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South Carolina

$68+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:51 pmIND - CHS
1 stop20h 19mMultiple Airlines
Sun 1/42:59 pmCHS - IND
2 stops26h 43mMultiple Airlines
Deal found 12/16$251
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:39 pmIND - SAV
2 stops21h 18mMultiple Airlines
Mon 1/51:23 pmSAV - IND
1 stop17h 50mMultiple Airlines
Deal found 12/14$253
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2412:36 pmIND - CHS
1 stop6h 56mUnited Airlines
Wed 12/317:45 pmCHS - IND
1 stop4h 14mUnited Airlines
Deal found 12/14$255
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amIND - CHS
2 stops7h 20mAmerican Airlines
Thu 1/18:08 pmCHS - IND
1 stop4h 12mAmerican Airlines
Deal found 12/14$260
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:39 pmIND - CHS
2 stops37h 58mMultiple Airlines
Tue 1/133:01 pmCHS - IND
1 stop27h 22mMultiple Airlines
Deal found 12/14$265
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:48 amIND - SAV
1 stop27h 40mSpirit Airlines
Mon 1/51:23 pmSAV - IND
1 stop26h 33mSpirit Airlines
Deal found 12/14$270
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:39 pmIND - CHS
2 stops37h 58mMultiple Airlines
Mon 1/52:15 pmCHS - IND
1 stop16h 58mMultiple Airlines
Deal found 12/15$276
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:51 pmIND - CHS
1 stop20h 19mSpirit Airlines
Sat 1/32:15 pmCHS - IND
1 stop16h 58mSpirit Airlines
Deal found 12/16$279
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:45 amIND - CAE
1 stop4h 20mUnited Airlines
Wed 12/316:20 amCAE - IND
1 stop4h 53mUnited Airlines
Deal found 12/15$279
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:45 pmIND - CAE
1 stop4h 11mAmerican Airlines
Sat 12/205:16 amCAE - IND
1 stop3h 29mAmerican Airlines
Deal found 12/13$309
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:51 pmIND - CHS
1 stop20h 19mSpirit Airlines
Sun 1/42:15 pmCHS - IND
1 stop16h 58mSpirit Airlines
Deal found 12/16$315
This Orbitz deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:48 pmIND - CLT
1 stop21h 49mFrontier
Sun 12/219:33 pmCLT - IND
1 stop18h 37mFrontier
Deal found 12/14$317

Find flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated December 16, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$134
(Priceline)

One-way from

$68
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$431
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
Search Deals
From Indianapolis to South Carolina
Search Deals
One-way flight from Indianapolis to South Carolina
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Wed 2/18

8:18 pm-8:26 am

1 stop12h 08m

Charlotte Douglas

Sun 2/22

1:24 pm-10:48 pm

1 stop9h 24m

$162

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sun 1/11

6:55 am-4:10 pm

1 stop9h 15m

Charleston

Sun 1/18

5:05 pm-12:18 am

1 stop7h 13m

$164

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sat 2/28

6:00 am-4:05 pm

1 stop10h 05m

Charleston

Sun 3/1

5:00 pm-11:25 pm

1 stop6h 25m

$173

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Wed 2/25

6:00 am-4:05 pm

1 stop10h 05m

Charleston

Fri 2/27

5:00 pm-11:25 pm

1 stop6h 25m

$173

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 2/9

7:33 pm-1:51 pm

1 stop18h 18m

Charlotte Douglas

Fri 2/13

10:20 pm-9:33 am

1 stop11h 13m

$177

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 2/28

6:00 am-2:44 pm

1 stop8h 44m

Myrtle Beach Intl

Wed 3/4

9:09 am-7:23 pm

1 stop10h 14m

$187

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sun 1/4

4:51 pm-1:10 pm

1 stop20h 19m

Charleston

Fri 1/9

5:05 pm-12:18 am

1 stop7h 13m

$192

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sun 1/4

4:51 pm-11:03 am

1 stop18h 12m

Charlotte Douglas

Thu 1/8

1:24 pm-10:48 pm

1 stop9h 24m

$198

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Tue 2/24

6:00 am-4:05 pm

1 stop10h 05m

Charleston

Thu 2/26

6:35 pm-9:33 am

2 stops14h 58m

$209

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sun 1/11

6:55 am-4:10 pm

1 stop9h 15m

Charleston

Sun 1/18

5:05 pm-3:34 pm

2 stops22h 29m

$213

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

It’s optimal to fly from Indianapolis to South Carolina in the afternoon. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Indianapolis to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Indianapolis to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indianapolis to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 16, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,009 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,047 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
700 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,188 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Overall

7.9

Entertainment

7.5

Food

7.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indianapolis to South Carolina?

    For as low as $251, Spirit Airlines can have you in South Carolina from Indianapolis in 6h 45m. The distance between Indianapolis and South Carolina is about 490 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $40. However, be on the lookout for offers from Spirit Airlines and American Airlines, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charleston or Indianapolis - Myrtle Beach Intl, Indianapolis - Charlotte Douglas is the most popular route from Indianapolis to South Carolina.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$128Average$208FlexibilityNo cancel feeOn-time65%
DeltaCheapest$189Average$361FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$200Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$371FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$253Average$416FlexibilityNo cancel feeOn-time63%

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