$208+ Cheap flights from Sioux Falls (FSD) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — CHS
Jun 8 — Jun 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Sioux Falls to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Sioux Falls to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Sioux Falls to South CarolinaExplore the most affordable flight options available from Sioux Falls to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
Explore the most affordable flight options available from Sioux Falls to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:18 pm
FSD
- CLT
1 stop22h 00m
Frontier
Sun 5/247:14 pm
CLT
- FSD
1 stop21h 26m
Frontier
Deal found 5/5![Frontier logo]()
$280
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/151:01 pm
FSD
- CHS
1 stop7h 47m
United Airlines
Tue 8/184:26 pm
CHS
- FSD
1 stop8h 24m
United Airlines
Deal found 5/4![United Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:46 pm
FSD
- CHS
1 stop5h 14m
American Airlines
Sat 6/67:21 am
CHS
- FSD
1 stop5h 27m
American Airlines
Deal found 5/4![American Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:16 pm
FSD
- CHS
2 stops6h 43m
Delta
Tue 6/23:00 pm
CHS
- FSD
1 stop5h 49m
Delta
Deal found 5/6![Delta logo]()
$320
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:24 am
FSD
- CLT
1 stop5h 08m
Delta
Wed 6/246:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 5/6![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:09 pm
FSD
- SAV
1 stop8h 05m
American Airlines
Wed 12/93:43 pm
SAV
- FSD
1 stop6h 20m
American Airlines
Deal found 5/4![American Airlines logo]()
$331
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:35 pm
FSD
- CLT
1 stop6h 18m
American Airlines
Tue 6/98:10 pm
CLT
- FSD
1 stop5h 10m
American Airlines
Deal found 5/6![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:22 am
FSD
- SAV
1 stop7h 01m
Delta
Tue 8/115:18 pm
SAV
- FSD
1 stop6h 33m
Delta
Deal found 5/4![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:40 am
FSD
- MYR
1 stop5h 35m
United Airlines
Tue 8/253:21 pm
MYR
- FSD
1 stop7h 31m
United Airlines
Deal found 5/4![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:46 pm
FSD
- CAE
1 stop5h 07m
American Airlines
Sat 6/64:57 pm
CAE
- FSD
1 stop7h 59m
American Airlines
Deal found 5/6![American Airlines logo]()
$339
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:26 pm
FSD
- CLT
1 stop4h 31m
Delta
Mon 8/242:12 pm
CLT
- FSD
1 stop6h 47m
Delta
Deal found 5/6![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:46 pm
FSD
- CHS
1 stop5h 14m
American Airlines
Tue 6/23:43 pm
CHS
- FSD
1 stop7h 37m
American Airlines
Deal found 5/6![American Airlines logo]()
$341
Best flights from Sioux Falls to South CarolinaDiscover carefully curated flight deals from Sioux Falls to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
Discover carefully curated flight deals from Sioux Falls to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:24 am
FSD
- CHS
1 stop5h 40m
Delta
Tue 6/162:26 pm
CHS
- FSD
1 stop6h 33m
Delta
Deal found 5/8![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 am
FSD
- CHS
2 stops7h 25m
United Airlines
Tue 8/184:26 pm
CHS
- FSD
1 stop8h 24m
United Airlines
Deal found 5/4![United Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:40 pm
FSD
- CHS
1 stop5h 09m
American Airlines
Sat 6/137:21 am
CHS
- FSD
1 stop5h 27m
American Airlines
Deal found 5/8![American Airlines logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:13 pm
FSD
- MYR
1 stop22h 06m
Multiple Airlines
Sun 5/313:58 pm
MYR
- FSD
2 stops24h 42m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$586
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:16 pm
FSD
- CHS
2 stops6h 43m
Delta
Tue 6/23:00 pm
CHS
- FSD
1 stop5h 49m
Delta
Deal found 5/6![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:00 am
FSD
- MYR
1 stop7h 15m
United Airlines
Tue 8/2510:28 am
MYR
- FSD
2 stops12h 24m
United Airlines
Deal found 5/4![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:46 pm
FSD
- CAE
1 stop5h 07m
American Airlines
Tue 6/95:22 pm
CAE
- FSD
1 stop7h 58m
American Airlines
Deal found 5/5![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:22 am
FSD
- SAV
1 stop7h 01m
Delta
Tue 8/115:18 pm
