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South Carolina

$55+ Cheap flights from St. Louis (STL) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from St. Louis to South Carolina

Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$119
(Mytrip)

One-way from

$55
(Priceline)

Popular in

December

Cheapest in

July

Average price

$359
Provider with most accurate pricing for Lambert-St Louis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Myrtle Beach Intl flights.
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From Lambert-St Louis to South Carolina
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One-way flight from Lambert-St Louis to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from St. Louis to South Carolina

Cheapest flights from St. Louis to South Carolina
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/154:33 pmSTL - CLT
1 stop17h 25mFrontier
Tue 11/182:27 pmCLT - STL
1 stop20h 38mFrontier
Deal found 10/26$119
This Booking.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:12 pmSTL - CLT
1 stop21h 42mFrontier
Mon 11/176:12 pmCLT - STL
1 stop15h 55mFrontier
Deal found 10/27$121
This Frontier deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/113:30 pmSTL - CLT
1 stop5h 08mFrontier
Mon 12/159:20 pmCLT - STL
1 stop26h 13mFrontier
Deal found 10/27$152
This CheapOair deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:30 pmSTL - CLT
1 stop15h 27mFrontier
Sun 12/1410:33 pmCLT - STL
1 stop11h 26mFrontier
Deal found 10/27$153
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:30 pmSTL - CLT
1 stop15h 27mMultiple Airlines
Sun 1/115:45 amCLT - STL
1 stop6h 16mMultiple Airlines
Deal found 10/27$159
This CheapOair deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/308:40 pmSTL - CLT
1 stop19h 37mFrontier
Thu 11/1311:37 amCLT - STL
1 stop6h 50mFrontier
Deal found 10/28$179
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:05 pmSTL - CLT
1 stop18h 18mFrontier
Sun 11/1611:53 amCLT - STL
1 stop22h 47mFrontier
Deal found 10/26$185
This Cheapflightsfares deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:47 pmSTL - CLT
1 stop8h 12mSpirit Airlines
Sun 12/77:00 amCLT - STL
1 stop7h 52mSpirit Airlines
Deal found 10/28$189
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:48 amSTL - CLT
2 stops27h 28mFrontier
Tue 1/68:46 pmCLT - STL
1 stop26h 47mFrontier
Deal found 10/26$190
This CheapOair deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:30 pmSTL - CLT
1 stop17h 20mFrontier
Thu 12/115:44 pmCLT - STL
1 stop17h 30mFrontier
Deal found 10/27$200
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/611:19 amSTL - CAE
1 stop6h 38mDelta
Sat 12/1312:53 pmCAE - STL
1 stop4h 15mDelta
Deal found 10/27$211
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:53 amSTL - MYR
1 stop12h 01mMultiple Airlines
Mon 11/246:15 amMYR - STL
2 stops13h 04mMultiple Airlines
Deal found 10/26$249

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

St. Louis

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 12/13

3:30 pm-7:57 am

1 stop15h 27m

Charlotte Douglas

Sun 1/11

5:45 am-11:01 am

1 stop6h 16m

$159

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Sat 12/6

11:19 am-6:57 pm

1 stop6h 38m

Columbia Metropolitan

Sat 12/13

12:53 pm-4:08 pm

1 stop4h 15m

$211

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 11/15

7:45 pm-8:00 am

2 stops11h 15m

Charlotte Douglas

Tue 11/18

2:27 pm-10:05 am

1 stop20h 38m

$211

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

1:50 pm-8:50 pm

1 stop6h 00m

Charlotte Douglas

Mon 12/15

12:55 pm-2:05 pm

Nonstop2h 10m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 12/8

1:50 pm-8:50 pm

1 stop6h 00m

Charlotte Douglas

Thu 12/11

12:55 pm-2:05 pm

Nonstop2h 10m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 12/6

5:00 pm-11:06 pm

1 stop5h 06m

Charlotte Douglas

Mon 12/8

7:18 pm-11:42 pm

1 stop5h 24m

$237

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 12/31

6:29 am-12:25 pm

1 stop4h 56m

Charlotte Douglas

Thu 1/1

6:00 am-8:58 am

1 stop3h 58m

$237

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/18

5:45 pm-11:10 pm

1 stop4h 25m

Charlotte Douglas

Mon 12/22

9:25 pm-12:05 am

1 stop3h 40m

$237

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 12/10

10:15 am-4:20 pm

1 stop5h 05m

Charlotte Douglas

Wed 12/10

6:20 pm-10:00 pm

1 stop4h 40m

$237

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 12/13

7:12 am-10:09 am

Nonstop1h 57m

Charlotte Douglas

Sun 1/11

1:59 pm-3:04 pm

Nonstop2h 05m

$240

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South Carolina

What is the cheapest month to book a flight from St. Louis to South Carolina?

Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SC?

Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from St. Louis to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from St. Louis to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their St. Louis to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 28, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,235 reviews

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,235 reviews
Southwest
8.0
Very good
4,235 reviews

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,995 reviews
Southwest
8.0
Very good
4,235 reviews

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,033 reviews
Southwest
8.0
Very good
4,235 reviews

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,112 reviews
Southwest
8.0
Very good
4,235 reviews

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South Carolina?

    For a flight from St. Louis to South Carolina, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this St. Louis to South Carolina flight route?

    Within the past month, 6 users have taken a look at flights from Lambert-St Louis to South Carolina.

  • How long is the flight from St. Louis to South Carolina?

    There are many flights that can get you from St. Louis to South Carolina in 6h. Fly via Delta, Frontier, or Southwest to get the fastest option. St. Louis and South Carolina are separated by a distance of 574 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South Carolina one-way?

    The cheapest airlines for a one-way flight from St. Louis to South Carolina are Spirit Airlines ($80), Frontier ($91), and Southwest ($109).

  • What are the most popular routes from St. Louis to South Carolina?

    While some choose either Lambert-St Louis - Savannah/Hilton Head or Lambert-St Louis - Charleston, Lambert-St Louis - Charlotte Douglas is the most popular route from St. Louis to South Carolina.

  • Can I find deals for flights from St. Louis to South Carolina that include hotel bookings?

    Yes. In addition to deals on St. Louis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South Carolina.

  • Can I find deals for business class flights from St. Louis to South Carolina?

    Yes. Cheapflights offers flight deals from St. Louis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from St. Louis to South Carolina

Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$84Average$216FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$226Average$383FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$283Average$400FlexibilityNo cancel feeOn-time63%

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