What are the cheapest airlines flying from Portland, Maine to Santiago de los Caballeros round-trip?

Our cheapest airline available from Portland, Maine to Santiago de los Caballeros is JetBlue. Our recent data shows that you can find tickets from as low as $737 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $780 and $1,759 round-trip.

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

What is the cheapest day to fly round-trip from Portland, Maine to Santiago de los Caballeros?

Thursday flights are generally found to be more expensive for flights from Portland, Maine to Santiago de los Caballeros. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Santiago de los Caballeros.

What is the cheapest time of day to fly from PWM to STI?

When flying from Portland, Maine to Santiago de los Caballeros, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How can I find direct flights from Portland to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Santiago de los Caballeros.

Can I find deals for business class flights from Portland to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Portland to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$737+ Flights from Portland, ME to Santiago de los Caballeros

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Cheap flight deals from Portland to Santiago de los Caballeros

Round-trip from	$737 (JetBlue)

From Portland to Santiago de los Caballeros

Search Deals

Find flight deals from Portland to Santiago de los Caballeros

Cheapest flights from Portland to Santiago de los Caballeros
Explore the most affordable flight options available from Portland to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Fri 8/86:10 amPWM - STI

1 stop13h 24mJetBlue

Sun 8/175:01 amSTI - PWM

1 stop8h 22mJetBlue

Deal found 7/28

$737

Fri 8/86:00 amPWM - STI

2 stops14h 48mAmerican Airlines

Sun 8/171:31 pmSTI - PWM

2 stops21h 10mAmerican Airlines

Deal found 7/29

$780

Fri 8/86:30 amPWM - STI

1 stop12h 58mDelta

Sun 8/178:55 pmSTI - PWM

2 stops15h 13mDelta

Deal found 7/28

$1,759

Best flights from Portland to Santiago de los Caballeros
Discover carefully curated flight deals from Portland to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2025.

Fri 8/86:10 amPWM - STI

1 stop13h 24mJetBlue

Sun 8/175:01 amSTI - PWM

1 stop8h 22mJetBlue

Deal found 7/28

$737

Fri 8/86:00 amPWM - STI

2 stops14h 48mAmerican Airlines

Sun 8/171:31 pmSTI - PWM

2 stops21h 10mAmerican Airlines

Deal found 7/29

$780

Fri 8/86:30 amPWM - STI

1 stop12h 58mDelta

Sun 8/178:55 pmSTI - PWM

2 stops15h 13mDelta

Deal found 7/28

$1,759

Last-minute flights from Portland to Santiago de los Caballeros
Discover last-minute flight deals from Portland to Santiago de los Caballeros. Data last updated July 29, 2025 and is based on user searches.

Fri 8/86:10 amPWM - STI

1 stop13h 24mJetBlue

Sun 8/175:01 amSTI - PWM

1 stop8h 22mJetBlue

Deal found 7/28

$737

Fri 8/86:00 amPWM - STI

2 stops14h 48mAmerican Airlines

Sun 8/171:31 pmSTI - PWM

2 stops21h 10mAmerican Airlines

Deal found 7/29

$780

Fri 8/86:30 amPWM - STI

1 stop12h 58mDelta

Sun 8/178:55 pmSTI - PWM

2 stops15h 13mDelta

Deal found 7/28

$1,759

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandSantiago de los Caballeros

PWM - STI

PWMSTI

Portland

Fri 8/8

6:10 am-7:34 pm

1 stop13h 24m

Santiago de los Caballeros

Sun 8/17

5:01 am-1:23 pm

1 stop8h 22m

$737

PortlandSantiago de los Caballeros

PWM - STI

PWMSTI

Portland

Fri 8/8

6:00 am-8:48 pm

2 stops14h 48m

Santiago de los Caballeros

Sun 8/17

1:31 pm-10:41 am

2 stops21h 10m

$780

PortlandSantiago de los Caballeros

PWM - STI

PWMSTI

Portland

Fri 8/8

6:30 am-7:28 pm

1 stop12h 58m

Santiago de los Caballeros

Sun 8/17

8:55 pm-12:08 pm

2 stops15h 13m

$1,759

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Portland to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Portland with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Santiago de los Caballeros

What is the cheapest month to book a flight from Portland, Maine to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Santiago de los Caballeros (average of $347). Flying from Portland, Maine to Santiago de los Caballeros in July is currently the most expensive (average of $612). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago de los Caballeros

Read through reviews of airlines operating flights from Portland to Santiago de los Caballeros, such as Delta, JetBlue, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,977 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

JetBlue

7.3

Good

2,913 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Portland, Maine to Santiago de los Caballeros round-trip?
Our cheapest airline available from Portland, Maine to Santiago de los Caballeros is JetBlue. Our recent data shows that you can find tickets from as low as $737 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $780 and $1,759 round-trip.
Can I find deals for flights from Portland to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Portland to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Portland to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Santiago de los Caballeros.
Can I find deals for business class flights from Portland to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Portland to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Portland, Maine to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Portland, Maine to Santiago de los Caballeros (average of $347). Flying from Portland, Maine to Santiago de los Caballeros in July is currently the most expensive (average of $612). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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$737+ Cheap flights from Portland, ME (PWM) to Santiago de los Caballeros (STI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Portland to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Portland to Santiago de los Caballeros

Round-trip from

Find flight deals from Portland to Santiago de los Caballeros

Cheapest flights from Portland to Santiago de los CaballerosExplore the most affordable flight options available from Portland to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Explore the most affordable flight options available from Portland to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Portland to Santiago de los Caballeros that are best for you.

Best time to book a flight from Portland to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Portland with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Portland to Santiago de los Caballeros

What is the cheapest month to book a flight from Portland, Maine to Santiago de los Caballeros?

Reviews of airlines servicing Santiago de los Caballeros

Read through reviews of airlines operating flights from Portland to Santiago de los Caballeros, such as Delta, JetBlue, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Portland to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Portland, Maine to Santiago de los Caballeros round-trip?

Can I find deals for flights from Portland to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Portland to Santiago de los Caballeros?

Can I find deals for business class flights from Portland to Santiago de los Caballeros?

What is the cheapest month to book a flight from Portland, Maine to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Portland to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

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Cheapest flights from Portland to Santiago de los Caballeros
Explore the most affordable flight options available from Portland to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.