SAV
- FSD
1 stop6h 33m
Delta
Deal found 5/4![Delta logo]()
$335
This KAYAK deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:26 pm
FSD
- CLT
1 stop4h 31m
Delta
Mon 8/242:12 pm
CLT
- FSD
1 stop6h 47m
Delta
Deal found 5/6![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:25 am
FSD
- CHS
1 stop9h 03m
United Airlines
Sat 8/296:43 pm
CHS
- FSD
1 stop5h 54m
United Airlines
Deal found 5/5![United Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:19 am
FSD
- CLT
1 stop4h 13m
Delta
Tue 6/96:58 pm
CLT
- FSD
1 stop5h 14m
Delta
Deal found 5/8![Delta logo]()
$342
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:07 pm
FSD
- CLT
1 stop6h 56m
American Airlines
Sat 5/305:45 am
CLT
- FSD
1 stop7h 27m
American Airlines
Deal found 5/7![American Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:20 am
FSD
- SAV
1 stop6h 52m
Delta
Tue 7/141:57 pm
SAV
- FSD
1 stop6h 59m
Delta
Deal found 5/6![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:01 pm
FSD
- SAV
1 stop7h 31m
United Airlines
Wed 8/267:05 pm
SAV
- FSD
1 stop5h 32m
United Airlines
Deal found 5/5![United Airlines logo]()
$421
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:30 am
FSD
- MYR
1 stop7h 07m
American Airlines
Sun 9/64:23 pm
MYR
- FSD
1 stop6h 33m
American Airlines
Deal found 5/6![American Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:40 am
FSD
- CAE
1 stop5h 32m
United Airlines
Sat 8/152:40 pm
CAE
- FSD
2 stops9h 57m
United Airlines
Deal found 5/7![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:46 pm
FSD
- CAE
1 stop5h 07m
American Airlines
Sat 6/65:00 am
CAE
- FSD
2 stops7h 48m
American Airlines
Deal found 5/6![American Airlines logo]()
$433
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:26 pm
FSD
- CHS
2 stops7h 58m
Delta
Mon 8/102:17 pm
CHS
- FSD
1 stop6h 42m
Delta
Deal found 5/4![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:47 am
FSD
- CAE
1 stop4h 53m
United Airlines
Sat 8/225:34 pm
CAE
- FSD
1 stop6h 18m
United Airlines
Deal found 5/8![United Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:58 am
FSD
- CLT
2 stops9h 47m
Delta
Mon 9/286:50 pm
CLT
- FSD
1 stop4h 56m
Delta
Deal found 5/5![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:20 am
FSD
- SAV
1 stop5h 09m
Delta
Sun 5/245:30 am
SAV
- FSD
2 stops8h 19m
Delta
Deal found 5/4![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:41 pm
FSD
- AGS
1 stop8h 15m
American Airlines
Sun 5/244:00 pm
AGS
- FSD
1 stop7h 17m
American Airlines
Deal found 5/5![American Airlines logo]()
$522
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:20 am
FSD
- CLT
1 stop4h 45m
Delta
Sun 5/242:18 pm
CLT
- FSD
2 stops9h 53m
Delta
Deal found 5/5![Delta logo]()
$374
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:20 am
FSD
- CLT
1 stop4h 51m
Delta
Sat 5/302:38 pm
CLT
- FSD
1 stop5h 49m
Delta
Deal found 5/5![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:06 am
FSD
- MYR
2 stops13h 38m
American Airlines
Sat 8/111:46 am
MYR
- FSD
2 stops13h 32m
American Airlines
Deal found 5/4![American Airlines logo]()
$563
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:30 am
FSD
- MYR
1 stop7h 12m
American Airlines
Mon 9/214:26 pm
MYR
- FSD
1 stop6h 29m
American Airlines
Deal found 5/9![American Airlines logo]()
$570
This Delta deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:30 pm
FSD
- SAV
2 stops9h 23m
Delta
Tue 7/283:43 pm
SAV
- FSD
1 stop5h 13m
Delta
Deal found 5/7![Delta logo]()
$428
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:20 pm
FSD
- MYR
2 stops9h 19m
Delta
Sun 9/611:10 am
MYR
- FSD
2 stops11h 59m
Delta
Deal found 5/8![Delta logo]()
$465
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:40 am
FSD
- HHH
1 stop5h 41m
United Airlines
Tue 7/143:05 pm
HHH
- FSD
1 stop9h 26m
United Airlines
Deal found 5/6![United Airlines logo]()
$901
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:40 pm
FSD
- HHH
2 stops16h 46m
American Airlines
Tue 6/910:57 am
HHH
- FSD
2 stops14h 23m
American Airlines
Deal found 5/8![American Airlines logo]()
$750
Last-minute flights from Sioux Falls to South CarolinaDiscover last-minute flight deals from Sioux Falls to South Carolina. Data last updated May 9, 2026 and is based on user searches.
