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Santo Domingo

$198+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from St. Louis to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$370
(Kiwi.com)

One-way from

$198
(Kiwi.com)

Popular in

October

Cheapest in

March

Average price

$558
From Lambert-St Louis to Santo Domingo Las Americas
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One-way flight from Lambert-St Louis to Santo Domingo Las Americas
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Highest demand for flights based on searches. 2% potential increase in price ($17 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/224:00 pmSTL - SDQ
2 stops23h 00mMultiple Airlines
Sat 9/273:47 pmSDQ - STL
1 stop18h 53mMultiple Airlines
Deal found 9/10$378
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2610:57 amSTL - SDQ
1 stop28h 10mMultiple Airlines
Sun 11/23:35 pmSDQ - STL
2 stops43h 32mMultiple Airlines
Deal found 9/11$485
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:23 amSTL - SDQ
1 stop14h 07mAmerican Airlines
Wed 10/154:20 pmSDQ - STL
1 stop8h 36mAmerican Airlines
Deal found 9/10$515
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2611:32 amSTL - SDQ
2 stops28h 49mFrontier
Sun 11/26:38 pmSDQ - STL
2 stops17h 02mFrontier
Deal found 9/11$518
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:40 amSTL - SDQ
2 stops10h 44mDelta
Sun 10/196:05 amSDQ - STL
1 stop11h 38mDelta
Deal found 9/9$529
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/155:23 amSTL - SDQ
1 stop14h 07mAmerican Airlines
Sun 10/192:35 pmSDQ - STL
1 stop10h 21mAmerican Airlines
Deal found 9/9$530
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:56 pmSTL - SDQ
2 stops16h 23mAmerican Airlines
Sat 11/154:45 pmSDQ - STL
1 stop7h 42mAmerican Airlines
Deal found 9/11$542
This Mytrip deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/151:00 pmSTL - SDQ
3 stops31h 45mMultiple Airlines
Sun 10/193:54 pmSDQ - STL
3 stops21h 06mMultiple Airlines
Deal found 9/9$566
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/117:22 amSTL - SDQ
2 stops12h 08mAmerican Airlines
Sun 9/1412:15 pmSDQ - STL
1 stop12h 44mAmerican Airlines
Deal found 9/11$584

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

St. Louis

Fly to

Santo Domingo

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 9/22

4:00 pm-4:00 pm

2 stops23h 00m

Santo Domingo Las Americas

Sat 9/27

3:47 pm-9:40 am

1 stop18h 53m

$378

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 10/26

10:57 am-4:07 pm

1 stop28h 10m

Santo Domingo Las Americas

Sun 11/2

3:35 pm-9:07 am

2 stops43h 32m

$485

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 10/8

5:23 am-8:30 pm

1 stop14h 07m

Santo Domingo Las Americas

Wed 10/15

4:20 pm-11:56 pm

1 stop8h 36m

$515

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 10/26

11:32 am-5:21 pm

2 stops28h 49m

Santo Domingo Las Americas

Sun 11/2

6:38 pm-9:40 am

2 stops17h 02m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 10/15

6:40 am-6:24 pm

2 stops10h 44m

Santo Domingo Las Americas

Sun 10/19

6:05 am-4:43 pm

1 stop11h 38m

$529

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 10/26

6:08 pm-9:25 am

1 stop14h 17m

Santo Domingo Las Americas

Sun 11/2

5:00 am-9:52 pm

1 stop18h 52m

$530

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 11/7

5:56 pm-12:19 pm

2 stops16h 23m

Santo Domingo Las Americas

Sat 11/15

4:45 pm-10:27 pm

1 stop7h 42m

$542

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 9/21

10:35 am-4:00 pm

1 stop28h 25m

$198

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 9/21

4:00 pm-4:00 pm

3 stops23h 00m

$233

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 12/16

5:54 pm-12:01 pm

2 stops16h 07m

$307

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 11 results
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Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SDQ?

Find hourly flight availability from St. Louis to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from St. Louis to Santo Domingo at noon. Doing so could potentially save you 28% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta, American Airlines, and Frontier. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.8
Fair
3,177 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Santo Domingo?

    There are many flights that can get you from St. Louis to Santo Domingo in 14h 07m. Fly via American Airlines or Frontier to get the fastest option. There are 1873 mi between St. Louis and Santo Domingo. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

    Flying on Frontier is currently your cheapest option to Santo Domingo, with prices starting at $371. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $462 and $514, respectively. Frontier is currently priced 42% below the average price you’ll pay for this route.

  • Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.

  • Can I find deals for business class flights from St. Louis to Santo Domingo?

    Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 3 airlines flying from St. Louis to Santo Domingo

Discover the top 3 airlines that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$371Average$384FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$462Average$644FlexibilityNo cancel feeOn-time71%
DeltaCheapest$514Average$603FlexibilityNo cancel feeOn-timeN/A

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