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$188+ Cheap flights from Guayaquil (GYE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — CHS
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Guayaquil to South Carolina

Cheapest flights from Guayaquil to South Carolina
Explore the most affordable flight options available from Guayaquil to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Trip.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2812:49 amGYE - CLT
1 stop19h 44mSpirit Airlines
Thu 1/296:00 amCLT - GYE
1 stop18h 21mSpirit Airlines
Deal found 12/13$373
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:49 amGYE - CLT
1 stop13h 23mMultiple Airlines
Thu 1/226:02 pmCLT - GYE
1 stop30h 19mMultiple Airlines
Deal found 12/14$406
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2712:49 amGYE - CLT
1 stop19h 44mSpirit Airlines
Thu 1/221:24 pmCLT - GYE
1 stop10h 57mSpirit Airlines
Deal found 12/14$411
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:49 amGYE - CLT
1 stop13h 23mMultiple Airlines
Tue 1/2011:35 amCLT - GYE
2 stops12h 46mMultiple Airlines
Deal found 12/14$426
This CheapOair deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2712:49 amGYE - CLT
1 stop8h 50mSpirit Airlines
Mon 1/121:24 pmCLT - GYE
1 stop10h 57mSpirit Airlines
Deal found 12/14$430
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:49 amGYE - CLT
1 stop13h 13mMultiple Airlines
Tue 1/206:00 amCLT - GYE
1 stop18h 21mMultiple Airlines
Deal found 12/14$439
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2712:49 amGYE - CLT
1 stop19h 44mSpirit Airlines
Sun 1/251:24 pmCLT - GYE
1 stop10h 57mSpirit Airlines
Deal found 12/14$443
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2612:49 amGYE - CLT
1 stop22h 40mMultiple Airlines
Sun 1/256:28 pmCLT - GYE
1 stop29h 53mMultiple Airlines
Deal found 12/14$444

Find flight deals from Guayaquil to South Carolina

Keep the following information in mind while searching for Guayaquil to South Carolina flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$217
(Expedia)

One-way from

$188
(Mytrip)
Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Myrtle Beach Intl flights.
Search Deals
From Guayaquil Jose Joaquin de Olmedo to South Carolina
Search Deals
One-way flight from Guayaquil Jose Joaquin de Olmedo to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guayaquil to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Guayaquil to South Carolina that are best for you.

Fly from

Guayaquil

Fly to

South Carolina

Route

Depart

Return

Price

GuayaquilCharleston

GYE - CHS

GYECHS

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

1:26 am-4:10 pm

2 stops14h 44m

Charleston

Thu 2/5

6:35 pm-12:21 am

1 stop29h 46m

$264

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Sun 1/25

1:26 am-4:54 pm

2 stops15h 28m

Charlotte Douglas

Mon 2/9

6:00 am-12:21 am

1 stop18h 21m

$287

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Sun 1/18

1:26 am-12:40 am

1 stop23h 14m

Charlotte Douglas

Fri 1/30

11:12 am-12:21 am

2 stops13h 09m

$317

GuayaquilMyrtle Beach

GYE - MYR

GYEMYR

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

7:05 pm-9:04 pm

2 stops25h 59m

Myrtle Beach Intl

Tue 2/3

8:15 pm-12:21 am

1 stop28h 06m

$329

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Fri 2/13

6:50 pm-12:20 pm

1 stop17h 30m

Charlotte Douglas

Fri 2/20

7:05 pm-12:04 am

1 stop28h 59m

$348

GuayaquilMyrtle Beach

GYE - MYR

GYEMYR

Guayaquil Jose Joaquin de Olmedo

Thu 2/26

12:59 am-8:13 am

1 stop31h 14m

Myrtle Beach Intl

Tue 5/5

8:26 pm-11:01 pm

1 stop27h 35m

$370

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

12:59 am-4:54 pm

2 stops15h 55m

Charlotte Douglas

Tue 3/3

7:00 am-12:04 am

1 stop17h 04m

$383

GuayaquilMyrtle Beach

GYE - MYR

GYEMYR

Guayaquil Jose Joaquin de Olmedo

Mon 1/19

1:26 am-2:42 pm

2 stops13h 16m

Myrtle Beach Intl

Tue 2/3

3:39 pm-12:21 am

2 stops32h 42m

$389

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

12:59 am-11:54 pm

1 stop22h 55m

Charlotte Douglas

Tue 3/3

1:24 pm-12:04 am

1 stop10h 40m

$389

GuayaquilCharlotte

GYE - CLT

GYECLT

Guayaquil Jose Joaquin de Olmedo

Sat 12/27

12:49 am-8:33 pm

1 stop19h 44m

Charlotte Douglas

Fri 1/23

1:24 pm-12:21 am

1 stop10h 57m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 29 results
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Best time to book a flight from Guayaquil to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to South Carolina

What is the cheapest time of day to fly from GYE to SC?

Find hourly flight availability from Guayaquil to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Guayaquil to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 64% on your trip compared to booking a flight in the afternoon.

How much does it cost to fly round-trip from Guayaquil to South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Guayaquil to South Carolina?

    Located just 2.5 mi from the city center, Guayaquil Jose Joaquin de Olmedo (GYE) is the airport most travelers will use when flying to South Carolina from Guayaquil.

  • How long is the flight from Guayaquil to South Carolina?

    There are many flights that can get you from Guayaquil to South Carolina in 14h 44m. Fly via Spirit Airlines or JetBlue to get the fastest option. The distance between Guayaquil and South Carolina is about 2420 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Guayaquil to South Carolina?

    The most popular flight routes from Guayaquil to South Carolina are Guayaquil Jose Joaquin de Olmedo - Charlotte Douglas, Guayaquil Jose Joaquin de Olmedo - Charleston and Guayaquil Jose Joaquin de Olmedo - Myrtle Beach Intl.

  • Can I find deals for flights from Guayaquil to South Carolina that include hotel bookings?

    Yes. In addition to deals on Guayaquil to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to South Carolina.

  • Can I find deals for business class flights from Guayaquil to South Carolina?

    Yes. Cheapflights offers flight deals from Guayaquil to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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