Discover last-minute flight deals from Sioux Falls to South Carolina. Data last updated May 9, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:20 am
FSD
- CLT
1 stop4h 45m
Delta
Sun 5/246:15 am
CLT
- FSD
1 stop7h 34m
Delta
Deal found 5/5![Delta logo]()
$369
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:18 pm
FSD
- CLT
1 stop22h 00m
Frontier
Sun 5/247:14 pm
CLT
- FSD
1 stop21h 26m
Frontier
Deal found 5/5![Frontier logo]()
$280
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:00 am
FSD
- CLT
1 stop7h 45m
American Airlines
Sat 5/309:30 am
CLT
- FSD
1 stop7h 46m
American Airlines
Deal found 5/6![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:16 pm
FSD
- CHS
2 stops6h 43m
Delta
Tue 6/23:00 pm
CHS
- FSD
1 stop5h 49m
Delta
Deal found 5/6![Delta logo]()
$320
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:46 pm
FSD
- CHS
1 stop5h 14m
American Airlines
Tue 6/23:43 pm
CHS
- FSD
1 stop7h 37m
American Airlines
Deal found 5/6![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:07 pm
FSD
- CLT
1 stop7h 45m
American Airlines
Tue 6/94:37 pm
CLT
- FSD
1 stop6h 40m
American Airlines
Deal found 5/8![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:46 pm
FSD
- CAE
1 stop5h 07m
American Airlines
Tue 6/95:22 pm
CAE
- FSD
1 stop7h 58m
American Airlines
Deal found 5/5![American Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:46 pm
FSD
- CHS
1 stop5h 14m
American Airlines
Sat 6/67:21 am
CHS
- FSD
1 stop5h 27m
American Airlines
Deal found 5/4![American Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:46 pm
FSD
- CAE
1 stop5h 07m
American Airlines
Sat 6/64:57 pm
CAE
- FSD
1 stop7h 59m
American Airlines
Deal found 5/6![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:35 pm
FSD
- CLT
1 stop6h 18m
American Airlines
Tue 6/98:10 pm
CLT
- FSD
1 stop5h 10m
American Airlines
Deal found 5/6![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:24 am
FSD
- CHS
1 stop5h 40m
Delta
Tue 6/162:26 pm
CHS
- FSD
1 stop6h 33m
Delta
Deal found 5/8![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:24 am
FSD
- CLT
1 stop5h 08m
Delta
Wed 6/246:20 am
CLT
- FSD
1 stop4h 56m
Delta
Deal found 5/6![Delta logo]()
$325
One-way flights from Sioux Falls to South CarolinaSearch for one-way flight options from Sioux Falls to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 9, 2026.
Search for one-way flight options from Sioux Falls to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:21 pm
FSD
- CLT
1 stop21h 44m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:51 pm
FSD
- CLT
1 stop20h 52m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:02 pm
FSD
- CLT
2 stops19h 58m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:01 pm
FSD
- CLT
3 stops47h 24m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:25 pm
FSD
- CLT
2 stops42h 40m
Frontier
Deal found 5/5![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:26 am
FSD
- CHS
2 stops23h 32m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:42 pm
FSD
- CLT
3 stops36h 21m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:36 pm
FSD
- CHS
2 stops16h 02m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:25 pm
FSD
- CLT
2 stops23h 48m
Frontier
Deal found 5/5![Frontier logo]()
$291
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:46 pm
FSD
- CHS
1 stop17h 45m
American Airlines
Deal found 5/7![American Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:47 pm
FSD
- CLT
3 stops42h 13m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:04 pm
FSD
- CHS
2 stops10h 43m
American Airlines
Deal found 5/7![American Airlines logo]()
$308
Find flight deals from Sioux Falls to South Carolina
Keep the following information in mind while searching for Sioux Falls to South Carolina flight deals. Data was last updated May 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $280 (CheapOair) |
One-way from | $208 (Kiwi.com) |
Popular in | May |
Cheapest in | November |
Average price | $648 |
Cheapflights Fare Finder
