$90+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 17 — Apr 241
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
This Frontier deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 5/181:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/17![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/264:19 pm
STL
- CLT
1 stop23h 24m
Frontier
Wed 6/37:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 3/15![Frontier logo]()
$185
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:59 pm
STL
- CLT
1 stop13h 41m
Frontier
Sun 4/124:33 pm
CLT
- STL
1 stop16h 18m
Frontier
Deal found 3/14![Frontier logo]()
$189
This Booking.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/13![Frontier logo]()
$191
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Sat 4/187:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/16![American Airlines logo]()
$197
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:19 pm
STL
- CLT
1 stop18h 53m
Frontier
Wed 6/37:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 3/15![Frontier logo]()
$201
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/15![Frontier logo]()
$205
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/264:19 pm
STL
- CLT
1 stop23h 24m
Frontier
Tue 6/21:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/15![Frontier logo]()
$206
This CheapOair deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/13![Frontier logo]()
$212
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:54 pm
STL
- CLT
1 stop13h 36m
Frontier
Mon 4/610:49 pm
CLT
- STL
1 stop25h 36m
Frontier
Deal found 3/15![Frontier logo]()
$214
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:50 am
STL
- CLT
1 stop4h 10m
Delta
Tue 5/125:00 pm
CLT
- STL
1 stop5h 09m
Delta
Deal found 3/17![Delta logo]()
$217
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Wed 5/207:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/17![American Airlines logo]()
$218
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:30 am
STL
- CHS
1 stop4h 47m
United Airlines
Tue 5/195:08 pm
CHS
- STL
1 stop5h 05m
United Airlines
Deal found 3/17![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/162:25 pm
STL
- CLT
1 stop5h 50m
Southwest
Wed 5/207:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 3/17![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:29 am
STL
- HHH
2 stops10h 40m
American Airlines
Tue 5/192:54 pm
HHH
- STL
2 stops10h 02m
American Airlines
Deal found 3/14![American Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:45 pm
STL
- CAE
1 stop8h 02m
Delta
Mon 5/47:12 pm
CAE
- STL
1 stop5h 24m
Delta
Deal found 3/13![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1212:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 5/164:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/15![Southwest logo]()
$239
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:45 am
STL
- CAE
2 stops10h 18m
United Airlines
Wed 5/62:20 pm
CAE
- STL
1 stop7h 53m
United Airlines
Deal found 3/14![United Airlines logo]()
$288
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:25 am
STL
- CHS
1 stop8h 55m
Southwest
Tue 6/91:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 3/13![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:29 am
STL
- MYR
1 stop4h 47m
American Airlines
Wed 4/2212:36 pm
MYR
- STL
1 stop10h 41m
American Airlines
Deal found 3/17![American Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:12 am
STL
- CAE
1 stop4h 31m
Delta
Sat 4/45:34 am
CAE
- STL
1 stop4h 28m
Delta
Deal found 3/16![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 am
STL
- CHS
1 stop4h 47m
United Airlines
Wed 5/1310:15 am
CHS
- STL
2 stops11h 58m
United Airlines
Deal found 3/17![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:35 pm
STL
- CLT
1 stop4h 40m
Southwest
Sat 6/131:00 pm
CLT
- STL
1 stop7h 45m
Southwest
Deal found 3/14![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:09 pm
STL
- CLT
1 stop4h 36m
United Airlines
Wed 5/1310:10 am
CLT
- STL
2 stops12h 03m
United Airlines
Deal found 3/17![United Airlines logo]()
$313
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:10 pm
STL
- CLT
2 stops6h 30m
Southwest
Mon 6/811:35 am
CLT
- STL
1 stop5h 20m
Southwest
Deal found 3/15![Southwest logo]()
$296
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:25 am
STL
- CAE
1 stop8h 06m
Delta
Wed 4/227:03 am
CAE
- STL
1 stop6h 02m
Delta
Deal found 3/15![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:56 pm
STL
- GSP
1 stop6h 42m
American Airlines
Tue 6/237:32 pm
GSP
- STL
1 stop5h 12m
