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$53+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated julio 30, 2025.

Round-trip from

$126
(Cheapflightsfares)

One-way from

$53
(FlightHub)

Popular in

December

Cheapest in

August

Average price

$315

Good round-trip deal

$76 or less

Good one-way deal

$51 or less
From Indianapolis to South Carolina
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One-way flight from Indianapolis to South Carolina
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Highest demand for flights based on searches. 10% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Indianapolis to South Carolina.
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Price to beat on a one-way flight from Indianapolis to South Carolina.
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Find flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/27:26 pmIND - MYR
Nonstop1h 40mAllegiant Air
sáb. 8/910:33 amMYR - IND
Nonstop1h 45mAllegiant Air
Deal found 7/29$123
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/26:30 amIND - SAV
Nonstop1h 48mAllegiant Air
sáb. 8/912:38 pmSAV - IND
Nonstop1h 44mAllegiant Air
Deal found 7/28$126
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/29:00 amIND - CLT
1 stop5h 05mSpirit Airlines
jue. 9/49:10 amCLT - IND
1 stop9h 08mSpirit Airlines
Deal found 7/28$139
This CheapOair deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/3012:58 pmIND - CLT
1 stop7h 48mMultiple Airlines
jue. 9/45:05 pmCLT - IND
Nonstop1h 43mMultiple Airlines
Deal found 7/28$149
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/98:00 amIND - MYR
Nonstop1h 43mMultiple Airlines
mié. 8/209:00 amMYR - IND
1 stop5h 07mMultiple Airlines
Deal found 7/30$164
This Booking.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/2012:20 pmIND - MYR
1 stop7h 46mSpirit Airlines
sáb. 9/2712:23 pmMYR - IND
1 stop6h 51mSpirit Airlines
Deal found 7/29$168
This FlightHub deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/258:53 amIND - CHS
1 stop10h 53mSpirit Airlines
mié. 10/298:44 pmCHS - IND
1 stop21h 34mSpirit Airlines
Deal found 7/30$169
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/253:45 pmIND - CLT
Nonstop1h 45mAmerican Airlines
mar. 9/304:02 pmCLT - IND
Nonstop1h 39mAmerican Airlines
Deal found 7/30$169
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/278:53 amIND - SAV
1 stop5h 22mMultiple Airlines
vie. 10/36:00 amSAV - IND
1 stop11h 19mMultiple Airlines
Deal found 7/28$174
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/107:15 amIND - CLT
1 stop3h 46mDelta
mar. 9/165:20 pmCLT - IND
1 stop3h 52mDelta
Deal found 7/27$177
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/108:00 amIND - CLT
2 stops10h 00mSouthwest
mar. 9/164:10 pmCLT - IND
1 stop4h 05mSouthwest
Deal found 7/28$179
This Cheapflightsfares deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/112:31 pmIND - CHS
Nonstop1h 44mAllegiant Air
lun. 8/43:05 pmCHS - IND
Nonstop1h 50mAllegiant Air
Deal found 7/30$180

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

sáb. 8/2

7:26 pm-9:06 pm

Nonstop1h 40m

Myrtle Beach Intl

sáb. 8/9

10:33 am-12:18 pm

Nonstop1h 45m

$123

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

mar. 9/2

9:00 am-2:05 pm

1 stop5h 05m

Charlotte Douglas

jue. 9/4

9:10 am-6:18 pm

1 stop9h 08m

$139

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

sáb. 8/30

12:58 pm-8:46 pm

1 stop7h 48m

Charlotte Douglas

jue. 9/4

5:05 pm-6:48 pm

Nonstop1h 43m

$149

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

sáb. 8/9

8:00 am-9:43 am

Nonstop1h 43m

Myrtle Beach Intl

mié. 8/20

9:00 am-2:07 pm

1 stop5h 07m

$164

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

sáb. 9/20

12:20 pm-8:06 pm

1 stop7h 46m

Myrtle Beach Intl

sáb. 9/27

12:23 pm-7:14 pm

1 stop6h 51m

$168

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

jue. 9/25

3:45 pm-5:30 pm

Nonstop1h 45m

Charlotte Douglas

mar. 9/30

4:02 pm-5:41 pm

Nonstop1h 39m

$169

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

sáb. 10/25

8:53 am-7:46 pm

1 stop10h 53m

Charleston

mié. 10/29

8:44 pm-6:18 pm

1 stop21h 34m

$169

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

sáb. 9/27

8:53 am-2:15 pm

1 stop5h 22m

Savannah/Hilton Head

vie. 10/3

6:00 am-5:19 pm

1 stop11h 19m

$174

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

mié. 9/10

7:15 am-11:01 am

1 stop3h 46m

Charlotte Douglas

mar. 9/16

5:20 pm-9:12 pm

1 stop3h 52m

$177

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

mié. 9/10

8:00 am-6:00 pm

2 stops10h 00m

Charlotte Douglas

mar. 9/16

4:10 pm-8:15 pm

1 stop4h 05m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

When flying from Indianapolis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 30, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Allegiant Air
7.2
Good
703 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $53. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charlotte Douglas or Indianapolis - Myrtle Beach Intl, Indianapolis - Savannah/Hilton Head is the most popular route from Indianapolis to South Carolina.

  • What are the cheapest flights from Indianapolis to South Carolina?

    On average you can expect to pay $120 for a flight from Indianapolis to South Carolina. The cheapest flight overall is $51 while the most popular route, (Indianapolis - Savannah/Hilton Head) is currently priced at $126.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$116FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$134Average$215FlexibilityNo cancel feeOn-time65%
DeltaCheapest$197Average$327FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$209Average$359FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$360FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$396FlexibilityNo cancel feeOn-time63%

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