To save on the cost of your flight from Cape Girardeau to St Louis, book at least 31 days before your planned departure. Booking around this time can save you about 96% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $374 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $553.
August can be a great time to fly to St Louis from Cape Girardeau with a flight ticket averaging about $266. Cheapflights users have found deals in the month of August for as cheap as $158. The most expensive prices can be found in the month of December.