American Airlines
Deal found 3/16![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/81:13 pm
STL
- CHS
1 stop7h 38m
United Airlines
Sat 6/136:00 am
CHS
- STL
1 stop7h 07m
United Airlines
Deal found 3/14![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:01 pm
STL
- SAV
1 stop3h 39m
Delta
Sun 6/75:30 am
SAV
- STL
1 stop3h 37m
Delta
Deal found 3/13![Delta logo]()
$365
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:53 pm
STL
- AGS
1 stop4h 40m
American Airlines
Thu 4/165:08 pm
AGS
- STL
1 stop6h 51m
American Airlines
Deal found 3/14![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:45 pm
STL
- CLT
1 stop4h 25m
Southwest
Mon 8/1711:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 3/16![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:20 am
STL
- SAV
1 stop6h 26m
Delta
Mon 6/2212:26 pm
SAV
- STL
1 stop4h 32m
Delta
Deal found 3/15![Delta logo]()
$367
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:45 am
STL
- CLT
2 stops10h 04m
United Airlines
Sat 4/185:40 pm
CLT
- STL
1 stop4h 33m
United Airlines
Deal found 3/16![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:51 am
STL
- HHH
2 stops11h 18m
American Airlines
Wed 4/221:08 pm
HHH
- STL
2 stops10h 09m
American Airlines
Deal found 3/16![American Airlines logo]()
$378
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:40 pm
STL
- CLT
Nonstop1h 50m
Southwest
Sat 6/611:35 am
CLT
- STL
1 stop9h 25m
Southwest
Deal found 3/15![Southwest logo]()
$315
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:15 pm
STL
- SAV
1 stop5h 25m
Delta
Sat 6/135:30 am
SAV
- STL
1 stop5h 10m
Delta
Deal found 3/13![Delta logo]()
$367
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:53 pm
STL
- AGS
1 stop4h 40m
American Airlines
Tue 4/213:25 pm
AGS
- STL
1 stop5h 05m
American Airlines
Deal found 3/17![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:30 pm
STL
- GSP
1 stop6h 10m
Southwest
Sat 4/1810:45 am
GSP
- STL
2 stops8h 25m
Southwest
Deal found 3/13![Southwest logo]()
$316
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:45 am
STL
- GSP
1 stop5h 25m
United Airlines
Tue 5/510:40 am
GSP
- STL
1 stop6h 59m
United Airlines
Deal found 3/17![United Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:45 pm
STL
- CAE
1 stop8h 02m
Delta
Fri 5/87:01 am
CAE
- STL
1 stop6h 22m
Delta
Deal found 3/17![Delta logo]()
$374
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/32:00 pm
STL
- MYR
2 stops7h 28m
American Airlines
Mon 4/65:10 am
MYR
- STL
1 stop4h 25m
American Airlines
Deal found 3/13![American Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:10 am
STL
- CLT
1 stop6h 15m
Southwest
Mon 6/297:05 pm
CLT
- STL
1 stop4h 45m
Southwest
Deal found 3/16![Southwest logo]()
$319
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated March 18, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated March 18, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:47 am
STL
- CLT
1 stop8h 16m
Frontier
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/13![Frontier logo]()
$225
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:54 pm
STL
- CLT
1 stop13h 36m
Frontier
Mon 4/610:49 pm
CLT
- STL
1 stop25h 36m
Frontier
Deal found 3/15![Frontier logo]()
$214
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/15![Frontier logo]()
$205
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:10 am
STL
- CLT
2 stops8h 39m
United Airlines
Wed 4/85:28 pm
CLT
- STL
1 stop4h 45m
United Airlines
Deal found 3/17![United Airlines logo]()
$222
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:59 pm
STL
- CLT
1 stop13h 41m
Frontier
Sun 4/124:33 pm
CLT
- STL
1 stop16h 18m
Frontier
Deal found 3/14![Frontier logo]()
$189
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Sat 4/187:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/16![American Airlines logo]()
$197
This Frontier deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 5/181:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/17![Frontier logo]()
$180
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:50 am
STL
- CLT
1 stop4h 10m
Delta
Tue 5/125:00 pm
CLT
- STL
1 stop5h 09m
Delta
Deal found 3/17![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:15 pm
STL
- CLT
2 stops7h 25m
Southwest
Tue 4/218:00 am
CLT
- STL
2 stops8h 15m
Southwest
Deal found 3/17![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 4/1812:40 pm
CHS
- STL
1 stop7h 55m
Southwest
Deal found 3/17![Southwest logo]()
$238
This Booking.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/13![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/13![Frontier logo]()
