What’s the top layover airport for flights from Portland to St. Louis?

Seattle (SEA) – chosen by Cheapflights users on 75% of 1-stop itineraries from Portland to St. Louis on Cheapflights.

What’s the fastest layover option from Portland to St. Louis?

Flights via Seattle (SEA) have the shortest average one-way travel time for 1-stop routes: 12h 33m.

What’s the cheapest layover airport for flights from Portland to St. Louis?

Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $247.

Which airport typically offers the quickest layover for flights from Portland to St. Louis?

Flights via Seattle (SEA) offer the fastest connection on this route, with an average layover time of 5h 32m.

How long is the flight from Portland to St. Louis?

For as low as $251, United Airlines can have you in St. Louis from Portland in 5h 58m. There are 1702 mi between Portland and St. Louis. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Portland to St. Louis round-trip?

Currently priced at $124, Frontier will fly you from Portland to St. Louis and back. In addition to Frontier, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $221 and $226, respectively. Users have found that Frontier is 67% cheaper than the other options available to this destination.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Portland to St. Louis?

Before booking your flight from Portland to St. Louis check out the most popular airlines for this route: Delta, Southwest or United Airlines.

Where are the most common layover locations when flying from Portland to St. Louis?

Portland to St. Louis flights have a layover in Denver most of the time.

Where are the least popular layover locations for Portland to St. Louis flights?

Of the flights from Portland to St. Louis that have layovers, the fewest flights stop in Salt Lake City.

What are some popular things to do or see while on a layover in Denver?

If you're on a layover in Denver and looking for things to do, consider visiting Coors Field, 16th Street Mall, or Paramount Theatre. Coors Field, 16th Street Mall, and Paramount Theatre are located about 18.4 mi, 18.7 mi, and 18.6 mi, respectively from Denver Intl. Travelers can rent a car at Denver Intl for an average daily rate of $42 to make sightseeing during their layover a little easier.

Most accurate provider : When it comes to deals on Portland-St. Louis flights, users find the pricing of CheapOair to be most consistent on Cheapflights vs. CheapOair Users can find the same prices on Portland-St. Louis flight deals on Cheapflights vs. CheapOair >95% of the time. Price accuracy is based on data collected from Portland-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Portland-St. Louis flights, Cheapflights users trust CheapOair the most. CheapOair has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Portland to St. Louis that include hotel bookings?

Yes. In addition to deals on Portland to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Portland to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to St. Louis.

Can I find deals for business class flights from Portland to St. Louis?

Yes. Cheapflights offers flight deals from Portland to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$60+ Flights from Portland to St. Louis

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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Portland to Lambert-St Louis are usually found in January or September, booked 76 days in advance, depart on a Monday or Tuesday and return on a Tuesday

Find flight deals from Portland to St. Louis

Cheapest flights from Portland to St. Louis
Explore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Sun 12/710:29 amPDX - STL

1 stop7h 47mFrontier

Sun 12/1410:44 pmSTL - PDX

1 stop11h 52mFrontier

Deal found 11/26

$232

Fri 12/1212:55 pmPDX - STL

1 stop19h 19mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/24

$236

Thu 12/1112:51 pmPDX - STL

1 stop19h 23mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/24

$240

Mon 12/1512:32 amPDX - STL

1 stop6h 38mDelta

Wed 12/176:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$249

Wed 12/1011:59 pmPDX - STL

1 stop6h 51mAmerican Airlines

Wed 12/172:37 pmSTL - PDX

1 stop8h 13mAmerican Airlines

Deal found 11/25

$250

Tue 12/98:30 amPDX - STL

1 stop5h 58mUnited Airlines

Sat 12/134:37 pmSTL - PDX

1 stop6h 38mUnited Airlines

Deal found 11/25

$251

Sun 12/1410:29 amPDX - STL

1 stop23h 43mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/25

$256

Fri 12/1210:29 amPDX - STL

1 stop9h 19mFrontier

Sun 12/1410:44 pmSTL - PDX

1 stop11h 52mFrontier

Deal found 11/24

$262

Wed 12/107:44 pmPDX - STL

1 stop16h 43mMultiple Airlines

Sun 12/141:16 pmSTL - PDX

1 stop21h 20mMultiple Airlines

Deal found 11/25

$266

Tue 12/912:32 amPDX - STL

1 stop6h 38mDelta

Wed 12/176:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$268

Mon 12/1512:32 amPDX - STL

1 stop6h 38mDelta

Thu 12/186:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$274

Best flights from Portland to St. Louis
Discover carefully curated flight deals from Portland to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 26, 2025.

