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Santo Domingo

$291+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amSTL - SDQ
1 stop6h 42mDelta
Thu 12/183:57 pmSDQ - STL
1 stop8h 00mDelta
Deal found 12/11$568
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amSTL - SDQ
1 stop6h 42mDelta
Thu 12/183:57 pmSDQ - STL
1 stop8h 00mDelta
Deal found 12/11$623
This Frontier deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:30 pmSTL - SDQ
2 stops15h 41mFrontier
Thu 12/184:39 pmSDQ - STL
2 stops17h 33mFrontier
Deal found 12/10$645
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:10 amSTL - SDQ
1 stop8h 48mAmerican Airlines
Thu 12/1811:07 amSDQ - STL
2 stops10h 23mAmerican Airlines
Deal found 12/11$647
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:30 amSTL - SDQ
1 stop14h 30mAmerican Airlines
Mon 1/126:29 pmSDQ - STL
1 stop16h 39mAmerican Airlines
Deal found 12/11$658
This Frontier deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/143:30 pmSTL - SDQ
2 stops15h 41mFrontier
Thu 12/184:39 pmSDQ - STL
2 stops17h 33mFrontier
Deal found 12/10$678

Find flight deals from St. Louis to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$518
(American Airlines)

One-way from

$291
(Kiwi.com)

Popular in

November

Cheapest in

March

Average price

$692
Provider with most accurate pricing for Lambert-St Louis-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santo Domingo Las Americas flights.
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From Lambert-St Louis to Santo Domingo Las Americas
Search Deals
One-way flight from Lambert-St Louis to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

St. Louis

Fly to

Santo Domingo

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

5:05 am-5:23 pm

1 stop10h 18m

Santo Domingo Las Americas

Tue 2/24

7:00 am-10:05 pm

1 stop17h 05m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 4/28

6:00 am-1:21 pm

1 stop6h 21m

Santo Domingo Las Americas

Thu 5/14

2:45 pm-11:38 pm

1 stop9h 53m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 4/27

6:05 pm-10:50 am

1 stop15h 45m

Santo Domingo Las Americas

Tue 5/12

3:25 pm-9:35 pm

1 stop7h 10m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 4/27

6:00 am-1:21 pm

1 stop6h 21m

Santo Domingo Las Americas

Tue 5/12

2:45 pm-11:38 pm

1 stop9h 53m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

5:04 pm-1:10 pm

2 stops18h 06m

Santo Domingo Las Americas

Tue 2/24

7:30 am-7:22 pm

2 stops13h 52m

$522

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 1/21

5:05 am-5:23 pm

1 stop10h 18m

Santo Domingo Las Americas

Sat 1/31

6:00 am-4:20 pm

2 stops12h 20m

$532

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 12/23

10:10 pm-3:32 am

2 stops51h 22m

$291

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 12/23

11:51 am-2:54 am

1 stop13h 03m

$412

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Compare providers for flights from St. Louis to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santo Domingo in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Santo Domingo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Santo Domingo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Santo Domingo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Currently, March is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $380). Flying from St. Louis to Santo Domingo in June is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SDQ?

Find hourly flight availability from St. Louis to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from St. Louis to Santo Domingo at noon. Doing so could potentially save you 59% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated December 12, 2025.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santo Domingo?

    There are many flights that can get you from St. Louis to Santo Domingo in 6h 21m. Fly via American Airlines or Delta to get the fastest option. There are 1873 mi between St. Louis and Santo Domingo. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

    Flying on Delta is currently your cheapest option to Santo Domingo, with prices starting at $514. Another option worth looking into is American Airlines, starting at $517 round trip. Delta is currently priced 19% below the average price you’ll pay for this route.

  • Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.

  • Can I find deals for business class flights from St. Louis to Santo Domingo?

    Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santo Domingo?

    Currently, March is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $380). Flying from St. Louis to Santo Domingo in June is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 2 airlines flying from St. Louis to Santo Domingo

Discover the top 2 airlines that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$514Average$594FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$517Average$644FlexibilityNo cancel feeOn-time71%

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