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$104+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — STL
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Panama City to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$207
(Delta)

One-way from

$104
(Delta)

Popular in

February

Cheapest in

October

Average price

$243

Good round-trip deal

$503 or less

Good one-way deal

$214 or less
Provider with most accurate pricing for Panama City NW Florida Beaches-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Lambert-St Louis flights.
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From Panama City NW Florida Beaches to Lambert-St Louis
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One-way flight from Panama City NW Florida Beaches to Lambert-St Louis
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Highest demand for flights based on searches. 27% potential increase in price ($157 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.
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Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.
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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:00 amECP - STL
1 stop6h 06mDelta
Sun 12/77:02 pmSTL - ECP
1 stop4h 04mDelta
Deal found 10/29$207
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:08 pmECP - STL
2 stops9h 39mAmerican Airlines
Sun 12/76:53 pmSTL - ECP
1 stop5h 02mAmerican Airlines
Deal found 10/29$212
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/225:02 pmECP - STL
1 stop5h 20mUnited Airlines
Wed 11/264:35 pmSTL - ECP
1 stop5h 14mUnited Airlines
Deal found 10/30$379
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2212:10 pmECP - STL
2 stops7h 35mSouthwest
Wed 11/269:50 amSTL - ECP
1 stop7h 30mSouthwest
Deal found 10/30$384
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/284:26 pmECP - STL
1 stop5h 32mDelta
Wed 12/311:40 amSTL - ECP
1 stop3h 50mDelta
Deal found 10/29$488
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/287:15 amECP - STL
1 stop6h 02mAmerican Airlines
Wed 12/32:11 pmSTL - ECP
2 stops8h 59mAmerican Airlines
Deal found 10/30$493

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Panama City

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

10:00 am-4:06 pm

1 stop6h 06m

Lambert-St Louis

Sun 12/7

7:02 pm-11:06 pm

1 stop4h 04m

$207

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

12:08 pm-9:47 pm

2 stops9h 39m

Lambert-St Louis

Sun 12/7

6:53 pm-11:55 pm

1 stop5h 02m

$212

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 2/6

4:30 pm-10:35 pm

1 stop6h 05m

Lambert-St Louis

Wed 2/11

11:35 am-6:10 pm

1 stop6h 35m

$289

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 2/6

12:03 pm-9:51 pm

2 stops9h 48m

Lambert-St Louis

Wed 2/11

7:00 am-5:33 pm

2 stops10h 33m

$320

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 11/22

12:10 pm-7:45 pm

2 stops7h 35m

Lambert-St Louis

Wed 11/26

9:50 am-5:20 pm

1 stop7h 30m

$384

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/5

1:32 pm-5:56 pm

1 stop4h 24m

$104

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 12/17

10:00 am-5:25 pm

2 stops7h 25m

$109

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 12/15

5:00 pm-9:58 pm

1 stop4h 58m

$145

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 1/26

12:15 pm-5:50 pm

1 stop5h 35m

$145

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 1/10

2:35 pm-8:10 pm

1 stop5h 35m

$145

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 17 results
1
2

Compare providers for flights from Panama City to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to St. Louis in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City, Florida-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City, Florida-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in May is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 43% on your trip compared to booking a flight in the evening.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 30, 2025.
See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,998 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to St. Louis?

    For as low as $207, Delta can have you in St. Louis from Panama City, Florida in 6h 06m. Airlines will cover a distance of 635 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

    Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $206 round trip. Southwest is 62% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest flights from Panama City, Florida to St. Louis?

    Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $389, our data indicates the cheapest price to be $214. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $207.

  • Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

  • Can I find deals for business class flights from Panama City to St. Louis?

    Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $78). Flying from Panama City, Florida to St. Louis in May is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Top 2 airlines flying from Panama City to St. Louis

Discover the top 2 airlines that operate flights from Panama City to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$157Average$405FlexibilityNo cancel feeOn-time63%
DeltaCheapest$206Average$369FlexibilityNo cancel feeOn-timeN/A

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