$269+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Best
Last-minute
One-way
Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:09 am -
1 stop4h 15m
Wed 12/166:10 am -
1 stop4h 40m
Deal found 10/25![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
2 stops8h 15m
Wed 12/168:05 am -
1 stop4h 20m
Deal found 10/25![Southwest logo]()
$344
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:10 am -
1 stop3h 55m
Thu 12/246:55 pm -
1 stop4h 10m
Deal found 10/25![Southwest logo]()
$371
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:29 pm -
1 stop5h 29m
Tue 11/1712:00 pm -
1 stop5h 49m
Deal found 10/26![Delta logo]()
$438
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:50 am -
1 stop6h 12m
Tue 12/16:30 am -
1 stop7h 09m
Deal found 10/26![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Sun 11/155:58 pm -
1 stop4h 57m
Deal found 10/27![United Airlines logo]()
$537
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:05 am -
2 stops7h 15m
Sat 11/145:49 pm -
1 stop6h 10m
Deal found 10/25![United Airlines logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:27 pm -
1 stop8h 06m
Tue 11/171:53 pm -
2 stops10h 49m
Deal found 10/26![United Airlines logo]()
$543
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
2 stops9h 30m
Wed 12/1612:45 pm -
2 stops10h 20m
Deal found 10/25![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:50 am -
1 stop6h 12m
Tue 12/16:30 am -
1 stop7h 09m
Deal found 10/26![United Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:09 am -
1 stop5h 59m
Fri 11/136:46 pm -
1 stop6h 40m
Deal found 10/25![American Airlines logo]()
$537
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:24 am -
1 stop3h 51m
Thu 11/126:35 am -
1 stop4h 09m
Deal found 10/27![Delta logo]()
$537
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:10 am -
1 stop3h 55m
Thu 12/246:55 pm -
1 stop4h 10m
Deal found 10/25![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:09 am -
1 stop5h 59m
Fri 11/137:37 pm -
1 stop5h 20m
Deal found 10/27![American Airlines logo]()
$537
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:05 am -
2 stops7h 15m
Sat 11/145:49 pm -
1 stop6h 10m
Deal found 10/25![United Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:30 pm -
1 stop4h 25m
Sat 11/144:35 pm -
1 stop4h 10m
Deal found 10/25![Southwest logo]()
$537
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:24 pm -
1 stop4h 12m
Fri 11/1310:35 am -
2 stops9h 41m
Deal found 10/25![United Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:28 am -
1 stop6h 19m
Tue 11/174:16 pm -
2 stops9h 02m
Deal found 10/29![American Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
1 stop4h 00m
Thu 11/1212:40 pm -
2 stops11h 25m
Deal found 10/27![Southwest logo]()
$542
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated October 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:40 am -
2 stops7h 45m
Thu 11/1212:05 pm -
2 stops12h 00m
Deal found 10/27![Southwest logo]()
$547
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:55 am -
1 stop6h 07m
Sat 11/146:00 am -
1 stop7h 20m
Deal found 10/26![United Airlines logo]()
$637
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Sun 11/155:58 pm -
1 stop4h 57m
Deal found 10/27![United Airlines logo]()
$537
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:05 am -
2 stops7h 15m
Sat 11/145:49 pm -
1 stop6h 10m
Deal found 10/25![United Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops9h 30m
Sun 11/1512:40 pm -
2 stops11h 25m
Deal found 10/27![Southwest logo]()
$624
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:29 pm -
1 stop5h 29m
Tue 11/1712:00 pm -
1 stop5h 49m
Deal found 10/26![Delta logo]()
$438
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:27 pm -
1 stop8h 06m
Tue 11/171:53 pm -
2 stops10h 49m
Deal found 10/26![United Airlines logo]()
$543
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:50 am -
1 stop6h 12m
Tue 12/16:30 am -
1 stop7h 09m
Deal found 10/26![United Airlines logo]()
$509
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:00 am -
3 stops13h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$539
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $269 (American Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $452 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 11/10
6:00 am-11:35 am
1 stop4h 35m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$269
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 12/9
6:00 am-4:30 pm
2 stops9h 30m
Buffalo
Wed 12/16
12:45 pm-10:05 pm
2 stops10h 20m
$349
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sun 12/20
5:10 am-10:05 am
1 stop3h 55m
Buffalo
Thu 12/24
6:55 pm-10:05 pm
1 stop4h 10m
$371
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 11/24
9:50 am-5:02 pm
1 stop6h 12m
Buffalo
Tue 12/1
6:30 am-12:39 pm
1 stop7h 09m
$509
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Mon 11/9
11:09 am-6:08 pm
1 stop5h 59m
Buffalo
Fri 11/13
6:46 pm-12:26 am
1 stop6h 40m
$537
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Mon 11/9
10:24 am-3:15 pm
1 stop3h 51m
Buffalo
Thu 11/12
6:35 am-9:44 am
1 stop4h 09m
$537
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
11:09 am-6:08 pm
1 stop5h 59m
Buffalo
Fri 11/13
7:37 pm-11:57 pm
1 stop5h 20m
$537
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
3:30 pm-8:55 pm
1 stop4h 25m
Buffalo
Sat 11/14
4:35 pm-7:45 pm
1 stop4h 10m
$537
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 11/10
8:00 am-10:59 pm
3 stops13h 59m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$539
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
6:05 am-2:20 pm
2 stops7h 15m
Buffalo
Sat 11/14
5:49 pm-10:59 pm
1 stop6h 10m
$542
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated October 30, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Entertainment
6.8
Overall
7.0
Crew
7.9
Food
6.4
Comfort
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Boarding
7.4
Entertainment
6.8
Overall
7.0
Crew
7.9
Food
6.4
Comfort
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on October 30, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Des Moines to Buffalo
Discover the top airline that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$284 | Average$406 | FlexibilityNo cancel fee | On-time71% |