$66+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Feb 28 — Mar 71
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to South Carolina
Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$131
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/27![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 1/28![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/273:49 pm
STL
- CLT
1 stop15h 44m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 1/28![Frontier logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Thu 3/510:46 pm
CLT
- STL
1 stop9h 16m
Frontier
Deal found 1/28![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:49 pm
STL
- CLT
1 stop15h 09m
Multiple Airlines
Tue 2/245:49 pm
CLT
- STL
1 stop29h 38m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:22 pm
STL
- CLT
2 stops21h 55m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:51 pm
STL
- CLT
2 stops16h 52m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:17 pm
STL
- CLT
2 stops22h 00m
Multiple Airlines
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:51 pm
STL
- CLT
2 stops16h 52m
Frontier
Mon 3/210:42 pm
CLT
- STL
1 stop24h 45m
Frontier
Deal found 1/27![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Tue 3/35:00 pm
CHS
- STL
2 stops14h 51m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$188
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated January 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $125 (Kiwi.com) |
One-way from | $66 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $415 |
Good round-trip deal | $360 or less |
Good one-way deal | $216 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
St. Louis
Fly to
South Carolina
Route
Depart
Return
Price
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 3/2
3:49 pm-8:38 am
1 stop15h 49m
Charleston
Tue 3/3
5:00 pm-6:51 am
2 stops14h 51m
$188
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 2/25
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Wed 3/4
8:25 am-9:35 am
Nonstop2h 10m
$231
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 2/24
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Tue 3/3
8:25 am-9:35 am
Nonstop2h 10m
$231
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Fri 2/27
1:13 pm-9:45 pm
1 stop7h 32m
Savannah/Hilton Head
Fri 3/6
4:46 pm-8:41 pm
1 stop4h 55m
$237
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Sat 5/2
7:45 am-3:13 pm
1 stop6h 28m
Savannah/Hilton Head
Sat 5/9
4:44 pm-9:52 pm
1 stop6h 08m
$237
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Fri 4/17
6:50 pm-11:59 pm
1 stop4h 09m
Savannah/Hilton Head
Sun 4/19
5:35 am-8:30 am
1 stop3h 55m
$237
St. LouisColumbia
STL - CAE
STLCAE
Lambert-St Louis
Thu 2/19
2:00 pm-9:21 pm
1 stop6h 21m
Columbia Metropolitan
Wed 3/4
7:18 am-12:33 pm
1 stop6h 15m
$240
St. LouisColumbia
STL - CAE
STLCAE
Lambert-St Louis
Thu 2/19
6:30 am-3:40 pm
1 stop8h 10m
Columbia Metropolitan
Wed 3/4
7:00 am-12:23 pm
1 stop6h 23m
$240
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Thu 6/11
6:00 am-2:18 pm
1 stop7h 18m
Savannah/Hilton Head
Mon 6/15
12:20 pm-9:11 pm
2 stops9h 51m
$242
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 2/28
3:05 pm-5:50 pm
Nonstop1h 45m
Charlotte Douglas
Mon 3/2
5:05 pm-6:15 pm
Nonstop2h 10m
$242
Showing 1-10 of 60 results
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.
Unlike in the morning, when flights are generally more expensive, you can save up to 65% on flights from St. Louis to South Carolina by exploring options for tickets in the evening.
What is the cheapest day to fly from St. Louis to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from St. Louis to South Carolina. Price data was last updated on January 24, 2026.
Travelers seeking maximum savings on their St. Louis to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for St. Louis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$84 | Average$193 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$356 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$274 | Average$398 | FlexibilityNo cancel fee | On-time63% |