HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$145+ Cheap flights from Moline (MLI) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
MLI — CHS
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Moline to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Moline to South Carolina

Cheapest flights from Moline to South Carolina
Explore the most affordable flight options available from Moline to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:48 pmMLI - CLT
1 stop17h 48mAmerican Airlines
Sat 12/133:30 pmCLT - MLI
Nonstop2h 31mAmerican Airlines
Deal found 10/28$223
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/191:00 pmMLI - CHS
1 stop5h 18mUnited Airlines
Tue 12/236:05 amCHS - MLI
1 stop7h 08mUnited Airlines
Deal found 10/27$249
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:05 amMLI - MYR
1 stop6h 51mDelta
Mon 11/246:50 pmMYR - MLI
1 stop4h 45mDelta
Deal found 10/27$249
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:05 amMLI - SAV
1 stop4h 16mDelta
Fri 12/55:27 pmSAV - MLI
1 stop6h 06mDelta
Deal found 10/27$249
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:37 pmMLI - CAE
1 stop5h 54mAmerican Airlines
Tue 12/93:09 pmCAE - MLI
1 stop8h 50mAmerican Airlines
Deal found 10/27$249
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/199:50 amMLI - MYR
2 stops9h 59mAmerican Airlines
Mon 11/243:32 pmMYR - MLI
1 stop6h 35mAmerican Airlines
Deal found 10/27$254
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:17 amMLI - SAV
1 stop6h 55mAmerican Airlines
Fri 12/51:24 pmSAV - MLI
2 stops11h 23mAmerican Airlines
Deal found 10/27$254
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/111:00 pmMLI - CHS
1 stop7h 08mUnited Airlines
Sat 11/156:15 amCHS - MLI
1 stop5h 00mUnited Airlines
Deal found 10/27$259
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:17 amMLI - HHH
1 stop5h 12mAmerican Airlines
Sat 11/152:51 pmHHH - MLI
2 stops10h 04mAmerican Airlines
Deal found 10/27$264
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:55 pmMLI - CAE
1 stop4h 35mUnited Airlines
Mon 11/175:24 pmCAE - MLI
1 stop4h 53mUnited Airlines
Deal found 10/29$279
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amMLI - SAV
1 stop4h 24mDelta
Wed 12/245:59 pmSAV - MLI
1 stop5h 31mDelta
Deal found 10/27$284
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/213:35 pmMLI - GSP
1 stop7h 20mAmerican Airlines
Fri 12/58:14 pmGSP - MLI
1 stop4h 33mAmerican Airlines
Deal found 10/27$284

Cheap flight deals from Moline to South Carolina

Keep the following information in mind while searching for Moline to South Carolina flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$223
(American Airlines)

One-way from

$146
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$368
Provider with most accurate pricing for Moline Quad-City-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Moline Quad-City-Myrtle Beach Intl flights.
Search Deals
From Moline Quad-City to South Carolina
Search Deals
One-way flight from Moline Quad-City to South Carolina
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($10 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Moline to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Moline to South Carolina that are best for you.

