HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$64+ Cheap flights from St. Louis (STL) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to South Carolina

Cheapest flights from St. Louis to South Carolina
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/247:43 pmSTL - CLT
1 stop14h 39mFrontier
jue. 1/17:19 pmCLT - STL
1 stop15h 26mFrontier
Deal found 12/9$196
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:00 amSTL - CLT
1 stop5h 46mDelta
mié. 12/318:15 amCLT - STL
1 stop5h 06mDelta
Deal found 12/9$237
This Frontier deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2910:40 amSTL - CLT
1 stop9h 18mFrontier
mié. 1/74:32 pmCLT - STL
1 stop7h 01mFrontier
Deal found 12/9$242
This Frontier deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2910:40 amSTL - CLT
1 stop9h 18mFrontier
mié. 12/312:51 pmCLT - STL
1 stop8h 42mFrontier
Deal found 12/10$243
This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/242:55 pmSTL - CLT
Nonstop1h 45mSouthwest
jue. 1/15:10 pmCLT - STL
1 stop6h 00mSouthwest
Deal found 12/9$262
This Frontier deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/143:30 pmSTL - CLT
1 stop5h 08mFrontier
lun. 12/222:51 pmCLT - STL
1 stop8h 42mFrontier
Deal found 12/10$268
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:00 amSTL - CLT
1 stop5h 46mDelta
sáb. 1/36:00 amCLT - STL
1 stop4h 15mDelta
Deal found 12/9$272
This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/133:30 pmSTL - CLT
1 stop15h 27mFrontier
lun. 12/159:20 pmCLT - STL
1 stop26h 13mFrontier
Deal found 12/9$275
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/242:04 pmSTL - CLT
Nonstop1h 56mAmerican Airlines
lun. 12/2912:15 pmCLT - STL
Nonstop1h 59mAmerican Airlines
Deal found 12/11$276
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:00 amSTL - CLT
1 stop5h 46mDelta
vie. 1/26:00 amCLT - STL
1 stop3h 58mDelta
Deal found 12/9$283
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/1611:00 amSTL - CLT
1 stop5h 21mAmerican Airlines
dom. 1/111:59 pmCLT - STL
Nonstop2h 05mAmerican Airlines
Deal found 12/10$285
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/258:15 amSTL - GSP
1 stop5h 00mUnited Airlines
mié. 12/318:34 amGSP - STL
1 stop4h 53mUnited Airlines
Deal found 12/9$325

Find flight deals from St. Louis to South Carolina

Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$128
(Expedia)

One-way from

$64
(Frontier)

Popular in

March

Cheapest in

July

Average price

$448
Provider with most accurate pricing for Lambert-St Louis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Myrtle Beach Intl flights.
Search Deals
From Lambert-St Louis to South Carolina
Search Deals
One-way flight from Lambert-St Louis to South Carolina
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($19 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

