HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$136+ Cheap flights from Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JFK
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travelers. Please note that the information is based on the most recent updates available. Data last updated June 12, 2025.

Good round-trip deal

$28 or less

Good one-way deal

$26 or less
Price to beat on a round-trip flight from Panama.
Search Deals
Price to beat on a one-way flight from Panama.
Search Deals

Find flights from Panama

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on June 12, 2025.

Fri 6/276:53 amPTY - MDE
Nonstop1h 24mCopa Airlines
Wed 7/29:42 amMDE - PTY
Nonstop1h 27mCopa Airlines
Deal found 6/11$207
Mon 6/161:30 pmPTY - MDE
1 stop24h 30mAvianca
Wed 6/181:25 pmMDE - PTY
Nonstop1h 15mAvianca
Deal found 6/12$224
Sat 7/126:16 pmPTY - MIA
Nonstop3h 04mCopa Airlines
Sat 7/195:23 pmMIA - PTY
Nonstop3h 06mCopa Airlines
Deal found 6/12$280
Thu 9/43:20 amPTY - MEX
1 stop15h 45mAvianca
Wed 9/2412:40 amMEX - PTY
1 stop14h 50mAvianca
Deal found 6/10$283
Sat 7/53:20 amPTY - CUN
1 stop11h 20mAvianca
Fri 7/116:20 pmCUN - PTY
1 stop6h 25mAvianca
Deal found 6/11$283
Fri 6/273:20 pmPTY - MIA
Nonstop3h 05mAmerican Airlines
Mon 6/3010:30 amMIA - PTY
Nonstop3h 30mAmerican Airlines
Deal found 6/12$287
Sat 6/287:55 amPTY - MIA
1 stop13h 44mUnited Airlines
Wed 7/27:00 amMIA - PTY
1 stop12h 37mUnited Airlines
Deal found 6/12$290
Thu 8/1411:43 amPTY - MEX
Nonstop3h 47mCopa Airlines
Sat 8/302:00 amMEX - PTY
Nonstop3h 44mCopa Airlines
Deal found 6/12$292
Mon 9/17:11 amPTY - CUN
Nonstop2h 48mCopa Airlines
Wed 10/111:20 amCUN - PTY
Nonstop2h 41mCopa Airlines
Deal found 6/10$304
Mon 7/213:25 amPTY - MDE
1 stop5h 36mMultiple Airlines
Tue 7/297:38 amMDE - PTY
2 stops16h 32mMultiple Airlines
Deal found 6/11$312
Mon 6/165:25 pmPTY - MIA
1 stop15h 25mAvianca
Fri 6/207:20 pmMIA - PTY
1 stop6h 25mAvianca
Deal found 6/12$313
Fri 8/153:02 pmPTY - MEX
Nonstop3h 38mAeromexico
Sat 8/238:40 amMEX - PTY
Nonstop3h 51mAeromexico
Deal found 6/10$324

Find flights from Panama within your budget

Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on June 12, 2025. In the last 7 days, Cheapflights users made a total of 2,558,603 searches