Fly from

Moline

Fly to

South Carolina

Route

Depart

Return

Price

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 12/19

1:00 pm-7:18 pm

1 stop5h 18m

Charleston

Tue 12/23

6:05 am-12:13 pm

1 stop7h 08m

$249

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Wed 11/19

6:05 am-1:56 pm

1 stop6h 51m

Myrtle Beach Intl

Mon 11/24

6:50 pm-10:35 pm

1 stop4h 45m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/21

12:44 pm-7:38 pm

1 stop5h 54m

Savannah/Hilton Head

Tue 3/3

6:25 am-12:16 pm

1 stop6h 51m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Tue 1/13

6:30 am-2:02 pm

1 stop6h 32m

Charleston

Sun 1/18

6:05 am-10:12 am

1 stop5h 07m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Thu 12/11

6:00 am-11:24 am

1 stop4h 24m

Savannah/Hilton Head

Sun 12/14

7:10 pm-10:33 pm

1 stop4h 23m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Wed 11/19

5:46 am-2:54 pm

1 stop8h 08m

Savannah/Hilton Head

Fri 12/5

5:18 pm-9:16 pm

1 stop4h 58m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Tue 2/17

8:30 am-1:52 pm

1 stop4h 22m

Charleston

Sat 2/21

6:00 am-10:16 am

1 stop5h 16m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Wed 11/19

6:05 am-11:21 am

1 stop4h 16m

Savannah/Hilton Head

Fri 12/5

5:27 pm-10:33 pm

1 stop6h 06m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

6:13 am-2:55 pm

1 stop7h 42m

Savannah/Hilton Head

Fri 2/20

3:45 pm-10:49 pm

1 stop8h 04m

$249

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

6:13 am-2:55 pm

1 stop7h 42m

Savannah/Hilton Head

Sat 2/21

7:00 am-3:04 pm

1 stop9h 04m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 57 results
1
2
3
...
6

Best time to book a flight from Moline to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Moline with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Moline to South Carolina

What is the cheapest month to book a flight from Moline to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 29, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Moline to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Moline to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Moline to South Carolina?

    Most people fly from Moline Quad-City (MLI) if they book a flight from Moline to South Carolina. Moline Quad-City is conveniently located just 4.0 mi from Moline’s city center.

  • How long is the flight from Moline to South Carolina?

    There are many flights that can get you from Moline to South Carolina in 5h 18m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. Airlines will cover a distance of 824 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Moline to South Carolina one-way?

    One-way options have recently been found by users for as low as $145 on Delta. Other airlines that offer cheap prices include American Airlines from $197 and United Airlines from $239 one-way.

  • What are the most popular routes from Moline to South Carolina?

    Most travelers choose Moline Quad-City - Charlotte Douglas, Moline Quad-City - Savannah/Hilton Head or Moline Quad-City - Columbia Metropolitan when deciding on the best route from Moline to South Carolina.

  • Can I find deals for flights from Moline to South Carolina that include hotel bookings?

    Yes. In addition to deals on Moline to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Moline to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Moline to South Carolina.

  • Can I find deals for business class flights from Moline to South Carolina?

    Yes. Cheapflights offers flight deals from Moline to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Moline to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Moline to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Sky Harbor Intl flights
O'Hare Intl to Las Vegas flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Newark flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Orlando flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to Denver flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Miami flights
O'Hare Intl to Tampa flights
O'Hare Intl to Seattle flights
O'Hare Intl to San Francisco flights
O'Hare Intl to Fort Myers flights
Midway to Dallas/Fort Worth flights
O'Hare Intl to Boston flights
O'Hare Intl to Atlanta flights
O'Hare Intl to Dulles Intl flights
Midway to John F Kennedy Intl flights
O'Hare Intl to Ontario flights
O'Hare Intl to Baltimore flights
O'Hare Intl to Hobby flights
O'Hare Intl to Santa Ana flights
O'Hare Intl to New Orleans flights
Midway to Los Angeles flights
O'Hare Intl to George Bush Intcntl flights
O'Hare Intl to Reagan-National flights
Midway to Sky Harbor Intl flights
O'Hare Intl to San Diego flights
O'Hare Intl to Honolulu flights
O'Hare Intl to Nashville flights
Midway to LaGuardia flights
Midway to Atlanta flights
Midway to Miami flights
O'Hare Intl to Salt Lake City flights
Midway to Orlando flights
Midway to Tampa flights
O'Hare Intl to Philadelphia flights
Midway to Fort Lauderdale flights
O'Hare Intl to Austin flights
O'Hare Intl to Sarasota flights
St. Louis to Las Vegas flights
Midway to Denver flights
Midway to Las Vegas flights
Midway to Baltimore flights
St. Louis to LaGuardia flights
O'Hare Intl to Raleigh flights
O'Hare Intl to Charlotte flights
O'Hare Intl to West Palm Beach flights

Top 3 airlines flying from Moline to South Carolina

Discover the top 3 airlines that operate flights from Moline to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$351FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$221Average$362FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$338FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.