$329+ Cheap flights from Sioux Falls (FSD) to Spartanburg, SC
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — CLT
Oct 3 — Oct 101
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to Spartanburg with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to Spartanburg
Cheapest
Best
Last-minute
One-way
Cheapest flights from Sioux Falls to SpartanburgExplore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
Explore the most affordable flight options available from Sioux Falls to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:00 am -
1 stop6h 17m
Wed 12/22:27 pm -
1 stop6h 42m
Deal found 9/1![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:30 am -
1 stop7h 02m
Wed 9/307:16 pm -
1 stop4h 35m
Deal found 8/31![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:20 pm -
1 stop7h 09m
Sun 11/83:30 pm -
1 stop7h 07m
Deal found 9/1![United Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am -
1 stop6h 58m
Sat 9/196:15 pm -
1 stop7h 14m
Deal found 8/30![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/271:20 pm -
1 stop7h 09m
Tue 12/13:00 pm -
2 stops7h 43m
Deal found 9/1![United Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:47 am -
2 stops10h 09m
Sat 9/196:00 pm -
1 stop6h 12m
Deal found 8/30![United Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:05 am -
1 stop7h 09m
Sun 10/117:49 am -
1 stop7h 29m
Deal found 9/1![American Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:50 am -
1 stop5h 30m
Sun 10/116:45 am -
1 stop4h 44m
Deal found 8/30![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:28 pm -
1 stop6h 12m
Sun 9/137:16 pm -
1 stop4h 35m
Deal found 8/31![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/271:20 pm -
1 stop7h 09m
Wed 12/23:00 pm -
2 stops7h 43m
Deal found 9/1![United Airlines logo]()
$424
Best flights from Sioux Falls to SpartanburgDiscover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
Discover carefully curated flight deals from Sioux Falls to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:00 am -
1 stop6h 17m
Tue 12/12:27 pm -
1 stop6h 42m
Deal found 9/1![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:48 am -
2 stops8h 04m
Sun 11/83:30 pm -
1 stop7h 07m
Deal found 9/1![United Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1812:56 pm -
1 stop8h 37m
Sun 9/207:34 am -
1 stop5h 02m
Deal found 9/2![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:50 am -
2 stops10h 10m
Sun 10/116:45 am -
1 stop4h 44m
Deal found 9/1![United Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:05 am -
1 stop7h 09m
Wed 10/145:38 am -
1 stop7h 35m
Deal found 8/30![American Airlines logo]()
$566
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:50 am -
1 stop5h 30m
Wed 10/143:01 pm -
2 stops9h 10m
Deal found 8/29![United Airlines logo]()
$596
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
2 stops10h 10m
Fri 10/26:45 am -
1 stop4h 44m
Deal found 8/29![United Airlines logo]()
$622
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:40 pm -
2 stops15h 02m
Fri 10/304:20 pm -
1 stop21h 15m
Deal found 9/2![United Airlines logo]()
$688
Last-minute flights from Sioux Falls to SpartanburgDiscover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated September 3, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to Spartanburg. Data last updated September 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:28 pm -
1 stop6h 12m
Sun 9/137:16 pm -
1 stop4h 35m
Deal found 8/31![Delta logo]()
$422
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am -
1 stop6h 58m
Sat 9/196:15 pm -
1 stop7h 14m
Deal found 8/30![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:47 am -
2 stops10h 09m
Sat 9/196:00 pm -
1 stop6h 12m
Deal found 8/30![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:30 am -
1 stop7h 02m
Wed 9/307:16 pm -
1 stop4h 35m
Deal found 8/31![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:30 am -
1 stop7h 02m
Wed 10/217:15 pm -
1 stop5h 07m
Deal found 8/29![Delta logo]()
$434
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:05 am -
1 stop7h 09m
Sun 10/117:49 am -
1 stop7h 29m
Deal found 9/1![American Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:50 am -
1 stop5h 30m
Sun 10/116:45 am -
1 stop4h 44m
Deal found 8/30![United Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:53 pm -
1 stop8h 40m
Wed 10/145:38 am -
1 stop7h 35m
Deal found 8/31![American Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:53 pm -
1 stop7h 48m
Sun 10/255:38 am -
1 stop7h 35m
Deal found 9/2![American Airlines logo]()
$440
One-way flights from Sioux Falls to SpartanburgSearch for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
Search for one-way flight options from Sioux Falls to Spartanburg. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:29 pm -
1 stop7h 40m
Deal found 8/30![American Airlines logo]()
$495
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:10 pm -
2 stops7h 49m
Deal found 8/30![United Airlines logo]()
$679
Find flight deals from Sioux Falls to Spartanburg
Keep the following information in mind while searching for Sioux Falls to Spartanburg flight deals. Data was last updated September 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (United Airlines) |
Popular in | December |
Cheapest in | January |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
Use the filters below to find and compare flights from Sioux Falls to Spartanburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Thu 11/26
11:00 am-6:17 pm
1 stop6h 17m
Charlotte Douglas
Tue 12/1
2:27 pm-8:09 pm
1 stop6h 42m
$354
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Tue 11/3
7:48 am-4:52 pm
2 stops8h 04m
Charlotte Douglas
Sun 11/8
3:30 pm-9:37 pm
1 stop7h 07m
$417
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Wed 10/7
7:50 am-7:00 pm
2 stops10h 10m
Charlotte Douglas
Sun 10/11
6:45 am-10:29 am
1 stop4h 44m
$469
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Fri 9/18
12:56 pm-10:33 pm
1 stop8h 37m
Charlotte Douglas
Sun 9/20
7:34 am-11:36 am
1 stop5h 02m
$490
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Thu 10/8
7:05 am-3:14 pm
1 stop7h 09m
Charlotte Douglas
Wed 10/14
5:38 am-12:13 pm
1 stop7h 35m
$566
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Thu 10/8
7:50 am-2:20 pm
1 stop5h 30m
Charlotte Douglas
Wed 10/14
3:01 pm-11:11 pm
2 stops9h 10m
$596
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Wed 9/30
7:50 am-7:00 pm
2 stops10h 10m
Charlotte Douglas
Fri 10/2
6:45 am-10:29 am
1 stop4h 44m
$622
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Mon 10/26
6:40 pm-10:42 am
2 stops15h 02m
Charlotte Douglas
Fri 10/30
4:20 pm-12:35 pm
1 stop21h 15m
$688
Cheapest one-way
Quickest one-way
Sioux FallsCharlotte
FSD Sioux Falls Joe Foss Field - CLT Charlotte Douglas
FSDCLT
Sioux Falls Joe Foss Field
Fri 11/6
3:10 pm-11:59 pm
2 stops7h 49m
$679
Sorted by cheapest first
Best time to book a flight from Sioux Falls to Spartanburg
Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Sioux Falls with our price prediction graph.
FSD-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to Spartanburg
FSD-SB1
FSD-CLT
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Spartanburg
Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated September 3, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Sioux Falls to Spartanburg. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Spartanburg by adding a car rental and/or hotel reservation to your travel itinerary.
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Sioux Falls and Spartanburg flights
Browse other Sioux Falls and Spartanburg flight options. Last updated on September 3, 2026.
Other flights from Sioux Falls
Browse through other flights departing from Sioux Falls. Flights are based on user searches made on Cheapflights and were last updated on September 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to Spartanburg flights
Consider these flights traveling from Sioux Falls to Spartanburg.
Top 3 airlines flying from Sioux Falls to Spartanburg
Discover the top 3 airlines that operate flights from Sioux Falls to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$434 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$548 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$258 | Average$390 | FlexibilityNo cancel fee | On-timeN/A |