HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santo Domingo

$184+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to Santo Domingo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Priceline deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Frontier
Mon 3/910:46 am
SDQ
-
STL
1 stop13h 33m
Frontier
Deal found 1/24$367
This Kiwi.com deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:52 am
STL
-
SDQ
1 stop24h 49m
Frontier
Fri 3/1310:56 am
SDQ
-
STL
1 stop13h 23m
Frontier
Deal found 1/23$387
This Kiwi.com deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:52 am
STL
-
SDQ
1 stop24h 49m
Multiple Airlines
Thu 3/122:59 am
SDQ
-
STL
2 stops11h 35m
Multiple Airlines
Deal found 1/23$392
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Multiple Airlines
Sun 3/82:32 pm
SDQ
-
STL
2 stops23h 47m
Multiple Airlines
Deal found 1/24$428
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:47 am
STL
-
SDQ
1 stop25h 04m
Multiple Airlines
Sun 3/152:30 pm
SDQ
-
STL
2 stops24h 04m
Multiple Airlines
Deal found 1/24$432
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:09 pm
STL
-
SDQ
2 stops46h 11m
Multiple Airlines
Mon 3/1610:46 am
SDQ
-
STL
1 stop13h 33m
Multiple Airlines
Deal found 1/25$447
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Multiple Airlines
Sun 3/152:59 am
SDQ
-
STL
2 stops11h 35m
Multiple Airlines
Deal found 1/25$452
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Multiple Airlines
Mon 3/92:32 pm
SDQ
-
STL
2 stops33h 47m
Multiple Airlines
Deal found 1/24$459
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Multiple Airlines
Sun 3/152:30 pm
SDQ
-
STL
2 stops24h 04m
Multiple Airlines
Deal found 1/25$466
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/61:09 pm
STL
-
SDQ
2 stops23h 11m
Multiple Airlines
Sat 3/1410:56 am
SDQ
-
STL
1 stop13h 41m
Multiple Airlines
Deal found 1/25$481
This Priceline deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:47 am
STL
-
SDQ
1 stop25h 04m
Frontier
Mon 3/1610:46 am
SDQ
-
STL
1 stop13h 33m
Frontier
Deal found 1/25$484
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:49 pm
STL
-
SDQ
1 stop16h 52m
Frontier
Mon 3/1610:46 am
SDQ
-
STL
1 stop13h 33m
Frontier
Deal found 1/25$488

Find flight deals from St. Louis to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$367
(Priceline)

One-way from

$184
(Kiwi.com)

Popular in

November

Cheapest in

September

Average price

$594
Provider with most accurate pricing for Lambert-St Louis-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santo Domingo Las Americas flights.
Search Deals
From Lambert-St Louis to Santo Domingo Las Americas
Search Deals
One-way flight from Lambert-St Louis to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($68 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

St. Louis

Fly to

Santo Domingo

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 3/5

3:49 pm-10:41 am

1 stop16h 52m

Santo Domingo Las Americas

Mon 3/9

10:46 am-11:19 pm

1 stop13h 33m

$367

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 3/8

7:52 am-9:41 am

1 stop24h 49m

Santo Domingo Las Americas

Thu 3/12

2:59 am-1:34 pm

2 stops11h 35m

$392

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 3/5

3:49 pm-10:41 am

1 stop16h 52m

Santo Domingo Las Americas

Sun 3/8

2:32 pm-1:19 pm

2 stops23h 47m

$428

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/6

7:47 am-10:51 am

1 stop25h 04m

Santo Domingo Las Americas

Sun 3/15

2:30 pm-1:34 pm

2 stops24h 04m

$432

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 3/5

3:49 pm-10:41 am

1 stop16h 52m

Santo Domingo Las Americas

Sun 3/15

2:30 pm-1:34 pm

2 stops24h 04m

$466

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/6

1:09 pm-2:20 pm

2 stops23h 11m

Santo Domingo Las Americas

Sat 3/14

10:56 am-11:37 pm

1 stop13h 41m

$481

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 3/30

7:47 am-1:38 am

2 stops16h 51m

Santo Domingo Las Americas

Mon 4/6

11:12 am-11:25 pm

1 stop13h 13m

$544

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

6:20 pm-8:43 am

1 stop13h 23m

Santo Domingo Las Americas

Sat 4/4

5:50 pm-10:32 am

1 stop17h 42m

$559

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

6:02 pm-12:21 pm

1 stop16h 19m

Santo Domingo Las Americas

Tue 2/24

11:01 am-5:40 pm

1 stop8h 39m

$564

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 2/2

8:22 pm-2:27 pm

2 stops16h 05m

$184

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 11 results
1
2

Compare providers for flights from St. Louis to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santo Domingo in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $380). Flying from St. Louis to Santo Domingo in June is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from St. Louis to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated January 26, 2026.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,111 reviews

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,111 reviews
Delta
7.9
Good
8,111 reviews

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,111 reviews

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santo Domingo?

    There are many flights that can get you from St. Louis to Santo Domingo in 16h 52m. Fly via Frontier to get the fastest option. There are 1873 mi between St. Louis and Santo Domingo.

  • What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

    Flying on Delta is currently your cheapest option to Santo Domingo, with prices starting at $514. Another option worth looking into is American Airlines, starting at $549 round trip. Delta is currently priced 20% below the average price you’ll pay for this route.

  • Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.

  • Can I find deals for business class flights from St. Louis to Santo Domingo?

    Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santo Domingo?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $380). Flying from St. Louis to Santo Domingo in June is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from St. Louis to Santo Domingo

Discover the top 2 airlines that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$514Average$594FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$549Average$644FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.