$317+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Aug 22 — Aug 291
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Best
Last-minute
One-way
Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:08 am
DSM
- BUF
1 stop7h 19m
American Airlines
Sat 10/177:00 am
BUF
- DSM
1 stop6h 45m
American Airlines
Deal found 7/21![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:06 pm
DSM
- BUF
1 stop4h 03m
Delta
Wed 8/2612:02 pm
BUF
- DSM
1 stop6h 09m
Delta
Deal found 7/22![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
DSM
- BUF
1 stop7h 46m
American Airlines
Mon 8/176:09 pm
BUF
- DSM
1 stop7h 11m
American Airlines
Deal found 7/21![American Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:05 am
DSM
- BUF
1 stop4h 50m
Southwest
Sun 9/137:00 pm
BUF
- DSM
1 stop4h 55m
Southwest
Deal found 7/23![Southwest logo]()
$382
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:08 pm
DSM
- BUF
1 stop7h 47m
American Airlines
Wed 8/125:38 pm
BUF
- DSM
1 stop7h 06m
American Airlines
Deal found 7/22![American Airlines logo]()
$402
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:00 am
DSM
- BUF
1 stop7h 26m
American Airlines
Fri 9/255:18 pm
BUF
- DSM
1 stop5h 18m
American Airlines
Deal found 7/19![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:00 am
DSM
- BUF
2 stops10h 00m
United Airlines
Wed 8/262:53 pm
BUF
- DSM
2 stops7h 30m
United Airlines
Deal found 7/22![United Airlines logo]()
$408
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:01 am
DSM
- BUF
2 stops7h 51m
American Airlines
Sat 10/177:00 am
BUF
- DSM
2 stops7h 30m
American Airlines
Deal found 7/19![American Airlines logo]()
$441
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/911:23 am
DSM
- BUF
1 stop4h 18m
United Airlines
Fri 8/1410:30 am
BUF
- DSM
1 stop4h 46m
United Airlines
Deal found 7/22![United Airlines logo]()
$473
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:10 am
DSM
- BUF
2 stops10h 55m
Southwest
Sun 10/115:50 am
BUF
- DSM
2 stops8h 45m
Southwest
Deal found 7/19![Southwest logo]()
$491
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:59 am
DSM
- BUF
1 stop6h 24m
Delta
Tue 8/113:54 pm
BUF
- DSM
1 stop5h 45m
Delta
Deal found 7/23![Delta logo]()
$558
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
DSM
- BUF
1 stop6h 13m
United Airlines
Wed 8/126:55 am
BUF
- DSM
1 stop4h 31m
United Airlines
Deal found 7/19![United Airlines logo]()
$501
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:40 am
DSM
- BUF
2 stops11h 45m
Southwest
Tue 8/1112:35 pm
BUF
- DSM
2 stops9h 25m
Southwest
Deal found 7/22![Southwest logo]()
$507
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:00 am
DSM
- BUF
2 stops7h 18m
United Airlines
Sun 8/166:55 am
BUF
- DSM
1 stop4h 31m
United Airlines
Deal found 7/21![United Airlines logo]()
$538
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:40 pm
DSM
- BUF
2 stops9h 19m
United Airlines
Mon 8/316:55 am
BUF
- DSM
1 stop6h 25m
United Airlines
Deal found 7/21![United Airlines logo]()
$592
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated July 23, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated July 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:08 pm
DSM
- BUF
1 stop7h 47m
American Airlines
Wed 8/125:38 pm
BUF
- DSM
1 stop7h 06m
American Airlines
Deal found 7/22![American Airlines logo]()
$402
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:08 pm
DSM
- BUF
1 stop7h 47m
American Airlines
Sun 8/96:09 pm
BUF
- DSM
1 stop7h 11m
American Airlines
Deal found 7/19![American Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/911:23 am
DSM
- BUF
1 stop4h 18m
United Airlines
Fri 8/1410:30 am
BUF
- DSM
1 stop4h 46m
United Airlines
Deal found 7/22![United Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:21 pm
DSM
- BUF
1 stop6h 46m
United Airlines
Sun 8/166:55 am
BUF
- DSM
1 stop4h 31m
United Airlines
Deal found 7/21![United Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
DSM
- BUF
1 stop7h 46m
American Airlines
Mon 8/176:09 pm
BUF
- DSM
1 stop7h 11m
American Airlines
Deal found 7/21![American Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:35 pm
DSM
- BUF
1 stop8h 02m
United Airlines
Sun 8/166:55 am
BUF
- DSM
1 stop4h 31m
United Airlines
Deal found 7/22![United Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
DSM
- BUF
2 stops11h 45m
Southwest
Mon 8/171:40 pm
BUF
- DSM
2 stops9h 30m
Southwest
Deal found 7/21![Southwest logo]()
$453
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:06 pm
DSM
- BUF
1 stop4h 03m
Delta
Wed 8/2612:02 pm
BUF
- DSM
1 stop6h 09m
Delta
Deal found 7/22![Delta logo]()
$327
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:00 am
DSM
- BUF
2 stops10h 00m
United Airlines
Wed 8/262:53 pm
BUF
- DSM
2 stops7h 30m
United Airlines
Deal found 7/22![United Airlines logo]()
$408
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:49 pm
DSM
- BUF
2 stops19h 40m
Multiple Airlines
Deal found 7/20![Multiple Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:33 pm
DSM
- BUF
1 stop4h 26m
American Airlines
Deal found 7/20![American Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:00 am
DSM
- BUF
3 stops15h 58m
United Airlines
Deal found 7/20![United Airlines logo]()
$615
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $317 (American Airlines) |
Popular in | March |
Cheapest in | October |
Average price | $430 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 10/13
7:01 am-3:52 pm
2 stops7h 51m
Buffalo
Sat 10/17
7:00 am-1:30 pm
2 stops7h 30m
$441
Quickest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sun 8/9
11:23 am-4:41 pm
1 stop4h 18m
Buffalo
Fri 8/14
10:30 am-2:16 pm
1 stop4h 46m
$473
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 10/9
5:10 am-5:05 pm
2 stops10h 55m
Buffalo
Sun 10/11
5:50 am-1:35 pm
2 stops8h 45m
$491
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 8/8
6:00 am-1:13 pm
1 stop6h 13m
Buffalo
Wed 8/12
6:55 am-10:26 am
1 stop4h 31m
$501
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 8/7
5:40 am-6:25 pm
2 stops11h 45m
Buffalo
Tue 8/11
12:35 pm-9:00 pm
2 stops9h 25m
$507
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 8/13
6:00 am-2:18 pm
2 stops7h 18m
Buffalo
Sun 8/16
6:55 am-10:26 am
1 stop4h 31m
$538
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 8/8
10:59 am-6:23 pm
1 stop6h 24m
Buffalo
Tue 8/11
3:54 pm-8:39 pm
1 stop5h 45m
$558
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 8/1
1:40 pm-11:59 pm
2 stops9h 19m
Buffalo
Mon 8/31
6:55 am-12:20 pm
1 stop6h 25m
$592
Cheapest one-way
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 7/29
1:49 pm-10:29 am
2 stops19h 40m
$359
Quickest one-way
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 7/29
6:33 pm-11:59 pm
1 stop4h 26m
$389
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 23, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Buffalo by cabin class
Find flights from Des Moines to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on July 23, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to Buffalo
Discover the top 2 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$317 | FlexibilityNo cancel fee | On-time71% |