How long is the flight from Panama City, Florida to St. Louis?

For as low as $289, Delta can have you in St. Louis from Panama City, Florida in 6h 25m. Airlines will cover a distance of 635 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $206 round trip. Southwest is 60% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $83. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Most accurate provider : When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$145+ Flights from Panama City, FL to St. Louis

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Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 15, 2025.

sam. 12/276:00 pmECP - STL

1 stop6h 15mSouthwest

sam. 1/35:10 pmSTL - ECP

1 stop5h 25mSouthwest

Deal found 12/13

$344

mar. 12/308:02 amECP - STL

1 stop4h 19mDelta

sam. 1/35:55 amSTL - ECP

1 stop6h 33mDelta

Deal found 12/15

$359

mar. 12/306:46 amECP - STL

1 stop8h 14mAmerican Airlines

sam. 1/36:02 amSTL - ECP

2 stops9h 35mAmerican Airlines

Deal found 12/15

$390

lun. 12/155:50 pmECP - STL

1 stop5h 16mAmerican Airlines

mer. 12/176:00 amSTL - ECP

1 stop6h 53mAmerican Airlines

Deal found 12/15

$409

ven. 12/262:55 pmECP - STL

1 stop7h 00mUnited Airlines

ven. 1/26:30 amSTL - ECP

1 stop6h 57mUnited Airlines

Deal found 12/13

$413

lun. 12/222:10 pmECP - STL

1 stop5h 08mUnited Airlines

mar. 12/236:30 amSTL - ECP

1 stop6h 57mUnited Airlines

Deal found 12/14

$467

ven. 12/267:15 amECP - STL

2 stops9h 08mAmerican Airlines

ven. 1/26:02 amSTL - ECP

2 stops9h 35mAmerican Airlines

Deal found 12/13

$483

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated décembre 15, 2025.

ven. 1/167:20 amECP - STL

1 stop3h 45mDelta

lun. 1/196:57 pmSTL - ECP

1 stop3h 43mDelta

Deal found 12/15

$289

ven. 1/163:27 pmECP - STL

1 stop7h 32mAmerican Airlines

lun. 1/196:00 amSTL - ECP

2 stops11h 33mAmerican Airlines

Deal found 12/15

$294

jeu. 3/59:50 amECP - STL

2 stops8h 30mSouthwest

dim. 3/811:00 amSTL - ECP

1 stop4h 05mSouthwest

Deal found 12/13

$294

jeu. 3/54:04 pmECP - STL

1 stop4h 37mDelta

dim. 3/86:59 pmSTL - ECP

1 stop4h 03mDelta

Deal found 12/13

$289

mar. 1/1312:03 pmECP - STL

2 stops9h 48mAmerican Airlines

mar. 1/207:15 amSTL - ECP

1 stop7h 39mAmerican Airlines

Deal found 12/14

$294

mar. 1/135:14 pmECP - STL

1 stop6h 25mDelta

mar. 1/206:00 amSTL - ECP

1 stop5h 08mDelta

Deal found 12/14

$289

sam. 12/276:00 pmECP - STL

1 stop6h 15mSouthwest

sam. 1/35:10 pmSTL - ECP

1 stop5h 25mSouthwest

Deal found 12/13

$344

mar. 1/1310:30 amECP - STL

2 stops10h 05mSouthwest

mar. 1/206:00 amSTL - ECP

2 stops8h 55mSouthwest

Deal found 12/14

$349

sam. 12/277:02 pmECP - STL

1 stop4h 40mDelta

sam. 1/35:55 amSTL - ECP

1 stop6h 33mDelta

Deal found 12/13

$344

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated décembre 15, 2025 and is based on user searches.

lun. 12/155:50 pmECP - STL

1 stop5h 16mAmerican Airlines

mer. 12/176:00 amSTL - ECP

1 stop6h 53mAmerican Airlines

Deal found 12/15

$409

ven. 12/262:55 pmECP - STL

1 stop7h 00mUnited Airlines

ven. 1/26:30 amSTL - ECP

1 stop6h 57mUnited Airlines

Deal found 12/13

$413

sam. 12/276:00 pmECP - STL

1 stop6h 15mSouthwest

sam. 1/35:10 pmSTL - ECP

1 stop5h 25mSouthwest

Deal found 12/13

$344

mar. 12/308:02 amECP - STL

1 stop4h 19mDelta

sam. 1/35:55 amSTL - ECP

1 stop6h 33mDelta

Deal found 12/15

$359

mar. 12/306:46 amECP - STL

1 stop8h 14mAmerican Airlines

sam. 1/36:02 amSTL - ECP

2 stops9h 35mAmerican Airlines

Deal found 12/15

$390

mar. 1/136:00 amECP - STL

1 stop5h 05mDelta

mar. 1/205:04 pmSTL - ECP

1 stop5h 36mDelta

Deal found 12/15

$289

mar. 1/1312:03 pmECP - STL

2 stops9h 48mAmerican Airlines

mar. 1/207:15 amSTL - ECP

1 stop7h 39mAmerican Airlines

Deal found 12/15

$294

mar. 1/1310:30 amECP - STL

2 stops10h 05mSouthwest

mar. 1/206:00 amSTL - ECP

2 stops8h 55mSouthwest

Deal found 12/15

$349

ven. 1/1612:03 pmECP - STL

2 stops10h 41mAmerican Airlines

lun. 1/196:00 amSTL - ECP

2 stops11h 33mAmerican Airlines

Deal found 12/15

$364

sam. 1/316:30 amECP - STL

2 stops9h 33mUnited Airlines

mer. 2/410:20 amSTL - ECP

1 stop5h 52mUnited Airlines

Deal found 12/14

$389

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated décembre 15, 2025.

