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Santo Domingo

$139+ Cheap flights from South Carolina to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDQ
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to Santo Domingo

Keep the following information in mind while searching for South Carolina to Santo Domingo flight deals. Data was last updated September 17, 2025.

Round-trip from

$283
(Cheapflightsfares)

One-way from

$139
(Cheapflightsfares)

Popular in

December

Cheapest in

February

Average price

$498
From South Carolina to Santo Domingo Las Americas
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One-way flight from South Carolina to Santo Domingo Las Americas
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 4% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from South Carolina to Santo Domingo

Cheapest flights from South Carolina to Santo Domingo
Explore the most affordable flight options available from South Carolina to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/115:45 amCLT - SDQ
1 stop9h 09mSpirit Airlines
Fri 10/175:12 pmSDQ - CLT
1 stop16h 12mSpirit Airlines
Deal found 9/16$283
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2910:17 amCLT - SDQ
1 stop5h 43mSpirit Airlines
Mon 10/65:12 pmSDQ - CLT
1 stop6h 16mSpirit Airlines
Deal found 9/17$289
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/310:17 amCLT - SDQ
1 stop5h 43mSpirit Airlines
Fri 10/105:12 pmSDQ - CLT
1 stop16h 12mSpirit Airlines
Deal found 9/16$301
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2910:17 amCLT - SDQ
1 stop5h 43mMultiple Airlines
Sun 10/53:35 pmSDQ - CLT
1 stop16h 36mMultiple Airlines
Deal found 9/17$302
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/135:45 amCLT - SDQ
1 stop10h 22mSpirit Airlines
Sat 11/13:59 pmSDQ - CLT
1 stop7h 29mSpirit Airlines
Deal found 9/17$306
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/267:24 pmCLT - SDQ
1 stop21h 05mMultiple Airlines
Fri 10/3110:19 amSDQ - CLT
1 stop11h 38mMultiple Airlines
Deal found 9/16$311
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:45 amCLT - SDQ
1 stop9h 03mSpirit Airlines
Sat 10/183:59 pmSDQ - CLT
1 stop7h 29mSpirit Airlines
Deal found 9/17$313
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/149:42 amCHS - SDQ
1 stop5h 38mAmerican Airlines
Tue 10/217:00 amSDQ - CHS
1 stop12h 04mAmerican Airlines
Deal found 9/14$315
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amCHS - SDQ
1 stop9h 20mAmerican Airlines
Fri 11/146:14 pmSDQ - CHS
1 stop6h 45mAmerican Airlines
Deal found 9/14$316
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:45 amCLT - SDQ
1 stop10h 15mSpirit Airlines
Mon 10/65:12 pmSDQ - CLT
1 stop6h 16mSpirit Airlines
Deal found 9/17$316
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:00 amCHS - SDQ
1 stop12h 08mDelta
Wed 11/196:45 amSDQ - CHS
1 stop11h 20mDelta
Deal found 9/15$317
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:44 pmCHS - SDQ
1 stop13h 41mAmerican Airlines
Mon 10/134:20 pmSDQ - CHS
1 stop16h 41mAmerican Airlines
Deal found 9/16$322

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

South Carolina

Fly to

Santo Domingo

Route

Depart

Return

Price

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 10/14

9:42 am-3:20 pm

1 stop5h 38m

Santo Domingo Las Americas

Tue 10/21

7:00 am-7:04 pm

1 stop12h 04m

$315

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/2

12:51 pm-12:36 am

1 stop11h 45m

Santo Domingo Las Americas

Mon 10/6

6:05 am-5:51 pm

1 stop11h 46m

$315

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 10/30

6:00 am-6:24 pm

1 stop12h 24m

Santo Domingo Las Americas

Sun 11/2

7:05 am-9:00 pm

1 stop14h 55m

$316

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 11/14

6:00 am-7:08 pm

1 stop12h 08m

Santo Domingo Las Americas

Wed 11/19

6:45 am-5:05 pm

1 stop11h 20m

$317

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 10/15

7:41 pm-1:35 pm

2 stops17h 54m

Santo Domingo Las Americas

Fri 11/14

6:14 pm-8:29 am

2 stops15h 15m

$321

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 10/10

7:44 pm-9:25 am

1 stop13h 41m

Santo Domingo Las Americas

Mon 10/13

4:20 pm-9:01 am

1 stop16h 41m

$322

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 11/1

1:49 pm-9:45 pm

1 stop7h 56m

Santo Domingo Las Americas

Sat 11/8

6:55 pm-12:59 am

1 stop7h 04m

$326

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Fri 10/31

5:45 am-4:07 pm

1 stop10h 22m

Santo Domingo Las Americas

Fri 11/7

6:55 pm-9:27 am

1 stop15h 32m

$334

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 10/11

5:45 am-2:54 pm

1 stop9h 09m

Santo Domingo Las Americas

Fri 10/17

5:12 pm-9:24 am

1 stop16h 12m

$346

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 9/30

2:47 pm-4:00 pm

2 stops25h 13m

Santo Domingo Las Americas

Wed 10/15

10:19 am-12:39 pm

1 stop26h 20m

$356

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santo Domingo

What is the cheapest month to book a flight from South Carolina to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SDQ?

Find hourly flight availability from South Carolina to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from South Carolina to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from South Carolina?

    If you book a flight to Santo Domingo from South Carolina, you will be flying to Las Americas, which is the city’s only airport. Santo Domingo Las Americas (SDQ) is located 17.5 mi from the center of Santo Domingo.

  • How long is the flight from South Carolina to Santo Domingo?

    For as low as $315, American Airlines can have you in Santo Domingo from South Carolina in 5h 38m. There are 1187 mi between South Carolina and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Santo Domingo one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $141. Users have also found prices from $147 and $147 on Delta and United Airlines, respectively.

  • What are the most popular routes from South Carolina to Santo Domingo?

    The most popular route from South Carolina to Santo Domingo is Charlotte Douglas - Santo Domingo Las Americas. You may also consider Charleston - Santo Domingo Las Americas or Savannah/Hilton Head - Santo Domingo Las Americas.

  • Can I find deals for flights from South Carolina to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santo Domingo.

  • Can I find deals for business class flights from South Carolina to Santo Domingo?

    Yes. Cheapflights offers flight deals from South Carolina to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for South Carolina to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Baltimore to Santo Domingo flights
LaGuardia to Puerto Plata flights
Cleveland to Punta Cana flights
Reagan-National to Santo Domingo flights
Miami to Santiago de los Caballeros flights
Dallas/Fort Worth to Santo Domingo flights
Fort Lauderdale to Santiago de los Caballeros flights
Indianapolis to Punta Cana flights
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Top 3 airlines flying from South Carolina to Santo Domingo

Discover the top 3 airlines that operate flights from South Carolina to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$453FlexibilityNo cancel feeOn-time65%
DeltaCheapest$420Average$682FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$420Average$591FlexibilityNo cancel feeOn-time71%

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