What are the cheapest airlines flying from Panama City to St. Louis round-trip?

Our cheapest airline available from Panama City to St. Louis is American Airlines. Our recent data shows that you can find tickets from as low as $451 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $558 and $2,096 round-trip. You may be able to fly from Panama City to St. Louis for 18% less than the average price by searching for these airlines.

What is the cheapest month to book a flight from Panama City to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Panama City to St. Louis?

Travelers seeking maximum savings on their Panama City to St. Louis flight should consider departing on Sunday afternoons when fares are most often at their lowest. Wednesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Panama City to St. Louis?

It’s generally more expensive to depart on a Wednesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.

What is the cheapest month to fly from Panama City to St. Louis?

March can be a great time to fly to St. Louis from Panama City with a flight ticket averaging about $553. Cheapflights users have found deals in the month of March for as cheap as $386. The most expensive prices can be found in the month of January.

Most accurate provider : When it comes to deals on Panama City-St. Louis flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$247+ Flights from Panama City to St. Louis - Compare & Save Big

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1. Tell us where you want to go

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2. Select your favorite providers

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3. Compare prices and book

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Cheap flight deals from Panama City to St. Louis

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$451 (American Airlines)
One-way from	$247 (Delta)
Popular in	January
Cheapest in	March
Average price	$535

Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.

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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.

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From Panama City Tocumen Intl to Lambert-St Louis

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One-way flight from Panama City Tocumen Intl to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 5% potential increase in price ($35 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Wed 8/273:40 pmPTY - STL

1 stop8h 19mAmerican Airlines

Fri 9/55:31 amSTL - PTY

1 stop6h 54mAmerican Airlines

Deal found 4/29

$451

Sat 6/143:30 pmPTY - STL

1 stop25h 23mUnited Airlines

Sat 6/218:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Deal found 4/30

$558

Tue 5/62:20 pmPTY - STL

1 stop9h 16mDelta

Tue 5/136:00 amSTL - PTY

1 stop6h 48mDelta

Deal found 4/29

$607

Thu 5/223:20 amPTY - STL

2 stops20h 32mMultiple Airlines

Sat 5/2410:10 amSTL - PTY

1 stop10h 09mMultiple Airlines

Deal found 4/29

$860

Wed 5/73:20 amPTY - STL

2 stops16h 03mAvianca

Sun 5/119:40 amSTL - PTY

2 stops14h 30mAvianca

Deal found 4/29

$3,655

Mon 5/2610:29 pmPTY - STL

1 stop11h 27mCopa Airlines

Mon 6/98:10 amSTL - PTY

1 stop12h 25mCopa Airlines

Deal found 4/29

$3,978

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Wed 8/273:40 pmPTY - STL

1 stop8h 19mAmerican Airlines

Fri 9/55:31 amSTL - PTY

1 stop6h 54mAmerican Airlines

Deal found 4/29

$451

Sat 6/143:30 pmPTY - STL

1 stop25h 23mUnited Airlines

Sat 6/218:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Deal found 4/30

$558

Thu 5/223:20 amPTY - STL

2 stops20h 32mMultiple Airlines

Sat 5/2410:10 amSTL - PTY

1 stop10h 09mMultiple Airlines

Deal found 4/29

$860

Wed 5/282:13 pmPTY - STL

1 stop9h 25mDelta

Mon 6/96:00 amSTL - PTY

1 stop7h 08mDelta

Deal found 4/29

$2,096

Tue 8/263:20 amPTY - STL

2 stops30h 42mAvianca

Fri 9/58:15 amSTL - PTY

2 stops32h 15mAvianca

Deal found 4/29

$3,777

Mon 5/2610:29 pmPTY - STL

1 stop11h 27mCopa Airlines

Mon 6/98:10 amSTL - PTY

1 stop12h 25mCopa Airlines

Deal found 4/29

$3,978

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated May 1, 2025 and is based on user searches.

