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$319+ Cheap flights from Des Moines (DSM) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MAD
nov. 15 — nov. 221
sáb. 11/15
sáb. 11/22
1 adult, Economy
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Cheap flight deals from Des Moines to Spain

Keep the following information in mind while searching for Des Moines to Spain flight deals. Data was last updated octubre 16, 2025.

Round-trip from

$425
(Flighttix)

One-way from

$319
(Mytrip)

Popular in

June

Cheapest in

November

Average price

$852
From Des Moines to Spain
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One-way flight from Des Moines to Spain
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Highest demand for flights based on searches. 25% potential increase in price ($339 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($48 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Spain

Cheapest flights from Des Moines to Spain
Explore the most affordable flight options available from Des Moines to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 16, 2025.

This Flighttix deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/2710:50 amDSM - MAD
1 stop15h 15mVirgin Atlantic
mié. 11/1211:15 amMAD - DSM
1 stop18h 18mVirgin Atlantic
Deal found 10/14$425
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/15:35 amDSM - BCN
1 stop20h 05mDelta
mié. 12/1010:15 amBCN - DSM
2 stops31h 23mDelta
Deal found 10/15$438
This lastminute.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/2811:28 amDSM - MAD
1 stop13h 32mVirgin Atlantic
vie. 12/511:15 amMAD - DSM
2 stops41h 00mVirgin Atlantic
Deal found 10/14$454
This Ticket deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/305:35 amDSM - MAD
1 stop20h 40mKLM
dom. 12/76:00 amMAD - DSM
2 stops18h 03mKLM
Deal found 10/16$460
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/95:35 amDSM - MAD
1 stop20h 40mDelta
mar. 11/186:00 amMAD - DSM
2 stops23h 33mDelta
Deal found 10/14$462
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/85:15 pmDSM - MAD
1 stop33h 00mDelta
mar. 11/186:00 amMAD - DSM
2 stops23h 33mDelta
Deal found 10/14$467
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/1011:26 amDSM - MAD
2 stops22h 14mUnited Airlines
mar. 11/181:35 pmMAD - DSM
2 stops38h 57mUnited Airlines
Deal found 10/13$474
This Flighttix deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/288:02 amDSM - MAD
2 stops16h 58mMultiple Airlines
vie. 12/51:45 pmMAD - DSM
2 stops34h 39mMultiple Airlines
Deal found 10/14$479
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/112:17 pmDSM - MAD
2 stops21h 53mDelta
mar. 11/186:00 amMAD - DSM
2 stops23h 33mDelta
Deal found 10/14$480
This Finnair deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/176:00 amDSM - BCN
1 stop18h 05mMultiple Airlines
mié. 11/2611:00 amBCN - DSM
1 stop19h 38mMultiple Airlines
Deal found 10/16$484
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/172:19 pmDSM - BCN
2 stops16h 21mAmerican Airlines
mié. 11/2612:30 pmBCN - DSM
2 stops18h 51mAmerican Airlines
Deal found 10/16$485
This Expedia deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/139:01 amDSM - BCN
2 stops17h 34mAir Canada
jue. 11/201:35 pmBCN - DSM
2 stops27h 55mAir Canada
Deal found 10/16$486

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
Use the filters below to find and compare flights from Des Moines to Spain that are best for you.

