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$160+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Apr 14 — Apr 211
Tue 4/14
Tue 4/21
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 15, 2026.

This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:56 am
DSM
-
BUF
1 stop6h 40m
American Airlines
Tue 4/146:00 am
BUF
-
DSM
1 stop6h 30m
American Airlines
Deal found 3/11$339
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:25 am
DSM
-
BUF
1 stop3h 50m
Southwest
Mon 5/46:00 am
BUF
-
DSM
1 stop6h 45m
Southwest
Deal found 3/13$355
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:20 pm
DSM
-
BUF
1 stop4h 10m
Southwest
Thu 5/218:00 pm
BUF
-
DSM
1 stop4h 05m
Southwest
Deal found 3/11$381
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
-
BUF
1 stop4h 10m
Southwest
Fri 5/18:00 pm
BUF
-
DSM
1 stop4h 05m
Southwest
Deal found 3/10$387
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:40 am
DSM
-
BUF
1 stop4h 14m
United Airlines
Sun 5/1711:02 am
BUF
-
DSM
1 stop4h 22m
United Airlines
Deal found 3/11$391
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
DSM
-
BUF
1 stop7h 21m
American Airlines
Wed 5/206:00 am
BUF
-
DSM
1 stop8h 11m
American Airlines
Deal found 3/12$393

Find flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$339
(American Airlines)

One-way from

$160
(United Airlines)

Popular in

May

Cheapest in

October

Average price

$469
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Des Moines to Buffalo
Search Deals
One-way flight from Des Moines to Buffalo
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 4/27

5:25 am-10:15 am

1 stop3h 50m

Buffalo

Mon 5/4

6:00 am-11:45 am

1 stop6h 45m

$355
Quickest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 5/14

4:20 pm-9:30 pm

1 stop4h 10m

Buffalo

Thu 5/21

8:00 pm-11:05 pm

1 stop4h 05m

$381

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 5/14

11:40 am-4:54 pm

1 stop4h 14m

Buffalo

Sun 5/17

11:02 am-2:24 pm

1 stop4h 22m

$391

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 5/17

5:20 am-10:25 am

1 stop4h 05m

Buffalo

Wed 5/20

6:55 pm-10:10 pm

1 stop4h 15m

$401

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 4/29

1:32 pm-11:10 pm

1 stop8h 38m

Buffalo

Sat 5/2

11:02 am-2:18 pm

1 stop4h 16m

$407

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 5/14

4:20 pm-9:30 pm

1 stop4h 10m

Buffalo

Sun 5/17

5:50 am-11:25 am

2 stops6h 35m

$414
Cheapest one-way

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 4/1

6:20 am-2:17 pm

2 stops6h 57m

$165

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/18

1:37 pm-10:36 pm

1 stop7h 59m

$204

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/18

6:00 am-2:25 pm

2 stops7h 25m

$209

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 3/26

5:35 am-10:30 am

1 stop3h 55m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in November is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated March 15, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,293 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,293 reviews
Delta
7.9
Good
8,293 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
9,427 reviews
Delta
7.9
Good
8,293 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,472 reviews
Delta
7.9
Good
8,293 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.2

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Buffalo?

    A quick flight from Des Moines to Buffalo can take about 8h 02m. American Airlines provides one of the quickest options available for as low as $319. Des Moines and Buffalo are separated by a distance of 768 mi.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    Delta, at $148, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 60% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in November is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$331FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$334FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$460FlexibilityNo cancel feeOn-time69%

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