Fly to

John F Kennedy Intl

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 6/27

6:53 am-8:17 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Wed 7/2

9:42 am-11:09 am

Nonstop1h 27m

$207

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 6/15

1:30 pm-2:00 pm

1 stop24h 30m

Medellín Jose Maria Cordova Intl

Tue 6/17

1:25 pm-2:40 pm

Nonstop1h 15m

$225

Panama CityMiami

PTY - MIA

PTYMIA

Panama City Tocumen Intl

Sat 7/12

6:16 pm-10:20 pm

Nonstop3h 04m

Miami

Sat 7/19

5:23 pm-7:29 pm

Nonstop3h 06m

$280

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 9/4

3:20 am-6:05 pm

1 stop15h 45m

Mexico City Benito Juarez

Wed 9/24

12:40 am-4:30 pm

1 stop14h 50m

$283

Panama CityCancún

PTY - CUN

PTYCUN

Panama City Tocumen Intl

Sat 7/5

3:20 am-2:40 pm

1 stop11h 20m

Cancun

Fri 7/11

6:20 pm-12:45 am

1 stop6h 25m

$283

Panama CityMiami

PTY - MIA

PTYMIA

Panama City Tocumen Intl

Fri 6/27

3:20 pm-7:25 pm

Nonstop3h 05m

Miami

Mon 6/30

10:30 am-1:00 pm

Nonstop3h 30m

$287

Panama CityMiami

PTY - MIA

PTYMIA

Panama City Tocumen Intl

Sat 6/28

7:55 am-10:39 pm

1 stop13h 44m

Miami

Wed 7/2

7:00 am-6:37 pm

1 stop12h 37m

$290

Panama CityMexico City

PTY - MEX

PTYMEX

Panama City Tocumen Intl

Thu 8/14

11:43 am-2:30 pm

Nonstop3h 47m

Mexico City Benito Juarez

Sat 8/30

2:00 am-6:44 am

Nonstop3h 44m

$292

Panama CityCancún

PTY - CUN

PTYCUN

Panama City Tocumen Intl

Mon 9/1

7:11 am-9:59 am

Nonstop2h 48m

Cancun

Wed 10/1

11:20 am-2:01 pm

Nonstop2h 41m

$304

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 7/21

3:25 am-9:01 am

1 stop5h 36m

Medellín Jose Maria Cordova Intl

Tue 7/29

7:38 am-12:10 am

2 stops16h 32m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, January is the cheapest month in which you can book a flight from Panama (average of $169). Flying from Panama in July will prove the most costly (average of $435). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama?

For flights departing from Panama check dates and pricing for the following: Copa Airlines, Avianca, American Airlines. These airlines depart to the following popular destinations: New York.

Copa Airlines
Copa Airlines
From $61
Avianca
Avianca
From $157
United Airlines
United Airlines
From $194
Air Panama
Air Panama
From $78

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is David Enrique Malek, with prices starting at $25. Explore other affordable destinations below.

David Enrique Malek
David Enrique Malek
From $25
Panama City Tocumen Intl
Panama City Tocumen Intl
From $26
Bogotá El Dorado
Bogotá El Dorado
From $68
Medellín Jose Maria Cordova Intl
Medellín Jose Maria Cordova Intl
From $68

Airline reviews for flights from Panama

Read reviews and ratings of airlines operating flights from Panama. Gain insights into the quality of service, in-flight amenities, customer experiences, and overall satisfaction to choose the best airline for your Panama travel. Please note that the reviews are sourced from user searches and were last updated on June 12, 2025. In the last 7 days, Cheapflights users made a total of 2,558,603 searches.
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,451 reviews
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,345 reviews
Copa Airlines
7.5
Good
1,451 reviews

Overall

7.5

Food

6.8

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Popular international destinations from Panama

The most popular international flight routes departing from Panama we’ve come across at this time.
Flights from Panama City to Bogotá
Flights from Panama City to Miami
Flights from Panama City to Madrid
Flights from Panama City to Atlanta
Flights from Panama City to San Salvador
Flights from Panama City to Amsterdam
Flights from Panama City to San José
Flights from Panama City to Tampa
Flights from Panama City to Guatemala City
Flights from Panama City to San Francisco
Flights from Panama City to Los Angeles
Flights from Panama City to Cartagena
Flights from Panama City to Cancún
Flights from Panama City to Mexico City
Flights from Panama City to Managua
Flights from Panama City to Lima
Flights from Panama City to Punta Cana
Flights from Panama City to Santo Domingo

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated June 12, 2025.

  • What is the cheapest month to fly from Panama?

    January is currently the cheapest month to fly from Panama. At this moment in time July is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • Where are the cheapest places to fly to from Panama?

    Check out the cheapest flights from Panama to embark to:
    Fly from Panama City to Medellín from $139 round trip
    Fly from Panama City to Bogotá from $147 round trip
    Fly from Panama City to San Salvador from $186 round trip
    Fly from Panama City to San José from $188 round trip
    Fly from Panama City to Guatemala City from $202 round trip

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.