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Santo Domingo

$183+ Cheap flights from Missouri to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Missouri to Santo Domingo

Keep the following information in mind while searching for Missouri to Santo Domingo flight deals. Data was last updated July 3, 2025.

Round-trip from

$392
(Kiwi.com)

One-way from

$183
(FlightHub)

Popular in

December

Cheapest in

August

Average price

$793
From Missouri to Santo Domingo Las Americas
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One-way flight from Missouri to Santo Domingo Las Americas
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Highest demand for flights based on searches. 10% potential increase in price ($72 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Missouri to Santo Domingo

Cheapest flights from Missouri to Santo Domingo
Explore the most affordable flight options available from Missouri to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/46:04 pmMCI - SDQ
1 stop20h 43mSpirit Airlines
Mon 8/181:01 pmSDQ - MCI
1 stop10h 52mSpirit Airlines
Deal found 7/1$392
This Expedia deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/115:40 pmSTL - SDQ
2 stops41h 37mFrontier
Sun 7/131:48 amSDQ - STL
2 stops22h 59mFrontier
Deal found 7/1$439
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/275:26 pmSTL - SDQ
1 stop15h 24mSpirit Airlines
Fri 8/110:55 amSDQ - STL
1 stop28h 44mSpirit Airlines
Deal found 6/30$451
This FlightHub deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/95:40 pmSTL - SDQ
1 stop16h 05mMultiple Airlines
Tue 7/1510:55 amSDQ - STL
2 stops24h 34mMultiple Airlines
Deal found 7/1$491
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/95:45 amMCI - SDQ
1 stop6h 37mDelta
Tue 9/162:50 pmSDQ - MCI
1 stop9h 54mDelta
Deal found 7/1$515
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/294:45 pmSTL - SDQ
2 stops15h 30mAmerican Airlines
Tue 8/57:20 pmSDQ - STL
2 stops15h 09mAmerican Airlines
Deal found 7/1$519
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/49:47 amMCI - SDQ
2 stops10h 08mAmerican Airlines
Mon 8/187:20 pmSDQ - MCI
2 stops15h 52mAmerican Airlines
Deal found 7/1$524
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:04 pmMCI - SDQ
1 stop14h 46mMultiple Airlines
Thu 7/311:48 amSDQ - MCI
2 stops16h 21mMultiple Airlines
Deal found 7/2$535
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:00 amSTL - SDQ
1 stop6h 22mDelta
Mon 9/82:47 pmSDQ - STL
1 stop8h 15mDelta
Deal found 7/2$535
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:35 pmMCI - SDQ
3 stops27h 11mUnited Airlines
Thu 11/132:53 pmSDQ - MCI
2 stops20h 03mUnited Airlines
Deal found 7/2$627
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/46:33 amSTL - SDQ
2 stops18h 17mUnited Airlines
Sun 7/65:45 amSDQ - STL
2 stops18h 00mUnited Airlines
Deal found 7/2$754

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Missouri

Fly to

Santo Domingo

Route

Depart

Return

Price

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 8/4

6:04 pm-3:47 pm

1 stop20h 43m

Santo Domingo Las Americas

Mon 8/18

1:01 pm-10:53 pm

1 stop10h 52m

$392

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 7/27

5:26 pm-9:50 am

1 stop15h 24m

Santo Domingo Las Americas

Fri 8/1

10:55 am-2:39 pm

1 stop28h 44m

$451

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 7/27

2:36 pm-12:28 am

1 stop8h 52m

Santo Domingo Las Americas

Fri 8/1

10:17 am-9:11 am

2 stops23h 54m

$462

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 9/9

5:45 am-1:22 pm

1 stop6h 37m

Santo Domingo Las Americas

Tue 9/16

2:50 pm-11:44 pm

1 stop9h 54m

$515

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 7/29

4:45 pm-9:15 am

2 stops15h 30m

Santo Domingo Las Americas

Tue 8/5

7:20 pm-9:29 am

2 stops15h 09m

$519

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 8/4

9:47 am-8:55 pm

2 stops10h 08m

Santo Domingo Las Americas

Mon 8/18

7:20 pm-10:12 am

2 stops15h 52m

$524

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 7/25

6:04 pm-9:50 am

1 stop14h 46m

Santo Domingo Las Americas

Thu 7/31

1:48 am-5:09 pm

2 stops16h 21m

$535

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 9/5

6:00 am-1:22 pm

1 stop6h 22m

Santo Domingo Las Americas

Mon 9/8

2:47 pm-10:02 pm

1 stop8h 15m

$535

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/26

9:50 am-11:56 am

3 stops25h 06m

Santo Domingo Las Americas

Thu 8/28

5:05 pm-1:32 pm

2 stops21h 27m

$608

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 9/16

9:17 am-1:50 am

2 stops15h 33m

Santo Domingo Las Americas

Wed 10/1

5:45 am-9:47 pm

2 stops17h 02m

$769

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 20 results
1
2

Best time to book a flight from Missouri to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santo Domingo

What is the cheapest month to book a flight from Missouri to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SDQ?

Find hourly flight availability from Missouri to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santo Domingo as you normally would.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated July 3, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Missouri to Santo Domingo have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,363 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.6
Okay
7,093 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santo Domingo from Missouri?

    Most people fly into Santo Domingo Las Americas (SDQ) if they book a flight to Santo Domingo from Missouri. Las Americas is conveniently located just 17.5 mi from Santo Domingo’s city center.

  • What are the cheapest airlines to fly from Missouri to Santo Domingo one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $183. However, be on the lookout for offers from Spirit Airlines and American Airlines, as they are both options that can get you from Missouri to Santo Domingo for a low price.

  • Can I find deals for flights from Missouri to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Missouri to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santo Domingo.

  • Can I find deals for business class flights from Missouri to Santo Domingo?

    Yes. Cheapflights offers flight deals from Missouri to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Santo Domingo (average of $362). Flying from Missouri to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Missouri to Santo Domingo

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Santo Domingo

Discover the top 3 airlines that operate flights from Missouri to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$262Average$554FlexibilityNo cancel feeOn-timeN/A
FrontierCheapest$371Average$384FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$453Average$655FlexibilityNo cancel feeOn-time71%

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