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South Carolina

$47+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Mytrip deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:14 pm
IND
-
SAV
Nonstop1h 46m
Allegiant Air
Fri 3/137:30 am
SAV
-
IND
Nonstop1h 51m
Allegiant Air
Deal found 1/28$90
This Mytrip deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Wed 2/255:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Deal found 1/28$105
This Expedia deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
IND
-
CLT
1 stop7h 43m
Spirit Airlines
Thu 2/261:24 pm
CLT
-
IND
1 stop9h 24m
Spirit Airlines
Deal found 1/28$113
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Wed 3/45:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Deal found 1/27$118
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Wed 3/45:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Deal found 1/28$121
This Expedia deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
IND
-
CLT
1 stop8h 17m
Spirit Airlines
Tue 3/171:24 pm
CLT
-
IND
1 stop9h 08m
Spirit Airlines
Deal found 1/29$121
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Thu 2/265:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Deal found 1/27$128
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:52 pm
IND
-
CHS
Nonstop1h 48m
Allegiant Air
Fri 6/269:30 pm
CHS
-
IND
Nonstop1h 56m
Allegiant Air
Deal found 1/28$136
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
IND
-
CLT
1 stop8h 17m
Spirit Airlines
Mon 3/23:12 pm
CLT
-
IND
1 stop8h 13m
Spirit Airlines
Deal found 1/28$138
This Cheapflightsfares deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:45 am
IND
-
CHS
1 stop11h 55m
Spirit Airlines
Wed 2/255:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Deal found 1/26$141
This CheapOair deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
IND
-
CLT
1 stop17h 59m
Spirit Airlines
Sun 3/19:07 pm
CLT
-
IND
1 stop26h 18m
Spirit Airlines
Deal found 1/26$144
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:00 am
IND
-
CHS
1 stop10h 05m
Multiple Airlines
Wed 3/45:00 pm
CHS
-
IND
2 stops25h 31m
Multiple Airlines
Deal found 1/28$150

Find flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$90
(Mytrip)

One-way from

$47
(Expedia)

Popular in

November

Cheapest in

August

Average price

$335

Good round-trip deal

$197 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
Search Deals
From Indianapolis to South Carolina
Search Deals
One-way flight from Indianapolis to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Indianapolis to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Tue 2/24

6:00 am-1:43 pm

1 stop7h 43m

Charlotte Douglas

Thu 2/26

1:24 pm-10:48 pm

1 stop9h 24m

$113

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sat 3/7

5:45 am-5:40 pm

1 stop11h 55m

Charleston

Sat 3/14

5:02 pm-11:15 pm

1 stop6h 13m

$155

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Thu 2/26

6:00 am-2:55 pm

1 stop8h 55m

Myrtle Beach Intl

Tue 3/3

10:09 am-11:25 pm

1 stop13h 16m

$155

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 2/23

6:10 pm-10:17 am

1 stop16h 07m

Charlotte Douglas

Thu 2/26

9:21 am-11:25 pm

1 stop14h 04m

$163

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Tue 2/24

6:00 am-1:43 pm

1 stop7h 43m

Charlotte Douglas

Thu 2/26

5:55 am-6:31 pm

2 stops12h 36m

$173

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 2/23

7:31 pm-1:43 pm

2 stops18h 12m

Charlotte Douglas

Wed 2/25

3:12 pm-11:25 pm

1 stop8h 13m

$173

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 2/28

6:00 am-11:02 am

1 stop5h 02m

Myrtle Beach Intl

Sat 3/7

11:57 am-11:25 pm

1 stop11h 28m

$177

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Tue 3/10

6:00 am-6:48 pm

1 stop12h 48m

Charlotte Douglas

Thu 3/12

7:48 pm-9:21 am

1 stop13h 33m

$180

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 2/20

8:18 pm-8:26 am

1 stop12h 08m

Charlotte Douglas

Mon 2/23

9:07 pm-11:25 pm

1 stop26h 18m

$185

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Wed 2/18

8:18 pm-6:18 pm

1 stop22h 00m

Charlotte Douglas

Sun 2/22

9:07 pm-11:25 pm

1 stop26h 18m

$185

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

It’s optimal to fly from Indianapolis to South Carolina in the afternoon. By choosing this option you can save up to 44% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Indianapolis to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Indianapolis to South Carolina. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Indianapolis to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,127 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,206 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
706 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,394 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indianapolis to South Carolina?

    For as low as $247, Spirit Airlines can have you in South Carolina from Indianapolis in 4h 41m. The distance between Indianapolis and South Carolina is about 500 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $146. However, be on the lookout for offers from Southwest and Aeromexico, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charlotte Douglas or Indianapolis - Savannah/Hilton Head, Indianapolis - Charleston is the most popular route from Indianapolis to South Carolina.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $82). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$61Average$118FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$95Average$176FlexibilityNo cancel feeOn-time65%
DeltaCheapest$173Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$200Average$399FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$371FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$253Average$422FlexibilityNo cancel feeOn-time63%

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