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$44+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$88
(Mytrip)

One-way from

$44
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$243

Good round-trip deal

$88 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indianapolis to South Carolina
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One-way flight from Indianapolis to South Carolina
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Highest demand for flights based on searches. 17% potential increase in price ($64 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Price to beat on a round-trip flight from Indianapolis to South Carolina.
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Find flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/246:25 pmIND - MYR
Nonstop1h 43mAllegiant Air
Sat 5/318:58 pmMYR - IND
Nonstop1h 47mAllegiant Air
Deal found 4/30$88
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/247:00 amIND - SAV
Nonstop1h 48mAllegiant Air
Sat 5/319:38 amSAV - IND
Nonstop1h 49mAllegiant Air
Deal found 4/30$107
This Booking.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/241:15 pmIND - MYR
1 stop6h 10mMultiple Airlines
Sat 5/318:58 pmMYR - IND
Nonstop1h 47mMultiple Airlines
Deal found 4/30$111
This Gotogate deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/23:58 pmIND - CHS
Nonstop1h 57mAllegiant Air
Fri 6/203:04 pmCHS - IND
Nonstop1h 50mAllegiant Air
Deal found 4/30$121
This Booking.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/212:05 pmIND - CHS
1 stop10h 04mMultiple Airlines
Fri 6/203:04 pmCHS - IND
Nonstop1h 50mMultiple Airlines
Deal found 4/30$136
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/115:45 amIND - MYR
1 stop5h 14mSpirit Airlines
Wed 5/145:32 pmMYR - IND
1 stop5h 43mSpirit Airlines
Deal found 4/30$149
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/235:45 amIND - CLT
1 stop11h 54mSpirit Airlines
Sun 5/256:38 pmCLT - IND
Nonstop1h 41mSpirit Airlines
Deal found 4/30$157
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/212:05 pmIND - CHS
1 stop10h 04mSpirit Airlines
Thu 6/52:03 pmCHS - IND
1 stop4h 34mSpirit Airlines
Deal found 4/30$175
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:42 pmIND - CLT
1 stop11h 12mFrontier
Sun 5/1810:36 pmCLT - IND
1 stop11h 15mFrontier
Deal found 4/30$180
This Priceline deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1610:41 amIND - CLT
1 stop4h 50mMultiple Airlines
Sun 5/186:38 pmCLT - IND
Nonstop1h 41mMultiple Airlines
Deal found 4/30$182
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/286:00 amIND - CAE
1 stop4h 05mAmerican Airlines
Sat 5/3110:45 amCAE - IND
1 stop5h 23mAmerican Airlines
Deal found 4/30$191
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/239:05 amIND - CAE
2 stops9h 50mUnited Airlines
Sat 8/307:35 pmCAE - IND
1 stop4h 24mUnited Airlines
Deal found 4/30$196

Cheapflights Fare Finder

Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 5/24

6:25 pm-8:08 pm

Nonstop1h 43m

Myrtle Beach Intl

Sat 5/31

8:58 pm-10:45 pm

Nonstop1h 47m

$88

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Sat 5/24

7:00 am-8:48 am

Nonstop1h 48m

Savannah/Hilton Head

Sat 5/31

9:38 am-11:27 am

Nonstop1h 49m

$107

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 5/24

1:15 pm-7:25 pm

1 stop6h 10m

Myrtle Beach Intl

Sat 5/31

8:58 pm-10:45 pm

Nonstop1h 47m

$111

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Mon 6/2

3:58 pm-5:55 pm

Nonstop1h 57m

Charleston

Fri 6/20

3:04 pm-4:54 pm

Nonstop1h 50m

$121

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Mon 6/2

12:05 pm-10:09 pm

1 stop10h 04m

Charleston

Fri 6/20

3:04 pm-4:54 pm

Nonstop1h 50m

$136

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sun 5/11

5:45 am-10:59 am

1 stop5h 14m

Myrtle Beach Intl

Wed 5/14

5:32 pm-11:15 pm

1 stop5h 43m

$149

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 5/23

5:45 am-5:39 pm

1 stop11h 54m

Charlotte Douglas

Sun 5/25

6:38 pm-8:19 pm

Nonstop1h 41m

$157

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Mon 6/2

12:05 pm-10:09 pm

1 stop10h 04m

Charleston

Thu 6/5

2:03 pm-6:37 pm

1 stop4h 34m

$175

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 5/15

7:42 pm-6:54 am

1 stop11h 12m

Charlotte Douglas

Sun 5/18

10:36 pm-9:51 am

1 stop11h 15m

$180

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 5/16

10:41 am-3:31 pm

1 stop4h 50m

Charlotte Douglas

Sun 5/18

6:38 pm-8:19 pm

Nonstop1h 41m

$182

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Indianapolis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 1, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Southwest and Delta from Indianapolis to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,968 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,294 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,934 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.9

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $44. However, be on the lookout for offers from Spirit Airlines and Frontier, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Savannah/Hilton Head or Indianapolis - Hilton Head Island, Indianapolis - Charlotte Douglas is the most popular route from Indianapolis to South Carolina.

  • What are the cheapest flights from Indianapolis to South Carolina?

    On average you can expect to pay $207 for a flight from Indianapolis to South Carolina. The cheapest flight overall is $127 while the most popular route, (Indianapolis - Charlotte Douglas) is currently priced at $148.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $217). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$86Average$145FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$102Average$196FlexibilityNo cancel feeOn-time65%
DeltaCheapest$216Average$333FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$351FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$410FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$276Average$366FlexibilityNo cancel feeOn-time63%

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