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$145+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:10 pm
ECP
-
STL
1 stop7h 32m
United Airlines
Mon 3/97:40 am
STL
-
ECP
1 stop5h 34m
United Airlines
Deal found 1/28$289
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:57 pm
ECP
-
STL
1 stop5h 30m
United Airlines
Tue 4/146:30 am
STL
-
ECP
1 stop6h 53m
United Airlines
Deal found 1/28$308
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
ECP
-
STL
1 stop4h 45m
Delta
Sun 6/281:30 pm
STL
-
ECP
1 stop6h 06m
Delta
Deal found 1/27$309
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:20 pm
ECP
-
STL
1 stop6h 25m
Southwest
Tue 4/146:40 pm
STL
-
ECP
Nonstop1h 45m
Southwest
Deal found 1/28$315
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:19 am
ECP
-
STL
1 stop5h 24m
American Airlines
Mon 3/93:49 pm
STL
-
ECP
2 stops8h 00m
American Airlines
Deal found 1/28$319
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:55 pm
ECP
-
STL
Nonstop1h 55m
Southwest
Mon 3/911:25 am
STL
-
ECP
Nonstop1h 50m
Southwest
Deal found 1/28$321
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:00 pm
ECP
-
STL
Nonstop1h 50m
Southwest
Fri 5/154:10 pm
STL
-
ECP
1 stop5h 30m
Southwest
Deal found 1/28$336
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2310:25 am
ECP
-
STL
2 stops8h 00m
Southwest
Sun 6/286:00 am
STL
-
ECP
1 stop4h 35m
Southwest
Deal found 1/27$350
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/306:09 pm
ECP
-
STL
1 stop5h 28m
Delta
Mon 2/26:00 am
STL
-
ECP
1 stop5h 08m
Delta
Deal found 1/27$351

Find flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(United Airlines)

One-way from

$145
(Delta)

Popular in

February

Cheapest in

October

Average price

$460

Good round-trip deal

$572 or less

Good one-way deal

$205 or less
Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.
Search Deals
From Panama City NW Florida Beaches to Lambert-St Louis
Search Deals
One-way flight from Panama City NW Florida Beaches to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($163 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.
Search Deals
Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 3/5

2:10 pm-9:42 pm

1 stop7h 32m

Lambert-St Louis

Mon 3/9

7:40 am-1:14 pm

1 stop5h 34m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 4/10

4:57 pm-10:27 pm

1 stop5h 30m

Lambert-St Louis

Tue 4/14

6:30 am-1:23 pm

1 stop6h 53m

$308

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 4/10

12:20 pm-6:45 pm

1 stop6h 25m

Lambert-St Louis

Tue 4/14

6:40 pm-8:25 pm

Nonstop1h 45m

$315

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 3/5

7:19 am-12:43 pm

1 stop5h 24m

Lambert-St Louis

Mon 3/9

3:49 pm-11:49 pm

2 stops8h 00m

$319

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 3/5

6:00 pm-12:05 am

1 stop6h 05m

Lambert-St Louis

Mon 3/9

11:25 am-1:15 pm

Nonstop1h 50m

$331

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 5/11

7:00 pm-8:50 pm

Nonstop1h 50m

Lambert-St Louis

Fri 5/15

4:10 pm-9:40 pm

1 stop5h 30m

$336

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 6/23

10:25 am-6:25 pm

2 stops8h 00m

Lambert-St Louis

Sun 6/28

6:00 am-10:35 am

1 stop4h 35m

$350

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 2/11

4:45 pm-11:37 pm

1 stop6h 52m

Lambert-St Louis

Sun 2/15

10:13 am-4:15 pm

1 stop6h 02m

$351

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 2/10

3:45 pm-9:55 pm

1 stop6h 10m

Lambert-St Louis

Sat 2/14

9:45 am-4:30 pm

1 stop6h 45m

$351

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 3/11

2:10 pm-9:42 pm

1 stop7h 32m

Lambert-St Louis

Sun 3/15

7:41 am-1:10 pm

1 stop5h 29m

$354

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 21 results
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Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in April is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 13% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 29, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,127 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to St. Louis?

    For as low as $319, United Airlines can have you in St. Louis from Panama City, Florida in 5h 24m. Airlines will cover a distance of 635 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

    Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $206 round trip. Southwest is 58% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $83. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

  • What are the cheapest flights from Panama City, Florida to St. Louis?

    Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $392, our data indicates the cheapest price to be $114. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $289.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in April is currently the most expensive (average of $227). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

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Alternative routes for Panama City to St. Louis

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Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$157Average$386FlexibilityNo cancel feeOn-time63%
DeltaCheapest$206Average$366FlexibilityNo cancel feeOn-timeN/A

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