HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$157+ Cheap flights from Moline (MLI) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
MLI — CHS
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Moline to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Moline to South Carolina

Cheapest flights from Moline to South Carolina
Explore the most affordable flight options available from Moline to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:51 pm
MLI
-
CLT
1 stop19h 26m
American Airlines
Sun 4/1911:01 am
CLT
-
MLI
Nonstop2h 26m
American Airlines
Deal found 2/18$268
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:00 am
MLI
-
CHS
1 stop4h 54m
Delta
Sun 8/166:30 am
CHS
-
MLI
1 stop4h 56m
Delta
Deal found 2/17$269
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:00 pm
MLI
-
MYR
1 stop5h 38m
Delta
Mon 8/106:00 am
MYR
-
MLI
1 stop5h 26m
Delta
Deal found 2/16$269
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:15 pm
MLI
-
SAV
1 stop5h 44m
Delta
Tue 3/2412:33 pm
SAV
-
MLI
1 stop4h 59m
Delta
Deal found 2/17$269
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:00 pm
MLI
-
GSP
1 stop5h 37m
Delta
Wed 12/25:40 am
GSP
-
MLI
1 stop5h 46m
Delta
Deal found 2/18$269
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/213:31 pm
MLI
-
CHS
1 stop5h 53m
American Airlines
Wed 3/255:10 am
CHS
-
MLI
2 stops9h 11m
American Airlines
Deal found 2/17$274
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/231:30 pm
MLI
-
MYR
2 stops7h 58m
American Airlines
Sat 3/286:00 am
MYR
-
MLI
1 stop7h 11m
American Airlines
Deal found 2/15$274
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:30 am
MLI
-
SAV
2 stops11h 43m
United Airlines
Tue 3/245:00 pm
SAV
-
MLI
1 stop6h 22m
United Airlines
Deal found 2/17$274
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:02 pm
MLI
-
GSP
2 stops8h 10m
American Airlines
Sat 4/47:40 am
GSP
-
MLI
1 stop6h 41m
American Airlines
Deal found 2/15$274
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:31 pm
MLI
-
CHS
1 stop6h 17m
United Airlines
Tue 6/93:34 pm
CHS
-
MLI
2 stops9h 25m
United Airlines
Deal found 2/15$275
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:55 am
MLI
-
CHS
1 stop5h 01m
Delta
Sat 3/710:30 am
CHS
-
MLI
1 stop6h 46m
Delta
Deal found 2/16$279
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:01 pm
MLI
-
MYR
1 stop5h 56m
Delta
Tue 3/101:01 pm
MYR
-
MLI
2 stops10h 29m
Delta
Deal found 2/16$279

Find flight deals from Moline to South Carolina

Keep the following information in mind while searching for Moline to South Carolina flight deals. Data was last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$268
(American Airlines)

One-way from

$157
(Kiwi.com)

Popular in

June

Cheapest in

May

Average price

$413
Provider with most accurate pricing for Moline Quad-City-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Moline Quad-City-Myrtle Beach Intl flights.
Search Deals
From Moline Quad-City to South Carolina
Search Deals
One-way flight from Moline Quad-City to South Carolina
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Moline to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Moline to South Carolina that are best for you.

