$46+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Apr 17 — Apr 241
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to South Carolina with Cheapflights
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Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
This Booking.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/88:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$84
This Cheapflightsfares deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/158:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/18![Allegiant Air logo]()
$86
This Cheapflightsfares deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 6/199:30 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 3/14![Allegiant Air logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:47 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 6/129:30 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 3/15![Allegiant Air logo]()
$92
This Gotogate deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/179:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 3/15![Allegiant Air logo]()
$100
This Cheapflightsfares deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:15 pm
IND
- CHS
Nonstop1h 49m
Allegiant Air
Fri 6/59:25 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 3/18![Allegiant Air logo]()
$114
This Booking.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1511:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/188:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/17![Allegiant Air logo]()
$116
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/15![Allegiant Air logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 7/279:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/109:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:17 am
IND
- SAV
1 stop12h 31m
Multiple Airlines
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$139
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
This Frontier deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:38 am
IND
- CLT
1 stop7h 57m
Frontier
Wed 4/228:09 pm
CLT
- IND
1 stop11h 29m
Frontier
Deal found 3/17![Frontier logo]()
$225
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:00 am
IND
- MYR
1 stop5h 17m
United Airlines
Sat 4/253:15 pm
MYR
- IND
1 stop4h 47m
United Airlines
Deal found 3/17![United Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:50 am
IND
- CHS
1 stop5h 10m
Southwest
Wed 5/67:15 am
CHS
- IND
2 stops10h 00m
Southwest
Deal found 3/15![Southwest logo]()
$290
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:00 am
IND
- AGS
1 stop4h 09m
Delta
Sun 4/195:40 am
AGS
- IND
1 stop3h 20m
Delta
Deal found 3/15![Delta logo]()
$297
This Mytrip deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:45 am
IND
- MYR
1 stop11h 48m
Spirit Airlines
Mon 4/136:28 pm
MYR
- IND
3 stops28h 47m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:45 am
IND
- HHH
2 stops8h 47m
American Airlines
Tue 6/911:40 am
HHH
- IND
2 stops9h 28m
American Airlines
Deal found 3/18![American Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:34 pm
IND
- CHS
1 stop5h 25m
United Airlines
Thu 4/236:00 am
CHS
- IND
2 stops6h 52m
United Airlines
Deal found 3/16![United Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:10 am
IND
- GSP
1 stop5h 00m
Southwest
Tue 4/211:55 pm
GSP
- IND
2 stops7h 10m
Southwest
Deal found 3/15![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
IND
- GSP
1 stop3h 26m
Delta
Mon 4/136:26 pm
GSP
- IND
1 stop5h 41m
Delta
Deal found 3/16![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:45 am
IND
- CAE
1 stop4h 29m
United Airlines
Sat 4/1810:50 am
CAE
- IND
2 stops7h 03m
United Airlines
Deal found 3/14![United Airlines logo]()
$285
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:59 pm
IND
- AGS
1 stop6h 49m
American Airlines
Wed 7/295:00 am
AGS
- IND
1 stop3h 50m
American Airlines
Deal found 3/15![American Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:00 am
IND
- CAE
1 stop6h 28m
Delta
Sun 6/145:40 am
CAE
- IND
1 stop3h 17m
Delta
Deal found 3/16![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:05 pm
IND
- CHS
1 stop3h 25m
Southwest
Wed 5/207:40 am
CHS
- IND
1 stop5h 05m
Southwest
Deal found 3/17![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:19 am
IND
- HHH
1 stop4h 14m
Delta
Tue 6/94:00 pm
HHH
- IND
1 stop5h 51m
Delta
Deal found 3/17![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:10 pm
IND
- CHS
1 stop3h 55m
Southwest
Sun 5/104:30 pm
CHS
- IND
1 stop7h 20m
Southwest
Deal found 3/18![Southwest logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:45 am
IND
- SAV
1 stop5h 02m
United Airlines
Thu 4/165:45 am
SAV
- IND
2 stops7h 07m
United Airlines
Deal found 3/17![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:05 am
