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$102+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Myrtle Beach to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$257
(Kiwi.com)

One-way from

$102
(Priceline)

Popular in

February

Cheapest in

August

Average price

$396
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
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From Myrtle Beach Intl to Lambert-St Louis
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One-way flight from Myrtle Beach Intl to Lambert-St Louis
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:15 amMYR - STL
1 stop8h 02mMultiple Airlines
Sun 11/96:21 pmSTL - MYR
1 stop27h 05mMultiple Airlines
Deal found 10/16$257
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:15 amMYR - STL
1 stop8h 02mMultiple Airlines
Sun 11/96:21 pmSTL - MYR
1 stop27h 05mMultiple Airlines
Deal found 10/16$258
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/122:15 pmMYR - STL
1 stop9h 18mMultiple Airlines
Mon 12/1510:47 amSTL - MYR
2 stops20h 13mMultiple Airlines
Deal found 10/15$297
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:44 pmMYR - STL
1 stop4h 52mAmerican Airlines
Mon 11/176:02 amSTL - MYR
1 stop5h 11mAmerican Airlines
Deal found 10/14$325
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:11 pmMYR - STL
2 stops23h 01mMultiple Airlines
Sun 11/26:21 pmSTL - MYR
1 stop27h 05mMultiple Airlines
Deal found 10/14$335
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:40 pmMYR - STL
2 stops7h 55mSouthwest
Tue 12/232:15 pmSTL - MYR
1 stop4h 20mSouthwest
Deal found 10/15$340
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:09 amMYR - STL
2 stops7h 03mAmerican Airlines
Mon 11/245:56 pmSTL - MYR
1 stop3h 40mAmerican Airlines
Deal found 10/14$350
This Mytrip deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2912:11 pmMYR - STL
2 stops22h 51mSpirit Airlines
Sun 11/26:21 pmSTL - MYR
2 stops18h 30mSpirit Airlines
Deal found 10/14$351
This Southwest deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:15 pmMYR - STL
1 stop3h 55mSouthwest
Mon 11/107:20 amSTL - MYR
1 stop3h 45mSouthwest
Deal found 10/13$353

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Myrtle Beach

Fly to

St. Louis

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 11/7

6:15 am-1:17 pm

1 stop8h 02m

Lambert-St Louis

Sun 11/9

6:21 pm-10:26 pm

1 stop27h 05m

$257

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/6

6:15 am-5:27 pm

2 stops12h 12m

Lambert-St Louis

Sun 11/9

6:21 pm-10:26 pm

1 stop27h 05m

$278

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 12/18

8:10 pm-11:10 pm

1 stop4h 00m

Lambert-St Louis

Tue 12/23

2:15 pm-7:35 pm

1 stop4h 20m

$325

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/13

6:05 am-1:13 pm

2 stops8h 08m

Lambert-St Louis

Mon 11/17

8:13 am-2:46 pm

1 stop5h 33m

$330

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/20

9:09 am-3:12 pm

2 stops7h 03m

Lambert-St Louis

Mon 11/24

5:56 pm-10:36 pm

1 stop3h 40m

$350

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 11/7

12:40 pm-5:20 pm

1 stop5h 40m

Lambert-St Louis

Mon 11/10

5:10 am-10:35 am

1 stop4h 25m

$353

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 11/7

4:00 pm-9:19 pm

1 stop6h 19m

Lambert-St Louis

Mon 11/10

2:05 pm-6:55 pm

1 stop3h 50m

$353

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 11/12

11:13 am-5:57 pm

2 stops31h 44m

$122

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Mon 11/17

2:14 pm-9:07 am

2 stops43h 53m

$130

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 11/12

11:13 am-5:27 pm

3 stops31h 14m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 15 results
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Compare providers for flights from Myrtle Beach to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to St. Louis in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to STL?

Find hourly flight availability from Myrtle Beach to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

One of the essential ways to save on airfare from Myrtle Beach to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 54% on airfare.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 16, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,984 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,043 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Myrtle Beach to St. Louis flight route?

    Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

  • How long is the flight from Myrtle Beach to St. Louis?

    There are many flights that can get you from Myrtle Beach to St. Louis in 4h. Fly via Southwest or American Airlines to get the fastest option. Airlines will cover a distance of 727 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

    Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $168. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $310. You may be able to fly from Myrtle Beach to St. Louis for 54% less than the average price by searching for these airlines.

  • Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

  • Can I find deals for business class flights from Myrtle Beach to St. Louis?

    Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Myrtle Beach to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Myrtle Beach to St. Louis

Discover the top 3 airlines that operate flights from Myrtle Beach to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$366FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$396FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$310Average$385FlexibilityNo cancel feeOn-time63%

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