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South Carolina

$69+ Cheap flights from St. Louis (STL) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from St. Louis to South Carolina

Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated July 29, 2025.

Round-trip from

$185
(FlightHub)

One-way from

$69
(Booking.com)

Popular in

December

Cheapest in

October

Average price

$374

Good round-trip deal

$267 or less
From Lambert-St Louis to South Carolina
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One-way flight from Lambert-St Louis to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Lambert-St Louis to South Carolina.
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Find flight deals from St. Louis to South Carolina

Cheapest flights from St. Louis to South Carolina
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/95:40 pmSTL - CLT
1 stop17h 02mFrontier
Sat 8/167:03 pmCLT - STL
1 stop5h 44mFrontier
Deal found 7/28$185
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/312:30 pmSTL - MYR
1 stop4h 23mSpirit Airlines
Wed 9/38:48 pmMYR - STL
1 stop15h 02mSpirit Airlines
Deal found 7/29$192
This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/712:05 pmSTL - CLT
1 stop24h 24mSpirit Airlines
Wed 9/106:00 amCLT - STL
1 stop28h 40mSpirit Airlines
Deal found 7/27$192
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2810:37 amSTL - CLT
1 stop12h 18mMultiple Airlines
Mon 9/15:32 pmCLT - STL
1 stop16h 39mMultiple Airlines
Deal found 7/28$197
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/275:52 pmSTL - CAE
1 stop4h 52mAmerican Airlines
Wed 9/310:38 amCAE - STL
1 stop6h 37mAmerican Airlines
Deal found 7/28$211
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:00 amSTL - MYR
1 stop6h 35mDelta
Sat 8/306:35 pmMYR - STL
1 stop4h 20mDelta
Deal found 7/27$227
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/610:15 amSTL - SAV
1 stop4h 45mDelta
Sat 9/136:40 amSAV - STL
1 stop6h 41mDelta
Deal found 7/27$227
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:10 amSTL - CHS
1 stop5h 39mDelta
Sat 10/411:29 amCHS - STL
1 stop6h 13mDelta
Deal found 7/28$227
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:06 amSTL - MYR
2 stops8h 17mAmerican Airlines
Sat 8/306:19 amMYR - STL
1 stop6h 52mAmerican Airlines
Deal found 7/26$232
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/63:59 pmSTL - SAV
1 stop5h 45mAmerican Airlines
Sat 9/136:05 amSAV - STL
2 stops8h 26mAmerican Airlines
Deal found 7/26$232
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/273:10 pmSTL - CLT
Nonstop1h 50mSouthwest
Wed 9/36:30 amCLT - STL
2 stops8h 45mSouthwest
Deal found 7/28$232
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:23 amSTL - CHS
2 stops8h 13mAmerican Airlines
Sat 10/47:28 pmCHS - STL
1 stop4h 39mAmerican Airlines
Deal found 7/27$232

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

St. Louis

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 8/9

5:40 pm-11:42 am

1 stop17h 02m

Charlotte Douglas

Sat 8/16

7:03 pm-11:47 pm

1 stop5h 44m

$185

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sun 9/7

12:05 pm-1:29 pm

1 stop24h 24m

Charlotte Douglas

Wed 9/10

6:00 am-9:40 am

1 stop28h 40m

$192

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 8/28

10:37 am-11:55 pm

1 stop12h 18m

Charlotte Douglas

Mon 9/1

5:32 pm-9:11 am

1 stop16h 39m

$197

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Sun 8/17

2:30 pm-7:53 pm

1 stop4h 23m

Myrtle Beach Intl

Thu 8/21

8:48 pm-1:32 pm

1 stop17h 44m

$199

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 8/27

5:52 pm-11:44 pm

1 stop4h 52m

Columbia Metropolitan

Wed 9/3

10:38 am-4:15 pm

1 stop6h 37m

$211

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Wed 8/27

6:00 am-1:35 pm

1 stop6h 35m

Myrtle Beach Intl

Sat 8/30

6:35 pm-9:55 pm

1 stop4h 20m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 8/27

3:10 pm-6:00 pm

Nonstop1h 50m

Charlotte Douglas

Wed 9/3

4:50 pm-9:25 pm

1 stop5h 35m

$227

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Sat 9/6

10:15 am-4:00 pm

1 stop4h 45m

Savannah/Hilton Head

Sat 9/13

6:40 am-12:21 pm

1 stop6h 41m

$227

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Sat 9/27

7:10 am-1:49 pm

1 stop5h 39m

Charleston

Sat 10/4

11:29 am-4:42 pm

1 stop6h 13m

$227

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Wed 8/27

6:06 am-3:23 pm

2 stops8h 17m

Myrtle Beach Intl

Sat 8/30

6:19 am-12:11 pm

1 stop6h 52m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South Carolina

What is the cheapest month to book a flight from St. Louis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $217). Flying from St. Louis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SC?

Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,899 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Spirit Airlines
6.3
Okay
8,040 reviews
Southwest
8.0
Very good
4,238 reviews

Boarding

8.1

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South Carolina?

    For a flight from St. Louis to South Carolina, you will be flying from Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this St. Louis to South Carolina flight route?

    Within the past month, 6 users have taken a look at flights from Lambert-St Louis to South Carolina.

  • What are the cheapest airlines to fly from St. Louis to South Carolina one-way?

    The cheapest airlines for a one-way flight from St. Louis to South Carolina are Spirit Airlines ($69), Frontier ($93), and Southwest ($109).

  • What are the most popular routes from St. Louis to South Carolina?

    While some choose either Lambert-St Louis - Charleston or Lambert-St Louis - Myrtle Beach Intl, Lambert-St Louis - Charlotte Douglas is the most popular route from St. Louis to South Carolina.

  • What are the cheapest flights from St. Louis to South Carolina?

    Looking for the cheapest flight from St. Louis to South Carolina? While on average our users pay $364, our data indicates the cheapest price to be $192. The most popular route (Lambert-St Louis - Charlotte Douglas), is priced around $199.

  • Can I find deals for flights from St. Louis to South Carolina that include hotel bookings?

    Yes. In addition to deals on St. Louis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South Carolina.

  • Can I find deals for business class flights from St. Louis to South Carolina?

    Yes. Cheapflights offers flight deals from St. Louis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $217). Flying from St. Louis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from St. Louis to South Carolina

Discover the top 5 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$99Average$193FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$383FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$379FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$287Average$400FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$465Average$640FlexibilityNo cancel feeOn-time69%

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