HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$74+ Cheap flights from Islip, NY to St. Louis (ISP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
ISP — STL
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Islip to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Islip to St. Louis

Cheapest flights from Islip to St. Louis
Explore the most affordable flight options available from Islip to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:10 pm
ISP
-
STL
1 stop7h 30m
Southwest
Thu 5/145:00 am
STL
-
ISP
1 stop10h 30m
Southwest
Deal found 1/27$264
This Frontier deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/271:42 pm
ISP
-
STL
1 stop10h 42m
Frontier
Sun 3/297:52 am
STL
-
ISP
1 stop7h 21m
Frontier
Deal found 1/28$660
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3111:50 am
ISP
-
STL
2 stops12h 43m
Multiple Airlines
Mon 2/210:16 am
STL
-
ISP
1 stop7h 32m
Multiple Airlines
Deal found 1/27$746
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:40 am
ISP
-
STL
1 stop9h 00m
Southwest
Mon 2/22:35 pm
STL
-
ISP
1 stop6h 20m
Southwest
Deal found 1/27$845

Find flight deals from Islip to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Islip (ISP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$264
(Southwest)

One-way from

$74
(Priceline)

Popular in

November

Cheapest in

March

Average price

$334
Provider with most accurate pricing for Islip Long Island-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Islip Long Island-Lambert-St Louis flights.
Search Deals
From Islip Long Island to Lambert-St Louis
Search Deals
One-way flight from Islip Long Island to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Islip to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Islip to St. Louis that are best for you.

Fly from

Islip

Fly to

St. Louis

Route

Depart

Return

Price

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 5/11

5:10 pm-11:40 pm

1 stop7h 30m

Lambert-St Louis

Thu 5/14

5:00 am-4:30 pm

1 stop10h 30m

$264

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Fri 3/27

1:42 pm-11:24 pm

1 stop10h 42m

Lambert-St Louis

Sun 3/29

7:52 am-4:13 pm

1 stop7h 21m

$660

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 2/26

3:34 pm-11:59 pm

1 stop9h 25m

$74

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

2:17 pm-6:51 am

2 stops41h 34m

$98

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

3:34 pm-6:51 am

3 stops40h 17m

$115

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Tue 2/24

3:45 pm-9:00 pm

2 stops6h 15m

$127

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Mon 3/2

4:05 pm-10:40 pm

1 stop7h 35m

$130

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 2/26

1:10 pm-9:25 pm

2 stops9h 15m

$135

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 2/26

11:55 am-6:51 am

3 stops19h 56m

$154

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Tue 2/24

8:00 am-10:27 pm

3 stops39h 27m

$230

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 11 results
1
2
  • Most accurate provider: When it comes to deals on Islip, New York-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Islip, New York-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Islip, New York-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Islip, New York-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Islip, New York-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Islip to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Islip with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Islip to St. Louis

What is the cheapest month to book a flight from Islip, New York to St. Louis?

Currently, March is the cheapest month in which you can book a flight from Islip, New York to St. Louis (average of $59). Flying from Islip, New York to St. Louis in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Southwest from Islip to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Islip to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Islip, New York to St. Louis?

    Airlines like Southwest and Frontier fly from Islip, New York to St. Louis in about 7h 30m. The time it takes to get you to your destination can typically vary by up to 3h 12m. Islip, New York and St. Louis are separated by a distance of 926 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Islip, New York to St. Louis round-trip?

    According to our current data, Southwest ($259), offers the cheapest pricing from Islip, New York to St. Louis.

  • Can I find deals for flights from Islip to St. Louis that include hotel bookings?

    Yes. In addition to deals on Islip to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Islip to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Islip to St. Louis.

  • Can I find deals for business class flights from Islip to St. Louis?

    Yes. Cheapflights offers flight deals from Islip to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Islip, New York to St. Louis?

    Currently, March is the cheapest month in which you can book a flight from Islip, New York to St. Louis (average of $59). Flying from Islip, New York to St. Louis in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Islip to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Newark to St. Louis flights
John F Kennedy Intl to St. Louis flights
LaGuardia to St. Louis flights
LaGuardia to Kansas City flights
John F Kennedy Intl to Kansas City flights
Newark to Kansas City flights
Syracuse to Kansas City flights
Syracuse to St. Louis flights
John F Kennedy Intl to Springfield flights
White Plains to St. Louis flights
Newark to Springfield flights
LaGuardia to Springfield flights
Albany to St. Louis flights
Rochester to St. Louis flights
White Plains to Kansas City flights
Buffalo to St. Louis flights
Albany to Kansas City flights
Buffalo to Kansas City flights
Rochester to Kansas City flights
Newark to Columbia flights
LaGuardia to Columbia flights
Syracuse to Springfield flights
Newark to Joplin flights
Albany to Springfield flights
Buffalo to Springfield flights
LaGuardia to Joplin flights
John F Kennedy Intl to Columbia flights
Rochester to Springfield flights
Ithaca to St. Louis flights
Stewart to Kansas City flights
White Plains to Springfield flights
Buffalo to Columbia flights
Ithaca to Kansas City flights
Elmira to Kansas City flights
Newark to Quincy flights
Rochester to Columbia flights
Islip to Kansas City flights
Stewart to St. Louis flights
Watertown to Kansas City flights
Stewart to Columbia flights
Newark to Fort Leonard Wood flights
Syracuse to Columbia flights
White Plains to Columbia flights
Watertown to St. Louis flights
Binghamton to St. Louis flights
Albany to Joplin flights

Top airline flying from Islip to St. Louis

Discover the top airline that operate flights from Islip to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$259Average$366FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.