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Santo Domingo

$125+ Cheap flights from South Carolina to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDQ
Jan 19 — Jan 261
Mon 1/19
Mon 1/26
1 adult, Economy
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Cheap flight deals from South Carolina to Santo Domingo

Cheapest flights from South Carolina to Santo Domingo
Explore the most affordable flight options available from South Carolina to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 20, 2025.

This Frontier deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:16 amCLT - SDQ
1 stop8h 11mFrontier
Thu 1/84:27 pmSDQ - CLT
2 stops18h 09mFrontier
Deal found 12/18$411
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:34 pmCLT - SDQ
1 stop12h 46mMultiple Airlines
Mon 12/296:04 pmSDQ - CLT
1 stop27h 05mMultiple Airlines
Deal found 12/18$413
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:43 pmCLT - SDQ
1 stop12h 37mMultiple Airlines
Wed 12/313:59 amSDQ - CLT
1 stop6h 40mMultiple Airlines
Deal found 12/20$417
This Expedia deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:11 pmCLT - SDQ
1 stop16h 31mMultiple Airlines
Tue 12/303:59 amSDQ - CLT
1 stop17h 34mMultiple Airlines
Deal found 12/19$434
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:34 pmCLT - SDQ
2 stops28h 20mMultiple Airlines
Mon 12/296:04 pmSDQ - CLT
1 stop27h 05mMultiple Airlines
Deal found 12/18$439
This Priceline deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:11 pmCLT - SDQ
1 stop16h 31mFrontier
Mon 12/298:42 pmSDQ - CLT
1 stop13h 49mFrontier
Deal found 12/18$440
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:02 pmCLT - SDQ
1 stop29h 30mMultiple Airlines
Wed 12/246:04 pmSDQ - CLT
1 stop23h 34mMultiple Airlines
Deal found 12/18$442
This Booking.com deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:38 pmCLT - SDQ
1 stop11h 32mMultiple Airlines
Mon 12/294:21 pmSDQ - CLT
1 stop8h 08mMultiple Airlines
Deal found 12/19$444
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:34 pmCLT - SDQ
1 stop28h 58mSpirit Airlines
Wed 12/243:59 amSDQ - CLT
1 stop17h 34mSpirit Airlines
Deal found 12/17$447
This Priceline deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:24 pmCLT - SDQ
1 stop13h 46mFrontier
Sun 12/2810:41 amSDQ - CLT
1 stop23h 40mFrontier
Deal found 12/19$450
This Booking.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:39 pmCLT - SDQ
1 stop19h 31mMultiple Airlines
Mon 12/293:59 amSDQ - CLT
1 stop6h 40mMultiple Airlines
Deal found 12/20$452
This Priceline deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:54 amMYR - SDQ
1 stop16h 00mSpirit Airlines
Sat 12/273:59 amSDQ - MYR
1 stop15h 09mSpirit Airlines
Deal found 12/19$456

Find flight deals from South Carolina to Santo Domingo

Keep the following information in mind while searching for South Carolina to Santo Domingo flight deals. Data was last updated December 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$287
(Priceline)

One-way from

$125
(Frontier)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
Search Deals
From South Carolina to Santo Domingo Las Americas
Search Deals
One-way flight from South Carolina to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
Use the filters below to find and compare flights from South Carolina to Santo Domingo that are best for you.

