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Santo Domingo

$191+ Cheap flights from Missouri to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
feb. 17 — feb. 241
mar. 2/17
mar. 2/24
1 adult, Economy
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Cheap flight deals from Missouri to Santo Domingo

Keep the following information in mind while searching for Missouri to Santo Domingo flight deals. Data was last updated enero 18, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$305
(Kiwi.com)

One-way from

$191
(Mytrip)

Popular in

November

Cheapest in

March

Average price

$594
Provider with most accurate pricing for Lambert-St Louis-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santo Domingo Las Americas flights.
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From Missouri to Santo Domingo Las Americas
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One-way flight from Missouri to Santo Domingo Las Americas
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Highest demand for flights based on searches. 10% potential increase in price ($74 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Missouri to Santo Domingo

Cheapest flights from Missouri to Santo Domingo
Explore the most affordable flight options available from Missouri to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/74:54 pm
STL
-
SDQ
1 stop23h 58m
Frontier
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Frontier
Deal found 1/16$305
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/163:49 pm
STL
-
SDQ
1 stop18h 07m
Multiple Airlines
lun. 2/2310:19 am
SDQ
-
STL
2 stops46h 32m
Multiple Airlines
Deal found 1/17$318
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/23:49 pm
STL
-
SDQ
1 stop18h 07m
Frontier
lun. 3/910:56 am
SDQ
-
STL
1 stop13h 23m
Frontier
Deal found 1/16$349
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/711:21 am
STL
-
SDQ
2 stops17h 08m
Multiple Airlines
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Multiple Airlines
Deal found 1/17$350
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/84:54 pm
STL
-
SDQ
2 stops18h 27m
Frontier
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Frontier
Deal found 1/17$359
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/511:21 am
STL
-
SDQ
2 stops25h 35m
Frontier
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Frontier
Deal found 1/17$367
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/911:21 am
STL
-
SDQ
2 stops13h 17m
Multiple Airlines
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Multiple Airlines
Deal found 1/17$372
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/74:54 pm
STL
-
SDQ
1 stop23h 58m
Frontier
sáb. 4/116:57 pm
SDQ
-
STL
2 stops16h 33m
Frontier
Deal found 1/17$377
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/48:41 am
STL
-
SDQ
2 stops15h 57m
Multiple Airlines
vie. 4/102:02 pm
SDQ
-
STL
1 stop10h 53m
Multiple Airlines
Deal found 1/17$389
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/511:21 am
STL
-
SDQ
2 stops13h 17m
Multiple Airlines
mié. 4/86:57 pm
SDQ
-
STL
1 stop29h 28m
Multiple Airlines
Deal found 1/17$393
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/54:54 pm
STL
-
SDQ
1 stop19h 03m
Frontier
mié. 4/86:57 pm
SDQ
-
STL
1 stop29h 28m
Frontier
Deal found 1/17$394
This Kiwi.com deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/74:54 pm
STL
-
SDQ
1 stop23h 58m
Frontier
lun. 4/132:02 pm
SDQ
-
STL
1 stop10h 23m
Frontier
Deal found 1/17$401

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 18, 2026.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Missouri

Fly to

Santo Domingo

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

lun. 2/16

3:49 pm-11:56 am

1 stop18h 07m

Santo Domingo Las Americas

lun. 2/23

10:19 am-6:51 am

2 stops46h 32m

$318

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

lun. 3/2

3:49 pm-11:56 am

1 stop18h 07m

Santo Domingo Las Americas

lun. 3/9

10:56 am-11:19 pm

1 stop13h 23m

$349

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

mar. 4/7

11:21 am-4:29 pm

2 stops28h 08m

Santo Domingo Las Americas

vie. 4/10

2:02 pm-11:55 pm

1 stop10h 53m

$349

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

mar. 2/17

4:24 pm-2:20 pm

2 stops19h 56m

Santo Domingo Las Americas

mar. 2/24

1:11 pm-3:29 pm

1 stop28h 18m

$404

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

vie. 3/6

5:05 pm-9:45 pm

2 stops26h 40m

Santo Domingo Las Americas

lun. 3/16

2:30 pm-10:23 am

1 stop20h 53m

$416

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

vie. 3/6

5:05 pm-9:45 pm

2 stops26h 40m

Santo Domingo Las Americas

dom. 3/15

2:30 pm-10:23 am

1 stop20h 53m

$416

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

lun. 3/2

3:49 pm-11:56 am

1 stop18h 07m

Santo Domingo Las Americas

lun. 3/9

12:41 pm-11:19 pm

2 stops35h 38m

$424

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

mar. 4/7

11:21 am-5:52 pm

2 stops29h 31m

Santo Domingo Las Americas

vie. 4/10

4:08 pm-11:25 pm

2 stops32h 17m

$430

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

mar. 4/7

11:21 am-1:38 am

2 stops13h 17m

Santo Domingo Las Americas

mié. 4/8

4:08 pm-10:30 am

1 stop19h 22m

$438

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

vie. 2/27

11:26 am-2:20 pm

1 stop24h 54m

Santo Domingo Las Americas

mar. 3/10

2:32 pm-10:55 am

2 stops21h 23m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/16

Showing 1-10 of 28 results
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Best time to book a flight from Missouri to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santo Domingo

What is the cheapest month to book a flight from Missouri to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $255). Flying from Missouri to Santo Domingo in June is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Missouri?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Missouri. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • How long is the flight from Missouri to Santo Domingo?

    For as low as $349, Frontier can have you in Santo Domingo from Missouri in 18h 07m. Airlines will cover a distance of 1873 mi.

  • Can I find deals for flights from Missouri to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Missouri to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santo Domingo.

  • Can I find deals for business class flights from Missouri to Santo Domingo?

    Yes. Cheapflights offers flight deals from Missouri to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $255). Flying from Missouri to Santo Domingo in June is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Missouri to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Santo Domingo

Discover the top 2 airlines that operate flights from Missouri to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$262Average$562FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$492Average$638FlexibilityNo cancel feeOn-time71%

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