Tue 5/62:20 pmPTY - STL

1 stop9h 16mDelta

Tue 5/136:00 amSTL - PTY

1 stop6h 48mDelta

Deal found 4/29

$607

Wed 5/73:20 amPTY - STL

2 stops16h 03mAvianca

Sun 5/119:40 amSTL - PTY

2 stops14h 30mAvianca

Deal found 4/29

$3,655

Thu 5/87:55 amPTY - STL

1 stop14h 08mUnited Airlines

Sun 5/118:30 amSTL - PTY

1 stop29h 44mUnited Airlines

Deal found 4/29

$635

Mon 5/197:55 amPTY - STL

1 stop12h 37mUnited Airlines

Sat 6/710:53 amSTL - PTY

1 stop27h 21mUnited Airlines

Deal found 4/29

$600

Mon 5/191:20 pmPTY - STL

1 stop28h 09mAmerican Airlines

Sat 6/75:30 amSTL - PTY

2 stops8h 55mAmerican Airlines

Deal found 4/29

$615

Thu 5/223:20 amPTY - STL

2 stops20h 32mMultiple Airlines

Sat 5/2410:10 amSTL - PTY

1 stop10h 09mMultiple Airlines

Deal found 4/29

$860

Mon 5/2610:29 pmPTY - STL

1 stop11h 27mCopa Airlines

Mon 6/98:10 amSTL - PTY

1 stop12h 25mCopa Airlines

Deal found 4/29

$3,978

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Sun 6/88:10 amPTY - STL

1 stop8h 15mDelta

Deal found 4/30

$247

Sun 6/83:20 pmPTY - STL

2 stops20h 53mAmerican Airlines

Deal found 4/30

$284

Sun 6/86:34 pmPTY - STL

3 stops29h 03mMultiple Airlines

Deal found 4/30

$393

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 8/27

3:40 pm-11:59 pm

1 stop8h 19m

Lambert-St Louis

Fri 9/5

5:31 am-12:25 pm

1 stop6h 54m

$451

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 6/14

3:30 pm-4:53 pm

1 stop25h 23m

Lambert-St Louis

Sat 6/21

8:25 am-6:37 pm

1 stop10h 12m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/22

3:20 am-11:52 pm

2 stops20h 32m

Lambert-St Louis

Sat 5/24

10:10 am-8:19 pm

1 stop10h 09m

$860

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 5/28

2:13 pm-11:38 pm

1 stop9h 25m

Lambert-St Louis

Mon 6/9

6:00 am-1:08 pm

1 stop7h 08m

$2,096

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 8/26

3:20 am-10:02 am

2 stops30h 42m

Lambert-St Louis

Fri 9/5

8:15 am-4:30 pm

2 stops32h 15m

$3,777

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/26

10:29 pm-9:56 am

1 stop11h 27m

Lambert-St Louis

Mon 6/9

8:10 am-8:35 pm

1 stop12h 25m

$3,978

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 6/8

8:10 am-4:25 pm

1 stop8h 15m

$247

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 6/8

3:20 pm-12:13 pm

2 stops20h 53m

$284

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 6/8

6:34 pm-11:37 pm

3 stops29h 03m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Compare providers for flights from Panama City to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in May.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
AranGrant	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City-St. Louis flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Panama City-St. Louis flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Panama City-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-St. Louis flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 7% versus a flight in the morning.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Delta, Copa Airlines and United Airlines from Panama City to St. Louis to help guide your decision. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,934 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Copa Airlines

7.5

Good

1,414 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,696 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca

6.7

Okay

2,317 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Panama City to St. Louis round-trip?
Our cheapest airline available from Panama City to St. Louis is American Airlines. Our recent data shows that you can find tickets from as low as $451 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $558 and $2,096 round-trip. You may be able to fly from Panama City to St. Louis for 18% less than the average price by searching for these airlines.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fenton

Maryland Heights

Fairview Heights

Collinsville

Wentzville

Eureka

St. Peters

Festus

Glencoe

Alton

Farmington

O'Fallon

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Other flights to St. Louis

Top 2 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$252	Average$563	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$354	Average$558	FlexibilityNo cancel fee	On-timeN/A

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$247+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in May.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City to St. Louis round-trip?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City to St. Louis?

Traveling to a place near Panama City?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

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Top 2 airlines flying from Panama City to St. Louis

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Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.