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South Carolina

$188+ Cheap flights from Moline (MLI) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
MLI — CHS
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Moline to South Carolina

Cheapest flights from Moline to South Carolina
Explore the most affordable flight options available from Moline to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:50 amMLI - MYR
1 stop5h 41mDelta
Fri 1/26:59 pmMYR - MLI
1 stop4h 31mDelta
Deal found 12/25$311
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:00 pmMLI - GSP
1 stop6h 47mUnited Airlines
Thu 1/15:36 pmGSP - MLI
1 stop4h 45mUnited Airlines
Deal found 12/26$369
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:00 amMLI - CLT
Nonstop2h 25mAmerican Airlines
Sat 1/38:34 pmCLT - MLI
Nonstop2h 34mAmerican Airlines
Deal found 12/26$372
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:21 pmMLI - CLT
1 stop6h 17mAmerican Airlines
Sun 1/48:34 pmCLT - MLI
Nonstop2h 34mAmerican Airlines
Deal found 12/26$408
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:58 pmMLI - CLT
1 stop5h 48mDelta
Sun 1/46:53 pmCLT - MLI
1 stop4h 37mDelta
Deal found 12/26$418
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:47 amMLI - CLT
1 stop5h 51mUnited Airlines
Sat 1/36:00 amCLT - MLI
2 stops7h 13mUnited Airlines
Deal found 12/26$423
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:00 amMLI - CLT
Nonstop2h 25mAmerican Airlines
Thu 1/12:51 pmCLT - MLI
Nonstop2h 23mAmerican Airlines
Deal found 12/26$469
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:47 amMLI - CLT
2 stops7h 08mUnited Airlines
Sun 1/46:20 amCLT - MLI
1 stop4h 52mUnited Airlines
Deal found 12/26$494
This American Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:43 pmMLI - CLT
Nonstop2h 22mAmerican Airlines
Thu 1/12:51 pmCLT - MLI
Nonstop2h 23mAmerican Airlines
Deal found 12/27$495
This Delta deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:50 amMLI - CHS
1 stop7h 06mDelta
Mon 12/2911:15 amCHS - MLI
1 stop6h 01mDelta
Deal found 12/28$921
This American Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/285:43 pmMLI - CHS
1 stop5h 22mAmerican Airlines
Mon 12/294:13 pmCHS - MLI
2 stops8h 27mAmerican Airlines
Deal found 12/28$1,013

Find flight deals from Moline to South Carolina

Keep the following information in mind while searching for Moline to South Carolina flight deals. Data was last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$259
(Delta)

One-way from

$188
(Kiwi.com)

Popular in

June

Cheapest in

May

Average price

$436
Provider with most accurate pricing for Moline Quad-City-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Moline Quad-City-Myrtle Beach Intl flights.
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From Moline Quad-City to South Carolina
Search Deals
One-way flight from Moline Quad-City to South Carolina
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Moline to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Moline to South Carolina that are best for you.

Fly from

Moline

Fly to

South Carolina

Route

Depart

Return

Price

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

5:01 pm-11:57 pm

1 stop5h 56m

Savannah/Hilton Head

Sat 2/21

10:27 am-4:16 pm

1 stop6h 49m

$259

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

5:01 pm-11:57 pm

1 stop5h 56m

Savannah/Hilton Head

Fri 2/20

4:46 pm-10:24 pm

1 stop6h 38m

$259

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/23

6:15 am-11:39 am

1 stop4h 24m

Charleston

Fri 1/30

3:16 pm-9:58 pm

1 stop7h 42m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Thu 3/5

6:13 am-4:20 pm

1 stop9h 07m

Myrtle Beach Intl

Mon 3/9

5:18 pm-10:53 pm

1 stop6h 35m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

5:11 pm-11:55 pm

1 stop5h 44m

Charleston

Sun 1/18

5:18 pm-10:33 pm

1 stop6h 15m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Wed 2/11

6:19 am-11:35 am

1 stop4h 16m

Myrtle Beach Intl

Sat 2/14

6:00 am-12:15 pm

1 stop7h 15m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Tue 5/19

5:00 pm-11:38 pm

1 stop5h 38m

Myrtle Beach Intl

Sun 5/24

6:00 am-10:26 am

1 stop5h 26m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Tue 5/19

5:00 pm-11:38 pm

1 stop5h 38m

Myrtle Beach Intl

Wed 5/27

6:00 am-10:26 am

1 stop5h 26m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Fri 1/30

5:11 pm-11:58 pm

1 stop5h 47m

Savannah/Hilton Head

Sun 2/1

4:46 pm-10:33 pm

1 stop6h 47m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 1/31

5:20 pm-11:58 pm

1 stop5h 38m

Savannah/Hilton Head

Tue 2/3

4:46 pm-10:33 pm

1 stop6h 47m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 43 results
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Best time to book a flight from Moline to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Moline with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Moline to South Carolina

What is the cheapest month to book a flight from Moline to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 28, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Moline to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,019 reviews

Boarding

8.1

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,019 reviews
Delta
7.9
Good
8,019 reviews

Boarding

8.1

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,113 reviews
Delta
7.9
Good
8,019 reviews

Boarding

8.1

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,072 reviews
Delta
7.9
Good
8,019 reviews

Boarding

8.1

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Moline to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Moline to South Carolina?

    Most people fly from Moline Quad-City (MLI) if they book a flight from Moline to South Carolina. Moline Quad-City is conveniently located just 4.0 mi from Moline’s city center.

  • How long is the flight from Moline to South Carolina?

    There are many flights that can get you from Moline to South Carolina in 3h 49m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 637 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Moline to South Carolina?

    Most travelers choose Moline Quad-City - Charlotte Douglas, Moline Quad-City - Charleston or Moline Quad-City - Myrtle Beach Intl when deciding on the best route from Moline to South Carolina.

  • Can I find deals for flights from Moline to South Carolina that include hotel bookings?

    Yes. In addition to deals on Moline to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Moline to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Moline to South Carolina.

  • Can I find deals for business class flights from Moline to South Carolina?

    Yes. Cheapflights offers flight deals from Moline to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Moline to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Moline to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Moline to South Carolina

Discover the top 3 airlines that operate flights from Moline to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$357FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$221Average$397FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$315FlexibilityNo cancel feeOn-timeN/A

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