How long is the flight from Des Moines to Buffalo?

A quick flight from Des Moines to Buffalo can take about 5h 52m. Delta provides one of the quickest options available for as low as $319. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

Delta, at $216, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 47% lower than the current average price 3 months from now.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What are the most popular airlines that fly from Des Moines to Buffalo?

When booking a flight from Des Moines to Buffalo, you may want to consider flying on Delta, American Airlines or United Airlines as they are the most popular for this route.

What is the cheapest time of day to fly from DSM to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Buffalo as you normally would.

Most accurate provider : When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

Can I find deals for business class flights from Des Moines to Buffalo?

Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$126+ Flights from Des Moines to Buffalo

Q: How much does it cost to fly round-trip from Des Moines to Buffalo?

Airfare is typical for this route at the moment. Des Moines to Buffalo flights typically cost between $267 and $401 in December. The cheapest round-trip price found within the last 3 days was $285 on American Airlines (Dec 4-Dec 11).

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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

Thu 12/44:49 pmDSM - BUF

1 stop5h 50mAmerican Airlines

Thu 12/115:03 amBUF - DSM

1 stop8h 20mAmerican Airlines

Deal found 10/20

$285

Thu 12/45:43 pmDSM - BUF

1 stop4h 15mDelta

Thu 12/111:16 pmBUF - DSM

1 stop4h 00mDelta

Deal found 10/19

$371

Fri 11/73:15 pmDSM - BUF

1 stop6h 42mDelta

Tue 11/116:10 amBUF - DSM

1 stop8h 22mDelta

Deal found 10/20

$382

Fri 11/71:35 pmDSM - BUF

1 stop8h 17mUnited Airlines

Tue 11/116:00 amBUF - DSM

2 stops9h 19mUnited Airlines

Deal found 10/20

$387

Thu 12/48:00 amDSM - BUF

1 stop4h 12mUnited Airlines

Thu 12/1110:30 amBUF - DSM

1 stop4h 50mUnited Airlines

Deal found 10/19

$425

Fri 11/76:05 amDSM - BUF

1 stop5h 04mDelta

Mon 11/102:50 pmBUF - DSM

1 stop5h 49mDelta

Deal found 10/20

$427

Best flights from Des Moines to Buffalo
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2025.

Tue 3/310:15 amDSM - BUF

1 stop5h 52mDelta

Thu 3/56:00 amBUF - DSM

1 stop5h 23mDelta

Deal found 10/20

$319

Thu 12/44:07 pmDSM - BUF

1 stop7h 00mAmerican Airlines

Thu 12/1110:14 amBUF - DSM

1 stop7h 05mAmerican Airlines

Deal found 10/19

$356

Fri 11/71:35 pmDSM - BUF

1 stop8h 17mUnited Airlines

Tue 11/116:00 amBUF - DSM

2 stops9h 19mUnited Airlines

Deal found 10/20

$387

Thu 12/45:43 pmDSM - BUF

1 stop4h 15mDelta

Thu 12/111:16 pmBUF - DSM

1 stop4h 00mDelta

Deal found 10/19

$371

Tue 3/32:06 pmDSM - BUF

2 stops7h 37mAmerican Airlines

Thu 3/511:39 amBUF - DSM

1 stop3h 47mAmerican Airlines

Deal found 10/21

$394

Fri 11/73:15 pmDSM - BUF

1 stop6h 42mDelta

Tue 11/116:10 amBUF - DSM

1 stop8h 22mDelta

Deal found 10/20

$382

Thu 12/48:00 amDSM - BUF

1 stop4h 12mUnited Airlines

Thu 12/1110:30 amBUF - DSM

1 stop4h 50mUnited Airlines

Deal found 10/19

$425

Last-minute flights from Des Moines to Buffalo
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated October 22, 2025 and is based on user searches.

