$122+ Cheap flights from Islip, NY (ISP) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
ISP — STL
Oct 14 — Oct 211
Round-trip
1 adult, Economy
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Find cheap flights from Islip to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Islip to Missouri
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Cheapest flights from Islip to MissouriExplore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
Explore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 40m
Mon 11/166:00 am -
2 stops9h 15m
Deal found 9/9![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:30 pm -
1 stop7h 45m
Sun 11/85:00 am -
1 stop5h 45m
Deal found 9/12![Southwest logo]()
$457
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:15 pm -
1 stop6h 30m
Wed 9/301:40 pm -
1 stop6h 30m
Deal found 9/10![Southwest logo]()
$464
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:05 pm -
2 stops7h 25m
Sat 12/55:30 am -
1 stop5h 35m
Deal found 9/12![Southwest logo]()
$472
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:30 am -
1 stop5h 30m
Tue 12/299:00 pm -
1 stop10h 45m
Deal found 9/13![Southwest logo]()
$578
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:40 pm -
1 stop4h 20m
Sun 11/298:50 pm -
1 stop10h 55m
Deal found 9/14![Southwest logo]()
$671
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:10 am -
1 stop6h 20m
Sun 9/205:15 pm -
1 stop4h 25m
Deal found 9/10![Southwest logo]()
$887
Best flights from Islip to MissouriDiscover carefully curated flight deals from Islip to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
Discover carefully curated flight deals from Islip to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 40m
Tue 11/176:25 am -
1 stop8h 50m
Deal found 9/10![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 pm -
1 stop7h 40m
Mon 11/166:00 am -
2 stops9h 15m
Deal found 9/9![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
2 stops8h 05m
Sun 11/83:50 pm -
1 stop6h 45m
Deal found 9/12![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:15 pm -
1 stop6h 30m
Wed 9/301:40 pm -
1 stop6h 30m
Deal found 9/10![Southwest logo]()
$464
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:05 pm -
1 stop6h 10m
Sat 12/51:45 pm -
1 stop7h 00m
Deal found 9/12![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:40 pm -
1 stop4h 20m
Sun 11/298:50 pm -
1 stop10h 55m
Deal found 9/14![Southwest logo]()
$671
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1812:35 pm -
2 stops6h 50m
Sun 9/209:10 am -
2 stops8h 35m
Deal found 9/10![Southwest logo]()
$897
Last-minute flights from Islip to MissouriDiscover last-minute flight deals from Islip to Missouri. Data last updated September 14, 2026 and is based on user searches.
Discover last-minute flight deals from Islip to Missouri. Data last updated September 14, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:10 am -
1 stop6h 20m
Sun 9/205:15 pm -
1 stop4h 25m
Deal found 9/10![Southwest logo]()
$887
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:15 pm -
1 stop6h 30m
Wed 9/301:40 pm -
1 stop6h 30m
Deal found 9/10![Southwest logo]()
$464
One-way flights from Islip to MissouriSearch for one-way flight options from Islip to Missouri. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
Search for one-way flight options from Islip to Missouri. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:20 pm -
1 stop7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:00 pm -
2 stops50h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$152
This CheapOair deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:43 pm -
1 stop25h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:00 pm -
2 stops26h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:57 am -
2 stops27h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$201
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:40 pm -
1 stop8h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:00 pm -
3 stops32h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:00 pm -
3 stops29h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:43 pm -
2 stops26h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:43 pm -
2 stops42h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2811:52 am -
3 stops48h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:00 pm -
3 stops56h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$290
Find flight deals from Islip to Missouri
Keep the following information in mind while searching for Islip to Missouri flight deals. Data was last updated September 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $359 (Southwest) |
One-way from | $122 (Southwest) |
Popular in | July |
Cheapest in | January |
Average price | $370 |
Cheapflights Fare Finder
Customize your flight search to find flights from Islip to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
Use the filters below to find and compare flights from Islip to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Wed 10/7
4:20 pm-10:30 pm
1 stop7h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$122
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Wed 9/30
12:00 pm-1:10 pm
2 stops50h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$152
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Tue 9/29
12:00 pm-1:10 pm
2 stops26h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$186
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Wed 11/25
4:40 pm-11:59 pm
1 stop8h 19m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$210
IslipSt. Louis
ISP Islip Long Island - STL Lambert-St Louis
ISPSTL
Islip Long Island
Wed 10/7
12:00 pm-4:58 pm
3 stops29h 58m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$257
IslipKansas City
ISP Islip Long Island - MCI Kansas City
ISPMCI
Islip Long Island
Sat 9/19
5:43 pm-7:37 pm
2 stops50h 54m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$325
IslipKansas City
ISP Islip Long Island - MCI Kansas City
ISPMCI
Islip Long Island
Fri 9/18
11:52 am-7:37 pm
3 stops32h 45m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$338
IslipKansas City
ISP Islip Long Island - MCI Kansas City
ISPMCI
Islip Long Island
Fri 11/13
5:40 pm-12:20 am
1 stop7h 40m
Kansas City
Tue 11/17
6:25 am-4:15 pm
1 stop8h 50m
$359
IslipKansas City
ISP Islip Long Island - MCI Kansas City
ISPMCI
Islip Long Island
Fri 11/13
5:40 pm-12:20 am
1 stop7h 40m
Kansas City
Mon 11/16
6:00 am-4:15 pm
2 stops9h 15m
$359
IslipKansas City
ISP Islip Long Island - MCI Kansas City
ISPMCI
Islip Long Island
Sun 9/20
5:43 pm-7:37 pm
2 stops26h 54m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$367
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Islip to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Islip with our price prediction graph.
ISP-MCI
ISP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Islip to Missouri
ISP-USMO
ISP-MCI
ISP-STL
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 14, 2026.
Peruse reviews from past customers who have flown with Southwest from Islip to Missouri to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Islip to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
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Islip and Missouri flights
Browse other Islip and Missouri flight options. Last updated on September 14, 2026.
Popular flight searches
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Islip to Missouri flights
Consider these flights traveling from Islip to Missouri.
Top airline flying from Islip to Missouri
Discover the top airline that operate flights from Islip to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$214 | Average$327 | FlexibilityNo cancel fee | On-time63% |