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Santo Domingo

$393+ Cheap flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDQ
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$393
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$498
From Myrtle Beach Intl to Santo Domingo Las Americas
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 4% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Santo Domingo

Cheapest flights from Myrtle Beach to Santo Domingo
Explore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:05 pmMYR - SDQ
1 stop19h 02mSpirit Airlines
Thu 11/66:55 pmSDQ - MYR
1 stop16h 46mSpirit Airlines
Deal found 9/15$393
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/304:59 pmMYR - SDQ
2 stops23h 08mMultiple Airlines
Thu 11/66:55 pmSDQ - MYR
1 stop16h 46mMultiple Airlines
Deal found 9/15$417
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:36 pmMYR - SDQ
2 stops15h 49mAmerican Airlines
Thu 11/66:00 amSDQ - MYR
2 stops10h 21mAmerican Airlines
Deal found 9/15$481
This KAYAK deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/289:04 pmMYR - SDQ
2 stops18h 56mSpirit Airlines
Wed 10/15:05 pmSDQ - MYR
2 stops23h 20mSpirit Airlines
Deal found 9/13$513
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/288:18 pmMYR - SDQ
2 stops17h 17mAmerican Airlines
Wed 10/14:20 pmSDQ - MYR
2 stops16h 20mAmerican Airlines
Deal found 9/15$519
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:03 amMYR - SDQ
2 stops16h 42mAmerican Airlines
Sat 11/296:00 amSDQ - MYR
2 stops8h 59mAmerican Airlines
Deal found 9/14$852
This KAYAK deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:46 amMYR - SDQ
1 stop5h 04mSpirit Airlines
Sat 11/296:55 pmSDQ - MYR
2 stops24h 17mSpirit Airlines
Deal found 9/13$985
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:00 amMYR - SDQ
1 stop7h 24mDelta
Wed 10/12:50 pmSDQ - MYR
1 stop8h 59mDelta
Deal found 9/15$1,111
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amMYR - SDQ
1 stop7h 42mDelta
Sat 11/293:57 pmSDQ - MYR
1 stop8h 47mDelta
Deal found 9/15$1,338

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Myrtle Beach

Fly to

Santo Domingo

Route

Depart

Return

Price

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 10/30

9:05 pm-4:07 pm

1 stop19h 02m

Santo Domingo Las Americas

Thu 11/6

6:55 pm-10:41 am

1 stop16h 46m

$393

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 10/30

4:59 pm-4:07 pm

2 stops23h 08m

Santo Domingo Las Americas

Thu 11/6

6:55 pm-10:41 am

1 stop16h 46m

$417

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 10/30

5:36 pm-9:25 am

2 stops15h 49m

Santo Domingo Las Americas

Thu 11/6

6:00 am-3:21 pm

2 stops10h 21m

$481

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 9/28

9:04 pm-4:00 pm

2 stops18h 56m

Santo Domingo Las Americas

Wed 10/1

5:05 pm-4:25 pm

2 stops23h 20m

$513

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 9/28

8:18 pm-1:35 pm

2 stops17h 17m

Santo Domingo Las Americas

Wed 10/1

4:20 pm-8:40 am

2 stops16h 20m

$519

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 3/10

6:00 am-1:15 pm

1 stop7h 15m

Santo Domingo Las Americas

Wed 3/11

2:40 pm-11:35 pm

1 stop8h 55m

$552

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Myrtle Beach to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Santo Domingo

What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $362). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Myrtle Beach to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Delta and Spirit Airlines from Myrtle Beach to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,015 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santo Domingo?

    A quick flight from Myrtle Beach to Santo Domingo can take about 15h 49m. Spirit Airlines provides one of the quickest options available for as low as $481. The distance between Myrtle Beach and Santo Domingo is about 1198 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Myrtle Beach to Santo Domingo round-trip?

    Spirit Airlines, at $327, was found to be the cheapest airline from Myrtle Beach to Santo Domingo. An alternate airline flying to your destination would be Delta. Spirit Airlines is currently priced 48% below the average price you’ll pay for this route.

  • Can I find deals for flights from Myrtle Beach to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santo Domingo.

  • Can I find deals for business class flights from Myrtle Beach to Santo Domingo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $362). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Myrtle Beach to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Myrtle Beach to Santo Domingo

Discover the top 2 airlines that operate flights from Myrtle Beach to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$327Average$453FlexibilityNo cancel feeOn-time65%
DeltaCheapest$514Average$813FlexibilityNo cancel feeOn-timeN/A

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