$167+ Cheap flights from Sioux Falls (FSD) to Spartanburg, SC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — CLT
Aug 31 — Sep 71
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Spartanburg with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Spartanburg
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One-way
Cheapest flights from Sioux Falls to SpartanburgExplore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
Explore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:57 pm
FSD
- CLT
1 stop7h 08m
American Airlines
Mon 8/243:05 pm
CLT
- FSD
1 stop6h 26m
American Airlines
Deal found 7/28![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:57 pm
FSD
- CLT
1 stop8h 33m
American Airlines
Sun 9/65:00 pm
CLT
- FSD
1 stop6h 07m
American Airlines
Deal found 7/29![American Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:05 am
FSD
- CLT
1 stop4h 36m
Delta
Sun 9/136:20 am
CLT
- FSD
1 stop4h 59m
Delta
Deal found 7/31![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:57 pm
FSD
- CLT
1 stop5h 47m
American Airlines
Mon 9/75:45 am
CLT
- FSD
1 stop7h 32m
American Airlines
Deal found 7/30![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:23 pm
FSD
- CLT
1 stop5h 31m
American Airlines
Thu 9/38:31 pm
CLT
- FSD
1 stop4h 59m
American Airlines
Deal found 7/30![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:05 am
FSD
- CLT
1 stop6h 16m
Delta
Sun 9/61:57 pm
CLT
- FSD
1 stop7h 02m
Delta
Deal found 8/1![Delta logo]()
$371
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:47 am
FSD
- CLT
2 stops10h 09m
United Airlines
Thu 9/38:05 am
CLT
- FSD
1 stop7h 26m
United Airlines
Deal found 7/30![United Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:33 pm
FSD
- CLT
1 stop8h 53m
United Airlines
Tue 9/18:48 am
CLT
- FSD
1 stop8h 35m
United Airlines
Deal found 7/30![United Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:33 pm
FSD
- CLT
1 stop8h 53m
United Airlines
Mon 8/243:00 pm
CLT
- FSD
2 stops9h 22m
United Airlines
Deal found 7/31![United Airlines logo]()
$424
Best flights from Sioux Falls to SpartanburgDiscover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
Discover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:57 pm
FSD
- CLT
1 stop8h 33m
American Airlines
Fri 9/111:05 pm
CLT
- FSD
1 stop8h 40m
American Airlines
Deal found 7/28![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:05 am
FSD
- CLT
1 stop4h 36m
Delta
Sun 9/136:20 am
CLT
- FSD
1 stop4h 59m
Delta
Deal found 7/31![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:33 pm
FSD
- CLT
1 stop8h 53m
United Airlines
Tue 9/112:50 pm
CLT
- FSD
1 stop6h 08m
United Airlines
Deal found 7/27![United Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:28 pm
FSD
- CLT
1 stop6h 09m
Delta
Mon 8/242:12 pm
CLT
- FSD
1 stop6h 47m
Delta
Deal found 7/31![Delta logo]()
$343
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:05 am
FSD
- CLT
1 stop6h 16m
Delta
Sun 9/61:57 pm
CLT
- FSD
1 stop7h 02m
Delta
Deal found 8/1![Delta logo]()
$371
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:40 am
FSD
- CLT
1 stop5h 02m
United Airlines
Wed 11/183:30 pm
CLT
- FSD
1 stop7h 07m
United Airlines
Deal found 7/31![United Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:47 am
FSD
- CLT
2 stops10h 09m
United Airlines
Mon 8/243:00 pm
CLT
- FSD
2 stops9h 22m
United Airlines
Deal found 7/28![United Airlines logo]()
$429
Last-minute flights from Sioux Falls to SpartanburgDiscover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated August 1, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated August 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:40 pm
FSD
- CLT
1 stop8h 58m
American Airlines
Wed 8/128:31 pm
CLT
- FSD
1 stop4h 59m
American Airlines
Deal found 7/29![American Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:57 pm
FSD
- CLT
1 stop7h 08m
American Airlines
Mon 8/243:05 pm
CLT
- FSD
1 stop6h 26m
American Airlines
Deal found 7/28![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:28 pm
FSD
- CLT
1 stop6h 09m
Delta
Mon 8/242:12 pm
CLT
- FSD
1 stop6h 47m
Delta
Deal found 7/31![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:33 pm
FSD
- CLT
1 stop8h 53m
United Airlines
Mon 8/243:00 pm
CLT
- FSD
2 stops9h 22m
United Airlines
Deal found 7/31![United Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:22 am
FSD
- CLT
1 stop4h 35m
Delta
Thu 9/36:24 am
CLT
- FSD
1 stop7h 14m
Delta
Deal found 7/30![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:23 pm
FSD
- CLT
1 stop5h 31m
American Airlines
Thu 9/38:31 pm
CLT
- FSD
1 stop4h 59m
American Airlines
Deal found 7/30![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:47 am
FSD
- CLT
2 stops10h 09m
United Airlines
Thu 9/38:05 am
