HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$154+ Cheap flights from Guayaquil (GYE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — CHS
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Guayaquil to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Guayaquil to South Carolina

Keep the following information in mind while searching for Guayaquil to South Carolina flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$281
(Kiwi.com)

One-way from

$154
(Mytrip)
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Myrtle Beach Intl flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to South Carolina
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to South Carolina
Search Deals

Find flight deals from Guayaquil to South Carolina

Cheapest flights from Guayaquil to South Carolina
Explore the most affordable flight options available from Guayaquil to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This Mytrip deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/712:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Thu 1/297:00 amCLT - GYE
1 stop17h 21mSpirit Airlines
Deal found 11/24$309
This Mytrip deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:49 amGYE - CLT
2 stops19h 50mSpirit Airlines
Sat 2/281:24 pmCLT - GYE
1 stop10h 37mSpirit Airlines
Deal found 11/24$328
This CheapOair deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2712:49 amGYE - CLT
2 stops19h 50mSpirit Airlines
Mon 1/121:24 pmCLT - GYE
1 stop10h 57mSpirit Airlines
Deal found 11/26$337
This CheapOair deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2812:49 amGYE - CLT
2 stops19h 50mSpirit Airlines
Thu 1/811:12 amCLT - GYE
2 stops13h 09mSpirit Airlines
Deal found 11/25$342
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:30 amGYE - CLT
2 stops29h 33mMultiple Airlines
Thu 1/296:02 pmCLT - GYE
1 stop30h 19mMultiple Airlines
Deal found 11/24$347
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2812:49 amGYE - CLT
1 stop13h 23mMultiple Airlines
Thu 1/86:56 pmCLT - GYE
1 stop29h 25mMultiple Airlines
Deal found 11/25$354
This CheapOair deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:49 amGYE - CLT
2 stops19h 50mSpirit Airlines
Wed 1/147:00 amCLT - GYE
1 stop17h 21mSpirit Airlines
Deal found 11/25$365
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/712:49 amGYE - CHS
1 stop20h 05mSpirit Airlines
Sun 12/149:49 pmCHS - GYE
1 stop25h 54mSpirit Airlines
Deal found 11/24$524
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2412:49 amGYE - CHS
1 stop20h 34mMultiple Airlines
Thu 1/17:05 amCHS - GYE
2 stops16h 48mMultiple Airlines
Deal found 11/25$533
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amGYE - CHS
1 stop16h 34mAmerican Airlines
Thu 1/16:00 amCHS - GYE
1 stop17h 50mAmerican Airlines
Deal found 11/25$544
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/712:49 amGYE - CHS
1 stop20h 05mMultiple Airlines
Sun 12/142:59 pmCHS - GYE
2 stops32h 36mMultiple Airlines
Deal found 11/24$558
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:49 amGYE - CHS
1 stop20h 34mMultiple Airlines
Thu 1/17:05 amCHS - GYE
2 stops16h 48mMultiple Airlines
Deal found 11/25$564

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Guayaquil to South Carolina that are best for you.

