HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$176+ Cheap flights from Greenville to St. Louis (GSP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Jan 29 — Feb 51
Thu 1/29
Thu 2/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to St. Louis

Cheapest flights from Greenville to St. Louis
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 30, 2025.

This Southwest deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:45 pmGSP - STL
1 stop6h 15mSouthwest
Thu 1/15:45 amSTL - GSP
1 stop7h 40mSouthwest
Deal found 12/27$377
This Delta deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:05 amGSP - STL
1 stop5h 25mDelta
Wed 12/3110:04 amSTL - GSP
1 stop6h 31mDelta
Deal found 12/27$644
This American Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:43 amGSP - STL
1 stop6h 43mAmerican Airlines
Sat 1/35:00 amSTL - GSP
1 stop4h 11mAmerican Airlines
Deal found 12/28$762
This Southwest deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:40 amGSP - STL
2 stops11h 15mSouthwest
Wed 12/318:30 amSTL - GSP
1 stop6h 35mSouthwest
Deal found 12/27$831
This Kiwi.com deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2811:33 amGSP - STL
1 stop12h 00mMultiple Airlines
Tue 12/3010:48 amSTL - GSP
2 stops28h 07mMultiple Airlines
Deal found 12/27$832
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/274:23 pmGSP - STL
1 stop7h 33mAmerican Airlines
Mon 12/294:53 pmSTL - GSP
1 stop4h 17mAmerican Airlines
Deal found 12/26$841
This Southwest deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:40 amGSP - STL
2 stops7h 50mSouthwest
Sat 1/37:30 amSTL - GSP
1 stop3h 15mSouthwest
Deal found 12/28$846
This Southwest deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:40 amGSP - STL
2 stops7h 50mSouthwest
Tue 12/303:05 pmSTL - GSP
2 stops5h 50mSouthwest
Deal found 12/27$1,027

Find flight deals from Greenville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Kiwi.com)

One-way from

$176
(United Airlines)

Popular in

December

Cheapest in

October

Average price

$584
Provider with most accurate pricing for Greenville-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Lambert-St Louis flights.
Search Deals
From Greenville to Lambert-St Louis
Search Deals
One-way flight from Greenville to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($100 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 30, 2025.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.

Fly from

Greenville

Fly to

St. Louis

Route

Depart

Return

Price

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 1/29

5:45 pm-10:23 am

2 stops17h 38m

Lambert-St Louis

Sun 2/1

5:42 pm-3:59 pm

1 stop21h 17m

$249

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 1/27

6:50 am-11:54 am

1 stop6h 04m

Lambert-St Louis

Thu 1/29

12:00 pm-6:39 pm

1 stop5h 39m

$309

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 1/16

9:48 am-6:51 am

2 stops22h 03m

Lambert-St Louis

Mon 1/19

8:39 am-3:59 pm

1 stop6h 20m

$327

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 2/13

7:40 pm-11:36 pm

1 stop4h 56m

Lambert-St Louis

Sat 2/14

11:55 am-5:21 pm

1 stop4h 26m

$329

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 1/29

6:35 am-12:29 pm

1 stop6h 54m

Lambert-St Louis

Sun 2/1

8:30 am-2:19 pm

1 stop4h 49m

$344

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 2/12

8:19 am-11:02 am

1 stop3h 43m

Lambert-St Louis

Tue 2/17

6:00 am-11:13 am

1 stop4h 13m

$350

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 2/13

7:40 pm-11:36 pm

1 stop4h 56m

Lambert-St Louis

Tue 2/17

6:00 am-11:13 am

1 stop4h 13m

$350

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 1/16

5:40 am-11:05 am

1 stop6h 25m

Lambert-St Louis

Mon 1/19

6:00 am-11:03 am

1 stop4h 03m

$354

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Sun 1/18

10:51 am-2:30 pm

1 stop4h 39m

Lambert-St Louis

Thu 1/22

9:57 am-4:52 pm

1 stop5h 55m

$358

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 2/12

6:30 am-10:36 am

1 stop5h 06m

Lambert-St Louis

Sun 2/15

8:30 am-2:16 pm

1 stop4h 46m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/29

Showing 1-10 of 13 results
1
2

Compare providers for flights from Greenville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to St. Louis

What is the cheapest month to book a flight from Greenville to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $108). Flying from Greenville to St. Louis in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated December 30, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,017 reviews

Entertainment

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,017 reviews
Delta
7.9
Good
8,017 reviews

Entertainment

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,073 reviews
Delta
7.9
Good
8,017 reviews

Entertainment

7.9

Overall

7.9

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to St. Louis?

    There are many flights that can get you from Greenville to St. Louis in 6h 04m. Fly via Delta or United Airlines to get the fastest option. Airlines will cover a distance of 523 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to St. Louis round-trip?

    According to our current data, Delta ($158), and American Airlines ($286) offers the cheapest pricing from Greenville to St. Louis. Delta is priced at 61% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Greenville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to St. Louis.

  • Can I find deals for business class flights from Greenville to St. Louis?

    Yes. Cheapflights offers flight deals from Greenville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $108). Flying from Greenville to St. Louis in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to St. Louis flights
Charlotte to Kansas City flights
Columbia to Kansas City flights
Savannah to St. Louis flights
Myrtle Beach to St. Louis flights
Greenville to Kansas City flights
Charleston to St. Louis flights
Charlotte to Springfield flights
Savannah to Kansas City flights
Charleston to Kansas City flights
Savannah to Springfield flights
Columbia to Springfield flights
Myrtle Beach to Kansas City flights
Columbia to St. Louis flights
Augusta to Kansas City flights
Charleston to Springfield flights
Charlotte to Columbia flights
Charleston to Columbia flights
Myrtle Beach to Springfield flights
Charlotte to Joplin flights
Greenville to Springfield flights
Augusta to St. Louis flights
Columbia to Columbia flights
Myrtle Beach to Joplin flights
Florence to St. Louis flights
Hilton Head Island to Kansas City flights
Augusta to Columbia flights
Charlotte to Fort Leonard Wood flights
Hilton Head Island to St. Louis flights
Florence to Kansas City flights

Top 2 airlines flying from Greenville to St. Louis

Discover the top 2 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$286Average$421FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.