$269+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Best
Last-minute
One-way
Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Sat 11/146:00 am -
1 stop5h 32m
Deal found 9/15![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:58 pm -
1 stop6h 39m
Sat 11/145:19 pm -
2 stops8h 07m
Deal found 9/15![American Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:10 am -
1 stop4h 08m
Fri 11/136:10 am -
1 stop4h 36m
Deal found 9/15![Delta logo]()
$306
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:25 am -
2 stops7h 00m
Fri 11/136:21 pm -
1 stop5h 18m
Deal found 9/15![American Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:05 am -
1 stop5h 41m
Tue 10/207:00 am -
1 stop6h 45m
Deal found 9/14![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:10 am -
1 stop4h 15m
Sun 11/14:55 pm -
1 stop6h 05m
Deal found 9/16![Southwest logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 am -
1 stop5h 41m
Sun 11/14:16 pm -
2 stops9h 10m
Deal found 9/16![American Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:50 pm -
1 stop5h 09m
Sun 10/186:15 am -
1 stop4h 27m
Deal found 9/14![Delta logo]()
$412
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Sat 11/146:00 am -
1 stop5h 32m
Deal found 9/15![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:50 pm -
1 stop5h 09m
Sun 10/186:15 am -
1 stop4h 27m
Deal found 9/14![Delta logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:11 am -
2 stops9h 20m
Sun 11/2210:35 am -
2 stops9h 19m
Deal found 9/16![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:10 am -
2 stops10h 00m
Sun 11/13:05 pm -
2 stops8h 55m
Deal found 9/16![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:25 pm -
1 stop4h 27m
Wed 2/36:30 am -
1 stop6h 57m
Deal found 9/15![United Airlines logo]()
$349
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated September 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:44 pm -
1 stop6h 26m
Wed 9/306:30 am -
1 stop6h 34m
Deal found 9/15![American Airlines logo]()
$682
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:20 am -
2 stops12h 50m
Wed 9/306:25 pm -
1 stop4h 35m
Deal found 9/15![Southwest logo]()
$687
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:11 pm -
1 stop4h 36m
Sun 10/47:00 am -
1 stop4h 30m
Deal found 9/15![United Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:05 am -
1 stop5h 41m
Tue 10/207:00 am -
1 stop6h 45m
Deal found 9/14![American Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:50 pm -
1 stop5h 09m
Sun 10/186:15 am -
1 stop4h 27m
Deal found 9/14![Delta logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:12 am -
2 stops7h 45m
Sun 10/185:50 am -
1 stop5h 52m
Deal found 9/14![American Airlines logo]()
$462
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:10 am -
1 stop4h 15m
Sun 11/14:55 pm -
1 stop6h 05m
Deal found 9/16![Southwest logo]()
$380
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 am -
1 stop5h 41m
Sun 11/14:16 pm -
2 stops9h 10m
Deal found 9/16![American Airlines logo]()
$385
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:44 pm -
2 stops22h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:59 am -
1 stop6h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Delta logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:33 am -
2 stops8h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$409
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (United Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $388 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
1:27 pm-10:33 pm
1 stop8h 06m
Buffalo
Sat 11/14
6:00 am-10:32 am
1 stop5h 32m
$269
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sat 1/30
3:25 pm-8:52 pm
1 stop4h 27m
Buffalo
Wed 2/3
6:30 am-12:27 pm
1 stop6h 57m
$349
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 9/23
8:03 am-3:40 pm
1 stop6h 37m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$404
Quickest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 9/23
10:59 am-6:23 pm
1 stop6h 24m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$404
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 9/23
11:33 am-9:07 pm
2 stops8h 34m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$409
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/16
5:50 pm-11:59 pm
1 stop5h 09m
Buffalo
Sun 10/18
6:15 am-9:42 am
1 stop4h 27m
$412
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 11/20
7:11 am-5:31 pm
2 stops9h 20m
Buffalo
Sun 11/22
10:35 am-6:54 pm
2 stops9h 19m
$427
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/30
5:10 am-4:10 pm
2 stops10h 00m
Buffalo
Sun 11/1
3:05 pm-11:00 pm
2 stops8h 55m
$427
Sorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 16, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Comfort
7.2
Overall
7.1
Boarding
7.4
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Entertainment
6.8
Food
6.4
Comfort
7.2
Overall
7.1
Boarding
7.4
Crew
7.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on September 16, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Des Moines to Buffalo
Discover the top airline that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$388 | FlexibilityNo cancel fee | On-time71% |