Tue 11/412:54 pmDSM - BUF

2 stops9h 02mAmerican Airlines

Sat 11/85:33 pmBUF - DSM

1 stop5h 37mAmerican Airlines

Deal found 10/19

$452

Tue 11/43:15 pmDSM - BUF

1 stop4h 45mUnited Airlines

Sat 11/88:10 amBUF - DSM

1 stop9h 03mUnited Airlines

Deal found 10/20

$517

Thu 11/66:05 amDSM - BUF

1 stop5h 04mDelta

Mon 11/106:10 amBUF - DSM

1 stop5h 32mDelta

Deal found 10/22

$447

Thu 11/65:45 amDSM - BUF

2 stops10h 25mSouthwest

Sun 11/912:45 pmBUF - DSM

2 stops11h 50mSouthwest

Deal found 10/20

$474

Fri 11/73:15 pmDSM - BUF

1 stop6h 42mDelta

Tue 11/116:10 amBUF - DSM

1 stop8h 22mDelta

Deal found 10/20

$382

Fri 11/71:35 pmDSM - BUF

1 stop8h 17mUnited Airlines

Tue 11/116:00 amBUF - DSM

2 stops9h 19mUnited Airlines

Deal found 10/20

$387

Fri 11/76:05 amDSM - BUF

1 stop5h 04mDelta

Mon 11/102:50 pmBUF - DSM

1 stop5h 49mDelta

Deal found 10/20

$427

Fri 11/71:35 pmDSM - BUF

1 stop8h 17mUnited Airlines

Mon 11/106:00 amBUF - DSM

2 stops9h 19mUnited Airlines

Deal found 10/20

$432

One-way flights from Des Moines to Buffalo
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 22, 2025.

Sat 12/63:00 pmDSM - BUF

1 stop7h 59mDelta

Deal found 10/22

$126

Thu 12/44:07 pmDSM - BUF

1 stop7h 00mAmerican Airlines

Deal found 10/20

$143

Thu 12/42:56 pmDSM - BUF

2 stops46h 19mMultiple Airlines

Deal found 10/20

$149

Fri 12/53:17 pmDSM - BUF

1 stop6h 45mDelta

Deal found 10/20

$177

Sat 12/65:45 amDSM - BUF

2 stops28h 02mUnited Airlines

Deal found 10/22

$372

Fri 12/56:50 pmDSM - BUF

2 stops18h 32mUnited Airlines

Deal found 10/20

$426

Cheap flight deals from Des Moines to Buffalo

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$285 (American Airlines)
One-way from	$126 (Delta)
Popular in	February
Cheapest in	October
Average price	$250

Provider with most accurate pricing for Des Moines-Buffalo flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.

Search Deals

From Des Moines to Buffalo

Search Deals

One-way flight from Des Moines to Buffalo

Search Deals

Highest demand for flights based on searches. 22% potential increase in price ($122 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 3/3

10:15 am-5:07 pm

1 stop5h 52m

Buffalo

Thu 3/5

6:00 am-10:23 am

1 stop5h 23m

$319

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

4:07 pm-12:07 am

1 stop7h 00m

Buffalo

Thu 12/11

10:14 am-4:19 pm

1 stop7h 05m

$356

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

5:43 pm-10:58 pm

1 stop4h 15m

Buffalo

Thu 12/11

1:16 pm-4:16 pm

1 stop4h 00m

$371

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 11/7

3:15 pm-10:57 pm

1 stop6h 42m

Buffalo

Tue 11/11

6:10 am-1:32 pm

1 stop8h 22m

$382

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 11/7

1:35 pm-10:52 pm

1 stop8h 17m

Buffalo

Tue 11/11

6:00 am-2:19 pm

2 stops9h 19m

$387

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 3/3

2:06 pm-10:43 pm

2 stops7h 37m

Buffalo

Thu 3/5

11:39 am-2:26 pm

1 stop3h 47m

$394

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

8:00 am-1:12 pm

1 stop4h 12m

Buffalo

Thu 12/11

10:30 am-2:20 pm

1 stop4h 50m

$425

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 12/6

3:00 pm-11:59 pm

1 stop7h 59m

$126

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

4:07 pm-12:07 am

1 stop7h 00m

$143

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

2:56 pm-2:15 pm

2 stops46h 19m

$149

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 13 results

Compare providers for flights from Des Moines to Buffalo

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in January is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Buffalo?

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Delta

7.9

Good

7,981 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

United Airlines

7.4

Good

8,990 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

American Airlines

7.2

Good

11,028 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

How long is the flight from Des Moines to Buffalo?
A quick flight from Des Moines to Buffalo can take about 5h 52m. Delta provides one of the quickest options available for as low as $319. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Des Moines to Buffalo round-trip?
Delta, at $216, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 47% lower than the current average price 3 months from now.
Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?
Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.
Can I find deals for business class flights from Des Moines to Buffalo?
Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in January is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Buffalo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$216	Average$332	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$238	Average$362	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$341	Average$441	FlexibilityNo cancel fee	On-time69%

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$126+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Buffalo with Cheapflights

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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

Cheap flight deals from Des Moines to Buffalo

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Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in October.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

How much does it cost to fly round-trip from Des Moines to Buffalo?

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Buffalo?

What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

How can I find direct flights from Des Moines to Buffalo?

Can I find deals for business class flights from Des Moines to Buffalo?

What is the cheapest month to book a flight from Des Moines to Buffalo?

Traveling to a place near Buffalo?

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Top 3 airlines flying from Des Moines to Buffalo

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Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.