In terms of precipitation, rainfall in La Serena ranges from 0.0 - 1.2 inches per month. June is typically the wettest month, when rainfall can reach 1.2 in. January is typically the driest time to visit La Serena when rainfall is around 0.0 in.

If weather is an important factor for your trip to La Serena, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from SFO to LSC?

When flying from San Francisco to La Serena, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Can I find deals for flights from San Francisco to La Serena that include hotel bookings?

Yes. In addition to deals on San Francisco to La Serena flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to La Serena?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to La Serena.

Can I find deals for business class flights from San Francisco to La Serena?

Yes. Cheapflights offers flight deals from San Francisco to La Serena by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$970+ Flights from San Francisco to La Serena

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Cheap flight deals from San Francisco to La Serena

Round-trip from	$970 (LATAM Airlines)

From San Francisco to La Serena La Florida

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Find flight deals from San Francisco to La Serena

Cheapest flights from San Francisco to La Serena
Explore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Mon 8/2512:30 pmSFO - LSC

2 stops17h 25mLATAM Airlines

Wed 8/279:40 amLSC - SFO

2 stops27h 20mLATAM Airlines

Deal found 6/30

$970

Fri 8/156:00 amSFO - LSC

2 stops23h 55mMultiple Airlines

Fri 8/223:33 pmLSC - SFO

2 stops21h 27mMultiple Airlines

Deal found 7/1

$1,019

Best flights from San Francisco to La Serena
Discover carefully curated flight deals from San Francisco to La Serena that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Mon 8/2512:30 pmSFO - LSC

2 stops17h 25mLATAM Airlines

Wed 8/279:40 amLSC - SFO

2 stops27h 20mLATAM Airlines

Deal found 6/30

$970

Fri 8/156:00 amSFO - LSC

2 stops23h 55mMultiple Airlines

Fri 8/223:33 pmLSC - SFO

2 stops21h 27mMultiple Airlines

Deal found 7/1

$1,019

Last-minute flights from San Francisco to La Serena
Discover last-minute flight deals from San Francisco to La Serena. Data last updated July 1, 2025 and is based on user searches.

Fri 8/156:00 amSFO - LSC

2 stops23h 55mMultiple Airlines

Fri 8/223:33 pmLSC - SFO

2 stops21h 27mMultiple Airlines

Deal found 7/1

$1,019

Mon 8/2512:30 pmSFO - LSC

2 stops17h 25mLATAM Airlines

Wed 8/279:40 amLSC - SFO

2 stops27h 20mLATAM Airlines

Deal found 6/30

$970

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoLa Serena

SFO - LSC

SFOLSC

San Francisco

Mon 8/25

12:30 pm-8:55 am

2 stops17h 25m

La Serena La Florida

Wed 8/27

9:40 am-10:00 am

2 stops27h 20m

$970

San FranciscoLa Serena

SFO - LSC

SFOLSC

San Francisco

Fri 8/15

6:00 am-8:55 am

2 stops23h 55m

La Serena La Florida

Fri 8/22

3:33 pm-10:00 am

2 stops21h 27m

$1,019

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from San Francisco to La Serena

Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing La Serena

Peruse reviews from past customers who have flown with LATAM Airlines from San Francisco to La Serena to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

LATAM Airlines

7.5

Good

1,801 reviews

Reviews

1 / 20

4.0

Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

LATAM Airlines

7.5

Good

1,801 reviews

LATAM Airlines

7.5

Good

1,801 reviews

Reviews

1 / 20

4.0

Okay

Murilo,Jun 2025

SFO - LAX

Related info for your journey

Can I find deals for flights from San Francisco to La Serena that include hotel bookings?
Yes. In addition to deals on San Francisco to La Serena flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to La Serena?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to La Serena.
Can I find deals for business class flights from San Francisco to La Serena?
Yes. Cheapflights offers flight deals from San Francisco to La Serena by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Browse thousands of different options on Cheapflights for your next trip

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$970+ Cheap flights from San Francisco (SFO) to La Serena (LSC)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to La Serena with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from San Francisco to La Serena

Round-trip from

Find flight deals from San Francisco to La Serena

Cheapest flights from San Francisco to La SerenaExplore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.

Best time to book a flight from San Francisco to La Serena

Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.

Reviews of airlines servicing La Serena

Peruse reviews from past customers who have flown with LATAM Airlines from San Francisco to La Serena to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to La Serena. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

Can I find deals for flights from San Francisco to La Serena that include hotel bookings?

How can I find direct flights from San Francisco to La Serena?

Can I find deals for business class flights from San Francisco to La Serena?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Francisco to La Serena

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Cheapest flights from San Francisco to La Serena
Explore the most affordable flight options available from San Francisco to La Serena. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.