$139+ Cheap flights from Sioux Falls (FSD) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — CHS
Oct 26 — Nov 21
Round-trip
1 adult, Economy
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Find cheap flights from Sioux Falls to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Sioux Falls to South CarolinaExplore the most affordable flight options available from Sioux Falls to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
Explore the most affordable flight options available from Sioux Falls to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:48 pm -
1 stop8h 11m
Sat 10/311:06 pm -
1 stop9h 07m
Deal found 9/24![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:53 pm -
1 stop8h 12m
Sat 10/316:43 pm -
1 stop6h 58m
Deal found 9/22![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/21:08 pm -
1 stop8h 18m
Sun 12/612:17 pm -
1 stop7h 43m
Deal found 9/24![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:17 pm -
1 stop5h 43m
Thu 11/267:00 am -
1 stop6h 31m
Deal found 9/22![American Airlines logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:30 pm -
1 stop17h 01m
Sat 12/53:42 pm -
1 stop19h 06m
Deal found 9/23![Multiple Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:53 pm -
1 stop8h 40m
Sat 10/107:00 am -
1 stop6h 13m
Deal found 9/21![American Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:25 am -
1 stop6h 49m
Mon 11/233:47 pm -
1 stop5h 09m
Deal found 9/22![Delta logo]()
$404
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:06 pm -
1 stop6h 05m
Tue 9/297:46 pm -
1 stop5h 43m
Deal found 9/22![American Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:23 pm -
1 stop7h 32m
Mon 11/234:11 pm -
2 stops9h 33m
Deal found 9/25![American Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:03 pm -
1 stop4h 55m
Sat 10/3111:58 am -
2 stops12h 31m
Deal found 9/22![United Airlines logo]()
$426
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:03 pm -
1 stop5h 14m
Sat 10/174:25 pm -
1 stop8h 19m
Deal found 9/23![United Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
2 stops9h 22m
Sat 10/1012:30 pm -
2 stops11h 41m
Deal found 9/21![United Airlines logo]()
$435
Best flights from Sioux Falls to South CarolinaDiscover carefully curated flight deals from Sioux Falls to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
Discover carefully curated flight deals from Sioux Falls to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:53 pm -
1 stop8h 12m
Sat 10/316:43 pm -
1 stop6h 58m
Deal found 9/22![American Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:25 am -
1 stop6h 49m
Mon 11/233:47 pm -
1 stop5h 09m
Deal found 9/25![Delta logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:03 pm -
1 stop4h 55m
Sat 10/3111:58 am -
2 stops12h 31m
Deal found 9/22![United Airlines logo]()
$426
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/12:48 pm -
2 stops8h 08m
Tue 3/93:11 pm -
2 stops10h 20m
Deal found 9/24![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:40 am -
1 stop5h 11m
Sat 1/94:45 pm -
1 stop6h 38m
Deal found 9/25![United Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:53 pm -
1 stop8h 40m
Sat 10/107:00 am -
1 stop6h 13m
Deal found 9/21![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:03 pm -
1 stop5h 14m
Sat 10/174:25 pm -
1 stop8h 19m
Deal found 9/23![United Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:53 pm -
2 stops10h 04m
Wed 10/145:02 am -
2 stops10h 16m
Deal found 9/25![American Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
2 stops9h 22m
Sat 10/1012:30 pm -
2 stops11h 41m
Deal found 9/21![United Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:30 am -
1 stop4h 30m
Mon 10/193:39 pm -
1 stop5h 16m
Deal found 9/23![Delta logo]()
$559
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/252:48 pm -
2 stops8h 10m
Sun 2/287:16 am -
1 stop5h 25m
Deal found 9/25![American Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/237:40 am -
1 stop5h 11m
Tue 1/265:33 pm -
1 stop7h 17m
Deal found 9/22![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:53 pm -
2 stops8h 59m
Sat 10/173:58 pm -
2 stops9h 43m
Deal found 9/23![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:27 am -
2 stops10h 30m
Sun 12/612:18 pm -
2 stops7h 56m
Deal found 9/22![Delta logo]()
$629
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:14 pm -
1 stop4h 52m
Sun 12/67:02 am -
1 stop5h 36m
Deal found 9/24![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:40 am -
1 stop5h 11m
Tue 1/125:33 pm -
1 stop5h 50m
