How popular is this Myrtle Beach to St. Louis flight route?

Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

How long is the flight from Myrtle Beach to St. Louis?

There are many flights that can get you from Myrtle Beach to St. Louis in 3h 53m. Fly via Delta to get the fastest option. Airlines will cover a distance of 727 mi.

What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $128. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $310. You may be able to fly from Myrtle Beach to St. Louis for 66% less than the average price by searching for these airlines.

What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?

For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $93. Users have also found prices from $94 and $113 on Spirit Airlines and Delta, respectively.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Myrtle Beach to St. Louis?

The most popular airlines flying from Myrtle Beach to St. Louis are Southwest, American Airlines and Delta. Something to consider prior to booking your flight.

Most accurate provider : When it comes to deals on Myrtle Beach-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Myrtle Beach-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

Can I find deals for business class flights from Myrtle Beach to St. Louis?

Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$94+ Flights from Myrtle Beach to St. Louis

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Cheap flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Wed 12/319:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Sat 1/34:27 pmSTL - MYR

1 stop25h 10mMultiple Airlines

Deal found 12/8

$356

Mon 12/152:15 pmMYR - STL

1 stop9h 18mMultiple Airlines

Thu 12/2510:42 amSTL - MYR

2 stops30h 26mMultiple Airlines

Deal found 12/8

$363

Mon 12/152:15 pmMYR - STL

1 stop9h 18mMultiple Airlines

Sun 12/2110:57 amSTL - MYR

2 stops30h 11mMultiple Airlines

Deal found 12/8

$368

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Thu 12/2510:42 amSTL - MYR

2 stops30h 26mMultiple Airlines

Deal found 12/8

$369

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Sun 12/2110:57 amSTL - MYR

2 stops30h 11mMultiple Airlines

Deal found 12/8

$373

Wed 12/319:54 amMYR - STL

1 stop26h 02mSpirit Airlines

Sun 1/411:51 amSTL - MYR

1 stop29h 17mSpirit Airlines

Deal found 12/8

$381

Mon 12/152:15 pmMYR - STL

1 stop9h 18mMultiple Airlines

Tue 12/2310:48 amSTL - MYR

2 stops30h 20mMultiple Airlines

Deal found 12/8

$384

Mon 12/299:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Wed 12/314:27 pmSTL - MYR

1 stop25h 10mMultiple Airlines

Deal found 12/8

$385

Thu 12/187:32 pmMYR - STL

1 stop25h 10mMultiple Airlines

Thu 12/2510:42 amSTL - MYR

2 stops30h 26mMultiple Airlines

Deal found 12/8

$386

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Tue 12/2310:48 amSTL - MYR

2 stops30h 20mMultiple Airlines

Deal found 12/8

$389

Wed 12/179:54 amMYR - STL

1 stop26h 02mSpirit Airlines

Thu 12/2511:51 amSTL - MYR

1 stop29h 17mSpirit Airlines

Deal found 12/8

$396

Wed 12/179:54 amMYR - STL

2 stops24h 46mMultiple Airlines

Wed 12/244:27 pmSTL - MYR

1 stop25h 10mMultiple Airlines

Deal found 12/8

$397

Best flights from Myrtle Beach to St. Louis
Discover carefully curated flight deals from Myrtle Beach to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 8, 2025.

