HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$80+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Mar 11 — Mar 181
Wed 3/11
Wed 3/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:10 am
MYR
-
STL
1 stop4h 25m
American Airlines
Mon 2/236:06 am
STL
-
MYR
1 stop4h 33m
American Airlines
Deal found 2/7$189
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:15 pm
MYR
-
STL
1 stop6h 53m
United Airlines
Mon 4/207:45 am
STL
-
MYR
1 stop5h 32m
United Airlines
Deal found 2/7$192
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:57 pm
MYR
-
STL
1 stop8h 17m
Delta
Mon 4/204:41 pm
STL
-
MYR
1 stop6h 33m
Delta
Deal found 2/8$197
This Delta deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:00 am
MYR
-
STL
1 stop4h 06m
Delta
Mon 2/236:47 pm
STL
-
MYR
1 stop4h 10m
Delta
Deal found 2/6$205
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:00 am
MYR
-
STL
2 stops7h 33m
American Airlines
Wed 2/256:06 am
STL
-
MYR
1 stop4h 33m
American Airlines
Deal found 2/6$210
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:00 am
MYR
-
STL
2 stops7h 45m
American Airlines
Sun 5/106:29 am
STL
-
MYR
1 stop4h 47m
American Airlines
Deal found 2/8$222

Find flight deals from Myrtle Beach to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$189
(American Airlines)

One-way from

$80
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$350

Good round-trip deal

$456 or less
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From Myrtle Beach Intl to Lambert-St Louis
Search Deals
One-way flight from Myrtle Beach Intl to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Myrtle Beach Intl to Lambert-St Louis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Myrtle Beach

Fly to

St. Louis

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/17

3:15 pm-9:08 pm

1 stop6h 53m

Lambert-St Louis

Mon 4/20

7:45 am-2:17 pm

1 stop5h 32m

$192

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 5/7

3:14 pm-9:08 pm

1 stop6h 54m

Lambert-St Louis

Sun 5/10

7:45 am-2:18 pm

1 stop5h 33m

$192

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/17

3:57 pm-11:14 pm

1 stop8h 17m

Lambert-St Louis

Mon 4/20

4:41 pm-12:14 am

1 stop6h 33m

$197

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/17

4:52 pm-10:59 pm

1 stop7h 07m

Lambert-St Louis

Mon 4/20

6:55 pm-11:57 pm

1 stop4h 02m

$197

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 2/21

6:26 pm-10:52 pm

1 stop5h 26m

Lambert-St Louis

Mon 2/23

2:19 pm-11:55 pm

2 stops8h 36m

$198

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 2/21

6:00 am-9:06 am

1 stop4h 06m

Lambert-St Louis

Mon 2/23

6:47 pm-11:57 pm

1 stop4h 10m

$205

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 2/21

9:10 am-12:42 pm

1 stop4h 32m

Lambert-St Louis

Wed 2/25

6:06 am-11:39 am

1 stop4h 33m

$205

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 2/20

6:55 pm-11:36 pm

1 stop5h 41m

Lambert-St Louis

Mon 2/23

6:35 am-12:11 pm

1 stop4h 36m

$231

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 2/20

3:17 pm-7:30 pm

1 stop5h 13m

Lambert-St Louis

Mon 2/23

6:00 am-2:27 pm

2 stops7h 27m

$236

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 4/7

3:15 pm-9:08 pm

1 stop6h 53m

$94

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/8

Showing 1-10 of 17 results
1
2

Compare providers for flights from Myrtle Beach to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to St. Louis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 9, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,282 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,282 reviews
Southwest
8.0
Very good
4,282 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,174 reviews
Southwest
8.0
Very good
4,282 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,258 reviews
Southwest
8.0
Very good
4,282 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Myrtle Beach to St. Louis flight route?

    Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

  • How long is the flight from Myrtle Beach to St. Louis?

    There are many flights that can get you from Myrtle Beach to St. Louis in 6h 53m. Fly via United Airlines, Delta, or American Airlines to get the fastest option. Airlines will cover a distance of 727 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

    Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $128. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $310. You may be able to fly from Myrtle Beach to St. Louis for 65% less than the average price by searching for these airlines.

  • What are the cheapest flights from Myrtle Beach to St. Louis?

    On average you can expect to pay $487 for a flight from Myrtle Beach to St. Louis. The cheapest flight overall is $442 while the most popular route, (Myrtle Beach Intl - Lambert-St Louis) is currently priced at $192.

  • Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

  • Can I find deals for business class flights from Myrtle Beach to St. Louis?

    Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Myrtle Beach to St. Louis

Discover the top 3 airlines that operate flights from Myrtle Beach to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$128Average$351FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$367FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$310Average$381FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.