Deal found 9/24![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:40 am -
2 stops8h 09m
Tue 1/1211:28 am -
2 stops13h 22m
Deal found 9/21![United Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:18 pm -
1 stop17h 06m
Sat 11/141:55 pm -
1 stop5h 53m
Deal found 9/23![American Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:50 am -
2 stops10h 10m
Sun 10/116:20 am -
1 stop5h 09m
Deal found 9/22![United Airlines logo]()
$631
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:53 pm -
1 stop8h 59m
Tue 10/277:00 am -
1 stop6h 13m
Deal found 9/21![American Airlines logo]()
$616
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:03 pm -
1 stop5h 14m
Sun 10/186:20 am -
1 stop17h 51m
Deal found 9/23![United Airlines logo]()
$678
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
1 stop6h 26m
Mon 10/125:00 pm -
1 stop7h 11m
Deal found 9/25![United Airlines logo]()
$770
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:20 am -
3 stops10h 18m
Wed 10/212:56 pm -
2 stops10h 45m
Deal found 9/23![American Airlines logo]()
$969
Last-minute flights from Sioux Falls to South CarolinaDiscover last-minute flight deals from Sioux Falls to South Carolina. Data last updated September 26, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to South Carolina. Data last updated September 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:06 pm -
1 stop6h 05m
Tue 9/297:46 pm -
1 stop5h 43m
Deal found 9/22![American Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:03 pm -
2 stops8h 12m
Tue 9/293:00 pm -
2 stops9h 11m
Deal found 9/22![United Airlines logo]()
$431
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:56 pm -
1 stop8h 13m
Sat 10/32:02 pm -
1 stop7h 43m
Deal found 9/22![American Airlines logo]()
$489
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:53 pm -
1 stop8h 40m
Sat 10/107:00 am -
1 stop6h 13m
Deal found 9/21![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:50 am -
2 stops9h 22m
Sat 10/1012:30 pm -
2 stops11h 41m
Deal found 9/21![United Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:53 pm -
1 stop8h 12m
Sun 10/116:01 am -
1 stop6h 33m
Deal found 9/22![American Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:03 pm -
1 stop5h 14m
Sat 10/174:25 pm -
1 stop8h 19m
Deal found 9/23![United Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:53 pm -
1 stop8h 12m
Sat 10/172:25 pm -
2 stops11h 16m
Deal found 9/23![American Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:53 pm -
1 stop8h 40m
Sun 11/17:13 am -
1 stop5h 25m
Deal found 9/21![American Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:48 pm -
1 stop8h 11m
Sat 10/311:06 pm -
1 stop9h 07m
Deal found 9/24![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:53 pm -
1 stop8h 12m
Sat 10/316:43 pm -
1 stop6h 58m
Deal found 9/22![American Airlines logo]()
$321
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:03 pm -
1 stop4h 55m
Sat 10/3111:58 am -
2 stops12h 31m
Deal found 9/22![United Airlines logo]()
$426
One-way flights from Sioux Falls to South CarolinaSearch for one-way flight options from Sioux Falls to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
Search for one-way flight options from Sioux Falls to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1411:05 am -
1 stop21h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:37 pm -
1 stop15h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:33 pm -
1 stop8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops10h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/207:00 am -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Delta logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:45 pm -
3 stops42h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:33 am -
3 stops29h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$403
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:59 pm -
2 stops8h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Delta logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:04 pm -
1 stop27h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![United Airlines logo]()
$478
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:30 am -
1 stop4h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$638
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/911:35 am -
3 stops28h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![United Airlines logo]()
$817
Find flight deals from Sioux Falls to South Carolina