$212
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
This Priceline deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Deal found 3/13![Frontier logo]()
$90
This Trip.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:54 pm
STL
- CLT
1 stop13h 36m
Frontier
Deal found 3/14![Frontier logo]()
$99
This CheapOair deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/13![Frontier logo]()
$102
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
STL
- CLT
1 stop6h 06m
United Airlines
Deal found 3/17![United Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Deal found 3/16![Frontier logo]()
$111
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/81:29 pm
STL
- CHS
1 stop7h 57m
American Airlines
Deal found 3/17![American Airlines logo]()
$119
This Trip.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/254:51 pm
STL
- CLT
1 stop14h 12m
Frontier
Deal found 3/15![Frontier logo]()
$120
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 3/14![Southwest logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:21 am
STL
- CLT
2 stops12h 17m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$122
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:51 pm
STL
- CLT
1 stop14h 12m
Frontier
Deal found 3/17![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:25 am
STL
- SAV
2 stops34h 23m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$124
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 am
STL
- CHS
2 stops7h 23m
United Airlines
Deal found 3/17![United Airlines logo]()
$124
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated March 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $180 (Frontier) |
One-way from | $90 (Priceline) |
Popular in | March |
Cheapest in | February |
Average price | $482 |
Good round-trip deal | $393 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/19
6:30 am-12:17 pm
1 stop4h 47m
Charleston
Tue 5/19
5:08 pm-9:13 pm
1 stop5h 05m
$237
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 5/16
2:25 pm-9:15 pm
1 stop5h 50m
Charlotte Douglas
Wed 5/20
7:20 pm-10:00 pm
1 stop3h 40m
$238
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/12
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Sat 5/16
4:40 pm-6:00 pm
Nonstop2h 20m
$239
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sun 6/7
6:25 am-4:20 pm
1 stop8h 55m
Charleston
Tue 6/9
1:50 pm-3:00 pm
Nonstop2h 10m
$284
St. LouisColumbia
STL - CAE
STLCAE
Lambert-St Louis
Sat 5/2
7:45 am-7:03 pm
2 stops10h 18m
Columbia Metropolitan
Wed 5/6
2:20 pm-9:13 pm
1 stop7h 53m
$288
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 6/8
5:35 pm-11:15 pm
1 stop4h 40m
Charlotte Douglas
Sat 6/13
1:00 pm-7:45 pm
1 stop7h 45m
$292
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 6/1
2:10 pm-9:40 pm
2 stops6h 30m
Charlotte Douglas
Mon 6/8
11:35 am-3:55 pm
1 stop5h 20m
$296
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/11
4:45 pm-10:10 pm
1 stop4h 25m
Charlotte Douglas
Mon 8/17
11:50 am-12:45 pm
Nonstop1h 55m
$309
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/12
6:30 am-12:17 pm
1 stop4h 47m
Charleston
Wed 5/13
10:15 am-9:13 pm
2 stops11h 58m
$312
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 5/11
7:09 pm-12:45 am
1 stop4h 36m
Charlotte Douglas
Wed 5/13
10:10 am-9:13 pm
2 stops12h 03m
$313
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-CLT
STL-CHS
STL-GSP
STL-HHH
STL-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-CLT
STL-CHS
STL-GSP
STL-HHH
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $89). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 18, 2026.
Unlike in the morning, when flights are generally more expensive, you can save up to 65% on flights from St. Louis to South Carolina by exploring options for tickets in the evening.
What is the cheapest day to fly from St. Louis to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from St. Louis to South Carolina. Price data was last updated on March 14, 2026.
Travelers seeking maximum savings on their St. Louis to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 18, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on March 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 5 airlines flying from St. Louis to South Carolina
Discover the top 5 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$193 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$388 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$386 | FlexibilityNo cancel fee | On-time63% |