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$153+ Cheap flights from Islip, NY (ISP) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
ISP — MCI
Jul 18 — Jul 251
Sat 7/18
Sat 7/25
1 adult, Economy
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Cheap flight deals from Islip to Missouri

Cheapest flights from Islip to Missouri
Explore the most affordable flight options available from Islip to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.

This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:05 pm
ISP
-
STL
1 stop7h 05m
Southwest
Sun 7/195:10 pm
STL
-
ISP
1 stop5h 30m
Southwest
Deal found 6/16$313
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:50 pm
ISP
-
STL
1 stop6h 25m
Southwest
Sat 7/183:45 pm
STL
-
ISP
2 stops6h 30m
Southwest
Deal found 6/16$318
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:10 am
ISP
-
STL
1 stop6h 20m
Southwest
Sat 10/315:40 am
STL
-
ISP
1 stop6h 20m
Southwest
Deal found 6/15$345
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:35 am
ISP
-
MCI
1 stop5h 30m
Southwest
Mon 11/95:00 am
MCI
-
ISP
1 stop5h 45m
Southwest
Deal found 6/16$375
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/123:30 pm
ISP
-
STL
1 stop8h 10m
Southwest
Sat 7/183:45 pm
STL
-
ISP
2 stops6h 30m
Southwest
Deal found 6/14$390
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:35 pm
ISP
-
MCI
1 stop5h 25m
Southwest
Sun 10/119:55 am
MCI
-
ISP
1 stop6h 15m
Southwest
Deal found 6/14$401
This Booking.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:52 pm
ISP
-
STL
1 stop26h 57m
Frontier
Thu 6/254:17 pm
STL
-
ISP
1 stop27h 40m
Frontier
Deal found 6/17$403
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am
ISP
-
MCI
1 stop5h 10m
Southwest
Sun 10/116:15 pm
MCI
-
ISP
1 stop4h 35m
Southwest
Deal found 6/14$427
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
ISP
-
MCI
1 stop4h 45m
Southwest
Tue 8/411:20 am
MCI
-
ISP
1 stop4h 35m
Southwest
Deal found 6/15$430

Find flight deals from Islip to Missouri

Keep the following information in mind while searching for Islip to Missouri flight deals. Data was last updated June 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$313
(Southwest)

One-way from

$153
(Gotogate)

Popular in

November

Cheapest in

August

Average price

$377
Provider with most accurate pricing for New York (NYC)-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for New York (NYC)-Lambert-St Louis flights.
Search Deals
From Islip Long Island to Missouri
Search Deals
One-way flight from Islip Long Island to Missouri
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Islip to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Islip to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 7/16

6:05 pm-12:10 am

1 stop7h 05m

Lambert-St Louis

Sun 7/19

5:10 pm-11:40 pm

1 stop5h 30m

$313

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Thu 7/16

5:50 pm-11:15 pm

1 stop6h 25m

Lambert-St Louis

Sat 7/18

3:45 pm-11:15 pm

2 stops6h 30m

$318

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Wed 10/14

6:10 am-11:30 am

1 stop6h 20m

Lambert-St Louis

Sat 10/31

5:40 am-1:00 pm

1 stop6h 20m

$345

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Thu 11/5

5:35 am-10:05 am

1 stop5h 30m

Kansas City

Mon 11/9

5:00 am-11:45 am

1 stop5h 45m

$375

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Sun 7/12

3:30 pm-10:40 pm

1 stop8h 10m

Lambert-St Louis

Sat 7/18

3:45 pm-11:15 pm

2 stops6h 30m

$390

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Wed 10/7

6:10 am-11:20 am

1 stop6h 10m

Kansas City

Sun 10/11

9:00 am-5:10 pm

2 stops7h 10m

$406

IslipSt. Louis

ISP - STL

ISPSTL

Islip Long Island

Fri 7/3

6:05 pm-12:05 am

1 stop7h 00m

Lambert-St Louis

Mon 7/6

4:30 pm-11:45 pm

1 stop6h 15m

$411
Quickest round-trip

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Thu 10/8

6:00 am-10:10 am

1 stop5h 10m

Kansas City

Sun 10/11

6:15 pm-11:50 pm

1 stop4h 35m

$427

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Tue 7/7

6:00 am-9:45 am

1 stop4h 45m

Kansas City

Tue 8/4

11:55 am-9:05 pm

2 stops8h 10m

$435

IslipKansas City

ISP - MCI

ISPMCI

Islip Long Island

Thu 7/9

5:20 am-10:55 am

1 stop6h 35m

Kansas City

Sat 7/11

6:35 am-2:50 pm

2 stops7h 15m

$452

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Islip to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Islip with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Islip to Missouri
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Islip to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Islip to Missouri?

    If you book a flight to Missouri from Islip, you will be flying from Long Island, which is the city’s only airport. Islip Long Island (ISP) is located 7.2 mi from the center of Islip.

  • How long is the flight from Islip, New York to Missouri?

    There are many flights that can get you from Islip, New York to Missouri in 7h 05m. Fly via Southwest to get the fastest option. Airlines will cover a distance of 926 mi.

  • What are the most popular routes from Islip, New York to Missouri?

    While some choose either Islip Long Island - Kansas City or Islip Long Island - Columbia Regional, Islip Long Island - Lambert-St Louis is the most popular route from Islip, New York to Missouri.

  • Can I find deals for flights from Islip to Missouri that include hotel bookings?

    Yes. In addition to deals on Islip to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Islip to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Islip to Missouri.

  • Can I find deals for business class flights from Islip to Missouri?

    Yes. Cheapflights offers flight deals from Islip to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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