Keep the following information in mind while searching for Sioux Falls to South Carolina flight deals. Data was last updated September 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
One-way from | $139 (Kiwi.com) |
Popular in | May |
Cheapest in | November |
Average price | $403 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
Use the filters below to find and compare flights from Sioux Falls to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsMyrtle Beach
FSD Sioux Falls Joe Foss Field - MYR Myrtle Beach Intl
FSDMYR
Sioux Falls Joe Foss Field
Thu 12/17
12:33 pm-10:28 pm
1 stop8h 55m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$319
Sioux FallsGreenville
FSD Sioux Falls Joe Foss Field - GSP Greenville
FSDGSP
Sioux Falls Joe Foss Field
Sat 10/24
12:53 pm-10:05 pm
1 stop8h 12m
Greenville
Sat 10/31
6:43 pm-12:41 am
1 stop6h 58m
$321
Sioux FallsMyrtle Beach
FSD Sioux Falls Joe Foss Field - MYR Myrtle Beach Intl
FSDMYR
Sioux Falls Joe Foss Field
Tue 12/15
6:00 am-5:34 pm
2 stops10h 34m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$324
Sioux FallsMyrtle Beach
FSD Sioux Falls Joe Foss Field - MYR Myrtle Beach Intl
FSDMYR
Sioux Falls Joe Foss Field
Sun 12/20
7:00 am-1:14 pm
1 stop5h 14m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$359
Sioux FallsMyrtle Beach
FSD Sioux Falls Joe Foss Field - MYR Myrtle Beach Intl
FSDMYR
Sioux Falls Joe Foss Field
Mon 3/1
2:48 pm-11:56 pm
2 stops8h 08m
Myrtle Beach Intl
Tue 3/9
3:11 pm-12:31 am
2 stops10h 20m
$359
Sioux FallsCharleston
FSD Sioux Falls Joe Foss Field - CHS Charleston
FSDCHS
Sioux Falls Joe Foss Field
Thu 10/22
5:45 pm-1:24 pm
3 stops42h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$366
Sioux FallsCharleston
FSD Sioux Falls Joe Foss Field - CHS Charleston
FSDCHS
Sioux Falls Joe Foss Field
Tue 10/6
12:53 pm-10:33 pm
1 stop8h 40m
Charleston
Sat 10/10
7:00 am-12:13 pm
1 stop6h 13m
$399
Sioux FallsColumbia
FSD Sioux Falls Joe Foss Field - CAE Columbia Metropolitan
FSDCAE
Sioux Falls Joe Foss Field
Thu 11/19
5:25 am-1:14 pm
1 stop6h 49m
Columbia Metropolitan
Mon 11/23
3:47 pm-7:56 pm
1 stop5h 09m
$404
Sioux FallsCharleston
FSD Sioux Falls Joe Foss Field - CHS Charleston
FSDCHS
Sioux Falls Joe Foss Field
Sat 10/10
12:53 pm-11:57 pm
2 stops10h 04m
Charleston
Wed 10/14
5:02 am-2:18 pm
2 stops10h 16m
$409
Sioux FallsMyrtle Beach
FSD Sioux Falls Joe Foss Field - MYR Myrtle Beach Intl
FSDMYR
Sioux Falls Joe Foss Field
Thu 12/17
12:59 pm-10:47 pm
2 stops8h 48m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$418
Showing 1-10 of 31 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Sioux Falls with our price prediction graph.
FSD-CHS
FSD-GSP
FSD-MYR
FSD-CAE
FSD-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to South Carolina
FSD-USSC
FSD-CHS
FSD-GSP
FSD-MYR
FSD-CAE
What is the cheapest month to book a flight from Sioux Falls to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Sioux Falls to South Carolina (average of $349). Flying from Sioux Falls to South Carolina in October is currently the most expensive (average of $676). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Sioux Falls to South Carolina?
Airfare is below average for this route at the moment.
Sioux Falls to South Carolina flights typically cost between $351 and $676 in October.The cheapest round-trip price found within the last 5 days was $321 on American Airlines (Oct 24-Oct 31).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 26, 2026.
Read through reviews of airlines operating flights from Sioux Falls to South Carolina, such as Delta,United Airlines, andAmerican Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Overall
7.8
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Sioux Falls to South Carolina
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Complete your trip
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Sioux Falls and South Carolina flights
Browse other Sioux Falls and South Carolina flight options. Last updated on September 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to South Carolina flights
Consider these flights traveling from Sioux Falls to South Carolina.
Top 3 airlines flying from Sioux Falls to South Carolina
Discover the top 3 airlines that operate flights from Sioux Falls to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$409 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$264 | Average$480 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$308 | Average$484 | FlexibilityNo cancel fee | On-time71% |