What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

Flying on Delta is currently your cheapest option to St. Louis, with prices starting at $221. Additional round-trip tickets that might be worth considering are offered by American Airlines and Southwest, with the lowest prices starting at $226 and $251, respectively. Delta is 53% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $96. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.

What is the cheapest day to fly from Panama City, Florida to St. Louis?

Travelers seeking maximum savings on their Panama City, Florida to St. Louis flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from Panama City, Florida to St. Louis?

Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $353, our data indicates the cheapest price to be $208. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $221.

What are the most popular airlines that fly from Panama City, Florida to St. Louis?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Panama City, Florida to St. Louis.

What is the cheapest day to fly round-trip from Panama City, Florida to St. Louis?

Users have found that leaving on a Tuesday can be a cost-effective option. It’s possible to save up to 25% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City, Florida to St. Louis?

Our data shows that June tends to be the cheapest month to fly to St. Louis from Panama City, Florida. Users have commonly found prices around $474 for the month, but tickets can be as low as $295. Due to multiple factors, prepare for potentially higher prices in February.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$96+ Flights from Panama City, FL to St. Louis

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Cheap flight deals from Panama City to St. Louis

Round-trip from	$221 (Delta)
One-way from	$96 (American Airlines)
Popular in	February
Cheapest in	June
Average price	$369
Good round-trip deal	$341 or less
Good one-way deal	$219 or less

From Panama City NW Florida Beaches to Lambert-St Louis

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One-way flight from Panama City NW Florida Beaches to Lambert-St Louis

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Highest demand for flights based on searches. 17% potential increase in price ($98 potential increase over avg. RT price).

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Cheapest flight prices on average. 6% potential price decrease ($31 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.

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Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.

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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Wed 7/97:25 amECP - STL

1 stop5h 09mDelta

Wed 7/167:00 amSTL - ECP

1 stop3h 35mDelta

Deal found 6/11

$221

Wed 7/91:23 pmECP - STL

1 stop7h 01mAmerican Airlines

Wed 7/166:00 amSTL - ECP

2 stops8h 05mAmerican Airlines

Deal found 6/11

$226

Thu 7/312:35 pmECP - STL

Nonstop1h 50mSouthwest

Mon 7/74:40 pmSTL - ECP

1 stop5h 35mSouthwest

Deal found 6/10

$251

Thu 6/265:02 pmECP - STL

1 stop5h 13mUnited Airlines

Mon 6/308:00 amSTL - ECP

2 stops10h 55mUnited Airlines

Deal found 6/11

$472

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Wed 7/97:25 amECP - STL

1 stop5h 09mDelta

Wed 7/167:00 amSTL - ECP

1 stop3h 35mDelta

Deal found 6/11

$221

Wed 7/91:23 pmECP - STL

1 stop7h 01mAmerican Airlines

Wed 7/166:00 amSTL - ECP

2 stops8h 05mAmerican Airlines

Deal found 6/11

$226

Thu 7/312:35 pmECP - STL

Nonstop1h 50mSouthwest

Mon 7/74:40 pmSTL - ECP

1 stop5h 35mSouthwest

Deal found 6/10

$251

Thu 6/265:02 pmECP - STL

1 stop5h 13mUnited Airlines

Mon 6/308:00 amSTL - ECP

2 stops10h 55mUnited Airlines

Deal found 6/11

$472

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated June 12, 2025 and is based on user searches.