Wed 1/2110:00 amMYR - STL

2 stops14h 33mMultiple Airlines

Sat 1/245:42 pmSTL - MYR

1 stop17h 30mMultiple Airlines

Deal found 12/7

$234

Wed 1/216:00 amMYR - STL

1 stop3h 53mDelta

Sat 1/245:04 pmSTL - MYR

1 stop5h 37mDelta

Deal found 12/6

$357

Wed 1/2110:18 amMYR - STL

2 stops8h 56mAmerican Airlines

Sat 1/2411:05 amSTL - MYR

2 stops6h 44mAmerican Airlines

Deal found 12/6

$367

Tue 1/131:07 pmMYR - STL

1 stop10h 27mMultiple Airlines

Wed 1/148:32 pmSTL - MYR

2 stops17h 10mMultiple Airlines

Deal found 12/6

$270

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Sun 12/2110:57 amSTL - MYR

2 stops30h 11mMultiple Airlines

Deal found 12/8

$373

Wed 12/316:00 amMYR - STL

1 stop3h 58mDelta

Thu 1/17:00 amSTL - MYR

1 stop4h 31mDelta

Deal found 12/8

$437

Thu 1/111:27 amMYR - STL

1 stop6h 33mDelta

Sun 1/47:10 amSTL - MYR

1 stop8h 24mDelta

Deal found 12/8

$437

Mon 12/296:59 pmMYR - STL

1 stop5h 43mDelta

Sun 1/49:47 amSTL - MYR

1 stop4h 07mDelta

Deal found 12/8

$437

Tue 12/306:00 amMYR - STL

1 stop3h 58mDelta

Wed 12/316:00 amSTL - MYR

1 stop5h 31mDelta

Deal found 12/8

$437

Last-minute flights from Myrtle Beach to St. Louis
Discover last-minute flight deals from Myrtle Beach to St. Louis. Data last updated December 8, 2025 and is based on user searches.

Mon 12/152:15 pmMYR - STL

1 stop9h 18mMultiple Airlines

Thu 12/2510:42 amSTL - MYR

2 stops30h 26mMultiple Airlines

Deal found 12/8

$363

Mon 12/152:15 pmMYR - STL

1 stop9h 18mMultiple Airlines

Sun 12/2110:57 amSTL - MYR

2 stops30h 11mMultiple Airlines

Deal found 12/8

$368

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Thu 12/2510:42 amSTL - MYR

2 stops30h 26mMultiple Airlines

Deal found 12/8

$369

Wed 12/179:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Sun 12/2110:57 amSTL - MYR

2 stops30h 11mMultiple Airlines

Deal found 12/8

$373

Wed 12/319:54 amMYR - STL

1 stop26h 02mMultiple Airlines

Sat 1/34:27 pmSTL - MYR

1 stop25h 10mMultiple Airlines

Deal found 12/8

$356

Tue 1/131:07 pmMYR - STL

1 stop10h 27mMultiple Airlines

Wed 1/148:32 pmSTL - MYR

2 stops17h 10mMultiple Airlines

Deal found 12/6

$270

Tue 1/131:53 pmMYR - STL

2 stops8h 22mAmerican Airlines

Wed 1/146:52 amSTL - MYR

1 stop3h 43mAmerican Airlines

Deal found 12/7

$362

Wed 1/2110:00 amMYR - STL

2 stops14h 33mMultiple Airlines

Sat 1/245:42 pmSTL - MYR

1 stop17h 30mMultiple Airlines

Deal found 12/7

$234

Wed 1/2110:33 amMYR - STL

1 stop6h 34mDelta

Sat 1/245:04 pmSTL - MYR

1 stop5h 37mDelta

Deal found 12/7

$357

One-way flights from Myrtle Beach to St. Louis
Search for one-way flight options from Myrtle Beach to St. Louis. Find affordable one-way fares based on user searches. Data last updated December 8, 2025.

Tue 2/310:00 amMYR - STL

2 stops38h 33mMultiple Airlines

Deal found 12/7

$94

Fri 2/63:20 pmMYR - STL

1 stop9h 13mMultiple Airlines

Deal found 12/7

$107

Thu 2/51:07 pmMYR - STL

1 stop11h 26mMultiple Airlines

Deal found 12/7

$108

Wed 1/76:00 amMYR - STL

2 stops33h 48mMultiple Airlines

Deal found 12/7

$112

Wed 2/410:00 amMYR - STL

2 stops14h 33mMultiple Airlines

Deal found 12/7

$114

Sat 2/71:07 pmMYR - STL

1 stop11h 26mMultiple Airlines

Deal found 12/7

$119

Sun 2/810:00 amMYR - STL

2 stops21h 51mMultiple Airlines

Deal found 12/8

$125

Find flight deals from Myrtle Beach to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$234 (Kiwi.com)
One-way from	$94 (Kiwi.com)
Popular in	December
Cheapest in	August
Average price	$529

Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.

