What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

Flying on Spirit Airlines is currently your cheapest option to Santo Domingo, with prices starting at $407. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $525 and $530, respectively. Spirit Airlines is currently priced 34% below the average price you’ll pay for this route.

What is the cheapest day to fly from St. Louis to Santo Domingo?

Travelers seeking maximum savings on their St. Louis to Santo Domingo flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

What are the most popular airlines that fly from St. Louis to Santo Domingo?

When booking a flight from St. Louis to Santo Domingo, you may want to consider flying on American Airlines, Delta or Frontier as they are the most popular for this route.

What is the cheapest day to fly round-trip from St. Louis to Santo Domingo?

Tuesday is generally a great day to depart. Flying on this day could help you save up to 57%.

What is the cheapest month to fly from St. Louis to Santo Domingo?

September can be a great time to fly to Santo Domingo from St. Louis with a flight ticket averaging about $626. Cheapflights users have found deals in the month of September for as cheap as $524. The most expensive prices can be found in the month of July.

Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.

Can I find deals for business class flights from St. Louis to Santo Domingo?

Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$201+ Flights from St. Louis to Santo Domingo

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Cheap flight deals from St. Louis to Santo Domingo

Round-trip from	$407 (SmartFares)
One-way from	$201 (Kiwi.com)
Popular in	July
Cheapest in	September
Average price	$806

From Lambert-St Louis to Santo Domingo Las Americas

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One-way flight from Lambert-St Louis to Santo Domingo Las Americas

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Highest demand for flights based on searches. 10% potential increase in price ($73 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Tue 8/55:26 pmSTL - SDQ

1 stop21h 21mSpirit Airlines

Sun 8/245:05 pmSDQ - STL

2 stops21h 27mSpirit Airlines

Deal found 7/27

$407

Fri 9/121:57 pmSTL - SDQ

1 stop22h 10mMultiple Airlines

Sat 9/203:47 pmSDQ - STL

1 stop18h 53mMultiple Airlines

Deal found 7/26

$418

Sun 11/236:00 amSTL - SDQ

1 stop6h 57mDelta

Tue 12/26:40 amSDQ - STL

1 stop12h 00mDelta

Deal found 7/26

$515

Sun 8/245:26 amSTL - SDQ

1 stop14h 04mAmerican Airlines

Sun 8/312:35 pmSDQ - STL

1 stop10h 24mAmerican Airlines

Deal found 7/27

$530

Wed 7/305:40 pmSTL - SDQ

1 stop16h 05mFrontier

Tue 8/56:41 pmSDQ - STL

2 stops30h 06mFrontier

Deal found 7/27

$621

Best flights from St. Louis to Santo Domingo
Discover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Tue 8/55:26 pmSTL - SDQ

1 stop21h 21mSpirit Airlines

Sun 8/245:05 pmSDQ - STL

2 stops21h 27mSpirit Airlines

Deal found 7/27

$407

Fri 9/121:57 pmSTL - SDQ

1 stop22h 10mMultiple Airlines

Sat 9/203:47 pmSDQ - STL

1 stop18h 53mMultiple Airlines

Deal found 7/26

$418

Fri 9/266:01 amSTL - SDQ

1 stop6h 23mDelta

Tue 10/72:56 pmSDQ - STL

1 stop8h 08mDelta

Deal found 7/28

$525

Sun 8/245:26 amSTL - SDQ

1 stop14h 04mAmerican Airlines

Sun 8/312:35 pmSDQ - STL

1 stop10h 24mAmerican Airlines

Deal found 7/27

$530

Last-minute flights from St. Louis to Santo Domingo
Discover last-minute flight deals from St. Louis to Santo Domingo. Data last updated July 29, 2025 and is based on user searches.

