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Santo Domingo

$166+ Cheap flights from Missouri to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Missouri to Santo Domingo

Keep the following information in mind while searching for Missouri to Santo Domingo flight deals. Data was last updated August 20, 2025.

Round-trip from

$321
(FlightHub)

One-way from

$166
(Cheapflightsfares)

Popular in

December

Cheapest in

September

Average price

$534
From Missouri to Santo Domingo Las Americas
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One-way flight from Missouri to Santo Domingo Las Americas
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Highest demand for flights based on searches. 12% potential increase in price ($89 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Missouri to Santo Domingo

Cheapest flights from Missouri to Santo Domingo
Explore the most affordable flight options available from Missouri to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:44 pmMCI - SDQ
1 stop9h 55mSpirit Airlines
Wed 12/106:55 pmSDQ - MCI
2 stops19h 44mSpirit Airlines
Deal found 8/18$321
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:13 pmMCI - SDQ
1 stop27h 37mSpirit Airlines
Thu 11/136:55 pmSDQ - MCI
1 stop18h 13mSpirit Airlines
Deal found 8/19$352
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1012:13 pmMCI - SDQ
1 stop27h 37mSpirit Airlines
Thu 11/136:55 pmSDQ - MCI
1 stop18h 13mSpirit Airlines
Deal found 8/20$365
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/74:29 pmSTL - SDQ
2 stops23h 21mMultiple Airlines
Sat 11/156:55 pmSDQ - STL
1 stop18h 06mMultiple Airlines
Deal found 8/20$385
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/510:09 amMCI - SDQ
2 stops29h 41mSpirit Airlines
Thu 11/136:55 pmSDQ - MCI
1 stop18h 13mSpirit Airlines
Deal found 8/20$398
This FlightHub deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/95:15 amMCI - SDQ
1 stop6h 00mSpirit Airlines
Tue 9/165:05 pmSDQ - MCI
2 stops31h 02mSpirit Airlines
Deal found 8/17$400
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/712:13 pmMCI - SDQ
1 stop27h 37mSpirit Airlines
Tue 11/116:55 pmSDQ - MCI
2 stops40h 09mSpirit Airlines
Deal found 8/20$404
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/42:55 pmMCI - SDQ
2 stops23h 31mMultiple Airlines
Thu 11/136:55 pmSDQ - MCI
1 stop18h 13mMultiple Airlines
Deal found 8/20$405
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:28 amSTL - SDQ
1 stop14h 02mAmerican Airlines
Mon 9/294:20 pmSDQ - STL
1 stop8h 39mAmerican Airlines
Deal found 8/20$525
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:00 amSTL - SDQ
1 stop6h 41mDelta
Sun 11/96:40 amSDQ - STL
1 stop12h 00mDelta
Deal found 8/19$527
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/711:49 amSTL - SDQ
1 stop9h 57mUnited Airlines
Sat 11/152:53 pmSDQ - STL
1 stop10h 51mUnited Airlines
Deal found 8/19$537
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:00 amSTL - SDQ
1 stop6h 41mDelta
Sat 11/156:40 amSDQ - STL
1 stop12h 00mDelta
Deal found 8/19$557

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Missouri

Fly to

Santo Domingo

Route

Depart

Return

Price

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 12/5

1:44 pm-1:39 am

1 stop9h 55m

Santo Domingo Las Americas

Wed 12/10

6:55 pm-12:39 pm

2 stops19h 44m

$321

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 11/7

12:13 pm-5:50 pm

1 stop27h 37m

Santo Domingo Las Americas

Thu 11/13

6:55 pm-11:08 am

1 stop18h 13m

$352

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 11/10

12:13 pm-5:50 pm

1 stop27h 37m

Santo Domingo Las Americas

Thu 11/13

6:55 pm-11:08 am

1 stop18h 13m

$365

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 11/7

4:29 pm-5:50 pm

2 stops23h 21m

Santo Domingo Las Americas

Sat 11/15

6:55 pm-11:01 am

1 stop18h 06m

$385

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 11/5

10:09 am-5:50 pm

2 stops29h 41m

Santo Domingo Las Americas

Thu 11/13

6:55 pm-11:08 am

1 stop18h 13m

$398

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 9/25

5:28 am-8:30 pm

1 stop14h 02m

Santo Domingo Las Americas

Mon 9/29

4:20 pm-11:59 pm

1 stop8h 39m

$525

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 11/5

6:00 am-2:41 pm

1 stop6h 41m

Santo Domingo Las Americas

Sun 11/9

6:40 am-4:40 pm

1 stop12h 00m

$527

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 11/7

11:49 am-11:46 pm

1 stop9h 57m

Santo Domingo Las Americas

Sat 11/15

2:53 pm-11:44 pm

1 stop10h 51m

$537

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 1/28

6:40 am-8:40 pm

2 stops12h 00m

Santo Domingo Las Americas

Sun 2/1

8:50 am-11:32 pm

2 stops16h 42m

$537

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 11/7

5:56 pm-12:12 pm

2 stops16h 16m

Santo Domingo Las Americas

Sat 11/15

4:59 pm-10:32 pm

1 stop7h 33m

$542

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 20 results
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Best time to book a flight from Missouri to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santo Domingo

What is the cheapest month to book a flight from Missouri to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SDQ?

Find hourly flight availability from Missouri to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santo Domingo as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Missouri?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Missouri. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • How long is the flight from Missouri to Santo Domingo?

    For as low as $527, Spirit Airlines can have you in Santo Domingo from Missouri in 6h 41m. Airlines will cover a distance of 1873 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Missouri to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santo Domingo.

  • Can I find deals for business class flights from Missouri to Santo Domingo?

    Yes. Cheapflights offers flight deals from Missouri to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Missouri to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Santo Domingo

Discover the top 3 airlines that operate flights from Missouri to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$262Average$592FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$371Average$384FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$462Average$646FlexibilityNo cancel feeOn-time71%

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