How long is the flight from Panama City, Florida to St. Louis?

For as low as $207, Delta can have you in St. Louis from Panama City, Florida in 4h 41m. Airlines will cover a distance of 635 mi.

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $242 round trip. Southwest is 63% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Panama City, Florida to St. Louis?

Travelers seeking maximum savings on their Panama City, Florida to St. Louis flight should consider departing on Thursday at noon when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Panama City, Florida to St. Louis?

Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $396, our data indicates the cheapest price to be $78. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $207.

What is the cheapest day to fly round-trip from Panama City, Florida to St. Louis?

Users have found that leaving on a Tuesday can be a cost-effective option. It’s possible to save up to 30% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Panama City, Florida to St. Louis?

Our data shows that August tends to be the cheapest month to fly to St. Louis from Panama City, Florida. Users have commonly found prices around $436 for the month, but tickets can be as low as $175. Due to multiple factors, prepare for potentially higher prices in February.

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.

Can I find deals for business class flights from Panama City to St. Louis?

Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$86+ Flights from Panama City, FL to St. Louis

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Cheap flight deals from Panama City to St. Louis

Round-trip from	$207 (Delta)
One-way from	$86 (Southwest)
Popular in	February
Cheapest in	August
Average price	$394
Good round-trip deal	$377 or less
Good one-way deal	$168 or less

From Panama City NW Florida Beaches to Lambert-St Louis

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One-way flight from Panama City NW Florida Beaches to Lambert-St Louis

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Highest demand for flights based on searches. 23% potential increase in price ($136 potential increase over avg. RT price).

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Cheapest flight prices on average. 8% potential price decrease ($35 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Price to beat on a round-trip flight from Panama City NW Florida Beaches to Lambert-St Louis.

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Price to beat on a one-way flight from Panama City NW Florida Beaches to Lambert-St Louis.

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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 11, 2025.

ven. 12/56:00 amECP - STL

1 stop4h 41mDelta

dim. 12/77:02 pmSTL - ECP

1 stop3h 56mDelta

Deal found 9/11

$207

lun. 11/247:02 amECP - STL

1 stop5h 58mDelta

mar. 12/25:12 pmSTL - ECP

1 stop5h 26mDelta

Deal found 9/11

$249

ven. 11/76:00 amECP - STL

1 stop6h 35mDelta

dim. 11/97:02 pmSTL - ECP

1 stop3h 55mDelta

Deal found 9/10

$263

lun. 11/247:02 amECP - STL

1 stop5h 58mDelta

ven. 11/286:00 amSTL - ECP

1 stop4h 26mDelta

Deal found 9/11

$276

ven. 11/284:26 pmECP - STL

1 stop5h 32mDelta

mar. 12/25:12 pmSTL - ECP

1 stop5h 26mDelta

Deal found 9/11

$279

lun. 9/296:54 pmECP - STL

1 stop4h 30mDelta

jeu. 10/21:26 pmSTL - ECP

1 stop6h 04mDelta

Deal found 9/10

$290

lun. 11/247:02 amECP - STL

1 stop5h 58mDelta

jeu. 11/273:15 pmSTL - ECP

1 stop4h 23mDelta

Deal found 9/11

$291

ven. 10/33:29 pmECP - STL

1 stop5h 41mAmerican Airlines

dim. 10/55:18 amSTL - ECP

1 stop5h 48mAmerican Airlines

Deal found 9/9

$297

ven. 12/57:15 amECP - STL

1 stop4h 10mSouthwest

dim. 12/75:05 amSTL - ECP

2 stops7h 50mSouthwest

Deal found 9/10

$301

Best flights from Panama City to St. Louis
Discover carefully curated flight deals from Panama City to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated septembre 11, 2025.