Fly from

Guayaquil

Fly to

South Carolina

Route

Depart

Return

Price

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

1:26 am-4:54 pm

2 stops15h 28m

Charlotte Douglas

Wed 1/28

7:00 am-12:21 am

1 stop17h 21m

$327

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Tue 1/13

1:26 am-12:40 am

1 stop23h 14m

Charlotte Douglas

Wed 1/28

6:56 pm-12:21 am

1 stop29h 25m

$370

GuayaquilMyrtle Beach

GYE - MYR

GYEMYR

Guayaquil Jose Joaquin de Olmedo

Mon 2/9

1:26 am-2:34 pm

2 stops13h 08m

Myrtle Beach Intl

Tue 2/10

9:55 pm-12:21 am

3 stops26h 26m

$403

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Thu 2/26

7:05 pm-12:22 pm

1 stop17h 17m

Charlotte Douglas

Thu 3/5

7:00 am-5:35 am

1 stop22h 35m

$407

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Sun 1/11

6:50 pm-12:22 pm

1 stop17h 32m

Charlotte Douglas

Sat 1/24

7:00 am-5:20 am

1 stop22h 20m

$451

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Mon 1/26

6:55 pm-12:40 am

2 stops29h 45m

Charlotte Douglas

Mon 2/9

9:07 pm-12:21 am

3 stops27h 14m

$462

GuayaquilCharleston

GYE - CHS

GYECHS

Guayaquil Jose Joaquin de Olmedo

Sat 1/24

1:26 am-5:36 pm

1 stop16h 10m

Charleston

Thu 1/29

5:05 pm-12:21 am

2 stops31h 16m

$469

GuayaquilCharleston

GYE - CHS

GYECHS

Guayaquil Jose Joaquin de Olmedo

Sun 1/25

7:15 am-10:26 am

2 stops27h 11m

Charleston

Thu 1/29

5:57 pm-11:22 pm

2 stops29h 25m

$475

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Thu 1/8

7:05 pm-12:22 pm

1 stop17h 17m

Charlotte Douglas

Fri 2/27

7:00 am-5:20 am

1 stop22h 20m

$482

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Thu 12/18

12:49 am-9:39 am

1 stop8h 50m

Charlotte Douglas

Mon 1/5

9:34 pm-11:53 pm

2 stops26h 19m

$485

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/23

Showing 1-10 of 50 results
1
2
3
...
5

Best time to book a flight from Guayaquil to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to South Carolina

What is the cheapest month to book a flight from Guayaquil to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Guayaquil to South Carolina (average of $178). Flying from Guayaquil to South Carolina in June is currently the most expensive (average of $899). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SC?

Find hourly flight availability from Guayaquil to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

A simple way to save on the total cost of your ticket is to fly from Guayaquil to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 64% on your trip compared to booking a flight in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Guayaquil to South Carolina?

    Located just 2.5 mi from the city center, Guayaquil Jose Joaquin de Olmedo (GYE) is the airport most travelers will use when flying to South Carolina from Guayaquil.

  • How long is the flight from Guayaquil to South Carolina?

    There are many flights that can get you from Guayaquil to South Carolina in 15h 28m. Fly via Spirit Airlines or American Airlines to get the fastest option. The distance between Guayaquil and South Carolina is about 2582 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Guayaquil to South Carolina?

    The most popular flight routes from Guayaquil to South Carolina are Guayaquil Jose Joaquin de Olmedo - Charlotte Douglas, Guayaquil Jose Joaquin de Olmedo - Charleston and Guayaquil Jose Joaquin de Olmedo - Myrtle Beach Intl.

  • Can I find deals for flights from Guayaquil to South Carolina that include hotel bookings?

    Yes. In addition to deals on Guayaquil to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to South Carolina.

  • Can I find deals for business class flights from Guayaquil to South Carolina?

    Yes. Cheapflights offers flight deals from Guayaquil to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Guayaquil to South Carolina (average of $178). Flying from Guayaquil to South Carolina in June is currently the most expensive (average of $899). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Guayaquil to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Guayaquil to John F Kennedy Intl flights
Quito to Miami flights
Guayaquil to Miami flights
Quito to John F Kennedy Intl flights
Guayaquil to Fort Lauderdale flights
Guayaquil to Newark flights
Quito to Newark flights
Guayaquil to LaGuardia flights
Quito to Orlando flights
Quito to LaGuardia flights
Guayaquil to Orlando flights
Quito to Fort Lauderdale flights
Quito to Los Angeles flights
Guayaquil to Los Angeles flights
Quito to Las Vegas flights
Guayaquil to O'Hare Intl flights
Quito to Dulles Intl flights
Quito to Hobby flights
Guayaquil to Hobby flights
Quito to Baltimore flights
Quito to Atlanta flights
Guayaquil to Tampa flights
Quito to George Bush Intcntl flights
Quito to Reagan-National flights
Cuenca to John F Kennedy Intl flights
Quito to O'Hare Intl flights
Guayaquil to George Bush Intcntl flights
Guayaquil to Charlotte flights
Guayaquil to Dallas/Fort Worth flights
Manta to Miami flights
Quito to Tampa flights
Guayaquil to Las Vegas flights
Guayaquil to Atlanta flights
Quito to Charlotte flights
Quito to Seattle flights
Quito to Midway flights
Guayaquil to Reagan-National flights
Guayaquil to Dulles Intl flights
Guayaquil to San Francisco flights
Quito to San Francisco flights
Guayaquil to Baltimore flights
Quito to Boston flights
Quito to Dallas/Fort Worth flights
Quito to Denver flights
Manta to John F Kennedy Intl flights
Quito to Salt Lake City flights
Guayaquil to Boston flights
Guayaquil to Austin flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.