IND
- HHH
1 stop5h 32m
Delta
Wed 6/104:00 pm
HHH
- IND
1 stop5h 51m
Delta
Deal found 3/18![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:15 pm
IND
- GSP
2 stops9h 30m
Southwest
Sun 6/77:30 pm
GSP
- IND
1 stop3h 30m
Southwest
Deal found 3/13![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:15 pm
IND
- CAE
1 stop4h 40m
American Airlines
Sun 4/125:55 am
CAE
- IND
1 stop6h 15m
American Airlines
Deal found 3/13![American Airlines logo]()
$417
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
IND
- CAE
1 stop5h 29m
Delta
Sun 5/107:17 pm
CAE
- IND
1 stop5h 16m
Delta
Deal found 3/14![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:00 am
IND
- MYR
1 stop5h 17m
United Airlines
Thu 4/1611:00 am
MYR
- IND
1 stop6h 48m
United Airlines
Deal found 3/17![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:35 am
IND
- CHS
2 stops8h 30m
Southwest
Sat 4/2512:40 pm
CHS
- IND
2 stops8h 20m
Southwest
Deal found 3/17![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
IND
- MYR
1 stop4h 18m
United Airlines
Thu 4/1611:00 am
MYR
- IND
1 stop5h 52m
United Airlines
Deal found 3/13![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:02 am
IND
- HHH
1 stop5h 16m
Delta
Wed 8/54:00 pm
HHH
- IND
1 stop5h 51m
Delta
Deal found 3/16![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:34 pm
IND
- GSP
1 stop6h 23m
American Airlines
Sun 4/125:20 am
GSP
- IND
1 stop4h 21m
American Airlines
Deal found 3/18![American Airlines logo]()
$462
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:35 am
IND
- SAV
1 stop8h 15m
Southwest
Thu 4/168:05 am
SAV
- IND
1 stop7h 20m
Southwest
Deal found 3/17![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:05 am
IND
- HHH
1 stop5h 18m
Delta
Wed 7/14:00 pm
HHH
- IND
1 stop5h 51m
Delta
Deal found 3/13![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:45 am
IND
- CHS
1 stop4h 28m
United Airlines
Thu 5/146:00 am
CHS
- IND
1 stop6h 58m
United Airlines
Deal found 3/13![United Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:23 am
IND
- AGS
1 stop6h 28m
American Airlines
Wed 4/15:00 am
AGS
- IND
1 stop4h 32m
American Airlines
Deal found 3/17![American Airlines logo]()
$471
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:40 am
IND
- SAV
2 stops9h 45m
Southwest
Sat 5/307:15 am
SAV
- IND
1 stop4h 50m
Southwest
Deal found 3/16![Southwest logo]()
$354
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated March 18, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated March 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:45 am
IND
- CLT
1 stop8h 42m
Multiple Airlines
Tue 4/149:18 am
CLT
- IND
1 stop13h 57m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:45 am
IND
- CLT
1 stop8h 42m
Multiple Airlines
Wed 4/158:09 pm
CLT
- IND
1 stop14h 18m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$188
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/15![Allegiant Air logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:11 am
IND
- SAV
Nonstop1h 44m
Multiple Airlines
Wed 4/84:50 pm
SAV
- IND
1 stop6h 25m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
IND
- CLT
1 stop7h 52m
Multiple Airlines
Wed 4/229:32 pm
CLT
- IND
1 stop10h 06m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$185
This CheapOair deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
IND
- CLT
1 stop17h 53m
Spirit Airlines
Tue 4/149:18 am
CLT
- IND
1 stop13h 57m
Spirit Airlines
Deal found 3/14![Spirit Airlines logo]()
$171
This Cheapflightsfares deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/17![Allegiant Air logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:17 am
IND
- SAV
1 stop12h 31m
Multiple Airlines
Fri 4/178:30 am
SAV
- IND
Nonstop1h 51m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$144
This Super.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 4/208:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$150
This Priceline deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:30 pm
IND
- CLT
1 stop7h 06m
Frontier
Thu 4/169:31 am
CLT
- IND
1 stop9h 10m
Frontier
Deal found 3/17![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
IND
- CLT
1 stop7h 52m
Multiple Airlines
Fri 4/178:09 pm
CLT
- IND
1 stop13h 40m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$163
This CheapOair deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
IND
- CLT
1 stop7h 52m
Multiple Airlines
Wed 4/158:09 pm
CLT
- IND
1 stop14h 18m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$181
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
This Booking.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 3/16![Allegiant Air logo]()
$46
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Deal found 3/14![Allegiant Air logo]()
$51
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Deal found 3/13![Allegiant Air logo]()
