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South America

$226+ Cheap flights from Jacksonville (JAX) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — BOG
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
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Cheap flight deals from Jacksonville to South America

Keep the following information in mind while searching for Jacksonville to South America flight deals. Data was last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$426
(Delta)

One-way from

$226
(Kiwi.com)
Provider with most accurate pricing for Jacksonville-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Jacksonville-Sao Paulo (SAO) flights.
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From Jacksonville to South America
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One-way flight from Jacksonville to South America
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Find flight deals from Jacksonville to South America

Cheapest flights from Jacksonville to South America
Explore the most affordable flight options available from Jacksonville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 19, 2025.

This Mytrip deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:11 pmJAX - MDE
2 stops30h 58mMultiple Airlines
Sat 12/1311:50 amMDE - JAX
3 stops28h 30mMultiple Airlines
Deal found 11/18$497
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amJAX - CTG
1 stop15h 30mAmerican Airlines
Tue 12/164:30 pmCTG - JAX
1 stop7h 29mAmerican Airlines
Deal found 11/17$513
This Expedia deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:40 amJAX - CTG
2 stops27h 30mJetBlue
Wed 12/172:20 pmCTG - JAX
2 stops18h 55mJetBlue
Deal found 11/18$517
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:30 amJAX - MDE
1 stop15h 35mUnited Airlines
Mon 12/291:15 amMDE - JAX
1 stop22h 15mUnited Airlines
Deal found 11/19$541
This Expedia deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:52 amJAX - CTG
2 stops26h 23mJetBlue
Sun 12/142:20 pmCTG - JAX
2 stops26h 01mJetBlue
Deal found 11/19$545
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:41 pmJAX - CTG
1 stop19h 49mAmerican Airlines
Wed 12/172:30 pmCTG - JAX
1 stop9h 29mAmerican Airlines
Deal found 11/18$551
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:00 amJAX - CTG
1 stop7h 30mAmerican Airlines
Mon 12/228:00 amCTG - JAX
1 stop7h 56mAmerican Airlines
Deal found 11/17$559
This Expedia deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:33 pmJAX - MDE
2 stops18h 26mJetBlue
Fri 12/122:04 pmMDE - JAX
2 stops19h 48mJetBlue
Deal found 11/18$564
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:51 amJAX - CTG
1 stop5h 39mAmerican Airlines
Sun 12/148:00 amCTG - JAX
1 stop15h 59mAmerican Airlines
Deal found 11/19$576
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:30 amJAX - MDE
1 stop15h 35mUnited Airlines
Mon 12/291:15 amMDE - JAX
1 stop22h 15mUnited Airlines
Deal found 11/19$610
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:00 amJAX - MDE
1 stop15h 05mUnited Airlines
Sat 12/131:15 amMDE - JAX
1 stop14h 21mUnited Airlines
Deal found 11/18$611
This Expedia deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:33 pmJAX - MDE
2 stops18h 26mJetBlue
Fri 12/52:04 pmMDE - JAX
2 stops19h 48mJetBlue
Deal found 11/18$613

Cheapflights Fare Finder

 
Customize your flight search to find flights from Jacksonville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Jacksonville to South America that are best for you.

Fly from

Jacksonville

Fly to

South America

Route

Depart

Return

Price

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Wed 1/21

7:30 am-2:17 pm

1 stop6h 47m

Cartagena Rafael Nunez

Wed 1/28

3:32 pm-11:59 pm

1 stop8h 27m

$426

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Wed 1/21

6:00 am-1:30 pm

1 stop7h 30m

Cartagena Rafael Nunez

Wed 1/28

4:30 pm-11:03 am

2 stops18h 33m

$461

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Fri 2/13

6:00 am-9:30 pm

1 stop15h 30m

Cartagena Rafael Nunez

Sat 2/21

2:30 pm-11:59 pm

1 stop9h 29m

$476

JacksonvilleCali

JAX - CLO

JAXCLO

Jacksonville

Thu 1/22

10:40 am-5:37 pm

2 stops30h 57m

Cali Alfonso B. Aragon Intl

Thu 1/29

12:03 pm-9:47 pm

2 stops33h 44m

$497

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Thu 12/11

6:00 am-9:30 pm

1 stop15h 30m

Cartagena Rafael Nunez

Tue 12/16

4:30 pm-11:59 pm

1 stop7h 29m

$513

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sun 12/7

10:40 am-2:10 pm

2 stops27h 30m

Cartagena Rafael Nunez

Wed 12/17

2:20 pm-9:15 am

2 stops18h 55m

$517

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Sat 1/31

11:40 am-10:05 pm

1 stop10h 25m

Medellín Jose Maria Cordova Intl

Sat 2/7

10:45 am-9:47 pm

1 stop11h 02m

$518

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Sat 2/7

7:00 am-10:05 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

Sat 2/14

10:45 am-9:32 pm

1 stop10h 47m

$518

JacksonvilleCali

JAX - CLO

JAXCLO

Jacksonville

Thu 1/22

10:40 am-11:34 pm

2 stops12h 54m

Cali Alfonso B. Aragon Intl

Mon 1/26

12:03 pm-10:42 am

2 stops22h 39m

$521

JacksonvilleCali

JAX - CLO

JAXCLO

Jacksonville

Thu 1/29

10:40 am-5:37 pm

2 stops30h 57m

Cali Alfonso B. Aragon Intl

Mon 2/2

8:48 am-9:47 pm

2 stops36h 59m

$521

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Showing 1-10 of 60 results
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Best time to book a flight from Jacksonville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Jacksonville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Jacksonville to South America

What is the cheapest month to book a flight from Jacksonville to South America?

Currently, January is the cheapest month in which you can book a flight from Jacksonville to South America (average of $236). Flying from Jacksonville to South America in July is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from JAX to SA?

Find hourly flight availability from Jacksonville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 19, 2025.

One of the essential ways to save on airfare from Jacksonville to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Jacksonville to South America?

Use this chart to determine the cheapest time to fly round-trip from Jacksonville to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Jacksonville to South America flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 19, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and American Airlines from Jacksonville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
LATAM Airlines
7.5
Good
1,879 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Jacksonville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Jacksonville to South America?

    If you book a flight to South America from Jacksonville, you will be flying from Jacksonville, which is the city’s only airport. Jacksonville (JAX) is located 11.2 mi from the center of Jacksonville.

  • How long is the flight from Jacksonville to South America?

    Departing from Jacksonville to South America will take you 6h 47m. Jacksonville and South America are separated by a distance of 1440 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Jacksonville to South America?

    Most travelers choose Jacksonville - Medellín Jose Maria Cordova Intl, Jacksonville - Lima J Chavez Intl or Jacksonville - Quito Mariscal Sucr when deciding on the best route from Jacksonville to South America.

  • Can I find deals for flights from Jacksonville to South America that include hotel bookings?

    Yes. In addition to deals on Jacksonville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Jacksonville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Jacksonville to South America.

  • Can I find deals for business class flights from Jacksonville to South America?

    Yes. Cheapflights offers flight deals from Jacksonville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Jacksonville to South America?

    Currently, January is the cheapest month in which you can book a flight from Jacksonville to South America (average of $236). Flying from Jacksonville to South America in July is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Jacksonville to South America

Discover the top 3 airlines that operate flights from Jacksonville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$471Average$753FlexibilityNo cancel feeOn-time71%
DeltaCheapest$478Average$927FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$588Average$782FlexibilityNo cancel feeOn-time81%

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