Tue 12/98:30 amPDX - STL

1 stop5h 58mUnited Airlines

Sat 12/134:37 pmSTL - PDX

1 stop6h 38mUnited Airlines

Deal found 11/25

$251

Wed 12/105:30 amPDX - STL

1 stop6h 00mDelta

Sat 12/135:00 pmSTL - PDX

1 stop7h 10mDelta

Deal found 11/26

$251

Thu 12/1111:14 amPDX - STL

1 stop22h 08mFrontier

Fri 12/1910:10 pmSTL - PDX

2 stops15h 42mFrontier

Deal found 11/26

$304

Thu 1/2211:10 amPDX - STL

2 stops10h 15mDelta

Mon 1/263:31 pmSTL - PDX

2 stops10h 46mDelta

Deal found 11/24

$285

Sat 1/32:11 pmPDX - STL

1 stop6h 05mDelta

Wed 1/146:10 amSTL - PDX

1 stop8h 36mDelta

Deal found 11/25

$286

Mon 12/812:32 amPDX - STL

1 stop6h 38mDelta

Sat 12/135:00 pmSTL - PDX

1 stop7h 10mDelta

Deal found 11/25

$287

Wed 12/105:30 amPDX - STL

1 stop6h 00mDelta

Wed 12/176:00 amSTL - PDX

2 stops11h 33mDelta

Deal found 11/25

$297

Tue 12/912:32 amPDX - STL

1 stop6h 38mDelta

Thu 12/186:15 amSTL - PDX

2 stops20h 00mDelta

Deal found 11/26

$304

Wed 12/106:15 amPDX - STL

1 stop8h 34mDelta

Mon 12/152:20 pmSTL - PDX

2 stops11h 55mDelta

Deal found 11/24

$326

Last-minute flights from Portland to St. Louis
Discover last-minute flight deals from Portland to St. Louis. Data last updated November 26, 2025 and is based on user searches.

Sun 12/710:29 amPDX - STL

1 stop7h 47mFrontier

Sun 12/1410:44 pmSTL - PDX

1 stop11h 52mFrontier

Deal found 11/26

$232

Tue 12/98:30 amPDX - STL

1 stop5h 58mUnited Airlines

Sat 12/134:37 pmSTL - PDX

1 stop6h 38mUnited Airlines

Deal found 11/25

$251

Tue 12/912:32 amPDX - STL

1 stop6h 38mDelta

Wed 12/176:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$268

Wed 12/1011:59 pmPDX - STL

1 stop6h 51mAmerican Airlines

Wed 12/172:37 pmSTL - PDX

1 stop8h 13mAmerican Airlines

Deal found 11/25

$250

Wed 12/107:44 pmPDX - STL

1 stop16h 43mMultiple Airlines

Sun 12/141:16 pmSTL - PDX

1 stop21h 20mMultiple Airlines

Deal found 11/25

$266

Thu 12/1112:51 pmPDX - STL

1 stop19h 23mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/24

$240

Fri 12/1212:55 pmPDX - STL

1 stop19h 19mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/24

$236

Fri 12/1210:29 amPDX - STL

1 stop9h 19mFrontier

Sun 12/1410:44 pmSTL - PDX

1 stop11h 52mFrontier

Deal found 11/24

$262

Sun 12/1410:29 amPDX - STL

1 stop23h 43mFrontier

Wed 12/177:43 pmSTL - PDX

1 stop18h 00mFrontier

Deal found 11/25

$256

Mon 12/1512:32 amPDX - STL

1 stop6h 38mDelta

Wed 12/176:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$249

Mon 12/1512:32 amPDX - STL

1 stop6h 38mDelta

Thu 12/186:00 amSTL - PDX

1 stop8h 54mDelta

Deal found 11/25

$274

One-way flights from Portland to St. Louis
Search for one-way flight options from Portland to St. Louis. Find affordable one-way fares based on user searches. Data last updated November 26, 2025.