Search Deals

From Myrtle Beach Intl to Lambert-St Louis

Search Deals

One-way flight from Myrtle Beach Intl to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 1/21

10:00 am-11:33 pm

2 stops14h 33m

Lambert-St Louis

Sat 1/24

5:42 pm-12:12 pm

1 stop17h 30m

$234

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 1/13

1:07 pm-10:34 pm

1 stop10h 27m

Lambert-St Louis

Wed 1/14

8:32 pm-2:42 pm

2 stops17h 10m

$270

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 1/21

6:00 am-8:53 am

1 stop3h 53m

Lambert-St Louis

Sat 1/24

5:04 pm-11:41 pm

1 stop5h 37m

$357

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 1/21

10:18 am-6:14 pm

2 stops8h 56m

Lambert-St Louis

Sat 1/24

11:05 am-6:49 pm

2 stops6h 44m

$367

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 12/17

9:54 am-10:56 am

1 stop26h 02m

Lambert-St Louis

Sun 12/21

10:57 am-6:08 pm

2 stops30h 11m

$373

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 12/31

6:00 am-8:58 am

1 stop3h 58m

Lambert-St Louis

Thu 1/1

7:00 am-12:31 pm

1 stop4h 31m

$437

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 1/1

11:27 am-5:00 pm

1 stop6h 33m

Lambert-St Louis

Sun 1/4

7:10 am-4:34 pm

1 stop8h 24m

$437

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Mon 12/29

6:59 pm-11:42 pm

1 stop5h 43m

Lambert-St Louis

Sun 1/4

9:47 am-2:54 pm

1 stop4h 07m

$437

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 12/30

6:00 am-8:58 am

1 stop3h 58m

Lambert-St Louis

Wed 12/31

6:00 am-12:31 pm

1 stop5h 31m

$437

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 2/3

10:00 am-11:33 pm

2 stops38h 33m

$94

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 14 results

Compare providers for flights from Myrtle Beach to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Myrtle Beach-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Myrtle Beach-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to STL?

One of the essential ways to save on airfare from Myrtle Beach to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 56% on airfare.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,252 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,013 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,042 reviews

Southwest

8.0

Very good

4,252 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How popular is this Myrtle Beach to St. Louis flight route?
Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.
How long is the flight from Myrtle Beach to St. Louis?
There are many flights that can get you from Myrtle Beach to St. Louis in 3h 53m. Fly via Delta to get the fastest option. Airlines will cover a distance of 727 mi.
What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?
Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $128. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $310. You may be able to fly from Myrtle Beach to St. Louis for 66% less than the average price by searching for these airlines.
What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?
For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $93. Users have also found prices from $94 and $113 on Spirit Airlines and Delta, respectively.
Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.
Can I find deals for business class flights from Myrtle Beach to St. Louis?
Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to St. Louis?
Currently, June is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $128). Flying from Myrtle Beach to St. Louis in July is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 3 airlines flying from Myrtle Beach to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$168	Average$356	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$260	Average$396	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$310	Average$382	FlexibilityNo cancel fee	On-time63%

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$94+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. LouisExplore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Find flight deals from Myrtle Beach to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Compare providers for flights from Myrtle Beach to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to St. Louis in December.

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

What is the cheapest time of day to fly from MYR to STL?

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Myrtle Beach to St. Louis flight route?

How long is the flight from Myrtle Beach to St. Louis?

What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?

Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

How can I find direct flights from Myrtle Beach to St. Louis?

Can I find deals for business class flights from Myrtle Beach to St. Louis?

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Traveling to a place near St. Louis?

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Alternative routes for Myrtle Beach to St. Louis

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Top 3 airlines flying from Myrtle Beach to St. Louis

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Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.