Fly from

Moline

Fly to

South Carolina

Route

Depart

Return

Price

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 6/5

5:16 pm-12:09 am

1 stop5h 53m

Charleston

Tue 6/9

5:30 am-10:26 am

1 stop5h 56m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Thu 5/28

4:24 pm-10:04 pm

1 stop4h 40m

Charleston

Tue 6/2

12:21 pm-6:17 pm

1 stop6h 56m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Mon 6/15

1:15 pm-9:48 pm

1 stop7h 33m

Charleston

Sat 6/20

6:00 am-9:59 am

1 stop4h 59m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 8/14

11:00 am-4:54 pm

1 stop4h 54m

Charleston

Sun 8/16

6:30 am-10:26 am

1 stop4h 56m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Sat 4/25

8:30 am-2:17 pm

1 stop4h 47m

Myrtle Beach Intl

Sat 5/2

3:14 pm-8:57 pm

1 stop6h 43m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sun 5/3

6:40 pm-12:17 am

1 stop4h 37m

Savannah/Hilton Head

Sat 5/9

4:11 pm-11:29 pm

1 stop8h 18m

$269

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 6/26

5:00 pm-10:56 pm

1 stop4h 56m

Charleston

Mon 6/29

6:30 am-10:26 am

1 stop4h 56m

$269

MolineSavannah

MLI - SAV

MLISAV

Moline Quad-City

Sat 5/2

10:39 am-5:37 pm

1 stop5h 58m

Savannah/Hilton Head

Fri 5/8

4:50 pm-8:57 pm

1 stop5h 07m

$269

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Tue 3/31

3:31 pm-10:45 pm

1 stop6h 14m

Greenville

Sat 4/4

7:40 am-1:21 pm

1 stop6h 41m

$269

MolineMyrtle Beach

MLI - MYR

MLIMYR

Moline Quad-City

Tue 7/28

5:00 pm-11:38 pm

1 stop5h 38m

Myrtle Beach Intl

Fri 8/7

6:00 am-10:26 am

1 stop5h 26m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 52 results
1
2
3
...
6

Best time to book a flight from Moline to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Moline with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Moline to South Carolina

What is the cheapest month to book a flight from Moline to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $297). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 19, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Moline to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,212 reviews

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,212 reviews
Delta
7.9
Good
8,212 reviews

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,321 reviews
Delta
7.9
Good
8,212 reviews

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,313 reviews
Delta
7.9
Good
8,212 reviews

Overall

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Moline to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Moline to South Carolina?

    Most people fly from Moline Quad-City (MLI) if they book a flight from Moline to South Carolina. Moline Quad-City is conveniently located just 4.0 mi from Moline’s city center.

  • How long is the flight from Moline to South Carolina?

    There are many flights that can get you from Moline to South Carolina in 4h 40m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. Airlines will cover a distance of 824 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Moline to South Carolina?

    Most travelers choose Moline Quad-City - Charlotte Douglas, Moline Quad-City - Charleston or Moline Quad-City - Myrtle Beach Intl when deciding on the best route from Moline to South Carolina.

  • Can I find deals for flights from Moline to South Carolina that include hotel bookings?

    Yes. In addition to deals on Moline to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Moline to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Moline to South Carolina.

  • Can I find deals for business class flights from Moline to South Carolina?

    Yes. Cheapflights offers flight deals from Moline to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Moline to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Moline to South Carolina (average of $124). Flying from Moline to South Carolina in December is currently the most expensive (average of $297). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Moline to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to Sky Harbor Intl flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Tampa flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to Miami flights
O'Hare Intl to Orlando flights
O'Hare Intl to Hobby flights
O'Hare Intl to Seattle flights
O'Hare Intl to Denver flights
O'Hare Intl to San Francisco flights
O'Hare Intl to Newark flights
O'Hare Intl to LaGuardia flights
Midway to Miami flights
O'Hare Intl to George Bush Intcntl flights
O'Hare Intl to Atlanta flights
Midway to Dallas/Fort Worth flights
O'Hare Intl to Fort Myers flights
Midway to Fort Lauderdale flights
O'Hare Intl to Ontario flights
Midway to Sky Harbor Intl flights
Midway to Hobby flights
O'Hare Intl to Santa Ana flights
Midway to Las Vegas flights
O'Hare Intl to Austin flights
O'Hare Intl to Dulles Intl flights
Midway to Orlando flights
O'Hare Intl to San Diego flights
O'Hare Intl to Reagan-National flights
O'Hare Intl to New Orleans flights
O'Hare Intl to Baltimore flights
O'Hare Intl to Love Field flights
O'Hare Intl to Philadelphia flights
Midway to John F Kennedy Intl flights
Midway to Los Angeles flights
St. Louis to Las Vegas flights
Midway to Atlanta flights
O'Hare Intl to Sarasota flights
O'Hare Intl to Nashville flights
O'Hare Intl to Salt Lake City flights
O'Hare Intl to Honolulu flights
O'Hare Intl to Boston flights
St. Louis to Orlando flights
O'Hare Intl to Charleston flights
O'Hare Intl to West Palm Beach flights
Midway to Fort Myers flights
O'Hare Intl to Burbank flights
O'Hare Intl to Savannah flights

Top 3 airlines flying from Moline to South Carolina

Discover the top 3 airlines that operate flights from Moline to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$303FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$376FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$415FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.