -
1 stop7h 22m
Sat 10/177:00 am -
2 stops7h 30m
Deal found 8/31![American Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
2 stops8h 45m
Sat 10/173:40 pm -
2 stops6h 10m
Deal found 8/31![Southwest logo]()
$401
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:11 pm -
1 stop4h 36m
Sun 10/187:00 am -
1 stop4h 30m
Deal found 8/31![United Airlines logo]()
$404
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
1 stop3h 50m
Sun 10/185:50 am -
2 stops8h 45m
Deal found 8/31![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:10 am -
1 stop4h 15m
Mon 10/267:35 pm -
1 stop4h 40m
Deal found 9/4![Southwest logo]()
$387
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:35 pm -
1 stop8h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![United Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
1 stop3h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Southwest logo]()
$183
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:20 am -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/30![Southwest logo]()
$196
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:00 am -
2 stops10h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/30![United Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:42 pm -
3 stops20h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:00 am -
3 stops10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![United Airlines logo]()
$730
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $371 (American Airlines) |
One-way from | $163 (United Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $317 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 9/23
1:35 pm-10:37 pm
1 stop8h 02m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Quickest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 10/7
5:35 am-10:25 am
1 stop3h 50m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$183
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sat 10/31
5:20 am-10:50 am
1 stop4h 30m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$196
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sat 10/31
9:00 am-8:51 pm
2 stops10h 51m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$201
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Thu 11/19
1:58 pm-9:46 pm
1 stop6h 48m
Buffalo
Mon 11/23
7:52 am-1:28 pm
1 stop6h 36m
$371
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 10/7
2:42 pm-11:58 am
3 stops20h 16m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$387
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Mon 10/19
5:10 am-10:25 am
1 stop4h 15m
Buffalo
Mon 10/26
2:50 pm-11:15 pm
2 stops9h 25m
$392
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 10/7
5:35 am-3:20 pm
2 stops8h 45m
Buffalo
Sat 10/17
3:40 pm-8:50 pm
2 stops6h 10m
$401
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 10/7
3:11 pm-8:47 pm
1 stop4h 36m
Buffalo
Sun 10/18
7:00 am-10:30 am
1 stop4h 30m
$404
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/25
1:27 pm-10:33 pm
1 stop8h 06m
Buffalo
Fri 11/27
6:01 pm-9:55 pm
1 stop4h 54m
$424
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 4, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Food
6.4
Boarding
7.5
Crew
7.9
Comfort
7.2
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Complete your trip
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on September 4, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Des Moines to Buffalo
Discover the top airline that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$364 | FlexibilityNo cancel fee | On-time71% |