Tue 6/173:55 pmECP - STL

1 stop7h 24mAmerican Airlines

Tue 7/1510:08 amSTL - ECP

1 stop4h 59mAmerican Airlines

Deal found 6/12

$314

Thu 6/196:10 pmECP - STL

1 stop5h 55mSouthwest

Tue 7/157:50 pmSTL - ECP

Nonstop1h 45mSouthwest

Deal found 6/12

$390

Fri 6/201:47 pmECP - STL

1 stop4h 18mDelta

Wed 6/259:28 amSTL - ECP

1 stop4h 24mDelta

Deal found 6/11

$435

Sat 6/2112:50 pmECP - STL

2 stops9h 55mUnited Airlines

Wed 6/258:10 amSTL - ECP

1 stop4h 56mUnited Airlines

Deal found 6/11

$558

Thu 6/265:02 pmECP - STL

1 stop5h 13mUnited Airlines

Mon 6/308:00 amSTL - ECP

2 stops10h 55mUnited Airlines

Deal found 6/11

$472

Thu 7/312:35 pmECP - STL

Nonstop1h 50mSouthwest

Mon 7/74:40 pmSTL - ECP

1 stop5h 35mSouthwest

Deal found 6/10

$251

Wed 7/97:25 amECP - STL

1 stop5h 09mDelta

Wed 7/167:00 amSTL - ECP

1 stop3h 35mDelta

Deal found 6/11

$221

Wed 7/91:23 pmECP - STL

1 stop7h 01mAmerican Airlines

Wed 7/166:00 amSTL - ECP

2 stops8h 05mAmerican Airlines

Deal found 6/11

$226

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Thu 7/101:23 pmECP - STL

1 stop7h 01mAmerican Airlines

Deal found 6/9

$96

Wed 7/166:05 amECP - STL

Nonstop1h 50mSouthwest

Deal found 6/10

$101

Fri 7/117:38 pmECP - STL

1 stop4h 15mDelta

Deal found 6/10

$111

Sat 8/96:30 amECP - STL

2 stops9h 17mUnited Airlines

Deal found 6/11

$254

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 7/9

7:25 am-12:34 pm

1 stop5h 09m

Lambert-St Louis

Wed 7/16

7:00 am-10:35 am

1 stop3h 35m

$221

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Wed 7/9

1:23 pm-8:24 pm

1 stop7h 01m

Lambert-St Louis

Wed 7/16

6:00 am-2:05 pm

2 stops8h 05m

$226

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 7/3

12:35 pm-2:25 pm

Nonstop1h 50m

Lambert-St Louis

Mon 7/7

4:40 pm-10:15 pm

1 stop5h 35m

$251

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Thu 6/26

5:02 pm-10:15 pm

1 stop5h 13m

Lambert-St Louis

Mon 6/30

8:00 am-6:55 pm

2 stops10h 55m

$472

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/29

6:05 am-7:55 am

Nonstop1h 50m

$101

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 7/29

7:25 am-12:34 pm

1 stop5h 09m

$111

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Tue 8/5

12:25 pm-8:19 pm

2 stops7h 54m

$116

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

Fri 11/7

11:05 am-11:44 pm

2 stops12h 39m

$228

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 6% on your trip compared to booking a flight in the afternoon.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta and United Airlines from Panama City to St. Louis. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,950 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?
Flying on Delta is currently your cheapest option to St. Louis, with prices starting at $221. Additional round-trip tickets that might be worth considering are offered by American Airlines and Southwest, with the lowest prices starting at $226 and $251, respectively. Delta is 53% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?
The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $96. However, be on the lookout for offers from Southwest and Delta, as they are both options that can get you from Panama City, Florida to St. Louis for a low price.
What are the cheapest flights from Panama City, Florida to St. Louis?
Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $353, our data indicates the cheapest price to be $208. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $221.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Eureka

St. Peters

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Alton

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Top 3 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$206	Average$349	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$311	Average$439	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$341	Average$437	FlexibilityNo cancel fee	On-time63%

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$96+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

What is the cheapest time of day to fly from ECP to STL?

Find hourly flight availability from Panama City to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta and United Airlines from Panama City to St. Louis. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

What are the cheapest airlines to fly from Panama City, Florida to St. Louis one-way?

What are the cheapest flights from Panama City, Florida to St. Louis?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Traveling to a place near Panama City?

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Alternative routes for Panama City to St. Louis

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Top 3 airlines flying from Panama City to St. Louis

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Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.