$111+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Jun 10 — Jun 171
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:10 am
DSM
- BUF
1 stop5h 16m
American Airlines
Wed 6/106:26 am
BUF
- DSM
1 stop7h 26m
American Airlines
Deal found 5/8![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
DSM
- BUF
1 stop3h 50m
Southwest
Fri 5/298:00 pm
BUF
- DSM
1 stop4h 05m
Southwest
Deal found 5/8![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:33 am
DSM
- BUF
1 stop4h 46m
American Airlines
Fri 5/296:02 am
BUF
- DSM
2 stops7h 50m
American Airlines
Deal found 5/9![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Thu 6/111:56 pm
BUF
- DSM
1 stop7h 47m
American Airlines
Deal found 5/9![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:23 am
DSM
- BUF
1 stop4h 18m
United Airlines
Sat 7/116:04 pm
BUF
- DSM
1 stop5h 47m
United Airlines
Deal found 5/9![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- BUF
2 stops8h 00m
Southwest
Thu 6/117:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 5/8![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:35 pm
DSM
- BUF
1 stop3h 45m
Southwest
Sat 8/87:50 am
BUF
- DSM
1 stop4h 40m
Southwest
Deal found 5/8![Southwest logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Sun 6/285:34 pm
BUF
- DSM
1 stop7h 16m
American Airlines
Deal found 5/6![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Tue 6/236:02 am
BUF
- DSM
2 stops8h 19m
American Airlines
Deal found 5/8![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:43 pm
DSM
- BUF
1 stop6h 09m
American Airlines
Thu 6/111:56 pm
BUF
- DSM
1 stop7h 47m
American Airlines
Deal found 5/8![American Airlines logo]()
$417
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
DSM
- BUF
1 stop3h 50m
Southwest
Fri 5/298:00 pm
BUF
- DSM
1 stop4h 05m
Southwest
Deal found 5/9![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Thu 6/111:56 pm
BUF
- DSM
1 stop7h 47m
American Airlines
Deal found 5/9![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/135:34 pm
DSM
- BUF
1 stop4h 11m
Delta
Fri 6/196:29 am
BUF
- DSM
1 stop4h 15m
Delta
Deal found 5/10![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- BUF
2 stops8h 00m
Southwest
Thu 6/117:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 5/8![Southwest logo]()
$394
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:45 am
DSM
- BUF
2 stops11h 19m
American Airlines
Sat 7/118:08 am
BUF
- DSM
1 stop5h 55m
American Airlines
Deal found 5/9![American Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Mon 6/227:32 pm
BUF
- DSM
1 stop5h 40m
American Airlines
Deal found 5/7![American Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:35 pm
DSM
- BUF
1 stop3h 45m
Southwest
Sat 8/87:50 am
BUF
- DSM
1 stop4h 40m
Southwest
Deal found 5/8![Southwest logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:43 pm
DSM
- BUF
1 stop6h 09m
American Airlines
Fri 6/121:49 pm
BUF
- DSM
1 stop7h 54m
American Airlines
Deal found 5/6![American Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Thu 6/117:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 5/8![Southwest logo]()
$422
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:10 am
DSM
- BUF
2 stops13h 05m
Southwest
Sat 8/16:45 pm
BUF
- DSM
1 stop5h 05m
Southwest
Deal found 5/7![Southwest logo]()
$428
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated May 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated May 11, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:30 am
DSM
- BUF
1 stop3h 50m
Southwest
Fri 5/298:00 pm
BUF
- DSM
1 stop4h 05m
Southwest
Deal found 5/8![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:33 am
DSM
- BUF
1 stop4h 46m
American Airlines
Fri 5/296:02 am
BUF
- DSM
2 stops7h 50m
American Airlines
Deal found 5/9![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:10 am
DSM
- BUF
1 stop5h 16m
American Airlines
Wed 6/106:26 am
BUF
- DSM
1 stop7h 26m
American Airlines
Deal found 5/8![American Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:43 pm
DSM
- BUF
1 stop6h 09m
American Airlines
Fri 6/121:49 pm
BUF
- DSM
1 stop7h 54m
American Airlines
Deal found 5/6![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:43 pm
DSM
- BUF
1 stop6h 09m
American Airlines
Thu 6/111:56 pm
BUF
- DSM
1 stop7h 47m
American Airlines
