$227+ Cheap flights from Portland, ME (PWM) to Santo Domingo (SDQ)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — SDQ
Sep 19 — Sep 261
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Portland to Santo Domingo
Cheapest
Best
One-way
Cheapest flights from Portland to Santo DomingoExplore the most affordable flight options available from Portland to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
Explore the most affordable flight options available from Portland to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
1 stop16h 46m
Sun 10/111:10 pm -
1 stop7h 12m
Deal found 8/19![United Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:50 am -
1 stop6h 51m
Fri 10/303:18 pm -
1 stop8h 03m
Deal found 8/17![United Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/283:40 pm -
1 stop7h 06m
Sun 11/14:18 pm -
2 stops22h 58m
Deal found 8/16![United Airlines logo]()
$647
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 pm -
2 stops19h 33m
Sun 10/117:00 am -
2 stops15h 31m
Deal found 8/19![American Airlines logo]()
$660
Best flights from Portland to Santo DomingoDiscover carefully curated flight deals from Portland to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
Discover carefully curated flight deals from Portland to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
1 stop16h 46m
Sun 10/111:10 pm -
1 stop7h 12m
Deal found 8/19![United Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:50 am -
1 stop6h 51m
Fri 10/303:18 pm -
1 stop8h 03m
Deal found 8/19![United Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:47 am -
2 stops13h 59m
Sun 11/16:00 am -
2 stops29h 07m
Deal found 8/16![United Airlines logo]()
$647
One-way flights from Portland to Santo DomingoSearch for one-way flight options from Portland to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
Search for one-way flight options from Portland to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:02 am -
1 stop6h 36m
Deal found 8/19![Delta logo]()
$227
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:00 am -
2 stops40h 46m
Deal found 8/19![United Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:01 am -
3 stops30h 28m
Deal found 8/19![Multiple Airlines logo]()
$463
Find flight deals from Portland to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2026.
Round-trip from | $440 (United Airlines) |
|---|---|
One-way from | $222 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
Use the filters below to find and compare flights from Portland to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandSanto Domingo
PWM Portland - SDQ Santo Domingo Las Americas
PWMSDQ
Portland
Sun 10/4
6:00 am-10:46 pm
1 stop16h 46m
Santo Domingo Las Americas
Sun 10/11
1:10 pm-8:22 pm
1 stop7h 12m
$423
Quickest round-trip
PortlandSanto Domingo
PWM Portland - SDQ Santo Domingo Las Americas
PWMSDQ
Portland
Mon 10/26
5:50 am-12:41 pm
1 stop6h 51m
Santo Domingo Las Americas
Fri 10/30
3:18 pm-11:21 pm
1 stop8h 03m
$440
PortlandSanto Domingo
PWM Portland - SDQ Santo Domingo Las Americas
PWMSDQ
Portland
Wed 10/28
8:47 am-10:46 pm
2 stops13h 59m
Santo Domingo Las Americas
Sun 11/1
6:00 am-10:07 am
2 stops29h 07m
$647
Cheapest one-way
Quickest one-way
PortlandSanto Domingo
PWM Portland - SDQ Santo Domingo Las Americas
PWMSDQ
Portland
Sun 9/20
6:02 am-12:38 pm
1 stop6h 36m
$227
PortlandSanto Domingo
PWM Portland - SDQ Santo Domingo Las Americas
PWMSDQ
Portland
Sun 9/20
6:00 am-10:46 pm
2 stops40h 46m
$297
Sorted by cheapest first
Best time to book a flight from Portland to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Portland with our price prediction graph.
PWM-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Portland to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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