St. Louis

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

sáb. 1/17

12:00 pm-7:25 pm

1 stop6h 25m

Columbia Metropolitan

sáb. 1/24

10:15 am-3:56 pm

1 stop6h 41m

$204

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

vie. 1/9

5:11 pm-4:42 pm

1 stop22h 31m

Charlotte Douglas

vie. 1/16

8:19 pm-2:48 pm

2 stops19h 29m

$204

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

lun. 1/19

5:11 pm-12:12 pm

1 stop18h 01m

Myrtle Beach Intl

mar. 1/27

10:00 am-6:51 am

2 stops21h 51m

$207

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

vie. 2/6

5:42 pm-9:55 am

1 stop15h 13m

Charlotte Douglas

dom. 2/8

4:13 pm-6:51 am

2 stops15h 38m

$209

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

mié. 2/18

3:56 pm-10:42 pm

1 stop5h 46m

Columbia Metropolitan

sáb. 2/21

9:05 am-12:46 pm

1 stop4h 41m

$211

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

mié. 2/11

7:10 am-11:58 am

1 stop3h 48m

Columbia Metropolitan

sáb. 2/14

5:35 am-9:06 am

1 stop4h 31m

$211

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

mié. 2/11

9:54 am-5:39 pm

1 stop6h 45m

Columbia Metropolitan

sáb. 2/14

4:12 pm-11:02 pm

2 stops7h 50m

$216

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

mié. 1/7

6:52 am-9:50 am

Nonstop1h 58m

Charlotte Douglas

sáb. 1/24

5:25 pm-6:34 pm

Nonstop2h 09m

$217

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

lun. 1/26

2:30 pm-5:15 pm

Nonstop1h 45m

Charlotte Douglas

mié. 1/28

8:25 am-9:35 am

Nonstop2h 10m

$228

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

jue. 1/8

3:43 pm-2:42 pm

2 stops21h 59m

Myrtle Beach Intl

jue. 1/15

1:07 pm-7:54 am

1 stop19h 47m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from St. Louis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South Carolina

What is the cheapest month to book a flight from St. Louis to South Carolina?

Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SC?

Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 12, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from St. Louis to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from St. Louis to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their St. Louis to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated diciembre 12, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,253 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,253 reviews
Southwest
7.9
Good
4,253 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,007 reviews
Southwest
7.9
Good
4,253 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,050 reviews
Southwest
7.9
Good
4,253 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,180 reviews
Southwest
7.9
Good
4,253 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South Carolina?

    For a flight from St. Louis to South Carolina, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this St. Louis to South Carolina flight route?

    Within the past month, 6 users have taken a look at flights from Lambert-St Louis to South Carolina.

  • How long is the flight from St. Louis to South Carolina?

    There are many flights that can get you from St. Louis to South Carolina in 5h 46m. Fly via Delta, Frontier, or American Airlines to get the fastest option. St. Louis and South Carolina are separated by a distance of 611 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South Carolina one-way?

    The cheapest airlines for a one-way flight from St. Louis to South Carolina are American Airlines ($99), Delta ($117), and Southwest ($138).

  • What are the most popular routes from St. Louis to South Carolina?

    While some choose either Lambert-St Louis - Charleston or Lambert-St Louis - Savannah/Hilton Head, Lambert-St Louis - Charlotte Douglas is the most popular route from St. Louis to South Carolina.

  • Can I find deals for flights from St. Louis to South Carolina that include hotel bookings?

    Yes. In addition to deals on St. Louis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South Carolina.

  • Can I find deals for business class flights from St. Louis to South Carolina?

    Yes. Cheapflights offers flight deals from St. Louis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in December is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
St. Louis to Las Vegas flights
Kansas City to Las Vegas flights
St. Louis to Orlando flights
St. Louis to LaGuardia flights
Kansas City to Denver flights
Kansas City to Orlando flights
St. Louis to Hobby flights
St. Louis to Denver flights
St. Louis to Los Angeles flights
St. Louis to Miami flights
Kansas City to Sky Harbor Intl flights
St. Louis to Newark flights
Kansas City to John F Kennedy Intl flights
St. Louis to John F Kennedy Intl flights
St. Louis to Sky Harbor Intl flights
Kansas City to LaGuardia flights
Kansas City to Hobby flights
Kansas City to Los Angeles flights
Kansas City to Seattle flights
St. Louis to Dallas/Fort Worth flights
St. Louis to George Bush Intcntl flights
Kansas City to Miami flights
St. Louis to Fort Lauderdale flights
St. Louis to Atlanta flights
St. Louis to Tampa flights
Kansas City to Atlanta flights
Kansas City to Newark flights
Kansas City to Fort Lauderdale flights
St. Louis to Seattle flights
Kansas City to George Bush Intcntl flights
St. Louis to Honolulu flights
Kansas City to Dallas/Fort Worth flights
Kansas City to O'Hare Intl flights
St. Louis to New Orleans flights
St. Louis to Jacksonville flights
St. Louis to Dulles Intl flights
St. Louis to San Francisco flights
Kansas City to Tampa flights
St. Louis to San Diego flights
Kansas City to Boston flights
St. Louis to O'Hare Intl flights
Kansas City to Honolulu flights
Kansas City to San Francisco flights
Kansas City to New Orleans flights
St. Louis to Ontario flights
St. Louis to Boston flights
Kansas City to San Diego flights
St. Louis to Key West flights
St. Louis to Salt Lake City flights
St. Louis to Philadelphia flights

Top 4 airlines flying from St. Louis to South Carolina

Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$84Average$209FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$367FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$226Average$384FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$274Average$401FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.