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Santo Domingo

$164+ Cheap flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDQ
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Santo Domingo

Cheapest flights from Myrtle Beach to Santo Domingo
Explore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:43 pm
MYR
-
SDQ
1 stop8h 46m
Multiple Airlines
Sun 5/102:35 pm
SDQ
-
MYR
1 stop6h 23m
Multiple Airlines
Deal found 3/19$385
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:43 pm
MYR
-
SDQ
1 stop8h 46m
Multiple Airlines
Sat 5/92:35 pm
SDQ
-
MYR
1 stop6h 23m
Multiple Airlines
Deal found 3/22$421
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:32 pm
MYR
-
SDQ
2 stops21h 57m
Spirit Airlines
Sat 5/92:35 pm
SDQ
-
MYR
1 stop6h 23m
Spirit Airlines
Deal found 3/22$441
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:07 pm
MYR
-
SDQ
2 stops15h 05m
American Airlines
Sat 11/214:59 pm
SDQ
-
MYR
2 stops16h 40m
American Airlines
Deal found 3/19$593
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:00 am
MYR
-
SDQ
2 stops17h 52m
American Airlines
Sun 5/106:00 am
SDQ
-
MYR
2 stops17h 57m
American Airlines
Deal found 3/19$598
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
MYR
-
SDQ
1 stop7h 24m
Delta
Mon 5/112:49 pm
SDQ
-
MYR
1 stop9h 09m
Delta
Deal found 3/19$599
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:41 pm
MYR
-
SDQ
2 stops12h 43m
American Airlines
Sat 5/307:00 am
SDQ
-
MYR
2 stops16h 50m
American Airlines
Deal found 3/19$613

Find flight deals from Myrtle Beach to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$385
(Kiwi.com)

One-way from

$164
(Expedia)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
Search Deals
From Myrtle Beach Intl to Santo Domingo Las Americas
Search Deals
One-way flight from Myrtle Beach Intl to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

8:43 pm-5:29 am

1 stop8h 46m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:58 pm

1 stop6h 23m

$421

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

10:20 am-1:29 pm

3 stops27h 09m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:58 pm

1 stop6h 23m

$497

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

5:00 am-10:52 pm

2 stops17h 52m

Santo Domingo Las Americas

Sun 5/10

6:00 am-11:57 pm

2 stops17h 57m

$598

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 5/7

6:00 am-1:24 pm

1 stop7h 24m

Santo Domingo Las Americas

Mon 5/11

2:49 pm-11:58 pm

1 stop9h 09m

$599

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 5/7

5:00 am-2:59 pm

2 stops9h 59m

Santo Domingo Las Americas

Mon 5/11

10:20 am-11:57 pm

2 stops13h 37m

$603

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Mon 5/25

8:41 pm-3:18 pm

2 stops18h 37m

Santo Domingo Las Americas

Sat 5/30

7:00 am-11:50 pm

2 stops16h 50m

$613

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 7/12

12:25 pm-1:19 pm

1 stop24h 54m

Santo Domingo Las Americas

Sat 7/25

2:24 pm-9:25 pm

1 stop7h 01m

$643
Cheapest one-way
Quickest one-way

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 3/29

6:28 pm-1:38 am

1 stop7h 10m

$194

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 3/31

6:28 pm-1:15 pm

1 stop18h 47m

$232

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Mon 3/30

3:20 pm-1:15 pm

2 stops21h 55m

$236

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/18

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Santo Domingo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Santo Domingo

What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $324). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $523). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated March 23, 2026.
Peruse reviews from past customers who have flown with Delta from Myrtle Beach to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,319 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,319 reviews
Delta
7.9
Good
8,319 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santo Domingo?

    A quick flight from Myrtle Beach to Santo Domingo can take about 17h 52m. Spirit Airlines provides one of the quickest options available for as low as $598. The distance between Myrtle Beach and Santo Domingo is about 1198 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Myrtle Beach to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santo Domingo.

  • Can I find deals for business class flights from Myrtle Beach to Santo Domingo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $324). Flying from Myrtle Beach to Santo Domingo in December is currently the most expensive (average of $523). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top airline flying from Myrtle Beach to Santo Domingo

Discover the top airline that operate flights from Myrtle Beach to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$297Average$705FlexibilityNo cancel feeOn-timeN/A

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