Fly from

Des Moines

Fly to

Spain

Route

Depart

Return

Price

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

lun. 10/27

10:00 am-8:05 am

2 stops16h 05m

Madrid Barajas

mié. 11/12

10:00 am-8:47 pm

2 stops17h 47m

$443

Des MoinesBarcelona

DSM - BCN

DSMBCN

Des Moines

lun. 12/1

6:32 pm-5:05 pm

2 stops15h 33m

Barcelona-El Prat

mié. 12/10

10:15 am-9:40 am

2 stops30h 25m

$457

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

dom. 11/9

6:17 am-9:15 am

2 stops19h 58m

Madrid Barajas

mar. 11/18

6:00 am-10:33 pm

2 stops23h 33m

$466

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

lun. 11/10

11:26 am-4:40 pm

2 stops22h 14m

Madrid Barajas

mar. 11/18

1:35 pm-9:32 pm

2 stops38h 57m

$474

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

mar. 11/11

1:05 pm-4:40 pm

2 stops20h 35m

Madrid Barajas

mar. 11/18

1:35 pm-9:32 pm

2 stops38h 57m

$474

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

mié. 11/12

1:05 pm-4:40 pm

2 stops20h 35m

Madrid Barajas

mar. 11/18

1:35 pm-9:32 pm

2 stops38h 57m

$474

Des MoinesMadrid

DSM - MAD

DSMMAD

Des Moines

mié. 11/12

10:21 am-5:40 pm

2 stops24h 19m

Madrid Barajas

mar. 11/18

6:00 am-10:33 pm

2 stops23h 33m

$481

Des MoinesBarcelona

DSM - BCN

DSMBCN

Des Moines

lun. 11/17

6:00 am-7:05 am

1 stop18h 05m

Barcelona-El Prat

mié. 11/26

11:00 am-11:38 pm

1 stop19h 38m

$484

Des MoinesBarcelona

DSM - BCN

DSMBCN

Des Moines

jue. 11/13

11:28 am-8:40 am

1 stop14h 12m

Barcelona-El Prat

jue. 11/20

10:55 am-10:33 pm

1 stop18h 38m

$484

Des MoinesBarcelona

DSM - BCN

DSMBCN

Des Moines

lun. 12/1

6:00 am-7:05 am

1 stop18h 05m

Barcelona-El Prat

mié. 12/10

11:00 am-11:29 pm

1 stop19h 29m

$484

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Showing 1-10 of 25 results
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Best time to book a flight from Des Moines to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Spain

What is the cheapest month to book a flight from Des Moines to Spain?

Currently, November is the cheapest month in which you can book a flight from Des Moines to Spain (average of $575). Flying from Des Moines to Spain in June is currently the most expensive (average of $1,240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to ES?

Find hourly flight availability from Des Moines to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 16, 2025.

When flying from Des Moines to Spain, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 11% versus a flight at noon.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated octubre 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Spain to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,979 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,041 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Iberia
7.0
Good
2,992 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Spain?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Spain. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Spain?

    A quick flight from Des Moines to Spain can take about 15h 33m. Virgin Atlantic provides one of the quickest options available for as low as $457. The distance from Des Moines to Spain is about 4666 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Des Moines to Spain one-way?

    To fly one-way, consider booking your trip with Air Canada, which is currently one of the cheapest options available, starting at $397. Iberia flights start at $441 while deals on American Airlines start at $469 one-way.

  • What are the most popular routes from Des Moines to Spain?

    The most popular route from Des Moines to Spain is Des Moines - Barcelona-El Prat. You may also consider Des Moines - Madrid Barajas or Des Moines - Sevilla.

  • Can I find deals for flights from Des Moines to Spain that include hotel bookings?

    Yes. In addition to deals on Des Moines to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Spain.

  • Can I find deals for business class flights from Des Moines to Spain?

    Yes. Cheapflights offers flight deals from Des Moines to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Spain?

    Currently, November is the cheapest month in which you can book a flight from Des Moines to Spain (average of $575). Flying from Des Moines to Spain in June is currently the most expensive (average of $1,240). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to Spain

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Top 4 airlines flying from Des Moines to Spain

Discover the top 4 airlines that operate flights from Des Moines to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$583Average$847FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$584Average$1,035FlexibilityNo cancel feeOn-time71%
DeltaCheapest$644Average$735FlexibilityNo cancel feeOn-timeN/A
IberiaCheapest$686Average$1,340FlexibilityNo cancel feeOn-time77%

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