How popular is this Myrtle Beach to St. Louis flight route?

Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $187. Other airlines that can offer you cheap pricing are Spirit Airlines, from $201, and Southwest, from $207. You may be able to fly from Myrtle Beach to St. Louis for 49% less than the average price by searching for these airlines.

What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?

For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $79. Users have also found prices from $87 and $89 on Spirit Airlines and Southwest, respectively.

What is the cheapest day to fly from Myrtle Beach to St. Louis?

Travelers seeking maximum savings on their Myrtle Beach to St. Louis flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from Myrtle Beach to St. Louis?

On average you can expect to pay $692 for a flight from Myrtle Beach to St. Louis. The cheapest flight overall is $316 while the most popular route, (Myrtle Beach Intl - Lambert-St Louis) is currently priced at $197.

What are the most popular airlines that fly from Myrtle Beach to St. Louis?

The most popular airlines flying from Myrtle Beach to St. Louis are American Airlines, Delta and Southwest. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Myrtle Beach to St. Louis?

Saturday flights are found to be more expensive to fly from Myrtle Beach to St. Louis. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to St. Louis.

What is the cheapest month to fly from Myrtle Beach to St. Louis?

The best pricing can be found in the month of August. Prices to St. Louis from Myrtle Beach average $372. You can even find prices in August for less than $372, as users have found deals to St. Louis from as low as $210. The month of February appears to be one of the more expensive times to travel to St. Louis from Myrtle Beach. Flying in the targeted month can save you up to 13%.

Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

Can I find deals for business class flights from Myrtle Beach to St. Louis?

Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$79+ Flights from Myrtle Beach to St. Louis

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Myrtle Beach to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to St. Louis

Round-trip from	$187 (American Airlines)
One-way from	$79 (American Airlines)
Popular in	February
Cheapest in	August
Average price	$323
Good round-trip deal	$407 or less

From Myrtle Beach Intl to Lambert-St Louis

Search Deals

One-way flight from Myrtle Beach Intl to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in June 2025

Search Deals

Price to beat on a round-trip flight from Myrtle Beach Intl to Lambert-St Louis.

Search Deals

Find flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Thu 8/145:23 amMYR - STL

1 stop3h 41mAmerican Airlines

Sun 8/175:27 amSTL - MYR

1 stop3h 28mAmerican Airlines

Deal found 6/11

$187

Wed 7/98:58 pmMYR - STL

1 stop13h 54mSpirit Airlines

Wed 7/1611:24 amSTL - MYR

1 stop9h 53mSpirit Airlines

Deal found 6/11

$201

Thu 8/147:10 pmMYR - STL

1 stop5h 15mSouthwest

Sun 8/171:00 pmSTL - MYR

Nonstop1h 55mSouthwest

Deal found 6/11

$207

Thu 7/311:00 amMYR - STL

1 stop4h 36mDelta

Sat 7/56:30 amSTL - MYR

1 stop6h 27mDelta

Deal found 6/12

$307

Tue 7/811:28 amMYR - STL

3 stops30h 17mMultiple Airlines

Sat 7/1210:45 amSTL - MYR

1 stop10h 32mMultiple Airlines

Deal found 6/10

$336

Thu 6/264:50 pmMYR - STL

1 stop6h 55mUnited Airlines

Mon 6/308:00 amSTL - MYR

1 stop5h 35mUnited Airlines

Deal found 6/11

$507

Best flights from Myrtle Beach to St. Louis
Discover carefully curated flight deals from Myrtle Beach to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Thu 8/145:23 amMYR - STL

1 stop3h 41mAmerican Airlines

Sun 8/175:27 amSTL - MYR

1 stop3h 28mAmerican Airlines

Deal found 6/11

$187

Wed 7/98:58 pmMYR - STL

1 stop13h 54mSpirit Airlines

Wed 7/1611:24 amSTL - MYR

1 stop9h 53mSpirit Airlines

Deal found 6/11

$201

Thu 8/148:25 amMYR - STL

1 stop5h 30mSouthwest

Sun 8/171:00 pmSTL - MYR

Nonstop1h 55mSouthwest

Deal found 6/11

$207

Thu 7/311:00 amMYR - STL

1 stop4h 36mDelta

Sat 7/56:30 amSTL - MYR

1 stop6h 27mDelta

Deal found 6/12

$307

Tue 7/811:28 amMYR - STL

3 stops30h 17mMultiple Airlines

Sat 7/1210:45 amSTL - MYR

1 stop10h 32mMultiple Airlines

Deal found 6/10

$336

Thu 6/264:50 pmMYR - STL

1 stop6h 55mUnited Airlines

Mon 6/308:00 amSTL - MYR

1 stop5h 35mUnited Airlines

Deal found 6/11

$507

Last-minute flights from Myrtle Beach to St. Louis
Discover last-minute flight deals from Myrtle Beach to St. Louis. Data last updated June 12, 2025 and is based on user searches.

