What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $177 and $187, respectively. Southwest is 65% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $79. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

What is the cheapest day to fly from Panama City, Florida to St. Louis?

Travelers seeking maximum savings on their Panama City, Florida to St. Louis flight should consider departing on Friday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Panama City, Florida to St. Louis?

Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $233, our data indicates the cheapest price to be $66. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $157.

What is the cheapest day to fly round-trip from Panama City, Florida to St. Louis?

Users have found that leaving on a Tuesday can be a cost-effective option. It’s possible to save up to 30% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City, Florida to St. Louis?

Our data shows that May tends to be the cheapest month to fly to St. Louis from Panama City, Florida. Users have commonly found prices around $460 for the month, but tickets can be as low as $305. Due to multiple factors, prepare for potentially higher prices in February.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$79+ Flights from Panama City, FL to St. Louis

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to St. Louis

Round-trip from	$157 (Southwest)
One-way from	$79 (Southwest)
Popular in	February
Cheapest in	May
Average price	$436
Good round-trip deal	$194 or less
Good one-way deal	$129 or less

From Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

One-way flight from Panama City NW Florida Beaches to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 19% potential increase in price ($112 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.

Search Deals

Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.

Search Deals

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Thu 9/251:35 pmECP - STL

Nonstop1h 50mSouthwest

Sat 10/49:00 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 7/29

$157

Mon 9/296:54 pmECP - STL

1 stop4h 30mDelta

Mon 10/206:52 pmSTL - ECP

1 stop4h 18mDelta

Deal found 7/27

$177

Thu 8/285:30 amECP - STL

1 stop6h 41mAmerican Airlines

Mon 9/16:00 amSTL - ECP

1 stop6h 48mAmerican Airlines

Deal found 7/28

$187

Sat 10/46:30 amECP - STL

2 stops7h 57mUnited Airlines

Sat 10/1812:25 pmSTL - ECP

2 stops9h 23mUnited Airlines

Deal found 7/27

$317

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Thu 9/251:35 pmECP - STL

Nonstop1h 50mSouthwest

Sat 10/49:00 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 7/29

$157

Mon 9/296:54 pmECP - STL

1 stop4h 30mDelta

Mon 10/206:52 pmSTL - ECP

1 stop4h 18mDelta

Deal found 7/27

$177

Thu 8/285:30 amECP - STL

1 stop6h 41mAmerican Airlines

Mon 9/16:00 amSTL - ECP

1 stop6h 48mAmerican Airlines

Deal found 7/28

$187

Sat 10/46:30 amECP - STL

2 stops7h 57mUnited Airlines

Sat 10/1812:25 pmSTL - ECP

2 stops9h 23mUnited Airlines

Deal found 7/27

$317

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated July 29, 2025 and is based on user searches.

Sun 8/37:38 pmECP - STL

1 stop4h 15mDelta

Sun 8/101:29 pmSTL - ECP

1 stop5h 24mDelta

Deal found 7/27

$434

Sun 8/35:02 pmECP - STL

1 stop5h 13mUnited Airlines

Sat 8/96:33 amSTL - ECP

2 stops12h 26mUnited Airlines

Deal found 7/27

$619

Mon 8/49:40 amECP - STL

2 stops9h 45mSouthwest

Fri 8/87:50 amSTL - ECP

2 stops7h 45mSouthwest

Deal found 7/28

$509

Tue 8/512:39 pmECP - STL

1 stop8h 40mAmerican Airlines

Sun 8/101:01 pmSTL - ECP

1 stop5h 14mAmerican Airlines

Deal found 7/27

$423

Fri 8/159:24 amECP - STL

1 stop6h 42mDelta

Sun 8/176:49 pmSTL - ECP

1 stop4h 17mDelta

Deal found 7/27

$259

Thu 8/281:35 pmECP - STL

Nonstop1h 50mSouthwest

Mon 9/13:10 pmSTL - ECP

Nonstop1h 45mSouthwest

Deal found 7/28

$157

Thu 8/285:30 amECP - STL

1 stop6h 41mAmerican Airlines

Mon 9/16:00 amSTL - ECP

1 stop6h 48mAmerican Airlines

Deal found 7/28

$187

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 29, 2025.

Wed 8/271:15 pmECP - STL

Nonstop1h 50mSouthwest

Deal found 7/28

$79

Tue 10/286:00 amECP - STL

1 stop6h 35mDelta

Deal found 7/28

$89

Fri 10/3111:28 amECP - STL

1 stop6h 53mAmerican Airlines

Deal found 7/27

$93

Fri 12/199:52 amECP - STL

2 stops12h 51mUnited Airlines

Deal found 7/28

$237

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 9/25

1:35 pm-3:25 pm

Nonstop1h 50m

Lambert-St Louis

Sat 10/4

9:00 am-10:45 am

Nonstop1h 45m

$157

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Mon 9/29

6:54 pm-11:24 pm

1 stop4h 30m

Lambert-St Louis

Mon 10/20

6:52 pm-11:10 pm

1 stop4h 18m

$177

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 8/28

5:30 am-12:11 pm

1 stop6h 41m

Lambert-St Louis

Mon 9/1

6:00 am-12:48 pm

1 stop6h 48m

$187

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Sat 10/4

6:30 am-2:27 pm

2 stops7h 57m

Lambert-St Louis

Sat 10/18

12:25 pm-9:48 pm

2 stops9h 23m

$317

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 8/27

1:15 pm-3:05 pm

Nonstop1h 50m

$79

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 10/28

6:00 am-12:35 pm

1 stop6h 35m

$89

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 10/31

11:28 am-6:21 pm

1 stop6h 53m

$93

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 12/19

9:52 am-10:43 pm

2 stops12h 51m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest, Delta, and United Airlines from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Southwest

8.0

Very good

4,238 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Delta

8.0

Very good

7,977 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

United Airlines

7.4

Good

8,899 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Gina,Jul 2025

LAS - DEN

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?
Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $177 and $187, respectively. Southwest is 65% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?
The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $79. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.
What are the cheapest flights from Panama City, Florida to St. Louis?
Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $233, our data indicates the cheapest price to be $66. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $157.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

O'Fallon

Maryland Heights

Fairview Heights

Collinsville

Eureka

St. Peters

Glencoe

Alton

Chesterfield

Festus

Farmington

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$194	Average$410	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$290	Average$439	FlexibilityNo cancel fee	On-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$79+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest, Delta, and United Airlines from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

What are the cheapest flights from Panama City, Florida to St. Louis?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to St. Louis

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.