ven. 12/56:00 amECP - STL

1 stop4h 41mDelta

dim. 12/75:12 pmSTL - ECP

1 stop5h 46mDelta

Deal found 9/10

$207

ven. 10/33:29 pmECP - STL

1 stop5h 41mAmerican Airlines

dim. 10/55:18 amSTL - ECP

1 stop5h 48mAmerican Airlines

Deal found 9/9

$297

ven. 11/76:00 amECP - STL

1 stop6h 35mDelta

dim. 11/97:02 pmSTL - ECP

1 stop3h 55mDelta

Deal found 9/10

$263

lun. 11/247:02 amECP - STL

1 stop5h 58mDelta

mar. 12/25:12 pmSTL - ECP

2 stops19h 53mDelta

Deal found 9/11

$287

lun. 9/296:54 pmECP - STL

1 stop4h 30mDelta

jeu. 10/21:26 pmSTL - ECP

1 stop6h 04mDelta

Deal found 9/10

$290

lun. 11/247:02 amECP - STL

1 stop5h 58mDelta

jeu. 11/273:15 pmSTL - ECP

1 stop4h 23mDelta

Deal found 9/11

$291

jeu. 11/276:00 amECP - STL

1 stop4h 04mDelta

jeu. 11/273:15 pmSTL - ECP

1 stop4h 23mDelta

Deal found 9/11

$291

Last-minute flights from Panama City to St. Louis
Discover last-minute flight deals from Panama City to St. Louis. Data last updated septembre 11, 2025 and is based on user searches.

sam. 9/273:53 pmECP - STL

1 stop6h 57mAmerican Airlines

mer. 10/16:00 amSTL - ECP

1 stop8h 20mAmerican Airlines

Deal found 9/11

$313

sam. 9/273:15 pmECP - STL

Nonstop1h 50mSouthwest

mer. 10/11:20 pmSTL - ECP

1 stop6h 45mSouthwest

Deal found 9/11

$369

lun. 9/296:54 pmECP - STL

1 stop4h 30mDelta

jeu. 10/21:26 pmSTL - ECP

1 stop6h 04mDelta

Deal found 9/10

$290

lun. 9/293:03 pmECP - STL

1 stop6h 57mUnited Airlines

jeu. 10/28:25 amSTL - ECP

1 stop7h 51mUnited Airlines

Deal found 9/10

$374

ven. 10/33:29 pmECP - STL

1 stop5h 41mAmerican Airlines

dim. 10/55:18 amSTL - ECP

1 stop5h 48mAmerican Airlines

Deal found 9/9

$297

ven. 10/33:33 pmECP - STL

2 stops20h 48mDelta

dim. 10/56:01 amSTL - ECP

1 stop3h 54mDelta

Deal found 9/9

$339

ven. 10/37:20 pmECP - STL

1 stop3h 35mSouthwest

dim. 10/58:05 amSTL - ECP

Nonstop1h 45mSouthwest

Deal found 9/9

$378

dim. 10/267:10 pmECP - STL

1 stop4h 55mSouthwest

jeu. 10/306:45 pmSTL - ECP

1 stop3h 50mSouthwest

Deal found 9/10

$345

One-way flights from Panama City to St. Louis
Search for one-way flight options from Panama City to St. Louis. Find affordable one-way fares based on user searches. Data last updated septembre 11, 2025.