$61
This Cheapflightsfares deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
IND
- CLT
1 stop7h 52m
Spirit Airlines
Deal found 3/18![Spirit Airlines logo]()
$67
This Super.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:45 am
IND
- MYR
1 stop11h 48m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$80
This Priceline deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
IND
- CHS
1 stop5h 09m
Spirit Airlines
Deal found 3/16![Spirit Airlines logo]()
$83
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Deal found 3/13![Allegiant Air logo]()
$84
This Super.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:34 am
IND
- CLT
1 stop7h 06m
Frontier
Deal found 3/15![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:30 pm
IND
- CLT
1 stop7h 06m
Frontier
Deal found 3/16![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:59 pm
IND
- CLT
1 stop15h 28m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:41 pm
IND
- CLT
1 stop13h 40m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$94
This Expedia deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:36 pm
IND
- CLT
1 stop20h 54m
Frontier
Deal found 3/16![Frontier logo]()
$96
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated March 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $84 (Booking.com) |
One-way from | $46 (Booking.com) |
Popular in | March |
Cheapest in | August |
Average price | $425 |
Good round-trip deal | $113 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisCharlotte
IND - CLT
INDCLT
Indianapolis
Mon 4/20
8:38 am-4:35 pm
1 stop7h 57m
Charlotte Douglas
Wed 4/22
8:09 pm-7:38 am
1 stop11h 29m
$225
IndianapolisMyrtle Beach
IND - MYR
INDMYR
Indianapolis
Wed 4/22
9:00 am-2:17 pm
1 stop5h 17m
Myrtle Beach Intl
Sat 4/25
3:15 pm-8:02 pm
1 stop4h 47m
$280
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Tue 4/21
6:34 pm-11:59 pm
1 stop5h 25m
Charleston
Thu 4/23
6:00 am-12:52 pm
2 stops6h 52m
$283
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Sat 4/11
5:45 am-10:14 am
1 stop4h 29m
Columbia Metropolitan
Sat 4/18
10:50 am-5:53 pm
2 stops7h 03m
$285
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Wed 4/29
5:50 am-11:00 am
1 stop5h 10m
Charleston
Wed 5/6
7:15 am-5:15 pm
2 stops10h 00m
$290
Quickest round-trip
IndianapolisAugusta
IND - AGS
INDAGS
Indianapolis
Sun 4/12
8:00 am-12:09 pm
1 stop4h 09m
Augusta Bush Field
Sun 4/19
5:40 am-9:00 am
1 stop3h 20m
$297
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Tue 4/14
7:10 am-12:10 pm
1 stop5h 00m
Greenville
Tue 4/21
1:55 pm-9:05 pm
2 stops7h 10m
$300
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Thu 4/9
6:00 am-9:26 am
1 stop3h 26m
Greenville
Mon 4/13
6:26 pm-12:07 am
1 stop5h 41m
$311
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Fri 6/12
6:00 am-12:28 pm
1 stop6h 28m
Columbia Metropolitan
Sun 6/14
5:40 am-8:57 am
1 stop3h 17m
$319
IndianapolisMyrtle Beach
IND - MYR
INDMYR
Indianapolis
Mon 4/6
5:45 am-5:33 pm
1 stop11h 48m
Myrtle Beach Intl
Mon 4/13
6:28 pm-11:15 pm
3 stops28h 47m
$320
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-SAV
IND-CLT
IND-CHS
IND-MYR
IND-AGS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-SAV
IND-CLT
IND-CHS
IND-MYR
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in March is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 18, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the afternoon. By choosing this option you can save up to 45% on the cost of your flight, compared to a flight in the evening.
What is the cheapest day to fly from Indianapolis to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Indianapolis to South Carolina. Price data was last updated on March 14, 2026.
Travelers seeking maximum savings on their Indianapolis to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 18, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAllegiant Air from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Indianapolis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Indianapolis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on March 18, 2026.
Popular flight searches
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Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 6 airlines flying from Indianapolis to South Carolina
Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$58 | Average$118 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$95 | Average$192 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$151 | Average$347 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$417 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$371 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$247 | Average$434 | FlexibilityNo cancel fee | On-time63% |