South Carolina

$147+ Cheap flights from Oregon to South Carolina

PDX — CHS
Nov 29 — Dec 61
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Cheap flight deals from Oregon to South Carolina

Cheapest flights from Oregon to South Carolina

Thu 12/311:17 pm -
1 stop8h 24m
Tue 12/82:18 pm -
1 stop10h 40m
Deal found 10/27$319
Wed 12/210:00 pm -
1 stop9h 33m
Sat 12/127:20 am -
1 stop9h 21m
Deal found 10/27$352
Fri 12/411:17 pm -
1 stop8h 24m
Sat 12/124:04 pm -
1 stop8h 54m
Deal found 10/26$359
Thu 12/36:20 am -
2 stops10h 05m
Tue 12/83:25 pm -
2 stops11h 00m
Deal found 10/27$362
Fri 12/410:00 pm -
1 stop8h 45m
Sat 12/127:20 am -
1 stop9h 21m
Deal found 10/26$372
Thu 12/311:54 am -
1 stop9h 10m
Sat 12/54:01 pm -
1 stop8h 57m
Deal found 10/29$375
Sat 12/1211:10 pm -
1 stop9h 40m
Tue 2/97:01 am -
1 stop7h 36m
Deal found 10/27$377
Tue 12/111:21 pm -
1 stop9h 08m
Sat 12/53:38 pm -
1 stop9h 23m
Deal found 10/30$379
Wed 12/211:17 pm -
1 stop8h 24m
Sat 12/124:04 pm -
1 stop8h 54m
Deal found 10/30$381
Sat 12/127:00 am -
2 stops13h 59m
Tue 2/94:02 pm -
1 stop8h 13m
Deal found 10/27$382
Thu 12/311:17 pm -
1 stop8h 24m
Fri 12/112:18 pm -
1 stop10h 40m
Deal found 10/26$389
Fri 12/411:10 pm -
1 stop7h 20m
Mon 12/75:10 am -
1 stop8h 39m
Deal found 10/30$395

Find flight deals from Oregon to South Carolina

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Delta)

One-way from

$147
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$508
Provider with most accurate pricing for Portland-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Portland-Myrtle Beach Intl flights.
From Oregon to South Carolina
One-way flight from Oregon to South Carolina
Highest demand for flights based on searches. 4% potential increase in price ($26 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Average for round-trip flights in October 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Oregon to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandGreenville

PDX Portland - GSP Greenville

PDXGSP

Portland

Sat 11/21

11:20 pm-10:11 am

1 stop7h 51m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$160

PortlandGreenville

PDX Portland - GSP Greenville

PDXGSP

Portland

Sat 11/21

7:15 pm-10:02 am

2 stops11h 47m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$165

EugeneGreenville

EUG Eugene - GSP Greenville

EUGGSP

Eugene

Sat 12/5

5:20 am-7:57 pm

2 stops11h 37m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$165

PortlandCharleston

PDX Portland - CHS Charleston

PDXCHS

Portland

Wed 12/9

6:00 am-4:30 pm

1 stop7h 30m

Charleston

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$188
Quickest round-trip

PortlandCharleston

PDX Portland - CHS Charleston

PDXCHS

Portland

Wed 12/16

6:50 am-4:27 pm

1 stop6h 37m

Charleston

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$188

PortlandCharleston

PDX Portland - CHS Charleston

PDXCHS

Portland

Sat 4/24

6:15 am-4:36 pm

1 stop7h 21m

Charleston

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$190

EugeneGreenville

EUG Eugene - GSP Greenville

EUGGSP

Eugene

Sat 2/27

6:15 am-9:58 pm

2 stops12h 43m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$190

PortlandMyrtle Beach

PDX Portland - MYR Myrtle Beach Intl

PDXMYR

Portland

Mon 1/4

10:38 pm-10:25 am

1 stop8h 47m

Myrtle Beach Intl

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$193

PortlandGreenville

PDX Portland - GSP Greenville

PDXGSP

Portland

Sat 2/27

9:45 pm-9:25 am

1 stop8h 40m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$193

PortlandGreenville

PDX Portland - GSP Greenville

PDXGSP

Portland

Sat 2/27

7:00 pm-10:05 am

2 stops12h 05m

Greenville

Wed 12/31

12:00 am-9:00 pm

Nonstop0h 00m

$198

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Oregon to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Oregon with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Oregon to South Carolina

What is the cheapest month to book a flight from Oregon to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Oregon to South Carolina (average of $403). Flying from Oregon to South Carolina in March is currently the most expensive (average of $641). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Oregon to South Carolina?

Airfare is below average for this route at the moment.
Oregon to South Carolina flights typically cost between $402 and $600 in April.
The cheapest round-trip price found within the last 5 days was $374 on United Airlines (Apr 13-Apr 14).

How far ahead should I book a flight from Oregon to South Carolina?

To ensure you get the cheapest price possible for a flight from Oregon to South Carolina, you should look to book at least 90 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

Reviews of airlines servicing South Carolina

Read through reviews of airlines operating flights from Oregon to South Carolina, such as Alaska Airlines,Southwest, andDelta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Overall

7.9

Comfort

7.8

Food

7.0

Entertainment

7.0

Boarding

8.1

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Eugene,Mar 2026

MFR - SEA

Alaska Airlines is is always good. There where few choices of what to drink, and no food. No blankets, no pillows, and you h ats ok. I just had open heart surgery And i could have used something. But the flight and the crew where exelent. So all is well

Related info for your journey

  • How long is the flight from Oregon to South Carolina?

    There are many flights that can get you from Oregon to South Carolina in 8h 24m. Fly via Delta, United Airlines, or Southwest to get the fastest option. The distance between Oregon and South Carolina is about 2429 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Oregon to South Carolina one-way?

    The cheapest airlines for a one-way flight from Oregon to South Carolina are Volaris ($98), Delta ($124), and Alaska Airlines ($134).

  • Can I find deals for flights from Oregon to South Carolina that include hotel bookings?

    Yes. In addition to deals on Oregon to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Oregon to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Oregon to South Carolina.

  • Can I find deals for business class flights from Oregon to South Carolina?

    Yes. Cheapflights offers flight deals from Oregon to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Oregon to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Oregon to South Carolina (average of $403). Flying from Oregon to South Carolina in March is currently the most expensive (average of $641). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Oregon to South Carolina

Top 5 airlines flying from Oregon to South Carolina

AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$208Average$588FlexibilityNo cancel feeOn-time69%
DeltaCheapest$266Average$505FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$298Average$476FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$304Average$509FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$393Average$571FlexibilityNo cancel feeOn-time63%

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