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Santo Domingo

$129+ Cheap flights from South Carolina to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDQ
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Santo Domingo

Keep the following information in mind while searching for South Carolina to Santo Domingo flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$290
(Booking.com)

One-way from

$129
(Mytrip)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
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From South Carolina to Santo Domingo Las Americas
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One-way flight from South Carolina to Santo Domingo Las Americas
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Find flight deals from South Carolina to Santo Domingo

Cheapest flights from South Carolina to Santo Domingo
Explore the most affordable flight options available from South Carolina to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/78:46 pmCLT - SDQ
1 stop11h 52mFrontier
Sat 6/146:41 pmSDQ - CLT
1 stop24h 57mFrontier
Deal found 4/29$278
This Booking.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/98:50 amCLT - SDQ
1 stop6h 55mMultiple Airlines
Wed 7/96:41 pmSDQ - CLT
1 stop24h 56mMultiple Airlines
Deal found 4/29$359
This SmartFares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/198:50 amCLT - SDQ
1 stop6h 55mSpirit Airlines
Wed 6/44:05 pmSDQ - CLT
1 stop5h 55mSpirit Airlines
Deal found 4/30$392
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/169:31 pmCHS - SDQ
2 stops17h 04mMultiple Airlines
Fri 5/234:50 pmSDQ - CHS
1 stop15h 48mMultiple Airlines
Deal found 4/29$416
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/46:00 amCHS - SDQ
1 stop8h 10mUnited Airlines
Mon 6/93:20 pmSDQ - CHS
1 stop8h 28mUnited Airlines
Deal found 4/28$431
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/175:02 pmCHS - SDQ
1 stop5h 38mAmerican Airlines
Thu 7/1710:15 amSDQ - CHS
1 stop8h 33mAmerican Airlines
Deal found 4/29$432
This JetBlue deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/176:59 pmCHS - SDQ
1 stop8h 23mJetBlue
Sun 6/2211:30 pmSDQ - CHS
1 stop10h 45mJetBlue
Deal found 4/29$441
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/208:12 pmGSP - SDQ
1 stop13h 03mAmerican Airlines
Wed 7/3010:15 amSDQ - GSP
1 stop9h 27mAmerican Airlines
Deal found 4/30$465
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1710:44 amCHS - SDQ
2 stops13h 53mDelta
Sun 6/226:00 amSDQ - CHS
2 stops14h 46mDelta
Deal found 4/30$475
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/186:16 pmMYR - SDQ
2 stops14h 59mAmerican Airlines
Wed 7/237:00 amSDQ - MYR
2 stops8h 27mAmerican Airlines
Deal found 4/29$479
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/67:11 amSAV - SDQ
1 stop13h 36mAmerican Airlines
Thu 5/812:15 pmSDQ - SAV
1 stop5h 48mAmerican Airlines
Deal found 4/29$485
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:40 pmCLT - SDQ
1 stop14h 33mAmerican Airlines
Tue 7/810:15 amSDQ - CLT
1 stop11h 08mAmerican Airlines
Deal found 4/29$495

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

South Carolina

Fly to

Santo Domingo

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 6/7

8:46 pm-8:38 am

1 stop11h 52m

Santo Domingo Las Americas

Sat 6/14

6:41 pm-7:38 pm

1 stop24h 57m

$278

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 6/9

8:50 am-3:45 pm

1 stop6h 55m

Santo Domingo Las Americas

Wed 7/9

6:41 pm-7:37 pm

1 stop24h 56m

$359

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 5/19

8:50 am-3:45 pm

1 stop6h 55m

Santo Domingo Las Americas

Wed 6/4

4:05 pm-10:00 pm

1 stop5h 55m

$392

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Fri 5/16

9:31 pm-2:35 pm

2 stops17h 04m

Santo Domingo Las Americas

Fri 5/23

4:50 pm-8:38 am

1 stop15h 48m

$416

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Wed 6/4

6:00 am-2:10 pm

1 stop8h 10m

Santo Domingo Las Americas

Mon 6/9

3:20 pm-11:48 pm

1 stop8h 28m

$431

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Sat 5/17

5:02 pm-10:40 pm

1 stop5h 38m

Santo Domingo Las Americas

Thu 7/17

10:15 am-6:48 pm

1 stop8h 33m

$432

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/17

6:59 pm-3:22 am

1 stop8h 23m

Santo Domingo Las Americas

Sun 6/22

11:30 pm-10:15 am

1 stop10h 45m

$441

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 7/20

8:12 pm-9:15 am

1 stop13h 03m

Santo Domingo Las Americas

Wed 7/30

10:15 am-7:42 pm

1 stop9h 27m

$465

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 6/17

10:44 am-12:37 am

2 stops13h 53m

Santo Domingo Las Americas

Sun 6/22

6:00 am-8:46 pm

2 stops14h 46m

$475

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 7/18

6:16 pm-9:15 am

2 stops14h 59m

Santo Domingo Las Americas

Wed 7/23

7:00 am-3:27 pm

2 stops8h 27m

$479

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 30 results
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Best time to book a flight from South Carolina to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santo Domingo

What is the cheapest month to book a flight from South Carolina to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SDQ?

Find hourly flight availability from South Carolina to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South Carolina to Santo Domingo, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

Temperature in Santo Domingo by month

Plan your trip to Santo Domingo by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated May 1, 2025.
See what other customers who have flown with Delta, Copa Airlines and United Airlines from South Carolina to Santo Domingo have to say. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,414 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
JetBlue
7.3
Good
2,924 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from South Carolina?

    If you book a flight to Santo Domingo from South Carolina, you will be flying to Las Americas, which is the city’s only airport. Santo Domingo Las Americas (SDQ) is located 17.5 mi from the center of Santo Domingo.

  • What are the cheapest airlines to fly from South Carolina to Santo Domingo one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $129. Users have also found prices from $180 and $276 on Spirit Airlines and American Airlines, respectively.

  • What are the most popular routes from South Carolina to Santo Domingo?

    The most popular route from South Carolina to Santo Domingo is Charlotte Douglas - Santo Domingo Las Americas. You may also consider Charleston - Santo Domingo Las Americas or Greenville - Santo Domingo Las Americas.

  • Can I find deals for flights from South Carolina to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santo Domingo.

  • Can I find deals for business class flights from South Carolina to Santo Domingo?

    Yes. Cheapflights offers flight deals from South Carolina to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $362). Flying from South Carolina to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Juan Dolio

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Alternative routes for South Carolina to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Fort Lauderdale to Santo Domingo flights
Miami to Santo Domingo flights
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Midway to Punta Cana flights
Miami to Santiago de los Caballeros flights
Dulles Intl to Santo Domingo flights
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Dallas/Fort Worth to Santo Domingo flights
San Francisco to Punta Cana flights
New Orleans to Punta Cana flights
Atlantic City to Punta Cana flights
LaGuardia to Puerto Plata flights
Fort Lauderdale to Santiago de los Caballeros flights
Minneapolis to Punta Cana flights
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Denver to Punta Cana flights
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Reagan-National to Santo Domingo flights
Cincinnati to Punta Cana flights

Top 2 airlines flying from South Carolina to Santo Domingo

Discover the top 2 airlines that operate flights from South Carolina to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$320Average$510FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$653FlexibilityNo cancel feeOn-time71%

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