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$140+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:10 am
DSM
-
BUF
1 stop4h 29m
Delta
Sat 5/26:00 am
BUF
-
DSM
1 stop6h 05m
Delta
Deal found 1/27$341
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
DSM
-
BUF
1 stop7h 11m
American Airlines
Sat 5/22:25 pm
BUF
-
DSM
2 stops10h 04m
American Airlines
Deal found 1/27$346
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:15 am
DSM
-
BUF
1 stop4h 29m
Delta
Wed 4/16:15 am
BUF
-
DSM
1 stop4h 31m
Delta
Deal found 1/28$352
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2710:04 am
DSM
-
BUF
1 stop6h 25m
American Airlines
Wed 4/15:00 pm
BUF
-
DSM
2 stops7h 48m
American Airlines
Deal found 1/28$357
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:41 pm
DSM
-
BUF
1 stop7h 50m
American Airlines
Fri 6/1210:07 am
BUF
-
DSM
1 stop4h 08m
American Airlines
Deal found 1/27$427
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/148:00 am
DSM
-
BUF
1 stop4h 12m
United Airlines
Wed 2/187:00 am
BUF
-
DSM
1 stop4h 53m
United Airlines
Deal found 1/28$462

Find flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$341
(Delta)

One-way from

$140
(Kiwi.com)

Popular in

February

Cheapest in

October

Average price

$420
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
Search Deals
From Des Moines to Buffalo
Search Deals
One-way flight from Des Moines to Buffalo
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($133 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Des Moines

Fly to

Buffalo

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 4/30

7:00 am-3:11 pm

1 stop7h 11m

Buffalo

Sat 5/2

2:25 pm-11:29 pm

2 stops10h 04m

$346

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/27

6:15 am-11:44 am

1 stop4h 29m

Buffalo

Wed 4/1

6:15 am-9:46 am

1 stop4h 31m

$352

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/27

10:04 am-5:29 pm

1 stop6h 25m

Buffalo

Wed 4/1

5:00 pm-11:48 pm

2 stops7h 48m

$357

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 6/5

1:41 pm-10:31 pm

1 stop7h 50m

Buffalo

Fri 6/12

10:07 am-1:15 pm

1 stop4h 08m

$427

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 2/14

8:00 am-1:12 pm

1 stop4h 12m

Buffalo

Wed 2/18

7:00 am-10:53 am

1 stop4h 53m

$462

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/6

8:21 pm-11:05 am

2 stops37h 44m

$140

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/6

5:43 pm-10:57 pm

1 stop4h 14m

$194

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 2/22

5:43 pm-10:57 pm

1 stop4h 14m

$204

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 2/22

2:14 pm-10:50 pm

2 stops7h 36m

$286

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 3/6

8:32 pm-11:05 am

3 stops37h 33m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 11 results
1
2

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
9,215 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Buffalo?

    A quick flight from Des Moines to Buffalo can take about 4h 29m. American Airlines provides one of the quickest options available for as low as $352. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    Delta, at $148, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 62% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $135. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Des Moines to Buffalo for a low price.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Alternative routes for Des Moines to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$332FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$317FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$463FlexibilityNo cancel feeOn-time69%

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