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St. Louis

$106+ Cheap flights from Myrtle Beach to St. Louis (MYR - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Aug 24 — Aug 311
Sun 8/24
Sun 8/31
1 adult, Economy
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Cheap flight deals from Myrtle Beach to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 19, 2025.

Round-trip from

$241
(Mytrip)

One-way from

$106
(FlightHub)

Popular in

December

Cheapest in

August

Average price

$271

Good one-way deal

$178 or less
From Myrtle Beach Intl to Lambert-St Louis
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One-way flight from Myrtle Beach Intl to Lambert-St Louis
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Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a one-way flight from Myrtle Beach Intl to Lambert-St Louis.
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Find flight deals from Myrtle Beach to St. Louis

Cheapest flights from Myrtle Beach to St. Louis
Explore the most affordable flight options available from Myrtle Beach to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2025.

This Mytrip deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/31:15 pmMYR - STL
2 stops21h 25mSpirit Airlines
Sun 9/710:35 amSTL - MYR
1 stop8h 31mSpirit Airlines
Deal found 8/19$241
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/134:23 pmMYR - STL
1 stop18h 17mMultiple Airlines
Mon 9/154:00 pmSTL - MYR
2 stops26h 46mMultiple Airlines
Deal found 8/17$249
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:20 pmMYR - STL
1 stop20h 42mMultiple Airlines
Mon 9/291:57 pmSTL - MYR
1 stop21h 32mMultiple Airlines
Deal found 8/17$253
This FlightHub deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/134:23 pmMYR - STL
1 stop18h 17mMultiple Airlines
Sun 9/144:00 pmSTL - MYR
2 stops22h 19mMultiple Airlines
Deal found 8/17$269
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/115:20 pmMYR - STL
1 stop20h 42mMultiple Airlines
Mon 9/151:57 pmSTL - MYR
1 stop21h 32mMultiple Airlines
Deal found 8/17$276
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/115:20 pmMYR - STL
1 stop20h 42mMultiple Airlines
Sun 9/141:52 pmSTL - MYR
1 stop21h 05mMultiple Airlines
Deal found 8/17$285
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:30 pmMYR - STL
1 stop17h 47mMultiple Airlines
Mon 11/177:45 pmSTL - MYR
2 stops22h 50mMultiple Airlines
Deal found 8/17$290

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Myrtle Beach

Fly to

St. Louis

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 9/3

1:15 pm-9:40 am

2 stops21h 25m

Lambert-St Louis

Sun 9/7

10:35 am-8:06 pm

1 stop8h 31m

$241

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 9/13

4:23 pm-9:40 am

1 stop18h 17m

Lambert-St Louis

Mon 9/15

4:00 pm-7:46 pm

2 stops26h 46m

$249

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 9/25

5:20 pm-1:02 pm

1 stop20h 42m

Lambert-St Louis

Mon 9/29

1:57 pm-12:29 pm

1 stop21h 32m

$253

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 10/1

7:36 pm-9:40 am

1 stop15h 04m

Lambert-St Louis

Tue 10/7

10:57 am-8:04 pm

1 stop8h 07m

$253

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 9/13

4:23 pm-9:40 am

1 stop18h 17m

Lambert-St Louis

Sun 9/14

4:00 pm-3:19 pm

2 stops22h 19m

$269

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 9/11

5:20 pm-1:02 pm

1 stop20h 42m

Lambert-St Louis

Mon 9/15

1:57 pm-12:29 pm

1 stop21h 32m

$276

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 11/13

8:30 pm-1:17 pm

1 stop17h 47m

Lambert-St Louis

Mon 11/17

2:12 pm-7:35 pm

1 stop28h 23m

$276

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 9/11

5:20 pm-1:02 pm

1 stop20h 42m

Lambert-St Louis

Sun 9/14

1:52 pm-11:57 am

1 stop21h 05m

$285

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 10/18

10:26 am-5:45 pm

1 stop8h 19m

$106

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 10/22

8:06 pm-10:02 am

1 stop14h 56m

$106

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 17 results
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Best time to book a flight from Myrtle Beach to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to St. Louis

What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to STL?

Find hourly flight availability from Myrtle Beach to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 19, 2025.

One of the essential ways to save on airfare from Myrtle Beach to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 31% on airfare.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 19, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Myrtle Beach to St. Louis flight route?

    Flights from Myrtle Beach Intl to Lambert-St Louis have been viewed 1 times in the past calendar month.

  • How long is the flight from Myrtle Beach to St. Louis?

    There are many flights that can get you from Myrtle Beach to St. Louis in 21h 25m. Fly via Spirit Airlines to get the fastest option. Airlines will cover a distance of 727 mi.

  • What are the cheapest airlines flying from Myrtle Beach to St. Louis round-trip?

    Cheapflights users have booked flights from Myrtle Beach to St. Louis round-trip from $196. Other airlines that can offer you cheap pricing are American Airlines, from $260, and Southwest, from $292. You may be able to fly from Myrtle Beach to St. Louis for 47% less than the average price by searching for these airlines.

  • What are the cheapest flights from Myrtle Beach to St. Louis?

    On average you can expect to pay $178 for a flight from Myrtle Beach to St. Louis. The cheapest flight overall is $165 while the most popular route, (Myrtle Beach Intl - Lambert-St Louis) is currently priced at $253.

  • Can I find deals for flights from Myrtle Beach to St. Louis that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to St. Louis.

  • Can I find deals for business class flights from Myrtle Beach to St. Louis?

    Yes. Cheapflights offers flight deals from Myrtle Beach to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Myrtle Beach to St. Louis (average of $311). Flying from Myrtle Beach to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Farmington
Festus

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Top 3 airlines flying from Myrtle Beach to St. Louis

Discover the top 3 airlines that operate flights from Myrtle Beach to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$381FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$396FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$292Average$382FlexibilityNo cancel feeOn-time63%

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