dim. 1/116:00 amECP - STL

1 stop5h 05mDelta

Deal found 12/15

$145

mar. 1/1312:03 pmECP - STL

2 stops9h 48mAmerican Airlines

Deal found 12/14

$150

sam. 3/145:30 pmECP - STL

1 stop6h 12mDelta

Deal found 12/14

$170

lun. 1/1212:03 pmECP - STL

2 stops9h 48mAmerican Airlines

Deal found 12/12

$175

sam. 12/203:28 pmECP - STL

1 stop7h 28mAmerican Airlines

Deal found 12/15

$176

dim. 2/151:15 pmECP - STL

1 stop8h 37mAmerican Airlines

Deal found 12/15

$180

mer. 2/1112:03 pmECP - STL

2 stops9h 48mAmerican Airlines

Deal found 12/15

$185

sam. 6/137:45 amECP - STL

1 stop4h 49mDelta

Deal found 12/15

$190

lun. 1/194:54 pmECP - STL

1 stop5h 06mUnited Airlines

Deal found 12/13

$193

ven. 3/136:15 amECP - STL

2 stops9h 35mSouthwest

Deal found 12/14

$205

jeu. 3/125:55 pmECP - STL

Nonstop1h 55mSouthwest

Deal found 12/12

$213

Find flight deals from Panama City to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$289 (Delta)
One-way from	$145 (Delta)
Popular in	February
Cheapest in	October
Average price	$369

Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.

Search Deals

From Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

One-way flight from Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 30% potential increase in price ($172 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 10% potential price decrease ($37 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

ven. 1/16

7:20 am-11:05 am

1 stop3h 45m

Lambert-St Louis

lun. 1/19

6:57 pm-10:40 pm

1 stop3h 43m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

jeu. 3/5

4:04 pm-8:41 pm

1 stop4h 37m

Lambert-St Louis

dim. 3/8

6:59 pm-11:02 pm

1 stop4h 03m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mar. 1/13

5:14 pm-11:39 pm

1 stop6h 25m

Lambert-St Louis

mar. 1/20

6:00 am-11:08 am

1 stop5h 08m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

ven. 1/16

3:27 pm-10:59 pm

1 stop7h 32m

Lambert-St Louis

lun. 1/19

6:00 am-5:33 pm

2 stops11h 33m

$294

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

jeu. 3/5

9:50 am-6:20 pm

2 stops8h 30m

Lambert-St Louis

dim. 3/8

11:00 am-3:05 pm

1 stop4h 05m

$294

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mar. 1/13

12:03 pm-9:51 pm

2 stops9h 48m

Lambert-St Louis

mar. 1/20

7:15 am-2:54 pm

1 stop7h 39m

$294

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

sam. 12/27

6:00 pm-12:15 am

1 stop6h 15m

Lambert-St Louis

sam. 1/3

5:10 pm-10:35 pm

1 stop5h 25m

$344

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

sam. 12/27

7:02 pm-11:42 pm

1 stop4h 40m

Lambert-St Louis

sam. 1/3

5:55 am-12:28 pm

1 stop6h 33m

$344

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mar. 1/13

10:30 am-8:35 pm

2 stops10h 05m

Lambert-St Louis

mar. 1/20

6:00 am-2:55 pm

2 stops8h 55m

$349

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

lun. 1/12

5:14 pm-11:39 pm

1 stop6h 25m

$145

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 15 results

Compare providers for flights from Panama City to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in December is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 44% on your trip compared to booking a flight in the evening.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,250 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,008 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How long is the flight from Panama City, Florida to St. Louis?
For as low as $289, Delta can have you in St. Louis from Panama City, Florida in 6h 25m. Airlines will cover a distance of 635 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?
Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $206 round trip. Southwest is 60% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?
The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $83. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in December is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Edwardsville

O'Fallon

Fairview Heights

Maryland Heights

Collinsville

Swansea

Eureka

Glencoe

St. Peters

Chesterfield

Alton

Farmington

Festus

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Other flights to St. Louis

Top 2 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$157	Average$405	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$206	Average$362	FlexibilityNo cancel fee	On-timeN/A

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$145+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 15, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 15, 2025.

Find flight deals from Panama City to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in December.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

What is the cheapest time of day to fly from ECP to STL?

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Panama City, Florida to St. Louis?

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Traveling to a place near St. Louis?

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Alternative routes for Panama City to St. Louis

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Top 2 airlines flying from Panama City to St. Louis

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Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 15, 2025.