mer. 10/223:15 pmECP - STL

Nonstop1h 45mSouthwest

Deal found 9/11

$86

mer. 10/153:15 pmECP - STL

Nonstop1h 45mSouthwest

Deal found 9/10

$94

sam. 11/112:00 pmECP - STL

2 stops8h 30mSouthwest

Deal found 9/11

$101

jeu. 12/116:41 pmECP - STL

1 stop5h 00mDelta

Deal found 9/11

$104

mer. 10/223:41 pmECP - STL

2 stops8h 13mAmerican Airlines

Deal found 9/10

$109

ven. 10/36:00 amECP - STL

1 stop3h 59mDelta

Deal found 9/11

$114

sam. 1/102:43 pmECP - STL

1 stop4h 24mAmerican Airlines

Deal found 9/11

$115

sam. 11/222:37 pmECP - STL

1 stop4h 52mAmerican Airlines

Deal found 9/11

$116

mer. 12/247:19 amECP - STL

1 stop5h 55mAmerican Airlines

Deal found 9/11

$118

mar. 12/26:00 amECP - STL

1 stop7h 00mDelta

Deal found 9/11

$119

sam. 1/172:43 pmECP - STL

2 stops9h 06mAmerican Airlines

Deal found 9/10

$121

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

ven. 12/5

6:00 am-10:41 am

1 stop4h 41m

Lambert-St Louis

dim. 12/7

5:12 pm-10:58 pm

1 stop5h 46m

$207

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

ven. 11/7

6:00 am-12:35 pm

1 stop6h 35m

Lambert-St Louis

dim. 11/9

7:02 pm-10:57 pm

1 stop3h 55m

$263

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

lun. 11/24

7:02 am-1:00 pm

1 stop5h 58m

Lambert-St Louis

mar. 12/2

5:12 pm-1:05 pm

2 stops19h 53m

$287

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

lun. 9/29

6:54 pm-11:24 pm

1 stop4h 30m

Lambert-St Louis

jeu. 10/2

1:26 pm-7:30 pm

1 stop6h 04m

$290

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

lun. 11/24

7:02 am-1:00 pm

1 stop5h 58m

Lambert-St Louis

jeu. 11/27

3:15 pm-7:38 pm

1 stop4h 23m

$291

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

jeu. 11/27

6:00 am-10:04 am

1 stop4h 04m

Lambert-St Louis

jeu. 11/27

3:15 pm-7:38 pm

1 stop4h 23m

$291

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

ven. 10/3

3:29 pm-9:10 pm

1 stop5h 41m

Lambert-St Louis

dim. 10/5

5:18 am-11:06 am

1 stop5h 48m

$297

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mer. 10/15

3:15 pm-5:00 pm

Nonstop1h 45m

$94

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

sam. 10/18

6:00 am-12:35 pm

1 stop6h 35m

$104

Panama CitySt. Louis

ECP - STL

ECPSTL

Panama City NW Florida Beaches

mar. 10/21

6:00 am-10:26 am

1 stop4h 26m

$104

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 18 results

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to STL?

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,248 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,960 reviews

Southwest

8.0

Very good

4,248 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

How long is the flight from Panama City, Florida to St. Louis?
For as low as $207, Delta can have you in St. Louis from Panama City, Florida in 4h 41m. Airlines will cover a distance of 635 mi.
What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?
Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $157. Another option worth looking into is Delta, starting at $242 round trip. Southwest is 63% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest flights from Panama City, Florida to St. Louis?
Looking for the cheapest flight from Panama City, Florida to St. Louis? While on average our users pay $396, our data indicates the cheapest price to be $78. The most popular route (Panama City NW Florida Beaches - Lambert-St Louis), is priced around $207.
Can I find deals for flights from Panama City to St. Louis that include hotel bookings?
Yes. In addition to deals on Panama City to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to St. Louis.
Can I find deals for business class flights from Panama City to St. Louis?
Yes. Cheapflights offers flight deals from Panama City to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to St. Louis (average of $311). Flying from Panama City, Florida to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Edwardsville

O'Fallon

Fairview Heights

Maryland Heights

Collinsville

Eureka

Glencoe

St. Peters

Chesterfield

Alton

Farmington

Festus

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Top 2 airlines flying from Panama City to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$157	Average$410	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$242	Average$425	FlexibilityNo cancel fee	On-timeN/A

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$86+ Cheap flights from Panama City, FL to St. Louis (ECP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to St. Louis with Cheapflights

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Cheap flight deals from Panama City to St. Louis

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Find flight deals from Panama City to St. Louis

Cheapest flights from Panama City to St. LouisExplore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 11, 2025.

Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Best time to book a flight from Panama City to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to St. Louis

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

What is the cheapest time of day to fly from ECP to STL?

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest and Delta from Panama City to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Panama City, Florida to St. Louis?

What are the cheapest airlines flying from Panama City, Florida to St. Louis round-trip?

What are the cheapest flights from Panama City, Florida to St. Louis?

Can I find deals for flights from Panama City to St. Louis that include hotel bookings?

How can I find direct flights from Panama City to St. Louis?

Can I find deals for business class flights from Panama City to St. Louis?

What is the cheapest month to book a flight from Panama City, Florida to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Panama City to St. Louis

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Cheapest flights from Panama City to St. Louis
Explore the most affordable flight options available from Panama City to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 11, 2025.