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$259+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in April or May, booked 17 days in advance, depart on a Monday or Thursday and return on a Friday

Cheap flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:45 am
PTY
-
SCL
1 stop17h 45m
Avianca
Thu 3/197:25 am
SCL
-
PTY
1 stop11h 30m
Avianca
Deal found 1/26$481
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:25 pm
PTY
-
SCL
Nonstop6h 33m
Copa Airlines
Thu 3/195:21 am
SCL
-
PTY
Nonstop6h 42m
Copa Airlines
Deal found 1/26$491
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/109:45 am
PTY
-
SCL
1 stop12h 45m
Avianca
Fri 3/201:35 am
SCL
-
PTY
1 stop9h 15m
Avianca
Deal found 1/26$507
This Priceline deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3010:05 pm
PTY
-
SCL
1 stop14h 20m
Avianca
Mon 4/66:10 am
SCL
-
PTY
1 stop19h 35m
Avianca
Deal found 1/25$525
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:51 pm
PTY
-
SCL
Nonstop6h 43m
Copa Airlines
Tue 3/175:21 am
SCL
-
PTY
Nonstop6h 42m
Copa Airlines
Deal found 1/26$541
This Copa Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:51 pm
PTY
-
SCL
Nonstop6h 43m
Copa Airlines
Sat 3/145:44 am
SCL
-
PTY
Nonstop6h 51m
Copa Airlines
Deal found 1/25$542
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:18 pm
PTY
-
SCL
Nonstop6h 31m
Copa Airlines
Thu 3/53:32 am
SCL
-
PTY
Nonstop6h 44m
Copa Airlines
Deal found 1/26$559
This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/62:55 am
PTY
-
SCL
1 stop10h 25m
Avianca
Wed 3/181:35 am
SCL
-
PTY
1 stop9h 15m
Avianca
Deal found 1/26$560
This Priceline deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:25 am
PTY
-
SCL
1 stop9h 00m
Avianca
Tue 10/207:10 am
SCL
-
PTY
1 stop11h 20m
Avianca
Deal found 1/25$561
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
PTY
-
SCL
Nonstop6h 35m
Copa Airlines
Fri 5/84:41 am
SCL
-
PTY
Nonstop6h 54m
Copa Airlines
Deal found 1/26$566
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/49:45 am
PTY
-
SCL
1 stop12h 45m
Avianca
Mon 3/167:25 am
SCL
-
PTY
1 stop11h 30m
Avianca
Deal found 1/26$590
This Copa Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/313:51 pm
PTY
-
SCL
Nonstop6h 35m
Copa Airlines
Sun 8/94:14 am
SCL
-
PTY
Nonstop6h 49m
Copa Airlines
Deal found 1/26$594

Find flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$481
(Priceline)

One-way from

$259
(Avianca)

Popular in

February

Cheapest in

April

Average price

$572

Good round-trip deal

$588 or less

Good one-way deal

$1,051 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flights.
Search Deals
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($2 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 5/4

5:25 pm-4:15 am

1 stop9h 50m

Santiago Arturo Merino Benitez

Tue 5/12

11:55 pm-4:30 pm

1 stop17h 35m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 4/2

3:08 pm-11:43 pm

Nonstop6h 35m

Santiago Arturo Merino Benitez

Wed 4/15

11:25 am-5:11 pm

Nonstop6h 46m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 4/13

3:51 pm-11:26 pm

Nonstop6h 35m

Santiago Arturo Merino Benitez

Sat 4/18

4:49 am-10:35 am

Nonstop6h 46m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 4/11

3:08 pm-10:43 pm

Nonstop6h 35m

Santiago Arturo Merino Benitez

Sat 4/25

11:25 am-5:11 pm

Nonstop6h 46m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 5/8

7:25 pm-3:00 am

Nonstop6h 35m

Santiago Arturo Merino Benitez

Thu 5/14

11:17 am-5:11 pm

Nonstop6h 54m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 3/12

3:18 pm-11:49 pm

Nonstop6h 31m

Santiago Arturo Merino Benitez

Wed 3/18

1:17 am-6:00 am

Nonstop6h 43m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 4/20

3:08 pm-10:43 pm

Nonstop6h 35m

Santiago Arturo Merino Benitez

Thu 4/30

4:49 am-10:35 am

Nonstop6h 46m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 3/21

3:51 pm-12:34 am

Nonstop6h 43m

Santiago Arturo Merino Benitez

Wed 3/25

5:44 am-10:35 am

Nonstop6h 51m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 4/28

9:28 pm-5:03 am

Nonstop6h 35m

Santiago Arturo Merino Benitez

Tue 5/5

4:09 am-10:03 am

Nonstop6h 54m

$491

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 3/11

3:51 pm-12:34 am

Nonstop6h 43m

Santiago Arturo Merino Benitez

Wed 3/18

12:28 pm-5:11 pm

Nonstop6h 43m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 21 results
1
2
3
  • Most accurate provider: When it comes to deals on Panama City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on January 23, 2026.

Booking 17 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, January is the cheapest month in which you can book a flight from Panama City to Santiago (average of $260). Flying from Panama City to Santiago in October is currently the most expensive (average of $363). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 26, 2026.

When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Panama City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 26, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,558 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.6
Okay
2,492 reviews
Copa Airlines
7.6
Good
1,558 reviews

Comfort

7.4

Food

6.8

Boarding

7.8

Crew

8.1

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 9 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

    This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santiago?

    Avianca and Copa Airlines can get you from Panama City to Santiago in just under 6h 32m. Your travel time can differ by up to 6h 13m. Panama City and Santiago are separated by a distance of 2986 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $218. Another airline that can offer you cheap pricing is Copa Airlines. You may be able to fly from Panama City to Santiago for 61% less than the average price by searching for these airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider Turkish Airlines (93%), Copa Airlines (91%) or KLM (90%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $836 for a flight from Panama City to Santiago. The cheapest flight overall is $572 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $491.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Santiago (average of $260). Flying from Panama City to Santiago in October is currently the most expensive (average of $363). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$218Average$561FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$402Average$588FlexibilityNo cancel feeOn-time70%

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