$130+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Apr 15 — Apr 221
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to St. Louis
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Best
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Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:00 pm
ECP
- STL
1 stop6h 05m
Southwest
Tue 4/76:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 3/11![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:43 pm
ECP
- STL
1 stop5h 15m
Delta
Tue 4/77:03 am
STL
- ECP
1 stop5h 42m
Delta
Deal found 3/11![Delta logo]()
$288
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:20 pm
ECP
- STL
1 stop11h 35m
Southwest
Tue 4/148:35 am
STL
- ECP
1 stop7h 45m
Southwest
Deal found 3/11![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/114:57 pm
ECP
- STL
1 stop5h 31m
United Airlines
Sat 4/184:49 pm
STL
- ECP
1 stop5h 10m
United Airlines
Deal found 3/12![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:00 pm
ECP
- STL
1 stop6h 05m
Southwest
Sun 4/512:05 pm
STL
- ECP
1 stop3h 30m
Southwest
Deal found 3/11![Southwest logo]()
$310
Best flights from Panama City to St. LouisDiscover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:00 pm
ECP
- STL
1 stop6h 05m
Southwest
Tue 4/76:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 3/11![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:43 pm
ECP
- STL
1 stop5h 15m
Delta
Sun 4/56:59 pm
STL
- ECP
1 stop4h 05m
Delta
Deal found 3/11![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/114:57 pm
ECP
- STL
1 stop5h 31m
United Airlines
Sun 4/199:10 am
STL
- ECP
2 stops12h 49m
United Airlines
Deal found 3/13![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:00 pm
ECP
- STL
Nonstop1h 50m
Southwest
Sun 5/175:25 am
STL
- ECP
1 stop6h 30m
Southwest
Deal found 3/15![Southwest logo]()
$293
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:20 pm
ECP
- STL
1 stop6h 25m
Southwest
Tue 4/146:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 3/15![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:43 pm
ECP
- STL
1 stop5h 15m
Delta
Wed 4/86:59 pm
STL
- ECP
1 stop4h 05m
Delta
Deal found 3/14![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:15 am
ECP
- STL
2 stops8h 50m
Southwest
Mon 4/68:35 am
STL
- ECP
1 stop7h 40m
Southwest
Deal found 3/14![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:15 am
ECP
- STL
2 stops8h 50m
Southwest
Sun 4/512:05 pm
STL
- ECP
1 stop3h 30m
Southwest
Deal found 3/11![Southwest logo]()
$315
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:30 pm
ECP
- STL
1 stop4h 55m
Southwest
Sun 4/195:25 am
STL
- ECP
1 stop6h 30m
Southwest
Deal found 3/13![Southwest logo]()
$337
Last-minute flights from Panama City to St. LouisDiscover last-minute flight deals from Panama City to St. Louis. Data last updated March 16, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to St. Louis. Data last updated March 16, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:00 pm
ECP
- STL
1 stop6h 05m
Southwest
Sun 4/512:05 pm
STL
- ECP
1 stop3h 30m
Southwest
Deal found 3/11![Southwest logo]()
$310
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:00 pm
ECP
- STL
1 stop6h 05m
Southwest
Tue 4/76:40 pm
STL
- ECP
Nonstop1h 45m
Southwest
Deal found 3/11![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:43 pm
ECP
- STL
1 stop5h 15m
Delta
Tue 4/77:03 am
STL
- ECP
1 stop5h 42m
Delta
Deal found 3/11![Delta logo]()
$288
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:20 pm
ECP
- STL
1 stop11h 35m
Southwest
Tue 4/148:35 am
STL
- ECP
1 stop7h 45m
Southwest
Deal found 3/11![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:57 pm
ECP
- STL
1 stop5h 30m
United Airlines
Tue 4/1411:15 am
STL
- ECP
2 stops10h 44m
United Airlines
Deal found 3/11![United Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/114:57 pm
ECP
- STL
1 stop5h 31m
United Airlines
Sat 4/184:49 pm
STL
- ECP
1 stop5h 10m
United Airlines
Deal found 3/12![United Airlines logo]()
$303
One-way flights from Panama City to St. LouisSearch for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:41 am
ECP
- STL