Wed 7/305:40 pmSTL - SDQ

1 stop16h 05mFrontier

Tue 8/56:41 pmSDQ - STL

2 stops30h 06mFrontier

Deal found 7/27

$621

Thu 7/312:36 pmSTL - SDQ

1 stop8h 52mMultiple Airlines

Sat 8/235:05 pmSDQ - STL

1 stop17h 35mMultiple Airlines

Deal found 7/27

$459

Tue 8/55:26 pmSTL - SDQ

1 stop21h 21mSpirit Airlines

Sun 8/245:05 pmSDQ - STL

2 stops21h 27mSpirit Airlines

Deal found 7/27

$407

Tue 8/55:00 amSTL - SDQ

1 stop12h 20mAmerican Airlines

Sun 8/242:35 pmSDQ - STL

1 stop10h 24mAmerican Airlines

Deal found 7/27

$547

Tue 8/55:26 pmSTL - SDQ

1 stop21h 21mMultiple Airlines

Sat 8/233:24 amSDQ - STL

2 stops35h 57mMultiple Airlines

Deal found 7/27

$693

Sun 8/245:26 amSTL - SDQ

1 stop14h 04mAmerican Airlines

Sun 8/312:35 pmSDQ - STL

1 stop10h 24mAmerican Airlines

Deal found 7/27

$530

One-way flights from St. Louis to Santo Domingo
Search for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated July 29, 2025.

Sun 8/35:26 pmSTL - SDQ

1 stop21h 21mSpirit Airlines

Deal found 7/27

$201

Fri 8/293:16 pmSTL - SDQ

1 stop19h 40mMultiple Airlines

Deal found 7/29

$229

Mon 8/45:00 amSTL - SDQ

1 stop7h 28mAmerican Airlines

Deal found 7/27

$326

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/5

5:26 pm-3:47 pm

1 stop21h 21m

Santo Domingo Las Americas

Sun 8/24

5:05 pm-1:32 pm

2 stops21h 27m

$407

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 9/12

1:57 pm-1:07 pm

1 stop22h 10m

Santo Domingo Las Americas

Sat 9/20

3:47 pm-9:40 am

1 stop18h 53m

$418

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 9/26

6:01 am-1:24 pm

1 stop6h 23m

Santo Domingo Las Americas

Tue 10/7

2:56 pm-10:04 pm

1 stop8h 08m

$525

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 8/24

5:26 am-8:30 pm

1 stop14h 04m

Santo Domingo Las Americas

Sun 8/31

2:35 pm-11:59 pm

1 stop10h 24m

$530

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 8/3

5:26 pm-3:47 pm

1 stop21h 21m

$201

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 8/29

3:16 pm-11:56 am

1 stop19h 40m

$229

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 8/4

5:00 am-1:28 pm

1 stop7h 28m

$326

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SDQ?

It’s typically best to fly out from St. Louis to Santo Domingo at noon. Doing so could potentially save you 28% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santo Domingo

Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta, American Airlines, and Spirit Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,979 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,979 reviews

Delta

8.0

Very good

7,979 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,979 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Spirit Airlines

6.3

Okay

8,044 reviews

Delta

8.0

Very good

7,979 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?
Flying on Spirit Airlines is currently your cheapest option to Santo Domingo, with prices starting at $407. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $525 and $530, respectively. Spirit Airlines is currently priced 34% below the average price you’ll pay for this route.
Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?
Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.
Can I find deals for business class flights from St. Louis to Santo Domingo?
Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to Santo Domingo?
Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from St. Louis to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$371	Average$384	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$423	Average$631	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$453	Average$644	FlexibilityNo cancel fee	On-time71%

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$201+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to Santo Domingo with Cheapflights

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Cheap flight deals from St. Louis to Santo Domingo

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo DomingoExplore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

What is the cheapest time of day to fly from STL to SDQ?

Find hourly flight availability from St. Louis to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Reviews of airlines servicing Santo Domingo

Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta, American Airlines, and Spirit Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

How can I find direct flights from St. Louis to Santo Domingo?

Can I find deals for business class flights from St. Louis to Santo Domingo?

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Traveling to a place near Santo Domingo?

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Alternative routes for St. Louis to Santo Domingo

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Top 3 airlines flying from St. Louis to Santo Domingo

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Travel Smart

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.