CLT
- FSD
1 stop7h 26m
United Airlines
Deal found 7/30![United Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:33 pm
FSD
- CLT
1 stop8h 53m
United Airlines
Tue 9/18:48 am
CLT
- FSD
1 stop8h 35m
United Airlines
Deal found 7/30![United Airlines logo]()
$419
One-way flights from Sioux Falls to SpartanburgSearch for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
Search for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:58 am
FSD
- CLT
2 stops43h 03m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:05 am
FSD
- CLT
2 stops45h 30m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:56 pm
FSD
- CLT
1 stop18h 30m
Frontier
Deal found 7/31![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3010:00 pm
FSD
- CLT
2 stops17h 26m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$213
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 am
FSD
- CLT
1 stop8h 16m
United Airlines
Deal found 7/31![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:38 am
FSD
- CLT
1 stop6h 32m
Delta
Deal found 7/31![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:02 pm
FSD
- CLT
3 stops41h 24m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:47 am
FSD
- CLT
2 stops10h 09m
United Airlines
Deal found 7/31![United Airlines logo]()
$355
Find flight deals from Sioux Falls to Spartanburg
Keep the following information in mind while searching for Sioux Falls to Spartanburg flight deals. Data was last updated August 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (American Airlines) |
One-way from | $167 (Kiwi.com) |
Popular in | December |
Cheapest in | November |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Sioux Falls to Spartanburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Thu 9/3
12:57 pm-10:30 pm
1 stop8h 33m
Charlotte Douglas
Fri 9/11
1:05 pm-8:45 pm
1 stop8h 40m
$329
Quickest round-trip
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Wed 9/9
5:05 am-10:41 am
1 stop4h 36m
Charlotte Douglas
Sun 9/13
6:20 am-10:19 am
1 stop4h 59m
$343
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 8/21
4:28 pm-11:37 pm
1 stop6h 09m
Charlotte Douglas
Mon 8/24
2:12 pm-7:59 pm
1 stop6h 47m
$343
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Thu 9/3
11:05 am-6:21 pm
1 stop6h 16m
Charlotte Douglas
Sun 9/6
1:57 pm-7:59 pm
1 stop7h 02m
$371
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 8/28
1:33 pm-11:26 pm
1 stop8h 53m
Charlotte Douglas
Tue 9/1
12:50 pm-5:58 pm
1 stop6h 08m
$419
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 11/14
7:40 am-1:42 pm
1 stop5h 02m
Charlotte Douglas
Wed 11/18
3:30 pm-9:37 pm
1 stop7h 07m
$419
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 8/21
7:47 am-6:56 pm
2 stops10h 09m
Charlotte Douglas
Mon 8/24
3:00 pm-11:22 pm
2 stops9h 22m
$429
Cheapest one-way
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 9/11
10:05 am-8:35 am
2 stops45h 30m
$200
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 9/11
1:33 pm-11:29 pm
1 stop8h 56m
$213
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 8/28
8:56 pm-4:58 pm
2 stops19h 02m
$235
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Spartanburg
Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Sioux Falls with our price prediction graph.
FSD-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Spartanburg
FSD-SB1
FSD-CLT
How much does it cost to fly round-trip from Sioux Falls to Spartanburg?
Airfare is below average for this route at the moment.
Sioux Falls to Spartanburg flights typically cost between $338 and $358 in August.The cheapest round-trip price found within the last 5 days was $329 on American Airlines (Aug 21-Aug 24).
Reviews of airlines servicing Spartanburg
Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated August 1, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Sioux Falls to Spartanburg. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Comfort
7.8
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Comfort
7.8
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Comfort
7.8
Food
7.2
Overall
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Sioux Falls and Spartanburg flights
Browse other Sioux Falls and Spartanburg flight options. Last updated on August 1, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on August 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Spartanburg flights
Consider these flights traveling from Sioux Falls to Spartanburg.
Top 3 airlines flying from Sioux Falls to Spartanburg
Discover the top 3 airlines that operate flights from Sioux Falls to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$445 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$258 | Average$548 | FlexibilityNo cancel fee | On-time69% |