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St. Louis

$281+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
juin 17 — juin 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated juin 12, 2025.

Round-trip from

$515
(Delta)

One-way from

$281
(Kiwi.com)

Popular in

January

Cheapest in

June

Average price

$478
From Panama City Tocumen Intl to Lambert-St Louis
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One-way flight from Panama City Tocumen Intl to Lambert-St Louis
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Highest demand for flights based on searches. 5% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juin 12, 2025.

This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 8/272:05 pmPTY - STL
1 stop26h 01mDelta
mar. 9/96:00 amSTL - PTY
1 stop6h 50mDelta
Deal found 6/11$515
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 8/273:30 pmPTY - STL
1 stop8h 29mAmerican Airlines
ven. 9/55:28 amSTL - PTY
1 stop9h 03mAmerican Airlines
Deal found 6/11$525
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 8/223:30 pmPTY - STL
2 stops19h 10mUnited Airlines
jeu. 9/116:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Deal found 6/10$537
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 8/178:10 pmPTY - STL
3 stops23h 50mMultiple Airlines
dim. 12/211:00 pmSTL - PTY
3 stops34h 20mMultiple Airlines
Deal found 6/10$1,410
This Avianca deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/263:20 amPTY - STL
2 stops16h 07mAvianca
ven. 9/58:15 amSTL - PTY
2 stops16h 30mAvianca
Deal found 6/10$3,312

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated juin 12, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

mer. 8/27

2:05 pm-4:06 pm

1 stop26h 01m

Lambert-St Louis

mer. 9/10

5:11 pm-12:49 pm

1 stop19h 38m

$515

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

mer. 8/27

3:30 pm-11:59 pm

1 stop8h 29m

Lambert-St Louis

ven. 9/5

5:28 am-2:31 pm

1 stop9h 03m

$525

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

ven. 8/22

3:30 pm-10:40 am

2 stops19h 10m

Lambert-St Louis

jeu. 9/11

6:15 am-2:14 pm

1 stop7h 59m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

dim. 8/17

8:10 pm-8:00 pm

3 stops23h 50m

Lambert-St Louis

dim. 12/21

1:00 pm-12:20 am

3 stops34h 20m

$1,410

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

mar. 8/26

3:20 am-7:27 pm

2 stops16h 07m

Lambert-St Louis

ven. 9/5

8:15 am-12:45 am

2 stops16h 30m

$3,312

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

mer. 7/16

11:05 am-4:31 pm

3 stops29h 26m

$281

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

mer. 7/16

3:30 pm-12:27 pm

2 stops20h 57m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated juin 12, 2025.

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 7% versus a flight in the morning.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated juin 12, 2025.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,345 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is Delta. Our recent data shows that you can find tickets from as low as $515 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $525 and $537 round-trip. You may be able to fly from Panama City to St. Louis for 7% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Festus
Alton
Farmington

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated juin 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$460Average$569FlexibilityNo cancel feeOn-time69%

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