Customize your flight search to find flights from Sioux Falls to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Sioux Falls to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Sioux FallsCharleston
FSD - CHS
FSDCHS
Sioux Falls Joe Foss Field
Tue 6/9
5:24 am-12:04 pm
1 stop5h 40m
Charleston
Tue 6/16
2:26 pm-7:59 pm
1 stop6h 33m
$291
Sioux FallsCharleston
FSD - CHS
FSDCHS
Sioux Falls Joe Foss Field
Sat 8/15
6:00 am-2:25 pm
2 stops7h 25m
Charleston
Tue 8/18
4:26 pm-11:50 pm
1 stop8h 24m
$296
Sioux FallsCharleston
FSD - CHS
FSDCHS
Sioux Falls Joe Foss Field
Fri 5/29
4:16 pm-11:59 pm
2 stops6h 43m
Charleston
Tue 6/2
3:00 pm-7:49 pm
1 stop5h 49m
$320
Sioux FallsSavannah
FSD - SAV
FSDSAV
Sioux Falls Joe Foss Field
Mon 8/3
8:22 am-4:23 pm
1 stop7h 01m
Savannah/Hilton Head
Tue 8/11
5:18 pm-10:51 pm
1 stop6h 33m
$335
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 8/21
1:26 pm-6:57 pm
1 stop4h 31m
Charlotte Douglas
Mon 8/24
2:12 pm-7:59 pm
1 stop6h 47m
$339
Sioux FallsCharleston
FSD - CHS
FSDCHS
Sioux Falls Joe Foss Field
Tue 6/9
4:40 pm-10:49 pm
1 stop5h 09m
Charleston
Sat 6/13
7:21 am-11:48 am
1 stop5h 27m
$341
Quickest round-trip
Sioux FallsCharlotte
FSD - CLT
FSDCLT
Sioux Falls Joe Foss Field
Fri 6/5
8:19 am-1:32 pm
1 stop4h 13m
Charlotte Douglas
Tue 6/9
6:58 pm-11:12 pm
1 stop5h 14m
$342
Sioux FallsMyrtle Beach
FSD - MYR
FSDMYR
Sioux Falls Joe Foss Field
Sat 8/22
6:00 am-2:15 pm
1 stop7h 15m
Myrtle Beach Intl
Tue 8/25
10:28 am-9:52 pm
2 stops12h 24m
$344
Sioux FallsSavannah
FSD - SAV
FSDSAV
Sioux Falls Joe Foss Field
Fri 7/10
5:20 am-1:12 pm
1 stop6h 52m
Savannah/Hilton Head
Tue 7/14
1:57 pm-7:56 pm
1 stop6h 59m
$345
Sioux FallsColumbia
FSD - CAE
FSDCAE
Sioux Falls Joe Foss Field
Tue 6/2
4:46 pm-10:53 pm
1 stop5h 07m
Columbia Metropolitan
Tue 6/9
5:22 pm-12:20 am
1 stop7h 58m
$359
Showing 1-10 of 50 resultsSorted by cheapest first
Best time to book a flight from Sioux Falls to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Sioux Falls with our price prediction graph.
FSD-CLT
FSD-CHS
FSD-CAE
FSD-MYR
FSD-AGS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Sioux Falls to South Carolina
FSD-USSC
FSD-CLT
FSD-CHS
FSD-CAE
FSD-MYR
What is the cheapest month to book a flight from Sioux Falls to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Sioux Falls to South Carolina (average of $128). Flying from Sioux Falls to South Carolina in February is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Sioux Falls to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 9, 2026.
Read through reviews of airlines operating flights from Sioux Falls to South Carolina, such as Delta,United Airlines, andAmerican Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Food
7.2
Comfort
7.9
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Boarding
8.1
Food
7.2
Comfort
7.9
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Boarding
8.1
Food
7.2
Comfort
7.9
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Boarding
8.1
Food
7.2
Comfort
7.9
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Sioux Falls to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Sioux Falls to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Sioux Falls to South Carolina by cabin class
Find flights from Sioux Falls to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Sioux Falls and South Carolina flights
Browse other Sioux Falls and South Carolina flight options. Last updated on May 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Sioux Falls to South Carolina flights
Consider these flights traveling from Sioux Falls to South Carolina.
Top 3 airlines flying from Sioux Falls to South Carolina
Discover the top 3 airlines that operate flights from Sioux Falls to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$160 | Average$460 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$250 | Average$404 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$258 | Average$412 | FlexibilityNo cancel fee | On-time71% |