HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$173+ Cheap flights from Moline (MLI) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/11. Fares are subject to change and may not be available on all flights or dates of travel.
MLI — CHS
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Moline to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Moline to South Carolina

Cheapest flights from Moline to South Carolina
Explore the most affordable flight options available from Moline to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:48 pmMLI - CLT
1 stop21h 22mAmerican Airlines
Sat 12/138:31 pmCLT - MLI
Nonstop2h 32mAmerican Airlines
Deal found 12/12$349
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:08 pmMLI - MYR
1 stop5h 35mDelta
Thu 12/255:12 pmMYR - MLI
1 stop6h 18mDelta
Deal found 12/13$354
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:43 pmMLI - MYR
1 stop5h 12mAmerican Airlines
Mon 12/226:00 amMYR - MLI
2 stops9h 05mAmerican Airlines
Deal found 12/12$359
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amMLI - CLT
Nonstop2h 25mAmerican Airlines
Wed 12/315:10 amCLT - MLI
1 stop6h 29mAmerican Airlines
Deal found 12/13$382
This United Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:00 pmMLI - CLT
1 stop7h 20mUnited Airlines
Wed 12/316:20 amCLT - MLI
1 stop6h 53mUnited Airlines
Deal found 12/12$392
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:43 pmMLI - CLT
Nonstop2h 22mAmerican Airlines
Sat 1/178:08 pmCLT - MLI
Nonstop2h 25mAmerican Airlines
Deal found 12/14$398
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:43 pmMLI - MYR
1 stop5h 12mAmerican Airlines
Thu 1/16:00 amMYR - MLI
2 stops9h 05mAmerican Airlines
Deal found 12/12$406
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amMLI - CLT
1 stop6h 27mDelta
Sat 1/171:13 pmCLT - MLI
1 stop4h 13mDelta
Deal found 12/14$418
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:50 amMLI - MYR
1 stop5h 41mDelta
Thu 1/15:12 pmMYR - MLI
1 stop6h 18mDelta
Deal found 12/13$429
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:58 pmMLI - CLT
1 stop5h 48mDelta
Wed 12/314:51 pmCLT - MLI
1 stop6h 39mDelta
Deal found 12/13$441
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:35 pmMLI - MYR
2 stops6h 57mAmerican Airlines
Thu 12/2512:48 pmMYR - MLI
2 stops11h 03mAmerican Airlines
Deal found 12/13$456
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:00 pmMLI - CLT
1 stop7h 20mUnited Airlines
Sat 1/36:20 amCLT - MLI
1 stop4h 52mUnited Airlines
Deal found 12/13$462

Find flight deals from Moline to South Carolina

Keep the following information in mind while searching for Moline to South Carolina flight deals. Data was last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$243
(Delta)

One-way from

$173
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$436
Provider with most accurate pricing for Moline Quad-City-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Moline Quad-City-Myrtle Beach Intl flights.
Search Deals
From Moline Quad-City to South Carolina
Search Deals
One-way flight from Moline Quad-City to South Carolina
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($10 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Moline to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Moline to South Carolina that are best for you.