Fly from

South Carolina

Fly to

Santo Domingo

Route

Depart

Return

Price

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 2/7

6:00 am-2:27 pm

1 stop7h 27m

Santo Domingo Las Americas

Wed 2/11

3:32 pm-12:40 am

1 stop10h 08m

$305

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Fri 1/16

6:00 am-2:27 pm

1 stop7h 27m

Santo Domingo Las Americas

Fri 1/23

3:32 pm-12:40 am

1 stop10h 08m

$305

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Fri 1/23

11:33 am-11:37 am

1 stop23h 04m

Santo Domingo Las Americas

Wed 1/28

10:19 am-10:23 am

1 stop25h 04m

$310

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 1/8

6:00 am-2:27 pm

1 stop7h 27m

Santo Domingo Las Americas

Thu 1/15

3:32 pm-12:40 am

1 stop10h 08m

$313

CharlestonSanto Domingo

CHS - SDQ

CHSSDQ

Charleston

Thu 1/29

6:10 am-5:29 pm

2 stops10h 19m

Santo Domingo Las Americas

Mon 2/2

6:29 pm-9:48 am

2 stops16h 19m

$326

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 1/22

6:02 pm-2:27 pm

1 stop19h 25m

Santo Domingo Las Americas

Mon 1/26

3:32 pm-9:17 pm

1 stop6h 45m

$329

SavannahSanto Domingo

SAV - SDQ

SAVSDQ

Savannah/Hilton Head

Fri 1/23

7:00 am-2:27 pm

1 stop6h 27m

Santo Domingo Las Americas

Fri 2/6

9:34 pm-12:22 pm

2 stops39h 48m

$330

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Tue 2/3

9:07 pm-2:27 pm

2 stops16h 20m

Santo Domingo Las Americas

Tue 2/10

1:41 pm-1:51 pm

1 stop25h 10m

$332

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Thu 2/19

11:00 am-2:20 pm

1 stop26h 20m

Santo Domingo Las Americas

Mon 2/23

3:32 pm-8:26 am

1 stop17h 54m

$333

CharlotteSanto Domingo

CLT - SDQ

CLTSDQ

Charlotte Douglas

Sat 2/7

9:59 pm-8:29 pm

2 stops21h 30m

Santo Domingo Las Americas

Wed 2/11

3:32 pm-12:40 am

1 stop10h 08m

$333

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Showing 1-10 of 55 results
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Best time to book a flight from South Carolina to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santo Domingo

What is the cheapest month to book a flight from South Carolina to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $320). Flying from South Carolina to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SDQ?

Find hourly flight availability from South Carolina to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 20, 2025.

When flying from South Carolina to Santo Domingo, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 59% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from South Carolina?

    If you book a flight to Santo Domingo from South Carolina, you will be flying to Las Americas, which is the city’s only airport. Santo Domingo Las Americas (SDQ) is located 17.5 mi from the center of Santo Domingo.

  • How long is the flight from South Carolina to Santo Domingo?

    For as low as $305, Spirit Airlines can have you in Santo Domingo from South Carolina in 7h 27m. There are 1349 mi between South Carolina and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Santo Domingo one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $89. Users have also found prices from $153 and $295 on American Airlines and United Airlines, respectively.

  • What are the most popular routes from South Carolina to Santo Domingo?

    The most popular route from South Carolina to Santo Domingo is Charlotte Douglas - Santo Domingo Las Americas. You may also consider Charleston - Santo Domingo Las Americas or Greenville - Santo Domingo Las Americas.

  • Can I find deals for flights from South Carolina to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santo Domingo.

  • Can I find deals for business class flights from South Carolina to Santo Domingo?

    Yes. Cheapflights offers flight deals from South Carolina to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Santo Domingo (average of $320). Flying from South Carolina to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for South Carolina to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santo Domingo flights
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Boston to Santiago de los Caballeros flights
Minneapolis to Punta Cana flights
Dallas/Fort Worth to Punta Cana flights
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Atlanta to Santo Domingo flights
Philadelphia to Santo Domingo flights
Hobby to Punta Cana flights
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Tampa to Punta Cana flights
George Bush Intcntl to Punta Cana flights
Dulles Intl to Santo Domingo flights
Los Angeles to Punta Cana flights
Orlando to Santiago de los Caballeros flights
Atlanta to Puerto Plata flights
Cincinnati to Punta Cana flights
LaGuardia to Puerto Plata flights
Dallas/Fort Worth to Puerto Plata flights
Raleigh to Punta Cana flights
Pittsburgh to Punta Cana flights
Los Angeles to Puerto Plata flights
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Cleveland to Punta Cana flights
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Top 2 airlines flying from South Carolina to Santo Domingo

Discover the top 2 airlines that operate flights from South Carolina to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$321Average$642FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$338Average$525FlexibilityNo cancel feeOn-time71%

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