1 stop4h 39m
Delta
Deal found 3/12![Delta logo]()
$130
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:21 am
ECP
- STL
2 stops9h 20m
American Airlines
Deal found 3/12![American Airlines logo]()
$135
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:55 pm
ECP
- STL
Nonstop1h 55m
Southwest
Deal found 3/15![Southwest logo]()
$136
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:05 am
ECP
- STL
1 stop4h 51m
Delta
Deal found 3/13![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:00 pm
ECP
- STL
Nonstop1h 50m
Southwest
Deal found 3/12![Southwest logo]()
$142
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/114:57 pm
ECP
- STL
1 stop5h 31m
United Airlines
Deal found 3/12![United Airlines logo]()
$152
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:05 am
ECP
- STL
1 stop4h 51m
Delta
Deal found 3/14![Delta logo]()
$156
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:29 pm
ECP
- STL
1 stop4h 00m
Delta
Deal found 3/12![Delta logo]()
$157
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:44 pm
ECP
- STL
1 stop5h 15m
Delta
Deal found 3/12![Delta logo]()
$158
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/261:30 pm
ECP
- STL
1 stop4h 23m
Delta
Deal found 3/11![Delta logo]()
$159
Find flight deals from Panama City to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $283 (Southwest) |
One-way from | $130 (Delta) |
Popular in | April |
Cheapest in | October |
Average price | $409 |
Good round-trip deal | $448 or less |
Good one-way deal | $166 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Fri 4/3
6:00 pm-12:05 am
1 stop6h 05m
Lambert-St Louis
Tue 4/7
6:40 pm-8:25 pm
Nonstop1h 45m
$283
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Thu 5/14
7:00 pm-8:50 pm
Nonstop1h 50m
Lambert-St Louis
Sun 5/17
5:25 am-11:55 am
1 stop6h 30m
$293
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Fri 4/10
12:20 pm-6:45 pm
1 stop6h 25m
Lambert-St Louis
Tue 4/14
6:40 pm-8:25 pm
Nonstop1h 45m
$294
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Thu 4/2
6:15 am-3:05 pm
2 stops8h 50m
Lambert-St Louis
Mon 4/6
8:35 am-4:15 pm
1 stop7h 40m
$309
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Thu 4/2
6:15 am-3:05 pm
2 stops8h 50m
Lambert-St Louis
Sun 4/5
12:05 pm-3:35 pm
1 stop3h 30m
$315
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Fri 4/3
6:43 pm-11:58 pm
1 stop5h 15m
Lambert-St Louis
Sun 4/5
6:59 pm-11:04 pm
1 stop4h 05m
$317
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 4/11
4:57 pm-10:28 pm
1 stop5h 31m
Lambert-St Louis
Sun 4/19
9:10 am-9:59 pm
2 stops12h 49m
$322
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Mon 3/30
6:43 pm-11:58 pm
1 stop5h 15m
Lambert-St Louis
Wed 4/8
6:59 pm-11:04 pm
1 stop4h 05m
$337
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Sat 4/11
5:30 pm-10:25 pm
1 stop4h 55m
Lambert-St Louis
Sun 4/19
5:25 am-11:55 am
1 stop6h 30m
$337
Cheapest one-way
Panama CitySt. Louis
ECP - STL
ECPSTL
Panama City NW Florida Beaches
Wed 6/10
6:00 am-10:45 am
1 stop4h 45m
$130
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Panama City to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
ECP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to St. Louis
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in May is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to STL?
Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 16, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 29% on your trip compared to booking a flight in the morning.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 16, 2026.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Panama City and St. Louis flights
Browse other Panama City and St. Louis flight options. Last updated on March 16, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on March 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 16, 2026.
Top 2 airlines flying from Panama City to St. Louis
Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$157 | Average$377 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$206 | Average$362 | FlexibilityNo cancel fee | On-timeN/A |