Wed 6/186:14 pmMYR - STL

1 stop6h 45mAmerican Airlines

Sat 6/213:08 pmSTL - MYR

1 stop6h 49mAmerican Airlines

Deal found 6/10

$477

Wed 6/1811:05 amMYR - STL

1 stop7h 35mSouthwest

Sat 6/214:15 pmSTL - MYR

Nonstop1h 55mSouthwest

Deal found 6/10

$500

Wed 6/184:44 pmMYR - STL

2 stops25h 20mMultiple Airlines

Sat 6/219:50 amSTL - MYR

3 stops32h 32mMultiple Airlines

Deal found 6/10

$528

Thu 6/264:50 pmMYR - STL

1 stop6h 55mUnited Airlines

Mon 6/308:00 amSTL - MYR

1 stop5h 35mUnited Airlines

Deal found 6/11

$507

Thu 7/36:14 pmMYR - STL

1 stop6h 45mAmerican Airlines

Sat 7/54:07 pmSTL - MYR

1 stop4h 15mAmerican Airlines

Deal found 6/10

$272

Thu 7/311:00 amMYR - STL

1 stop4h 36mDelta

Sat 7/56:30 amSTL - MYR

1 stop6h 27mDelta

Deal found 6/12

$307

Tue 7/86:25 pmMYR - STL

1 stop5h 40mSouthwest

Sat 7/129:55 amSTL - MYR

1 stop4h 45mSouthwest

Deal found 6/10

$237

Tue 7/811:28 amMYR - STL

3 stops30h 17mMultiple Airlines

Sat 7/1210:45 amSTL - MYR

1 stop10h 32mMultiple Airlines

Deal found 6/10

$336

Wed 7/98:58 pmMYR - STL

1 stop13h 54mSpirit Airlines

Wed 7/1611:24 amSTL - MYR

1 stop9h 53mSpirit Airlines

Deal found 6/11

$201

One-way flights from Myrtle Beach to St. Louis
Search for one-way flight options from Myrtle Beach to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Thu 7/107:50 pmMYR - STL

1 stop5h 09mAmerican Airlines

Deal found 6/9

$79

Wed 7/168:58 pmMYR - STL

1 stop13h 54mSpirit Airlines

Deal found 6/10

$87

Thu 7/177:55 pmMYR - STL

1 stop4h 25mSouthwest

Deal found 6/11

$89

Mon 7/289:47 pmMYR - STL

2 stops19h 44mMultiple Airlines

Deal found 6/10

$146

Sat 9/276:00 amMYR - STL

1 stop4h 40mDelta

Deal found 6/10

$168

Wed 8/134:50 pmMYR - STL

3 stops30h 25mUnited Airlines

Deal found 6/11

$435

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 8/14

5:23 am-8:04 am

1 stop3h 41m

Lambert-St Louis

Sun 8/17

5:27 am-9:55 am

1 stop3h 28m

$187

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 7/9

8:58 pm-9:52 am

1 stop13h 54m

Lambert-St Louis

Wed 7/16

11:24 am-10:17 pm

1 stop9h 53m

$201

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 8/14

7:10 pm-11:25 pm

1 stop5h 15m

Lambert-St Louis

Sun 8/17

1:00 pm-3:55 pm

Nonstop1h 55m

$207

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 7/3

11:00 am-2:36 pm

1 stop4h 36m

Lambert-St Louis

Sat 7/5

6:30 am-1:57 pm

1 stop6h 27m

$307

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 7/8

11:28 am-4:45 pm

3 stops30h 17m

Lambert-St Louis

Sat 7/12

10:45 am-10:17 pm

1 stop10h 32m

$336

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 6/26

4:50 pm-10:45 pm

1 stop6h 55m

Lambert-St Louis

Mon 6/30

8:00 am-2:35 pm

1 stop5h 35m

$507

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 7/10

7:50 pm-11:59 pm

1 stop5h 09m

$79

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 7/16

8:58 pm-9:52 am

1 stop13h 54m

$87

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 7/17

7:55 pm-11:20 pm

1 stop4h 25m

$89

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Mon 7/28

9:47 pm-4:31 pm

2 stops19h 44m

$146

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 12 results

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to STL?

One of the essential ways to save on airfare from Myrtle Beach to St. Louis is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest, Delta and United Airlines from Myrtle Beach to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,950 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Spirit Airlines

6.3

Okay

8,052 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

How popular is this Myrtle Beach to St. Louis flight route?
Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.
What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?
Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $187. Other airlines that can offer you cheap pricing are Spirit Airlines, from $201, and Southwest, from $207. You may be able to fly from Myrtle Beach to St. Louis for 49% less than the average price by searching for these airlines.
What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?
For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $79. Users have also found prices from $87 and $89 on Spirit Airlines and Southwest, respectively.
What are the cheapest flights from Myrtle Beach to St. Louis?
On average you can expect to pay $692 for a flight from Myrtle Beach to St. Louis. The cheapest flight overall is $316 while the most popular route, (Myrtle Beach Intl - Lambert-St Louis) is currently priced at $197.
Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.
Can I find deals for business class flights from Myrtle Beach to St. Louis?
Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

O'Fallon

Maryland Heights

Fairview Heights

Collinsville

Eureka

St. Peters

Glencoe

Festus

Alton

Farmington

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Myrtle Beach to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$196	Average$381	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$256	Average$381	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$292	Average$382	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$79+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Myrtle Beach to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Find flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. LouisExplore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

What is the cheapest time of day to fly from MYR to STL?

Find hourly flight availability from Myrtle Beach to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest, Delta and United Airlines from Myrtle Beach to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Myrtle Beach to St. Louis flight route?

What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

What are the cheapest airlines to fly from Myrtle Beach to St. Louis one-way?

What are the cheapest flights from Myrtle Beach to St. Louis?

Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

How can I find direct flights from Myrtle Beach to St. Louis?

Can I find deals for business class flights from Myrtle Beach to St. Louis?

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Traveling to a place near Myrtle Beach?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Myrtle Beach to St. Louis

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.