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Santo Domingo

$249+ Cheap flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDQ
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Myrtle Beach to Santo Domingo

Cheapest flights from Myrtle Beach to Santo Domingo
Explore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:46 amMYR - SDQ
1 stop28h 44mSpirit Airlines
Sat 12/64:31 pmSDQ - MYR
1 stop26h 17mSpirit Airlines
Deal found 10/15$364
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/269:46 amMYR - SDQ
1 stop28h 44mMultiple Airlines
Sat 12/64:31 pmSDQ - MYR
2 stops18h 34mMultiple Airlines
Deal found 10/15$393
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/279:22 amMYR - SDQ
2 stops30h 07mMultiple Airlines
Sat 12/64:31 pmSDQ - MYR
1 stop26h 17mMultiple Airlines
Deal found 10/16$411
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:04 amMYR - SDQ
2 stops27h 41mAmerican Airlines
Sat 12/66:00 amSDQ - MYR
2 stops10h 19mAmerican Airlines
Deal found 10/16$508
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:59 pmMYR - SDQ
2 stops15h 26mAmerican Airlines
Mon 10/277:00 amSDQ - MYR
2 stops14h 50mAmerican Airlines
Deal found 10/15$530
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/209:05 pmMYR - SDQ
2 stops27h 47mMultiple Airlines
Mon 10/2710:19 amSDQ - MYR
1 stop11h 45mMultiple Airlines
Deal found 10/15$553

Cheap flight deals from Myrtle Beach to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$364
(Kiwi.com)

One-way from

$249
(KAYAK)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
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From Myrtle Beach Intl to Santo Domingo Las Americas
Search Deals
One-way flight from Myrtle Beach Intl to Santo Domingo Las Americas
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Myrtle Beach

Fly to

Santo Domingo

Route

Depart

Return

Price

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 11/26

9:46 am-3:30 pm

1 stop28h 44m

Santo Domingo Las Americas

Sat 12/6

4:31 pm-5:48 pm

1 stop26h 17m

$364

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 11/26

9:46 am-3:30 pm

1 stop28h 44m

Santo Domingo Las Americas

Sat 12/6

4:31 pm-10:05 am

2 stops18h 34m

$393

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 1/30

11:46 am-5:50 pm

1 stop5h 04m

Santo Domingo Las Americas

Sun 2/8

8:01 am-7:35 pm

1 stop12h 34m

$395

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 11/27

9:22 am-4:29 pm

2 stops30h 07m

Santo Domingo Las Americas

Sat 12/6

4:31 pm-5:48 pm

1 stop26h 17m

$411

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 1/30

4:03 pm-9:45 pm

2 stops28h 42m

Santo Domingo Las Americas

Sun 2/8

6:10 am-2:58 pm

1 stop9h 48m

$448

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 11/27

11:04 am-3:45 pm

2 stops27h 41m

Santo Domingo Las Americas

Sat 12/6

6:00 am-3:19 pm

2 stops10h 19m

$508

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 11/26

9:46 am-3:30 pm

1 stop4h 44m

$249

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 12/24

9:54 am-2:42 am

1 stop15h 48m

$400

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Compare providers for flights from Myrtle Beach to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Santo Domingo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Santo Domingo

What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $362). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $585). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Spirit Airlines from Myrtle Beach to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Spirit Airlines
6.3
Okay
8,097 reviews

Overall

6.3

Food

5.1

Boarding

6.6

Comfort

5.9

Entertainment

5.0

Crew

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Oct 2025

MCO - PIT

Did not get anything for free no snacks or drinks
Spirit Airlines
6.3
Okay
8,097 reviews
Spirit Airlines
6.3
Okay
8,097 reviews

Overall

6.3

Food

5.1

Boarding

6.6

Comfort

5.9

Entertainment

5.0

Crew

7.0

Reviews

1 / 20
6.0
Good

Anonymous,Oct 2025

MCO - PIT

Did not get anything for free no snacks or drinks

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santo Domingo?

    A quick flight from Myrtle Beach to Santo Domingo can take about 28h 44m. Spirit Airlines provides one of the quickest options available for as low as $364. The distance between Myrtle Beach and Santo Domingo is about 1198 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Santo Domingo round-trip?

    Spirit Airlines, at $327, was found to be the cheapest airline from Myrtle Beach to Santo Domingo..

  • Can I find deals for flights from Myrtle Beach to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santo Domingo.

  • Can I find deals for business class flights from Myrtle Beach to Santo Domingo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

    Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $362). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $585). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top airline flying from Myrtle Beach to Santo Domingo

Discover the top airline that operate flights from Myrtle Beach to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$453FlexibilityNo cancel feeOn-time65%

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