$137+ Cheap flights from Sioux Falls (FSD) to Spartanburg, SC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/24. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — CLT
Jun 1 — Jun 81
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Sioux Falls to SpartanburgExplore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
Explore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:14 pm
FSD
- CLT
1 stop21h 05m
Frontier
Thu 7/97:14 pm
CLT
- FSD
1 stop25h 09m
Frontier
Deal found 4/29![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:11 pm
FSD
- CLT
1 stop28h 29m
Multiple Airlines
Tue 5/192:40 pm
CLT
- FSD
2 stops25h 09m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$269
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:18 pm
FSD
- CLT
1 stop20h 07m
Frontier
Tue 5/195:20 pm
CLT
- FSD
1 stop26h 13m
Frontier
Deal found 4/29![Frontier logo]()
$287
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:00 am
FSD
- CLT
1 stop4h 35m
Delta
Tue 6/96:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/29![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 pm
FSD
- CLT
1 stop6h 18m
American Airlines
Sat 5/308:56 am
CLT
- FSD
1 stop8h 59m
American Airlines
Deal found 4/30![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:16 pm
FSD
- CLT
2 stops6h 37m
Delta
Tue 6/96:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/29![Delta logo]()
$337
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:16 pm
FSD
- CLT
1 stop6h 39m
Delta
Thu 6/116:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/29![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:16 pm
FSD
- CLT
2 stops6h 37m
Delta
Sun 6/76:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/29![Delta logo]()
$344
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:25 am
FSD
- CLT
1 stop7h 05m
Delta
Mon 9/286:50 pm
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/28![Delta logo]()
$352
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:50 am
FSD
- CLT
1 stop5h 42m
Delta
Sat 5/236:15 am
CLT
- FSD
1 stop7h 34m
Delta
Deal found 4/28![Delta logo]()
$354
Best flights from Sioux Falls to SpartanburgDiscover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
Discover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 pm
FSD
- CLT
1 stop6h 18m
American Airlines
Sat 5/306:25 pm
CLT
- FSD
1 stop5h 32m
American Airlines
Deal found 4/28![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:20 am
FSD
- CLT
1 stop4h 51m
Delta
Sat 5/305:35 am
CLT
- FSD
2 stops8h 14m
Delta
Deal found 5/1![Delta logo]()
$344
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:50 am
FSD
- CLT
1 stop5h 42m
Delta
Sat 5/236:15 am
CLT
- FSD
1 stop7h 34m
Delta
Deal found 4/26![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:25 am
FSD
- CLT
2 stops9h 22m
Delta
Mon 9/286:50 pm
CLT
- FSD
1 stop4h 56m
Delta
Deal found 4/28![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:20 am
FSD
- CLT
1 stop5h 12m
Delta
Wed 6/247:03 pm
CLT
- FSD
1 stop5h 09m
Delta
Deal found 4/30![Delta logo]()
$362
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:35 pm
FSD
- CLT
2 stops6h 58m
Delta
Tue 6/92:20 pm
CLT
- FSD
1 stop6h 39m
Delta
Deal found 5/1![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
FSD
- CLT
1 stop7h 15m
Delta
Sat 6/276:00 am
CLT
- FSD
2 stops7h 30m
Delta
Deal found 5/1![Delta logo]()
$367
Last-minute flights from Sioux Falls to SpartanburgDiscover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated May 2, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated May 2, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:18 pm
FSD
- CLT
1 stop20h 07m
Frontier
Tue 5/195:20 pm
CLT
- FSD
1 stop26h 13m
Frontier
Deal found 4/29![Frontier logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:11 pm
FSD
- CLT
1 stop28h 29m
Multiple Airlines
Tue 5/192:40 pm
CLT
- FSD
2 stops25h 09m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:35 pm
FSD
- CLT
2 stops9h 18m
Delta
Tue 5/195:35 am
CLT
- FSD
2 stops8h 14m
Delta
Deal found 4/30![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:50 am
FSD
- CLT
1 stop5h 42m
Delta
Sat 5/236:15 am
CLT
- FSD
1 stop7h 34m
Delta
Deal found 4/28![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 pm
FSD
- CLT
1 stop6h 18m
American Airlines
Sat 5/308:56 am
CLT
- FSD
1 stop8h 59m
American Airlines
Deal found 4/30![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:20 am
FSD
- CLT
1 stop7h 07m
Delta
Sat 5/305:35 am
CLT
- FSD
2 stops8h 14m
