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Santo Domingo

$116+ Cheap flights from South Carolina to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDQ
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from South Carolina to Santo Domingo

Cheapest flights from South Carolina to Santo Domingo
Explore the most affordable flight options available from South Carolina to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Travelocity deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:55 am
CLT
-
SDQ
1 stop7h 25m
Spirit Airlines
Sat 3/73:32 pm
SDQ
-
CLT
1 stop9h 24m
Spirit Airlines
Deal found 2/2$249
This Cheapflightsfares deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 am
CHS
-
SDQ
1 stop7h 32m
Spirit Airlines
Thu 4/303:37 pm
SDQ
-
CHS
1 stop7h 04m
Spirit Airlines
Deal found 2/2$267
This Priceline deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:28 pm
MYR
-
SDQ
1 stop7h 10m
Spirit Airlines
Fri 3/272:52 am
SDQ
-
MYR
1 stop14h 41m
Spirit Airlines
Deal found 2/2$270
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
-
SDQ
1 stop8h 29m
Multiple Airlines
Thu 3/512:31 pm
SDQ
-
CLT
1 stop20h 32m
Multiple Airlines
Deal found 2/3$273
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:42 pm
CLT
-
SDQ
1 stop12h 14m
Frontier
Thu 3/512:31 pm
SDQ
-
CLT
1 stop20h 32m
Frontier
Deal found 2/3$280
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:55 am
CLT
-
SDQ
1 stop7h 25m
Spirit Airlines
Wed 3/112:32 pm
SDQ
-
CLT
1 stop9h 24m
Spirit Airlines
Deal found 2/3$284
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
-
SDQ
1 stop8h 29m
Multiple Airlines
Fri 3/611:46 am
SDQ
-
CLT
1 stop22h 14m
Multiple Airlines
Deal found 2/3$285
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
CLT
-
SDQ
1 stop9h 29m
Multiple Airlines
Fri 3/1310:56 am
SDQ
-
CLT
1 stop22h 04m
Multiple Airlines
Deal found 2/2$286
This CheapOair deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/179:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Tue 3/242:20 pm
SDQ
-
CLT
1 stop5h 57m
Spirit Airlines
Deal found 2/4$287
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:00 am
CLT
-
SDQ
1 stop8h 29m
Multiple Airlines
Tue 3/102:32 pm
SDQ
-
CLT
1 stop23h 45m
Multiple Airlines
Deal found 2/3$288
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
CLT
-
SDQ
1 stop9h 29m
Multiple Airlines
Mon 4/133:01 pm
SDQ
-
CLT
1 stop21h 06m
Multiple Airlines
Deal found 2/3$290
This Cheapflightsfares deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:00 pm
CLT
-
SDQ
1 stop16h 15m
Spirit Airlines
Fri 3/202:52 am
SDQ
-
CLT
1 stop9h 15m
Spirit Airlines
Deal found 2/2$291

Find flight deals from South Carolina to Santo Domingo

Keep the following information in mind while searching for South Carolina to Santo Domingo flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Travelocity)

One-way from

$116
(FlightHub)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
Search Deals
From South Carolina to Santo Domingo Las Americas
Search Deals
One-way flight from South Carolina to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

South Carolina

Fly to

Santo Domingo

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 3/9

5:55 am-1:20 pm

1 stop7h 25m

Santo Domingo Las Americas

Wed 3/11

2:32 pm-11:56 pm

1 stop9h 24m

$256

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/23

7:00 am-2:32 pm

1 stop7h 32m

Santo Domingo Las Americas

Thu 4/30

3:37 pm-10:41 pm

1 stop7h 04m

$267

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 3/17

9:00 pm-1:15 pm

1 stop16h 15m

Santo Domingo Las Americas

Tue 3/24

2:20 pm-12:38 am

1 stop10h 18m

$287

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Wed 3/18

7:00 am-4:29 pm

1 stop9h 29m

Santo Domingo Las Americas

Sat 3/21

2:52 am-8:21 am

1 stop29h 29m

$293

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Fri 2/20

6:37 pm-2:20 pm

1 stop18h 43m

Santo Domingo Las Americas

Tue 2/24

1:11 pm-1:51 pm

1 stop25h 40m

$293

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 2/26

1:20 pm-4:00 am

1 stop13h 40m

Santo Domingo Las Americas

Fri 2/27

4:55 am-3:04 pm

1 stop11h 09m

$298

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 4/9

8:07 am-1:15 pm

1 stop5h 08m

Santo Domingo Las Americas

Mon 4/13

2:20 pm-10:13 pm

1 stop7h 53m

$299

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Tue 3/3

5:00 pm-5:25 am

1 stop11h 25m

Santo Domingo Las Americas

Sun 3/8

2:32 pm-5:40 pm

1 stop27h 08m

$300

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Mon 2/16

11:12 am-11:56 am

1 stop23h 44m

Santo Domingo Las Americas

Mon 3/16

10:46 am-8:03 am

1 stop21h 17m

$304

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 3/3

5:55 am-2:20 pm

1 stop7h 25m

Santo Domingo Las Americas

Mon 3/9

2:32 pm-8:26 am

1 stop17h 54m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 56 results
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Best time to book a flight from South Carolina to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santo Domingo

What is the cheapest month to book a flight from South Carolina to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $324). Flying from South Carolina to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from South Carolina?

    If you book a flight to Santo Domingo from South Carolina, you will be flying to Las Americas, which is the city’s only airport. Santo Domingo Las Americas (SDQ) is located 17.5 mi from the center of Santo Domingo.

  • How long is the flight from South Carolina to Santo Domingo?

    For as low as $256, Spirit Airlines can have you in Santo Domingo from South Carolina in 7h 25m. There are 1349 mi between South Carolina and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Santo Domingo one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $89. Users have also found prices from $153 and $295 on American Airlines and United Airlines, respectively.

  • What are the most popular routes from South Carolina to Santo Domingo?

    The most popular route from South Carolina to Santo Domingo is Charlotte Douglas - Santo Domingo Las Americas. You may also consider Greenville - Santo Domingo Las Americas or Charleston - Santo Domingo Las Americas.

  • Can I find deals for flights from South Carolina to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santo Domingo.

  • Can I find deals for business class flights from South Carolina to Santo Domingo?

    Yes. Cheapflights offers flight deals from South Carolina to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $324). Flying from South Carolina to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for South Carolina to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Santo Domingo

Discover the top 2 airlines that operate flights from South Carolina to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$297Average$642FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$333Average$518FlexibilityNo cancel feeOn-time71%

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