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$312+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$537
(United Airlines)

One-way from

$312
(United Airlines)

Popular in

July

Cheapest in

February

Average price

$541
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
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From Panama City Tocumen Intl to Lambert-St Louis
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One-way flight from Panama City Tocumen Intl to Lambert-St Louis
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Highest demand for flights based on searches. 0% potential increase in price ($1 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:00 amPTY - STL
2 stops27h 15mUnited Airlines
Wed 12/174:45 pmSTL - PTY
1 stop25h 53mUnited Airlines
Deal found 10/26$537
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:41 pmPTY - STL
1 stop18h 58mUnited Airlines
Tue 11/116:15 amSTL - PTY
1 stop7h 30mUnited Airlines
Deal found 10/27$629
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:53 pmPTY - STL
2 stops18h 42mAmerican Airlines
Sat 12/276:35 pmSTL - PTY
2 stops18h 18mAmerican Airlines
Deal found 10/26$671
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:55 amPTY - STL
1 stop8h 09mUnited Airlines
Fri 12/196:00 amSTL - PTY
1 stop12h 38mUnited Airlines
Deal found 10/28$815
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/92:55 amPTY - STL
2 stops35h 57mMultiple Airlines
Wed 12/176:00 amSTL - PTY
1 stop12h 23mMultiple Airlines
Deal found 10/26$949
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:55 amPTY - STL
2 stops20h 38mMultiple Airlines
Fri 12/196:58 pmSTL - PTY
1 stop18h 24mMultiple Airlines
Deal found 10/28$1,096
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:55 amPTY - STL
2 stops17h 18mAvianca
Fri 12/198:15 amSTL - PTY
2 stops15h 25mAvianca
Deal found 10/28$8,831

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 12/10

10:00 am-12:15 pm

2 stops27h 15m

Lambert-St Louis

Wed 12/17

4:45 pm-7:38 pm

1 stop25h 53m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/23

2:53 pm-10:35 pm

1 stop8h 42m

Lambert-St Louis

Sat 12/27

6:35 pm-3:54 pm

2 stops20h 19m

$671

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 12/12

8:55 am-4:04 pm

1 stop8h 09m

Lambert-St Louis

Fri 12/19

6:00 am-7:38 pm

1 stop12h 38m

$815

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/9

2:55 am-1:52 pm

2 stops35h 57m

Lambert-St Louis

Wed 12/17

6:00 am-7:23 pm

1 stop12h 23m

$949

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 12/11

2:55 am-10:33 pm

2 stops20h 38m

Lambert-St Louis

Fri 12/19

6:58 pm-2:22 pm

1 stop18h 24m

$1,096

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 12/11

2:55 am-7:13 pm

2 stops17h 18m

Lambert-St Louis

Fri 12/19

8:15 am-12:40 am

2 stops15h 25m

$8,831

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 1/27

4:41 pm-2:30 pm

2 stops22h 49m

$312

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 1/26

2:55 am-10:33 pm

2 stops20h 38m

$366

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 1/3

7:50 pm-10:33 pm

3 stops27h 43m

$617

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/2

8:11 am-10:02 am

3 stops26h 51m

$673

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 11 results
1
2

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 16% versus a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,001 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Food

6.6

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,001 reviews
United Airlines
7.4
Good
9,001 reviews

Boarding

7.7

Overall

7.4

Comfort

7.3

Food

6.6

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to St. Louis?

    Airlines like United Airlines and American Airlines fly from Panama City to St. Louis in about 8h 42m. The time it takes to get you to your destination can typically vary by up to 18h 33m. There are 2159 mi between Panama City and St. Louis. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $252 on this airline. You may be able to fly from Panama City to St. Louis for 51% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to St. Louis

Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$567FlexibilityNo cancel feeOn-time69%

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