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St. Louis

$333+ Cheap flights from Panama City (PTY) to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$515
(United Airlines)

One-way from

$333
(Delta)

Popular in

July

Cheapest in

February

Average price

$567
From Panama City Tocumen Intl to Lambert-St Louis
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One-way flight from Panama City Tocumen Intl to Lambert-St Louis
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Highest demand for flights based on searches. 2% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:55 amPTY - STL
1 stop7h 55mUnited Airlines
Tue 11/118:20 amSTL - PTY
1 stop10h 18mUnited Airlines
Deal found 9/10$515
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmPTY - STL
1 stop8h 41mAmerican Airlines
Tue 11/115:15 amSTL - PTY
1 stop7h 34mAmerican Airlines
Deal found 9/9$524
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/297:55 amPTY - STL
1 stop26h 44mUnited Airlines
Sun 11/166:43 pmSTL - PTY
2 stops19h 02mUnited Airlines
Deal found 9/11$537
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:15 pmPTY - STL
2 stops25h 02mAmerican Airlines
Tue 11/115:58 pmSTL - PTY
2 stops18h 51mAmerican Airlines
Deal found 9/10$540
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/133:30 pmPTY - STL
1 stop18h 27mUnited Airlines
Sat 10/116:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Deal found 9/11$659
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:25 pmPTY - STL
3 stops16h 37mMultiple Airlines
Sat 11/17:15 pmSTL - PTY
3 stops24h 10mMultiple Airlines
Deal found 9/10$692
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:30 pmPTY - STL
2 stops19h 21mUnited Airlines
Sat 11/18:20 amSTL - PTY
1 stop10h 18mUnited Airlines
Deal found 9/10$695
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:21 pmPTY - STL
1 stop7h 43mDelta
Sat 11/16:00 amSTL - PTY
1 stop6h 56mDelta
Deal found 9/10$700
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:15 pmPTY - STL
2 stops16h 54mAmerican Airlines
Sat 11/14:25 pmSTL - PTY
2 stops21h 24mAmerican Airlines
Deal found 9/10$714

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/30

7:55 am-10:22 pm

1 stop14h 27m

Lambert-St Louis

Tue 11/11

8:20 am-7:38 pm

1 stop10h 18m

$515

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 10/31

3:15 pm-11:56 pm

1 stop8h 41m

Lambert-St Louis

Tue 11/11

5:15 am-1:49 pm

1 stop7h 34m

$524

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 10/29

7:55 am-10:39 am

1 stop26h 44m

Lambert-St Louis

Sun 11/16

6:43 pm-2:45 pm

2 stops19h 02m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/30

3:15 pm-4:17 pm

2 stops25h 02m

Lambert-St Louis

Tue 11/11

5:58 pm-1:49 pm

2 stops18h 51m

$540

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 10/25

2:21 pm-10:04 pm

1 stop7h 43m

$333

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 10/25

3:15 pm-1:44 pm

2 stops22h 29m

$342

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/20

9:34 am-9:40 am

2 stops24h 06m

$375

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/20

3:30 pm-12:25 pm

2 stops20h 55m

$383

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/20

3:31 pm-11:59 pm

1 stop8h 28m

$387

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 10/24

3:25 am-6:17 pm

2 stops14h 52m

$1,894

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest time of day to fly from PTY to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Panama City to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 7% versus a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Panama City to St. Louis, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to St. Louis?

    Airlines like United Airlines and American Airlines fly from Panama City to St. Louis in about 8h 41m. The time it takes to get you to your destination can typically vary by up to 5h 46m. There are 2159 mi between Panama City and St. Louis. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Panama City to St. Louis round-trip?

    Our cheapest airline available from Panama City to St. Louis is United Airlines. Our recent data shows that you can find tickets from as low as $252 on this airline. An additional option worth looking into is Delta, starting at $354. You may be able to fly from Panama City to St. Louis for 52% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama City to St. Louis (average of $311). Flying from Panama City to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Kansas City flights
Panama City to Springfield flights

Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$598FlexibilityNo cancel feeOn-time69%
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A

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