$118+ Cheap flights from Islip, NY (ISP) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
ISP — STL
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Islip to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Islip to Missouri
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Best
Last-minute
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Cheapest flights from Islip to MissouriExplore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:05 pm -
1 stop7h 10m
Wed 11/186:35 am -
1 stop8h 40m
Deal found 10/26![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:05 pm -
1 stop7h 25m
Wed 11/252:35 pm -
2 stops8h 05m
Deal found 10/27![Southwest logo]()
$348
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:35 am -
1 stop10h 05m
Sun 12/135:10 pm -
1 stop5h 25m
Deal found 10/27![Southwest logo]()
$391
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:05 pm -
1 stop7h 10m
Mon 11/166:20 am -
2 stops8h 55m
Deal found 10/26![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 30m
Tue 11/176:35 am -
1 stop4h 10m
Deal found 10/29![Southwest logo]()
$461
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 pm -
1 stop4h 20m
Mon 11/166:35 am -
1 stop8h 40m
Deal found 10/28![Southwest logo]()
$466
Best flights from Islip to MissouriDiscover carefully curated flight deals from Islip to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Islip to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:05 pm -
1 stop7h 10m
Wed 11/186:35 am -
1 stop8h 40m
Deal found 10/26![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:05 pm -
2 stops7h 50m
Wed 11/252:35 pm -
2 stops8h 05m
Deal found 10/27![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:35 am -
1 stop10h 05m
Sun 12/134:40 pm -
2 stops5h 55m
Deal found 10/27![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:05 pm -
1 stop7h 10m
Mon 11/166:20 am -
2 stops8h 55m
Deal found 10/26![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 30m
Tue 11/176:35 am -
1 stop4h 10m
Deal found 10/29![Southwest logo]()
$461
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 pm -
1 stop7h 30m
Mon 11/166:20 am -
2 stops8h 55m
Deal found 10/28![Southwest logo]()
$466
Last-minute flights from Islip to MissouriDiscover last-minute flight deals from Islip to Missouri. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Islip to Missouri. Data last updated October 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:05 pm -
1 stop7h 10m
Mon 11/166:20 am -
2 stops8h 55m
Deal found 10/26![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 pm -
1 stop4h 20m
Mon 11/166:35 am -
1 stop8h 40m
Deal found 10/28![Southwest logo]()
$466
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 pm -
1 stop7h 30m
Sun 11/156:40 am -
1 stop4h 05m
Deal found 10/26![Southwest logo]()
$534
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 30m
Tue 11/176:35 am -
1 stop4h 10m
Deal found 10/29![Southwest logo]()
$461
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:05 pm -
1 stop7h 10m
Wed 11/186:35 am -
1 stop8h 40m
Deal found 10/26![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:05 pm -
1 stop7h 25m
Wed 11/252:35 pm -
2 stops8h 05m
Deal found 10/27![Southwest logo]()
$348
This Frontier deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/224:40 pm -
1 stop8h 19m
Mon 11/233:04 pm -
2 stops23h 41m
Deal found 10/28![Frontier logo]()
$563
One-way flights from Islip to MissouriSearch for one-way flight options from Islip to Missouri. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Islip to Missouri. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Frontier deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:10 pm -
1 stop7h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Frontier logo]()
$118
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/213:25 pm -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$143
This Priceline deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/304:40 pm -
1 stop8h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Frontier logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2110:57 am -
3 stops38h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:33 pm -
3 stops38h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$327
Find flight deals from Islip to Missouri
Keep the following information in mind while searching for Islip to Missouri flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (Southwest) |
One-way from | $118 (Frontier) |
Popular in | July |
Cheapest in | January |
Average price | $400 |
Cheapflights Fare Finder
Customize your flight search to find flights from Islip to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Islip to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Sun 12/6
6:10 pm-12:12 am
1 stop7h 02m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$118
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Thu 1/21
5:45 am-11:50 am
2 stops7h 05m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$148
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Mon 11/30
4:40 pm-11:59 pm
1 stop8h 19m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Mon 11/16
4:05 pm-10:15 pm
1 stop7h 10m
Lambert-St Louis
Wed 11/18
6:35 am-4:15 pm
1 stop8h 40m
$321
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Mon 11/30
9:33 pm-11:10 am
3 stops38h 37m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$327
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Sat 11/21
5:05 pm-11:55 pm
2 stops7h 50m
Lambert-St Louis
Wed 11/25
2:35 pm-11:40 pm
2 stops8h 05m
$353
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Sun 12/13
5:35 am-2:40 pm
1 stop10h 05m
Lambert-St Louis
Sun 12/13
4:40 pm-11:35 pm
2 stops5h 55m
$397
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Tue 11/10
4:05 pm-10:15 pm
1 stop7h 10m
Lambert-St Louis
Mon 11/16
6:20 am-4:15 pm
2 stops8h 55m
$432
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Fri 11/13
5:40 pm-12:10 am
1 stop7h 30m
Lambert-St Louis
Tue 11/17
6:35 am-11:45 am
1 stop4h 10m
$461
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Thu 11/12
5:40 pm-12:10 am
1 stop7h 30m
Lambert-St Louis
Mon 11/16
6:20 am-4:15 pm
2 stops8h 55m
$466
Sorted by cheapest first
Best time to book a flight from Islip to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Islip with our price prediction graph.
ISP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Islip to Missouri
ISP-USMO
ISP-STL
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 30, 2026.
Peruse reviews from past customers who have flown with Southwest from Islip to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Boarding
8.1
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Islip to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Islip to Missouri
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Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
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Islip and Missouri flights
Browse other Islip and Missouri flight options. Last updated on October 30, 2026.
Popular flight searches
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Islip to Missouri flights
Consider these flights traveling from Islip to Missouri.
Top airline flying from Islip to Missouri
Discover the top airline that operate flights from Islip to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$214 | Average$327 | FlexibilityNo cancel fee | On-time63% |