Deal found 5/8![American Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Thu 6/117:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 5/8![Southwest logo]()
$422
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Thu 6/111:56 pm
BUF
- DSM
1 stop7h 47m
American Airlines
Deal found 5/9![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- BUF
2 stops8h 00m
Southwest
Thu 6/117:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 5/8![Southwest logo]()
$394
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Sun 6/285:34 pm
BUF
- DSM
1 stop7h 16m
American Airlines
Deal found 5/6![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:09 pm
DSM
- BUF
1 stop4h 29m
American Airlines
Tue 6/236:02 am
BUF
- DSM
2 stops8h 19m
American Airlines
Deal found 5/8![American Airlines logo]()
$412
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- BUF
2 stops41h 55m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$111
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:24 pm
DSM
- BUF
1 stop4h 44m
United Airlines
Deal found 5/8![United Airlines logo]()
$178
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am
DSM
- BUF
1 stop5h 03m
American Airlines
Deal found 5/9![American Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/191:41 pm
DSM
- BUF
1 stop8h 11m
American Airlines
Deal found 5/9![American Airlines logo]()
$204
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:40 am
DSM
- BUF
2 stops7h 45m
Southwest
Deal found 5/9![Southwest logo]()
$209
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:00 am
DSM
- BUF
3 stops13h 37m
United Airlines
Deal found 5/9![United Airlines logo]()
$238
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:11 am
DSM
- BUF
1 stop5h 19m
American Airlines
Deal found 5/10![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:43 pm
DSM
- BUF
1 stop6h 09m
American Airlines
Deal found 5/7![American Airlines logo]()
$389
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $365 (American Airlines) |
One-way from | $111 (Kiwi.com) |
Popular in | March |
Cheapest in | June |
Average price | $538 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 5/27
5:30 am-10:20 am
1 stop3h 50m
Buffalo
Fri 5/29
8:00 pm-11:05 pm
1 stop4h 05m
$375
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 6/10
7:09 pm-12:38 am
1 stop4h 29m
Buffalo
Thu 6/11
1:56 pm-8:43 pm
1 stop7h 47m
$381
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 6/10
5:20 am-2:20 pm
2 stops8h 00m
Buffalo
Thu 6/11
7:55 pm-11:30 pm
1 stop4h 35m
$394
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 7/4
8:45 am-9:04 pm
2 stops11h 19m
Buffalo
Sat 7/11
8:08 am-1:03 pm
1 stop5h 55m
$396
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 6/13
5:34 pm-10:45 pm
1 stop4h 11m
Buffalo
Fri 6/19
6:29 am-9:44 am
1 stop4h 15m
$407
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 6/18
7:09 pm-12:38 am
1 stop4h 29m
Buffalo
Mon 6/22
7:32 pm-12:12 am
1 stop5h 40m
$407
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 8/1
3:35 pm-8:20 pm
1 stop3h 45m
Buffalo
Sat 8/8
7:50 am-11:30 am
1 stop4h 40m
$407
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 6/5
4:43 pm-11:52 pm
1 stop6h 09m
Buffalo
Fri 6/12
1:49 pm-8:43 pm
1 stop7h 54m
$407
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 6/5
4:40 pm-12:10 am
2 stops6h 30m
Buffalo
Thu 6/11
7:55 pm-11:30 pm
1 stop4h 35m
$422
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Mon 7/27
5:10 am-7:15 pm
2 stops13h 05m
Buffalo
Sat 8/1
6:45 pm-10:50 pm
1 stop5h 05m
$428
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
What is the cheapest month to book a flight from Des Moines to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $148). Flying from Des Moines to Buffalo in March is currently the most expensive (average of $736). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated May 11, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Amherst
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Williamsville
Orchard Park
Eden
West Seneca
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Top 3 airlines flying from Des Moines to Buffalo
Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$148 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$334 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$436 | FlexibilityNo cancel fee | On-time69% |