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$288+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in May or June, booked 15 days in advance, depart on a Thursday or Monday and return on a Friday

Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This Priceline deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/282:55 amPTY - SCL
1 stop10h 25mAvianca
Sat 1/317:25 amSCL - PTY
1 stop11h 30mAvianca
Deal found 11/10$516
This Priceline deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/272:55 amPTY - SCL
1 stop10h 25mAvianca
Tue 12/27:25 amSCL - PTY
1 stop11h 30mAvianca
Deal found 11/10$551
This Avianca deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:55 amPTY - SCL
1 stop10h 25mAvianca
Mon 12/87:25 amSCL - PTY
1 stop11h 30mAvianca
Deal found 11/10$561
This Copa Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:55 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Mon 2/163:34 amSCL - PTY
Nonstop6h 42mCopa Airlines
Deal found 11/12$562
This Copa Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/263:51 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Fri 1/21:16 amSCL - PTY
Nonstop6h 44mCopa Airlines
Deal found 11/12$578
This Copa Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/213:51 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Thu 12/255:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Deal found 11/11$579
This Copa Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:11 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Fri 1/301:16 amSCL - PTY
Nonstop6h 44mCopa Airlines
Deal found 11/11$595
This Copa Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:51 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Mon 12/85:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Deal found 11/11$596
This Avianca deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:45 amPTY - SCL
1 stop12h 45mAvianca
Tue 11/184:25 pmSCL - PTY
1 stop10h 35mAvianca
Deal found 11/10$604
This Copa Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:11 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Thu 1/812:28 pmSCL - PTY
Nonstop6h 43mCopa Airlines
Deal found 11/11$634
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/132:55 pmPTY - SCL
2 stops12h 19mMultiple Airlines
Sat 12/207:25 amSCL - PTY
1 stop11h 30mMultiple Airlines
Deal found 11/11$638

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$516
(Priceline)

One-way from

$293
(Mytrip)

Popular in

January

Cheapest in

May

Average price

$561

Good round-trip deal

$513 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flights.
Search Deals
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 12/24

7:11 pm-3:43 am

Nonstop6h 32m

Santiago Arturo Merino Benitez

Fri 2/27

3:34 am-8:16 am

Nonstop6h 42m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 12/17

3:08 pm-11:41 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Thu 2/19

1:16 am-6:00 am

Nonstop6h 44m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 3/12

3:18 pm-11:49 pm

Nonstop6h 31m

Santiago Arturo Merino Benitez

Mon 3/16

12:28 pm-5:11 pm

Nonstop6h 43m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 12/11

3:08 pm-11:41 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Thu 12/18

5:12 am-10:03 am

Nonstop6h 51m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 2/5

6:45 pm-3:17 am

Nonstop6h 32m

Santiago Arturo Merino Benitez

Sat 2/7

3:34 am-8:16 am

Nonstop6h 42m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 2/2

7:25 pm-4:14 am

Nonstop6h 49m

Santiago Arturo Merino Benitez

Sun 2/8

12:28 pm-5:11 pm

Nonstop6h 43m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 12/29

3:51 pm-12:24 am

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sat 1/31

5:20 am-10:03 am

Nonstop6h 43m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 2/10

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Fri 2/20

3:34 am-8:16 am

Nonstop6h 42m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 12/26

3:08 pm-11:41 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sat 1/3

5:44 am-10:35 am

Nonstop6h 51m

$562

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 4/25

9:55 am-4:15 am

1 stop17h 20m

$288

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 18 results
1
2

Compare providers for flights from Panama City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on November 7, 2025.

Booking 15 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of $249). Flying from Panama City to Santiago in October is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 12, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,563 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,563 reviews
Copa Airlines
7.6
Good
1,563 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,473 reviews
Copa Airlines
7.6
Good
1,563 reviews

Entertainment

6.8

Crew

8.1

Boarding

7.8

Comfort

7.4

Food

6.9

Overall

7.6

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

    This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santiago?

    Copa Airlines can get you from Panama City to Santiago in just under 6h 33m. Your travel time will be generally consistent. Panama City and Santiago are separated by a distance of 2986 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $284. Another airline that can offer you cheap pricing is Copa Airlines. You may be able to fly from Panama City to Santiago for 50% less than the average price by searching for these airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider Turkish Airlines (92%), Copa Airlines (89%) or KLM (87%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $561 for a flight from Panama City to Santiago. The cheapest flight overall is $497 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $562.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of $249). Flying from Panama City to Santiago in October is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Temuco car rentals
Lastarria car rentals

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$284Average$542FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$481Average$647FlexibilityNo cancel feeOn-time70%

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