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South America

$134+ Cheap flights from Jacksonville (JAX) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — BOG
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Jacksonville to South America

Keep the following information in mind while searching for Jacksonville to South America flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$456
(American Airlines)

One-way from

$134
(Kiwi.com)
Provider with most accurate pricing for Jacksonville-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Jacksonville-Sao Paulo (SAO) flights.
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From Jacksonville to South America
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One-way flight from Jacksonville to South America
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Find flight deals from Jacksonville to South America

Cheapest flights from Jacksonville to South America
Explore the most affordable flight options available from Jacksonville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:00 amJAX - CTG
1 stop7h 30mAmerican Airlines
Thu 12/182:30 pmCTG - JAX
1 stop9h 29mAmerican Airlines
Deal found 10/29$470
This Expedia deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:16 pmJAX - CTG
2 stops20h 54mJetBlue
Wed 12/172:20 pmCTG - JAX
2 stops18h 55mJetBlue
Deal found 10/29$487
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:41 pmJAX - CTG
1 stop19h 49mAmerican Airlines
Wed 12/172:30 pmCTG - JAX
1 stop9h 29mAmerican Airlines
Deal found 10/29$492
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:46 pmJAX - CTG
1 stop25h 44mAmerican Airlines
Sun 12/74:30 pmCTG - JAX
1 stop7h 29mAmerican Airlines
Deal found 10/30$502
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/279:45 amJAX - MDE
2 stops52h 16mMultiple Airlines
Sat 12/2711:30 amMDE - JAX
1 stop8h 35mMultiple Airlines
Deal found 10/29$516
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:14 pmJAX - CTG
1 stop19h 16mAmerican Airlines
Mon 12/88:00 amCTG - JAX
1 stop11h 10mAmerican Airlines
Deal found 10/29$527
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:16 pmJAX - MDE
1 stop28h 49mUnited Airlines
Sat 12/201:15 amMDE - JAX
2 stops20h 27mUnited Airlines
Deal found 10/30$539
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:00 amJAX - CTG
2 stops16h 00mUnited Airlines
Mon 12/86:25 amCTG - JAX
2 stops26h 49mUnited Airlines
Deal found 10/29$540
This SmartFares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:15 pmJAX - CTG
1 stop18h 55mJetBlue
Fri 11/213:15 pmCTG - JAX
1 stop18h 55mJetBlue
Deal found 10/29$565
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:00 amJAX - MDE
1 stop15h 05mUnited Airlines
Fri 12/261:15 amMDE - JAX
1 stop22h 15mUnited Airlines
Deal found 10/29$618
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/297:00 amJAX - UIO
1 stop17h 30mUnited Airlines
Sat 12/68:00 amUIO - JAX
1 stop14h 13mUnited Airlines
Deal found 10/29$625
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/298:08 pmJAX - UIO
1 stop22h 47mDelta
Sat 12/611:45 pmUIO - JAX
1 stop16h 48mDelta
Deal found 10/30$630

Cheapflights Fare Finder

 
Customize your flight search to find flights from Jacksonville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Jacksonville to South America that are best for you.

Fly from

Jacksonville

Fly to

South America

Route

Depart

Return

Price

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Wed 1/21

6:00 am-3:30 pm

1 stop9h 30m

Cartagena Rafael Nunez

Wed 1/28

4:30 pm-11:59 pm

1 stop7h 29m

$456

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Thu 1/22

6:00 am-3:30 pm

2 stops9h 30m

Cartagena Rafael Nunez

Thu 1/29

4:30 pm-1:51 pm

2 stops21h 21m

$461

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Mon 12/8

6:00 am-1:30 pm

1 stop7h 30m

Cartagena Rafael Nunez

Thu 12/18

2:30 pm-11:59 pm

1 stop9h 29m

$470

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Wed 1/21

6:30 am-2:17 pm

1 stop7h 47m

Cartagena Rafael Nunez

Tue 1/27

4:35 am-4:32 pm

2 stops11h 57m

$485

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Thu 3/5

7:00 am-10:05 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

Mon 3/9

9:45 am-9:52 pm

1 stop11h 07m

$522

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Wed 2/4

11:40 am-10:05 pm

1 stop10h 25m

Medellín Jose Maria Cordova Intl

Sun 2/8

10:45 am-9:47 pm

1 stop11h 02m

$532

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Sun 12/14

5:16 pm-10:05 pm

1 stop28h 49m

Medellín Jose Maria Cordova Intl

Sat 12/20

1:15 am-9:42 pm

2 stops20h 27m

$539

JacksonvilleQuito

JAX - UIO

JAXUIO

Jacksonville

Tue 3/3

7:00 am-12:30 am

1 stop17h 30m

Quito Mariscal Sucr

Tue 3/17

12:35 am-3:44 pm

1 stop14h 09m

$561

JacksonvilleQuito

JAX - UIO

JAXUIO

Jacksonville

Tue 3/3

5:05 pm-5:17 am

2 stops12h 12m

Quito Mariscal Sucr

Wed 3/18

7:00 pm-10:22 am

2 stops14h 22m

$566

JacksonvilleLima

JAX - LIM

JAXLIM

Jacksonville

Wed 3/18

7:30 am-8:15 pm

2 stops13h 45m

Lima J Chavez Intl

Sun 3/22

12:15 am-6:54 pm

2 stops17h 39m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from Jacksonville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Jacksonville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Jacksonville to South America

What is the cheapest month to book a flight from Jacksonville to South America?

Currently, January is the cheapest month in which you can book a flight from Jacksonville to South America (average of $236). Flying from Jacksonville to South America in July is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from JAX to SA?

Find hourly flight availability from Jacksonville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Jacksonville to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 12% on airfare.

What is the cheapest day to fly from Jacksonville to South America?

Use this chart to determine the cheapest time to fly round-trip from Jacksonville to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Jacksonville to South America flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 30, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and American Airlines from Jacksonville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
LATAM Airlines
7.5
Good
1,872 reviews
Delta
7.9
Good
7,993 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,030 reviews
Delta
7.9
Good
7,993 reviews

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Jacksonville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Jacksonville to South America?

    If you book a flight to South America from Jacksonville, you will be flying from Jacksonville, which is the city’s only airport. Jacksonville (JAX) is located 11.2 mi from the center of Jacksonville.

  • How long is the flight from Jacksonville to South America?

    Departing from Jacksonville to South America will take you 9h 30m. Jacksonville and South America are separated by a distance of 1440 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Jacksonville to South America one-way?

    The cheapest airlines for a one-way flight from Jacksonville to South America are Delta ($260), American Airlines ($294), and LATAM Airlines ($372).

  • What are the most popular routes from Jacksonville to South America?

    Most travelers choose Jacksonville - Lima J Chavez Intl, Jacksonville - Cartagena Rafael Nunez or Jacksonville - Quito Mariscal Sucr when deciding on the best route from Jacksonville to South America.

  • Can I find deals for flights from Jacksonville to South America that include hotel bookings?

    Yes. In addition to deals on Jacksonville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Jacksonville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Jacksonville to South America.

  • Can I find deals for business class flights from Jacksonville to South America?

    Yes. Cheapflights offers flight deals from Jacksonville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Jacksonville to South America?

    Currently, January is the cheapest month in which you can book a flight from Jacksonville to South America (average of $236). Flying from Jacksonville to South America in July is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Jacksonville to South America

Discover the top 3 airlines that operate flights from Jacksonville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$471Average$751FlexibilityNo cancel feeOn-time71%
DeltaCheapest$478Average$881FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$588Average$792FlexibilityNo cancel feeOn-time81%

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