$183+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Sep 6 — Sep 131
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Best
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One-way
Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 7, 2026.
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:21 pm -
1 stop6h 46m
Sat 9/195:50 pm -
1 stop6h 05m
Deal found 8/2![United Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:10 am -
2 stops7h 10m
Tue 9/223:00 pm -
2 stops8h 00m
Deal found 8/6![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 am -
1 stop5h 58m
Fri 8/285:38 pm -
1 stop7h 06m
Deal found 8/1![American Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
1 stop4h 35m
Sun 11/16:10 am -
1 stop4h 32m
Deal found 8/3![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
1 stop4h 05m
Mon 10/52:50 pm -
2 stops9h 05m
Deal found 8/6![Southwest logo]()
$393
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:22 am -
1 stop3h 51m
Tue 11/36:10 am -
1 stop4h 32m
Deal found 8/3![Delta logo]()
$401
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:00 am -
1 stop7h 26m
Fri 9/255:18 pm -
1 stop5h 18m
Deal found 8/1![American Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:36 pm -
1 stop5h 20m
Tue 9/86:09 pm -
1 stop7h 11m
Deal found 8/5![American Airlines logo]()
$406
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 7, 2026.
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:00 am -
1 stop4h 11m
Mon 10/265:58 pm -
1 stop5h 52m
Deal found 8/5![United Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am -
1 stop6h 53m
Tue 9/222:51 pm -
1 stop7h 45m
Deal found 8/2![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:10 am -
1 stop4h 15m
Tue 10/134:25 pm -
2 stops6h 30m
Deal found 8/5![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:32 am -
1 stop4h 24m
Tue 9/810:33 am -
2 stops7h 55m
Deal found 8/2![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:10 am -
1 stop4h 15m
Mon 10/262:50 pm -
2 stops9h 05m
Deal found 8/5![Southwest logo]()
$383
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:55 pm -
2 stops8h 41m
Fri 8/281:03 pm -
2 stops7h 16m
Deal found 8/1![American Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
2 stops7h 18m
Sat 9/196:10 am -
2 stops7h 06m
Deal found 8/2![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:10 am -
2 stops10h 00m
Mon 10/52:50 pm -
2 stops9h 05m
Deal found 8/5![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm -
1 stop4h 47m
Mon 9/76:12 am -
2 stops7h 08m
Deal found 8/4![United Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:11 pm -
1 stop4h 36m
Wed 10/2110:46 am -
1 stop4h 29m
Deal found 8/4![United Airlines logo]()
$445
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated August 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated August 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 am -
1 stop5h 58m
Fri 8/285:38 pm -
1 stop7h 06m
Deal found 8/1![American Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:21 pm -
1 stop6h 46m
Sat 9/195:50 pm -
1 stop6h 05m
Deal found 8/2![United Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:36 pm -
1 stop5h 20m
Tue 9/86:09 pm -
1 stop7h 11m
Deal found 8/5![American Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:10 am -
2 stops7h 10m
Tue 9/223:00 pm -
2 stops8h 00m
Deal found 8/6![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:30 pm -
1 stop7h 17m
Thu 9/245:18 pm -
1 stop5h 18m
Deal found 8/5![American Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:00 am -
1 stop7h 26m
Fri 9/255:18 pm -
1 stop5h 18m
Deal found 8/1![American Airlines logo]()
$404
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
1 stop4h 05m
Mon 10/52:50 pm -
2 stops9h 05m
Deal found 8/6![Southwest logo]()
$393
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated August 7, 2026.
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:41 am -
1 stop5h 57m
Deal found 8/3![American Airlines logo]()
$183
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am -
1 stop6h 53m
Deal found 8/3![American Airlines logo]()
$196
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am -
2 stops7h 18m
Deal found 8/3![United Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/71:25 pm -
3 stops46h 30m
Deal found 8/3![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/72:19 pm -
2 stops19h 10m
Deal found 8/3![Frontier logo]()
$246
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:40 am -
2 stops11h 45m
Deal found 8/3![Southwest logo]()
$304
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $365 (United Airlines) |
One-way from | $183 (American Airlines) |
Popular in | March |
Cheapest in | October |
Average price | $332 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sat 10/24
8:00 am-1:11 pm
1 stop4h 11m
Buffalo
Mon 10/26
5:58 pm-10:50 pm
1 stop5h 52m
$365
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 9/15
6:00 am-1:53 pm
1 stop6h 53m
Buffalo
Tue 9/22
2:51 pm-9:36 pm
1 stop7h 45m
$365
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Thu 10/8
5:10 am-10:25 am
1 stop4h 15m
Buffalo
Tue 10/13
4:25 pm-9:55 pm
2 stops6h 30m
$370
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 9/1
11:32 am-4:56 pm
1 stop4h 24m
Buffalo
Tue 9/8
10:33 am-5:28 pm
2 stops7h 55m
$370
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 9/1
6:00 am-2:18 pm
2 stops7h 18m
Buffalo
Sat 9/19
6:10 am-12:16 pm
2 stops7h 06m
$376
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/23
5:10 am-10:25 am
1 stop4h 15m
Buffalo
Mon 10/26
2:50 pm-10:55 pm
2 stops9h 05m
$383
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Mon 8/24
1:55 pm-11:36 pm
2 stops8h 41m
Buffalo
Fri 8/28
1:03 pm-7:19 pm
2 stops7h 16m
$388
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 9/4
3:20 pm-9:07 pm
1 stop4h 47m
Buffalo
Mon 9/7
6:12 am-12:20 pm
2 stops7h 08m
$425
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/2
5:10 am-4:10 pm
2 stops10h 00m
Buffalo
Mon 10/5
2:50 pm-10:55 pm
2 stops9h 05m
$437
Quickest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sat 10/17
3:11 pm-8:47 pm
1 stop4h 36m
Buffalo
Wed 10/21
10:46 am-2:15 pm
1 stop4h 29m
$445
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated August 7, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 7, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on August 7, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to Buffalo
Discover the top 2 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$317 | FlexibilityNo cancel fee | On-time71% |