HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$109+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$321
(American Airlines)

One-way from

$109
(Priceline)

Popular in

February

Cheapest in

August

Average price

$330

Good one-way deal

$199 or less
From Myrtle Beach Intl to Lambert-St Louis
Search Deals
One-way flight from Myrtle Beach Intl to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a one-way flight from Myrtle Beach Intl to Lambert-St Louis.
Search Deals

Find flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:44 pmMYR - STL
1 stop9h 35mAmerican Airlines
Mon 11/176:00 amSTL - MYR
1 stop8h 21mAmerican Airlines
Deal found 9/15$321
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:21 amMYR - STL
1 stop3h 55mAmerican Airlines
Tue 10/216:00 amSTL - MYR
1 stop11h 51mAmerican Airlines
Deal found 9/14$323
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:36 amMYR - STL
1 stop6h 34mDelta
Mon 11/107:05 amSTL - MYR
1 stop5h 51mDelta
Deal found 9/15$325
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:05 amMYR - STL
2 stops8h 35mAmerican Airlines
Tue 11/116:00 amSTL - MYR
1 stop8h 21mAmerican Airlines
Deal found 9/14$328
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/81:15 pmMYR - STL
2 stops8h 55mSouthwest
Tue 11/117:00 amSTL - MYR
2 stops6h 15mSouthwest
Deal found 9/14$335
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/612:40 pmMYR - STL
2 stops9h 50mSouthwest
Mon 11/109:20 amSTL - MYR
2 stops9h 15mSouthwest
Deal found 9/15$375
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:52 pmMYR - STL
1 stop5h 58mAmerican Airlines
Wed 10/12:11 pmSTL - MYR
1 stop5h 58mAmerican Airlines
Deal found 9/14$383
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/710:36 amMYR - STL
1 stop6h 34mDelta
Sun 11/97:02 pmSTL - MYR
1 stop3h 42mDelta
Deal found 9/14$386
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:41 pmMYR - STL
1 stop4h 26mAmerican Airlines
Sun 11/96:00 amSTL - MYR
2 stops6h 59mAmerican Airlines
Deal found 9/14$396

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Myrtle Beach

Fly to

St. Louis

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/13

12:44 pm-9:19 pm

1 stop9h 35m

Lambert-St Louis

Mon 11/17

6:00 am-3:21 pm

1 stop8h 21m

$321

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 10/16

5:21 am-8:16 am

1 stop3h 55m

Lambert-St Louis

Tue 10/21

6:00 am-6:51 pm

1 stop11h 51m

$323

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 11/8

6:12 pm-12:05 am

1 stop6h 53m

Lambert-St Louis

Tue 11/11

6:00 am-3:21 pm

1 stop8h 21m

$323

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/6

10:36 am-4:10 pm

1 stop6h 34m

Lambert-St Louis

Mon 11/10

7:05 am-1:56 pm

1 stop5h 51m

$325

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 10/16

6:58 pm-11:41 pm

1 stop5h 43m

Lambert-St Louis

Tue 10/21

1:30 pm-6:03 pm

1 stop3h 33m

$325

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 11/8

1:15 pm-9:10 pm

2 stops8h 55m

Lambert-St Louis

Tue 11/11

7:00 am-2:15 pm

2 stops6h 15m

$335

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/6

12:40 pm-9:30 pm

2 stops9h 50m

Lambert-St Louis

Mon 11/10

9:20 am-7:35 pm

2 stops9h 15m

$375

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/20

9:09 am-3:12 pm

2 stops7h 03m

Lambert-St Louis

Mon 11/24

6:02 am-2:49 pm

1 stop7h 47m

$381

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 10/25

10:26 am-6:10 pm

1 stop8h 44m

$109

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 10/25

8:14 am-9:22 am

2 stops26h 08m

$157

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 19 results
1
2

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to STL?

Find hourly flight availability from Myrtle Beach to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

One of the essential ways to save on airfare from Myrtle Beach to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 33% on airfare.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Myrtle Beach to St. Louis flight route?

    Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

  • How long is the flight from Myrtle Beach to St. Louis?

    There are many flights that can get you from Myrtle Beach to St. Louis in 6h 34m. Fly via American Airlines or Delta to get the fastest option. Airlines will cover a distance of 727 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

    Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $168. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $292. You may be able to fly from Myrtle Beach to St. Louis for 55% less than the average price by searching for these airlines.

  • What are the cheapest flights from Myrtle Beach to St. Louis?

    On average you can expect to pay $317 for a flight from Myrtle Beach to St. Louis. The cheapest flight overall is $173 while the most popular route, (Myrtle Beach Intl - Lambert-St Louis) is currently priced at $211.

  • Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

  • Can I find deals for business class flights from Myrtle Beach to St. Louis?

    Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Kansas City flights
Charlotte to St. Louis flights
Charleston to St. Louis flights
Columbia to St. Louis flights
Charlotte to Springfield flights
Savannah to St. Louis flights
Greenville to Kansas City flights
Charleston to Kansas City flights
Greenville to St. Louis flights
Savannah to Kansas City flights
Columbia to Kansas City flights
Savannah to Springfield flights
Augusta to St. Louis flights
Greenville to Springfield flights
Charleston to Springfield flights
Myrtle Beach to Kansas City flights
Augusta to Kansas City flights
Myrtle Beach to Springfield flights
Columbia to Springfield flights
Columbia to Columbia flights
Charlotte to Columbia flights
Hilton Head Island to Kansas City flights
Charlotte to Joplin flights
Hilton Head Island to St. Louis flights
Charleston to Columbia flights
Myrtle Beach to Joplin flights
Augusta to Columbia flights
Florence to Kansas City flights
Charlotte to Fort Leonard Wood flights
Florence to St. Louis flights

Top 3 airlines flying from Myrtle Beach to St. Louis

Discover the top 3 airlines that operate flights from Myrtle Beach to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$378FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$396FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$292Average$382FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.