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South Carolina

$74+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$143
(Priceline)

One-way from

$74
(Cheapflightsfares)

Popular in

December

Cheapest in

August

Average price

$259
From Indianapolis to South Carolina
Search Deals
One-way flight from Indianapolis to South Carolina
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Highest demand for flights based on searches. 11% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Priceline deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:06 pmIND - CLT
1 stop9h 54mFrontier
Mon 10/202:14 pmCLT - IND
1 stop6h 57mFrontier
Deal found 9/13$143
This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/310:47 amIND - CLT
1 stop8h 18mFrontier
Mon 10/611:47 amCLT - IND
1 stop6h 38mFrontier
Deal found 9/13$144
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:06 pmIND - CLT
Nonstop1h 45mSpirit Airlines
Wed 10/298:52 amCLT - IND
1 stop8h 15mSpirit Airlines
Deal found 9/13$148
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:06 pmIND - CLT
Nonstop1h 45mSpirit Airlines
Tue 10/288:52 amCLT - IND
1 stop8h 15mSpirit Airlines
Deal found 9/13$149
This Spirit deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:06 pmIND - CLT
Nonstop1h 45mSpirit Airlines
Sun 10/195:38 pmCLT - IND
Nonstop1h 43mSpirit Airlines
Deal found 9/15$150
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:43 pmIND - CLT
Nonstop1h 43mAmerican Airlines
Wed 10/293:53 pmCLT - IND
Nonstop1h 42mAmerican Airlines
Deal found 9/14$151
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:15 amIND - CLT
1 stop8h 20mMultiple Airlines
Wed 10/154:00 pmCLT - IND
1 stop16h 44mMultiple Airlines
Deal found 9/13$153
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/167:06 pmIND - CLT
Nonstop1h 45mMultiple Airlines
Mon 10/202:14 pmCLT - IND
1 stop6h 57mMultiple Airlines
Deal found 9/13$154
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:55 amIND - CHS
1 stop9h 46mSpirit Airlines
Fri 11/75:40 pmCHS - IND
1 stop5h 16mSpirit Airlines
Deal found 9/13$155
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:06 pmIND - CLT
Nonstop1h 45mMultiple Airlines
Mon 10/202:14 pmCLT - IND
1 stop6h 57mMultiple Airlines
Deal found 9/12$155
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:15 amIND - SAV
1 stop28h 41mSpirit Airlines
Tue 10/2111:14 amSAV - IND
1 stop5h 53mSpirit Airlines
Deal found 9/14$156
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:15 amIND - CLT
1 stop18h 14mSpirit Airlines
Tue 10/216:00 amCLT - IND
1 stop11h 07mSpirit Airlines
Deal found 9/13$156

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 10/3

10:47 am-7:05 pm

1 stop8h 18m

Charlotte Douglas

Sun 10/5

12:07 pm-6:27 pm

1 stop6h 20m

$149

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 10/16

7:06 pm-8:51 pm

Nonstop1h 45m

Charlotte Douglas

Sun 10/19

5:38 pm-7:21 pm

Nonstop1h 43m

$150

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 10/16

7:06 pm-8:51 pm

Nonstop1h 45m

Charlotte Douglas

Mon 10/20

2:14 pm-9:11 pm

1 stop6h 57m

$159

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Mon 11/10

1:57 pm-7:35 pm

1 stop5h 38m

Myrtle Beach Intl

Fri 11/14

11:46 am-10:56 pm

1 stop11h 10m

$173

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Fri 11/14

1:57 pm-7:35 pm

1 stop5h 38m

Myrtle Beach Intl

Tue 11/18

11:46 am-10:56 pm

1 stop11h 10m

$173

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Wed 10/1

5:45 am-12:29 pm

1 stop6h 44m

Myrtle Beach Intl

Wed 10/29

12:11 pm-5:07 pm

1 stop4h 56m

$173

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Tue 10/14

5:30 am-9:56 am

2 stops28h 26m

Savannah/Hilton Head

Tue 10/21

11:14 am-5:07 pm

1 stop5h 53m

$175

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sat 11/1

11:54 am-3:55 pm

1 stop4h 01m

Charlotte Douglas

Wed 11/5

9:39 am-1:16 pm

1 stop3h 37m

$177

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sat 10/18

10:33 am-3:55 pm

1 stop5h 22m

Charlotte Douglas

Wed 10/22

6:00 am-11:14 am

1 stop5h 14m

$177

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Wed 10/8

8:00 am-12:11 pm

1 stop4h 11m

Charlotte Douglas

Tue 10/14

5:25 pm-11:59 pm

1 stop6h 34m

$184

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Indianapolis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,245 reviews
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,956 reviews
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
699 reviews
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,016 reviews
Southwest
8.0
Very good
4,245 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indianapolis to South Carolina?

    For as low as $177, Spirit Airlines can have you in South Carolina from Indianapolis in 4h 01m. The distance between Indianapolis and South Carolina is about 427 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $74. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charleston or Indianapolis - Charlotte Douglas, Indianapolis - Savannah/Hilton Head is the most popular route from Indianapolis to South Carolina.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$134Average$211FlexibilityNo cancel feeOn-time65%
DeltaCheapest$196Average$330FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$365FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$225Average$360FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$399FlexibilityNo cancel feeOn-time63%

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