Delta
Deal found 4/27![Delta logo]()
$337
One-way flights from Sioux Falls to SpartanburgSearch for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
Search for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
This CheapOair deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:14 pm
FSD
- CLT
1 stop24h 09m
Frontier
Deal found 4/27![Frontier logo]()
$137
This KAYAK deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
FSD
- CLT
1 stop4h 35m
Delta
Deal found 4/27![Delta logo]()
$299
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:59 pm
FSD
- CLT
1 stop13h 26m
American Airlines
Deal found 4/30![American Airlines logo]()
$331
This KAYAK deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:00 am
FSD
- CLT
1 stop7h 32m
Delta
Deal found 4/29![Delta logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:40 pm
FSD
- CLT
3 stops49h 32m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:30 am
FSD
- CLT
1 stop5h 16m
United Airlines
Deal found 4/27![United Airlines logo]()
$403
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:00 pm
FSD
- CLT
2 stops9h 53m
Delta
Deal found 4/30![Delta logo]()
$443
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:00 am
FSD
- CLT
2 stops8h 12m
United Airlines
Deal found 4/29![United Airlines logo]()
$513
Find flight deals from Sioux Falls to Spartanburg
Keep the following information in mind while searching for Sioux Falls to Spartanburg flight deals. Data was last updated May 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $264 (CheapOair) |
One-way from | $137 (CheapOair) |
Popular in | December |
Cheapest in | January |
Average price | $428 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Sioux Falls to Spartanburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 5/23
5:35 pm-12:53 am
1 stop6h 18m
Charlotte Douglas
Sat 5/30
6:25 pm-10:57 pm
1 stop5h 32m
$332
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 5/23
5:20 am-11:11 am
1 stop4h 51m
Charlotte Douglas
Sat 5/30
5:35 am-12:49 pm
2 stops8h 14m
$344
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 5/16
6:50 am-1:32 pm
1 stop5h 42m
Charlotte Douglas
Sat 5/23
6:15 am-12:49 pm
1 stop7h 34m
$354
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 9/26
5:25 am-3:47 pm
2 stops9h 22m
Charlotte Douglas
Mon 9/28
6:50 pm-10:46 pm
1 stop4h 56m
$357
Quickest round-trip
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 6/20
5:20 am-11:32 am
1 stop5h 12m
Charlotte Douglas
Wed 6/24
7:03 pm-11:12 pm
1 stop5h 09m
$362
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Sat 6/6
1:35 pm-9:33 pm
2 stops6h 58m
Charlotte Douglas
Tue 6/9
2:20 pm-7:59 pm
1 stop6h 39m
$367
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Wed 6/24
5:20 am-1:35 pm
1 stop7h 15m
Charlotte Douglas
Sat 6/27
6:00 am-12:30 pm
2 stops7h 30m
$367
Cheapest one-way
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 7/24
8:14 pm-9:23 pm
1 stop24h 09m
$137
Quickest one-way
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Thu 5/28
5:00 am-10:35 am
1 stop4h 35m
$299
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 10/9
5:59 pm-8:25 am
1 stop13h 26m
$331
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to Spartanburg
Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Sioux Falls with our price prediction graph.
FSD-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Spartanburg
FSD-SB1
FSD-CLT
How much does it cost to fly round-trip from Sioux Falls to Spartanburg?
Reviews of airlines servicing Spartanburg
Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated May 2, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Sioux Falls to Spartanburg. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.9
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Sioux Falls and Spartanburg flights
Browse other Sioux Falls and Spartanburg flight options. Last updated on May 2, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on May 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Spartanburg flights
Consider these flights traveling from Sioux Falls to Spartanburg.
Top 3 airlines flying from Sioux Falls to Spartanburg
Discover the top 3 airlines that operate flights from Sioux Falls to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$160 | Average$494 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$250 | Average$395 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$328 | FlexibilityNo cancel fee | On-timeN/A |