Sun 1/1112:10 pmPDX - STL

1 stop19h 52mFrontier

Deal found 11/24

$60

Fri 1/1611:59 amPDX - STL

1 stop24h 49mFrontier

Deal found 11/26

$68

Thu 1/2911:28 amPDX - STL

1 stop7h 38mFrontier

Deal found 11/26

$91

Thu 1/81:18 pmPDX - STL

2 stops18h 44mFrontier

Deal found 11/25

$100

Thu 12/1112:51 pmPDX - STL

1 stop19h 23mFrontier

Deal found 11/25

$103

Thu 2/511:28 amPDX - STL

1 stop7h 38mFrontier

Deal found 11/26

$112

Sun 12/1410:29 amPDX - STL

1 stop9h 19mFrontier

Deal found 11/25

$116

Cheap flight deals from Portland to St. Louis

Most accurate provider	CheapOair 3 stars
Most trusted provider	CheapOair 3 stars
Round-trip from	$232 (Frontier)
One-way from	$60 (Trip.com)
Popular in	March
Cheapest in	January
Average price	$378

Provider with most accurate pricing for Portland-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Portland-Lambert-St Louis flights.

Search Deals

From Portland to Lambert-St Louis

Search Deals

One-way flight from Portland to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Tue 12/9

8:30 am-4:28 pm

1 stop5h 58m

Lambert-St Louis

Sat 12/13

4:37 pm-9:15 pm

1 stop6h 38m

$251

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Wed 12/10

5:30 am-1:30 pm

1 stop6h 00m

Lambert-St Louis

Sat 12/13

5:00 pm-10:10 pm

1 stop7h 10m

$251

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Thu 1/22

11:10 am-11:25 pm

2 stops10h 15m

Lambert-St Louis

Mon 1/26

3:31 pm-12:17 am

2 stops10h 46m

$285

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Sat 1/3

2:11 pm-10:16 pm

1 stop6h 05m

Lambert-St Louis

Wed 1/14

6:10 am-12:46 pm

1 stop8h 36m

$286

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Mon 12/8

12:32 am-9:10 am

1 stop6h 38m

Lambert-St Louis

Sat 12/13

5:00 pm-10:10 pm

1 stop7h 10m

$287

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Wed 12/10

5:30 am-1:30 pm

1 stop6h 00m

Lambert-St Louis

Wed 12/17

6:00 am-3:33 pm

2 stops11h 33m

$297

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Thu 12/11

11:14 am-11:22 am

1 stop22h 08m

Lambert-St Louis

Fri 12/19

10:10 pm-11:52 am

2 stops15h 42m

$304

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Tue 12/9

12:32 am-9:10 am

1 stop6h 38m

Lambert-St Louis

Thu 12/18

6:15 am-12:15 am

2 stops20h 00m

$304

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Wed 12/10

6:15 am-4:49 pm

1 stop8h 34m

Lambert-St Louis

Mon 12/15

2:20 pm-12:15 am

2 stops11h 55m

$326

PortlandSt. Louis

PDX - STL

PDXSTL

Portland

Wed 12/31

2:45 pm-10:22 pm

1 stop5h 37m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 17 results

Compare providers for flights from Portland to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to St. Louis in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
CheapOair	Price Accuracy3 stars	Trust Score*3 stars
Cheapflightsfares	Price Accuracy3 stars	Trust Score*2 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars
CheapTicketsDeal	Price Accuracy3 stars	Trust Score*3 stars
Cheapfaremart	Price Accuracy-	Trust Score*1 star
JustAirTicket	Price Accuracy-	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Portland-St. Louis flights, users find the pricing of CheapOair to be most consistent on Cheapflights vs. CheapOair Users can find the same prices on Portland-St. Louis flight deals on Cheapflights vs. CheapOair >95% of the time. Price accuracy is based on data collected from Portland-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Portland-St. Louis flights, Cheapflights users trust CheapOair the most. CheapOair has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Portland with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to St. Louis

Prices

How far ahead should I book a flight from Portland to St. Louis?

The best time to book flights from Portland to St. Louis is 76 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Portland to St. Louis?

Currently, February is the cheapest month in which you can book a flight from Portland to St. Louis (average of $162). Flying from Portland to St. Louis in March is currently the most expensive (average of $317). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PDX to STL?

Unlike at noon, when flights are generally more expensive, you can save up to 57% on flights from Portland to St. Louis by exploring options for tickets in the evening.