Fly from

Moline

Fly to

South Carolina

Route

Depart

Return

Price

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

5:11 pm-11:55 pm

1 stop5h 44m

Charleston

Sun 1/18

12:53 pm-4:26 pm

1 stop4h 33m

$243

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

5:00 pm-11:57 pm

1 stop5h 57m

Savannah/Hilton Head

Fri 2/20

4:51 pm-10:30 pm

1 stop6h 39m

$259

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

12:44 pm-7:41 pm

1 stop5h 57m

Savannah/Hilton Head

Sat 2/21

1:15 pm-11:45 pm

2 stops11h 30m

$264

MolineColumbia

MLI - CAE

MLICAE

Moline Quad-City

Thu 1/8

3:45 pm-9:21 pm

1 stop4h 36m

Columbia Metropolitan

Thu 1/22

5:07 pm-9:36 pm

1 stop5h 29m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Sat 3/7

6:13 am-4:20 pm

1 stop9h 07m

Myrtle Beach Intl

Wed 3/11

6:23 pm-9:58 pm

1 stop4h 35m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Mon 2/9

5:11 pm-10:07 pm

1 stop3h 56m

Charleston

Sat 2/14

1:04 pm-4:18 pm

1 stop4h 14m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 2/14

1:59 pm-9:44 pm

2 stops6h 45m

Savannah/Hilton Head

Fri 2/20

6:00 am-3:04 pm

2 stops10h 04m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Tue 3/17

3:26 pm-10:16 pm

1 stop5h 50m

Savannah/Hilton Head

Tue 3/24

5:31 pm-8:59 pm

1 stop4h 28m

$269

MolineColumbia

MLI - CAE

MLICAE

Moline Quad-City

Tue 1/6

5:51 am-11:58 am

1 stop5h 07m

Columbia Metropolitan

Fri 1/23

5:06 pm-10:33 pm

1 stop6h 27m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Mon 2/9

11:00 am-9:11 pm

2 stops9h 11m

Charleston

Sat 2/14

6:33 am-12:15 pm

1 stop6h 42m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 44 results
1
2
3
...
5

Best time to book a flight from Moline to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Moline with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Moline to South Carolina

What is the cheapest month to book a flight from Moline to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 14, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Moline to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,094 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Moline to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Moline to South Carolina?

    Most people fly from Moline Quad-City (MLI) if they book a flight from Moline to South Carolina. Moline Quad-City is conveniently located just 4.0 mi from Moline’s city center.

  • How long is the flight from Moline to South Carolina?

    There are many flights that can get you from Moline to South Carolina in 4h 39m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 728 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Moline to South Carolina?

    Most travelers choose Moline Quad-City - Charlotte Douglas, Moline Quad-City - Charleston or Moline Quad-City - Myrtle Beach Intl when deciding on the best route from Moline to South Carolina.

  • Can I find deals for flights from Moline to South Carolina that include hotel bookings?

    Yes. In addition to deals on Moline to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Moline to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Moline to South Carolina.

  • Can I find deals for business class flights from Moline to South Carolina?

    Yes. Cheapflights offers flight deals from Moline to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Moline to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Moline to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Orlando flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Sky Harbor Intl flights
O'Hare Intl to Miami flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to Denver flights
O'Hare Intl to Newark flights
O'Hare Intl to Tampa flights
O'Hare Intl to San Francisco flights
Midway to Los Angeles flights
O'Hare Intl to Atlanta flights
O'Hare Intl to Seattle flights
Midway to Orlando flights
Midway to Miami flights
O'Hare Intl to Santa Ana flights
Midway to Dallas/Fort Worth flights
O'Hare Intl to San Diego flights
Midway to Las Vegas flights
O'Hare Intl to Ontario flights
O'Hare Intl to Fort Myers flights
O'Hare Intl to Honolulu flights
Midway to Fort Lauderdale flights
Midway to Atlanta flights
St. Louis to Las Vegas flights
O'Hare Intl to George Bush Intcntl flights
O'Hare Intl to Salt Lake City flights
O'Hare Intl to New Orleans flights
O'Hare Intl to Love Field flights
Midway to John F Kennedy Intl flights
O'Hare Intl to Austin flights
O'Hare Intl to Reagan-National flights
Midway to Tampa flights
O'Hare Intl to Hobby flights
O'Hare Intl to Philadelphia flights
O'Hare Intl to Key West flights
O'Hare Intl to Palm Springs flights
O'Hare Intl to Nashville flights
O'Hare Intl to West Palm Beach flights
Midway to Sky Harbor Intl flights
O'Hare Intl to Sarasota flights
O'Hare Intl to Baltimore flights
Midway to LaGuardia flights
O'Hare Intl to Boston flights
O'Hare Intl to Burbank flights
O'Hare Intl to Dulles Intl flights
O'Hare Intl to Kahului flights

Top 3 airlines flying from Moline to South Carolina

Discover the top 3 airlines that operate flights from Moline to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$348FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$221Average$397FlexibilityNo cancel feeOn-time69%
DeltaCheapest$236Average$325FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.