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St. Louis

$312+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/303:30 pm
PTY
-
STL
1 stop18h 00m
United Airlines
Mon 5/46:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Deal found 3/11$622
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:30 pm
PTY
-
STL
2 stops16h 55m
United Airlines
Mon 5/48:30 pm
STL
-
PTY
2 stops17h 44m
United Airlines
Deal found 3/12$634
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:55 am
PTY
-
STL
1 stop8h 06m
United Airlines
Tue 5/196:00 am
STL
-
PTY
1 stop12h 37m
United Airlines
Deal found 3/12$643
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/161:49 pm
PTY
-
STL
1 stop9h 04m
American Airlines
Tue 5/195:24 am
STL
-
PTY
1 stop7h 22m
American Airlines
Deal found 3/15$654
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:00 am
PTY
-
STL
1 stop12h 28m
United Airlines
Mon 4/136:00 am
STL
-
PTY
1 stop8h 14m
United Airlines
Deal found 3/11$656
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/12:43 pm
PTY
-
STL
1 stop8h 49m
American Airlines
Sun 11/85:21 am
STL
-
PTY
1 stop7h 15m
American Airlines
Deal found 3/13$670

Find flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$622
(United Airlines)

One-way from

$312
(Kiwi.com)

Popular in

November

Cheapest in

March

Average price

$360
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama City Tocumen Intl to Lambert-St Louis
Search Deals
One-way flight from Panama City Tocumen Intl to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 4/30

3:30 pm-8:39 am

2 stops17h 09m

Lambert-St Louis

Mon 5/4

8:30 pm-4:12 pm

2 stops19h 42m

$626

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 4/27

3:30 pm-8:25 am

2 stops16h 55m

Lambert-St Louis

Mon 5/4

6:00 am-6:37 pm

1 stop12h 37m

$634

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/16

7:55 am-10:30 pm

1 stop14h 35m

Lambert-St Louis

Wed 5/20

8:30 pm-4:12 pm

2 stops19h 42m

$634

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/16

10:00 am-11:19 pm

2 stops13h 19m

Lambert-St Louis

Tue 5/19

7:45 am-6:37 pm

2 stops10h 52m

$648
Quickest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 4/8

10:00 am-10:28 pm

1 stop12h 28m

Lambert-St Louis

Mon 4/13

6:00 am-2:14 pm

1 stop8h 14m

$656

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/16

1:49 pm-8:54 am

2 stops19h 05m

Lambert-St Louis

Tue 5/19

5:24 am-12:46 pm

1 stop7h 22m

$659
Cheapest one-way

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

3:10 pm-8:55 am

3 stops41h 45m

$312
Quickest one-way

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

2:15 pm-11:59 pm

1 stop9h 44m

$361

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 4/19

4:25 am-6:50 am

3 stops26h 25m

$364

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 4/19

7:55 am-10:28 pm

1 stop14h 33m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 14 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City to St. Louis?

Currently, July is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $230). Flying from Panama City to St. Louis in January is currently the most expensive (average of $632). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 16, 2026.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,428 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
United Airlines
7.4
Good
9,428 reviews
United Airlines
7.4
Good
9,428 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to St. Louis?

    Airlines like United Airlines fly from Panama City to St. Louis in about 17h 09m. The time it takes to get you to your destination can typically vary by up to . There are 2159 mi between Panama City and St. Louis.

  • What is the cheapest airline to fly from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $387 on this airline. You may be able to fly from Panama City to St. Louis for 32% less than the average price by searching for this airline.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, July is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $230). Flying from Panama City to St. Louis in January is currently the most expensive (average of $632). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Kansas City flights

Top airline flying from Panama City to St. Louis

Discover the top airline that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$684FlexibilityNo cancel feeOn-time69%

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