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$330+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated July 3, 2025.

Round-trip from

$330
(American Airlines)
From Columbia Regional to South Carolina
Search Deals

Find flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:15 amCOU - CLT
1 stop4h 25mAmerican Airlines
Tue 8/195:30 pmCLT - COU
1 stop6h 19mAmerican Airlines
Deal found 7/2$330
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/3011:36 amCOU - MYR
2 stops10h 18mAmerican Airlines
Wed 8/68:08 amMYR - COU
2 stops9h 30mAmerican Airlines
Deal found 7/2$431
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/185:15 pmCOU - CHS
1 stop6h 41mAmerican Airlines
Tue 7/225:00 amCHS - COU
1 stop8h 05mAmerican Airlines
Deal found 7/3$469

Cheapflights Fare Finder

Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Columbia

Fly to

South Carolina

Route

Depart

Return

Price

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 8/13

7:27 am-1:45 pm

1 stop5h 18m

Charlotte Douglas

Tue 8/19

3:40 pm-6:47 pm

1 stop4h 07m

$330

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Wed 7/30

11:36 am-10:54 pm

2 stops10h 18m

Myrtle Beach Intl

Wed 8/6

8:08 am-4:38 pm

2 stops9h 30m

$431

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 7/29

12:35 pm-12:02 am

2 stops10h 27m

$384

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 8/20

6:15 am-3:40 pm

1 stop8h 25m

$425

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina

How much does it cost to fly round-trip from Columbia, Missouri to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 3, 2025.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Food

6.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Boarding

7.5

Food

6.5

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Myrtle Beach Intl, Columbia Regional - Charlotte Douglas or Columbia Regional - Charleston as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbia, Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Columbia, Missouri to South Carolina (average of $217). Flying from Columbia, Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$496FlexibilityNo cancel feeOn-time71%

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