What is the cheapest day to fly from Portland to St. Louis?

Travelers seeking maximum savings on their Portland to St. Louis flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Alaska Airlines, Southwest, and Delta from Portland to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

Alaska Airlines

8.0

Very good

11,363 reviews

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

Southwest

8.0

Very good

4,254 reviews

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

Delta

7.9

Good

8,003 reviews

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

United Airlines

7.4

Good

9,050 reviews

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

American Airlines

7.2

Good

11,037 reviews

Alaska Airlines

8.0

Very good

11,363 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Nov 2025

LAX - LIH

The staff were exceptional! They all were kind, accommodating, and professional.

Related info for your journey

How long is the flight from Portland to St. Louis?
For as low as $251, United Airlines can have you in St. Louis from Portland in 5h 58m. There are 1702 mi between Portland and St. Louis. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Portland to St. Louis round-trip?
Currently priced at $124, Frontier will fly you from Portland to St. Louis and back. In addition to Frontier, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $221 and $226, respectively. Users have found that Frontier is 67% cheaper than the other options available to this destination.
Where are the most common layover locations when flying from Portland to St. Louis?
Portland to St. Louis flights have a layover in Denver most of the time.
What are some popular things to do or see while on a layover in Denver?
If you're on a layover in Denver and looking for things to do, consider visiting Coors Field, 16th Street Mall, or Paramount Theatre. Coors Field, 16th Street Mall, and Paramount Theatre are located about 18.4 mi, 18.7 mi, and 18.6 mi, respectively from Denver Intl. Travelers can rent a car at Denver Intl for an average daily rate of $42 to make sightseeing during their layover a little easier.
Where are the least popular layover locations for Portland to St. Louis flights?
Of the flights from Portland to St. Louis that have layovers, the fewest flights stop in Salt Lake City.
Can I find deals for flights from Portland to St. Louis that include hotel bookings?
Yes. In addition to deals on Portland to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Portland to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to St. Louis.
Can I find deals for business class flights from Portland to St. Louis?
Yes. Cheapflights offers flight deals from Portland to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Portland to St. Louis?
Currently, February is the cheapest month in which you can book a flight from Portland to St. Louis (average of $162). Flying from Portland to St. Louis in March is currently the most expensive (average of $317). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 6 airlines flying from Portland to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$139	Average$262	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$221	Average$377	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$226	Average$395	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$226	Average$399	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$247	Average$412	FlexibilityNo cancel fee	On-time63%
Alaska Airlines	Cheapest$265	Average$430	FlexibilityNo cancel fee	On-time75%

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$60+ Cheap flights from Portland to St. Louis (PDX - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Portland to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Portland to Lambert-St Louis are usually found in January or September, booked 76 days in advance, depart on a Monday or Tuesday and return on a Tuesday

Find flight deals from Portland to St. Louis

Cheapest flights from Portland to St. LouisExplore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Explore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Cheap flight deals from Portland to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to St. Louis that are best for you.

Compare providers for flights from Portland to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to St. Louis in November.

Best time to book a flight from Portland to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Portland with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Portland to St. Louis

How far ahead should I book a flight from Portland to St. Louis?

What is the cheapest month to book a flight from Portland to St. Louis?

What is the cheapest time of day to fly from PDX to STL?

What is the cheapest day to fly from Portland to St. Louis?

What’s the top layover airport for flights from Portland to St. Louis?

What’s the cheapest layover airport for flights from Portland to St. Louis?

What’s the fastest layover option from Portland to St. Louis?

Which airport typically offers the quickest layover for flights from Portland to St. Louis?

Reviews of airlines servicing St. Louis

See what other customers who have flown with Alaska Airlines, Southwest, and Delta from Portland to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Portland to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Portland to St. Louis?

What are the cheapest airlines flying from Portland to St. Louis round-trip?

Where are the most common layover locations when flying from Portland to St. Louis?

What are some popular things to do or see while on a layover in Denver?

Where are the least popular layover locations for Portland to St. Louis flights?

Can I find deals for flights from Portland to St. Louis that include hotel bookings?

How can I find direct flights from Portland to St. Louis?

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Top 6 airlines flying from Portland to St. Louis

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Cheapest flights from Portland to St. Louis
Explore the most affordable flight options available from Portland to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.