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Santo Domingo

$188+ Cheap flights from Missouri to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Dec 31 — Jan 71
Wed 12/31
Wed 1/7
1 adult, Economy
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Cheap flight deals from Missouri to Santo Domingo

Keep the following information in mind while searching for Missouri to Santo Domingo flight deals. Data was last updated December 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$308
(Kiwi.com)

One-way from

$188
(Kiwi.com)

Popular in

November

Cheapest in

March

Average price

$699
Provider with most accurate pricing for Lambert-St Louis-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santo Domingo Las Americas flights.
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From Missouri to Santo Domingo Las Americas
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One-way flight from Missouri to Santo Domingo Las Americas
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Highest demand for flights based on searches. 9% potential increase in price ($70 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Find flight deals from Missouri to Santo Domingo

Cheapest flights from Missouri to Santo Domingo
Explore the most affordable flight options available from Missouri to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 1, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:01 pmMCI - SDQ
1 stop14h 50mSpirit Airlines
Wed 12/313:59 amSDQ - MCI
1 stop15h 11mSpirit Airlines
Deal found 11/30$459
This Cheapflightsfares deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:15 pmMCI - SDQ
1 stop6h 39mSpirit Airlines
Mon 12/293:59 amSDQ - MCI
1 stop15h 11mSpirit Airlines
Deal found 12/1$469
This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:15 pmMCI - SDQ
1 stop6h 39mSpirit Airlines
Sun 12/283:59 amSDQ - MCI
1 stop15h 11mSpirit Airlines
Deal found 11/30$473
This Frontier deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:30 pmSTL - SDQ
2 stops15h 41mFrontier
Thu 12/184:39 pmSDQ - STL
2 stops17h 33mFrontier
Deal found 11/30$477
This Frontier deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/143:30 pmSTL - SDQ
2 stops15h 41mFrontier
Thu 12/184:39 pmSDQ - STL
2 stops17h 33mFrontier
Deal found 11/30$480
This Mytrip deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:27 pmSTL - SDQ
2 stops25h 00mFrontier
Wed 12/316:04 pmSDQ - STL
2 stops17h 36mFrontier
Deal found 12/1$489
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:27 pmSTL - SDQ
2 stops32h 27mMultiple Airlines
Wed 12/318:20 amSDQ - STL
1 stop16h 13mMultiple Airlines
Deal found 12/1$504
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:27 pmSTL - SDQ
2 stops32h 27mMultiple Airlines
Sat 1/172:37 pmSDQ - STL
1 stop20h 34mMultiple Airlines
Deal found 12/1$512
This Mytrip deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:01 pmMCI - SDQ
3 stops24h 44mMultiple Airlines
Wed 12/313:59 amSDQ - MCI
1 stop15h 11mMultiple Airlines
Deal found 11/30$514
This Kiwi.com deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:47 pmSTL - SDQ
1 stop22h 36mSpirit Airlines
Sat 12/64:21 pmSDQ - STL
1 stop23h 31mSpirit Airlines
Deal found 12/1$530
This Mytrip deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:30 amMCI - SDQ
3 stops30h 53mSpirit Airlines
Fri 12/263:59 amSDQ - MCI
1 stop15h 11mSpirit Airlines
Deal found 11/30$590
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:10 amSTL - SDQ
1 stop10h 13mAmerican Airlines
Sat 12/66:00 amSDQ - STL
2 stops12h 19mAmerican Airlines
Deal found 12/1$592

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Missouri

Fly to

Santo Domingo

Route

Depart

Return

Price

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 2/2

11:26 am-3:35 pm

1 stop26h 09m

Santo Domingo Las Americas

Mon 2/9

4:40 pm-4:09 pm

2 stops25h 29m

$346

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Sun 2/1

5:04 pm-3:35 pm

2 stops20h 31m

Santo Domingo Las Americas

Sat 2/7

4:40 pm-10:31 am

1 stop19h 51m

$376

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 2/4

5:04 pm-3:35 pm

2 stops20h 31m

Santo Domingo Las Americas

Sat 2/7

4:40 pm-10:31 am

1 stop19h 51m

$379

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 12/12

7:01 pm-11:51 am

1 stop14h 50m

Santo Domingo Las Americas

Wed 12/31

3:59 am-5:10 pm

1 stop15h 11m

$459

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sat 12/13

3:30 pm-9:11 am

2 stops15h 41m

Santo Domingo Las Americas

Thu 12/18

4:39 pm-8:12 am

2 stops17h 33m

$477

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 12/14

3:30 pm-9:11 am

2 stops15h 41m

Santo Domingo Las Americas

Thu 12/18

4:39 pm-8:12 am

2 stops17h 33m

$480

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 12/24

4:27 pm-2:54 am

2 stops32h 27m

Santo Domingo Las Americas

Wed 12/31

8:20 am-10:33 pm

1 stop16h 13m

$504

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 2/2

6:30 am-7:14 pm

2 stops10h 44m

Santo Domingo Las Americas

Wed 2/11

7:30 am-10:02 pm

2 stops16h 32m

$509

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 2/4

6:30 am-7:14 pm

2 stops10h 44m

Santo Domingo Las Americas

Tue 2/10

7:30 am-6:56 pm

2 stops13h 26m

$509

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 2/2

7:00 am-12:30 am

2 stops15h 30m

Santo Domingo Las Americas

Tue 2/10

7:30 am-5:00 pm

2 stops11h 30m

$509

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/30

Showing 1-10 of 29 results
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Best time to book a flight from Missouri to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santo Domingo

What is the cheapest month to book a flight from Missouri to Santo Domingo?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $374). Flying from Missouri to Santo Domingo in June is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SDQ?

Find hourly flight availability from Missouri to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 1, 2025.

It’s optimal to fly from Missouri to Santo Domingo at noon. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Missouri?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Missouri. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • How long is the flight from Missouri to Santo Domingo?

    For as low as $509, Spirit Airlines can have you in Santo Domingo from Missouri in 10h 44m. Airlines will cover a distance of 2077 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Santo Domingo one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $199. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Missouri to Santo Domingo for a low price.

  • Can I find deals for flights from Missouri to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Missouri to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santo Domingo.

  • Can I find deals for business class flights from Missouri to Santo Domingo?

    Yes. Cheapflights offers flight deals from Missouri to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santo Domingo?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $374). Flying from Missouri to Santo Domingo in June is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Missouri to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santo Domingo flights
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Fort Lauderdale to Punta Cana flights
Miami to Punta Cana flights
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LaGuardia to Santiago de los Caballeros flights
Boston to Santiago de los Caballeros flights
John F Kennedy Intl to Puerto Plata flights
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Philadelphia to Santo Domingo flights
Atlanta to Santo Domingo flights
Orlando to Santiago de los Caballeros flights
Dallas/Fort Worth to Punta Cana flights
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Dulles Intl to Santo Domingo flights
Hobby to Punta Cana flights
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Baltimore to Santo Domingo flights
Pittsburgh to Punta Cana flights
Fort Lauderdale to Santiago de los Caballeros flights
Reagan-National to Santo Domingo flights
LaGuardia to Puerto Plata flights
Seattle to Punta Cana flights
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Top 2 airlines flying from Missouri to Santo Domingo

Discover the top 2 airlines that operate flights from Missouri to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$262Average$518FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$492Average$640FlexibilityNo cancel feeOn-time71%

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