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$255+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in June or May, booked 70 days in advance, depart on a Thursday or Tuesday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$481
(Copa Airlines)

One-way from

$255
(Avianca)

Popular in

January

Cheapest in

June

Average price

$567

Good round-trip deal

$561 or less

Good one-way deal

$1,004 or less
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
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Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:33 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Sat 11/153:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Deal found 9/16$481
This Avianca deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:55 amPTY - SCL
1 stop10h 25mAvianca
Sun 11/97:25 amSCL - PTY
1 stop11h 30mAvianca
Deal found 9/16$482
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:20 amPTY - SCL
1 stop9h 05mAvianca
Sat 10/412:55 amSCL - PTY
1 stop17h 35mAvianca
Deal found 9/16$489
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/307:11 pmPTY - SCL
Nonstop6h 31mCopa Airlines
Sat 11/291:29 amSCL - PTY
Nonstop6h 51mCopa Airlines
Deal found 9/16$497
This Avianca deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1711:00 amPTY - SCL
1 stop16h 15mAvianca
Mon 11/104:25 pmSCL - PTY
1 stop10h 15mAvianca
Deal found 9/16$503
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2811:48 amPTY - SCL
Nonstop6h 33mCopa Airlines
Sat 12/65:12 amSCL - PTY
Nonstop6h 51mCopa Airlines
Deal found 9/17$521
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/319:45 amPTY - SCL
1 stop12h 45mAvianca
Wed 11/57:25 amSCL - PTY
1 stop11h 30mAvianca
Deal found 9/15$523
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/227:11 pmPTY - SCL
Nonstop6h 31mCopa Airlines
Mon 1/121:16 amSCL - PTY
Nonstop6h 44mCopa Airlines
Deal found 9/16$537
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/133:08 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Mon 10/2012:29 pmSCL - PTY
Nonstop6h 51mCopa Airlines
Deal found 9/16$538
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:20 amPTY - SCL
1 stop9h 05mAvianca
Wed 10/2212:55 amSCL - PTY
1 stop17h 35mAvianca
Deal found 9/16$548
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:32 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Sat 12/61:08 amSCL - PTY
Nonstop6h 52mCopa Airlines
Deal found 9/16$554
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/113:08 pmPTY - SCL
Nonstop6h 32mCopa Airlines
Fri 10/171:13 amSCL - PTY
Nonstop6h 52mCopa Airlines
Deal found 9/17$555

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Sun 11/16

12:20 pm-5:11 pm

Nonstop6h 51m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 11/15

3:08 pm-11:41 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Tue 11/18

12:20 pm-5:11 pm

Nonstop6h 51m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 11/3

7:11 pm-3:43 am

Nonstop6h 32m

Santiago Arturo Merino Benitez

Wed 11/5

3:23 am-8:16 am

Nonstop6h 53m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 10/16

3:08 pm-11:40 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Wed 10/22

3:35 am-8:25 am

Nonstop6h 50m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

3:08 pm-11:40 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Thu 11/6

3:23 am-8:16 am

Nonstop6h 53m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Tue 11/4

1:12 am-6:05 am

Nonstop6h 53m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 10/1

7:11 pm-3:42 am

Nonstop6h 31m

Santiago Arturo Merino Benitez

Sat 10/4

3:35 am-8:25 am

Nonstop6h 50m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 10/7

3:08 pm-11:40 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Fri 10/10

12:29 pm-5:20 pm

Nonstop6h 51m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Thu 11/6

3:08 pm-11:41 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sat 11/15

3:23 am-8:16 am

Nonstop6h 53m

$481

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 10/13

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Sun 10/19

3:35 am-8:25 am

Nonstop6h 50m

$481

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 15 results
1
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Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on September 12, 2025.

Booking 70 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s optimal to fly from Panama City to Santiago in the afternoon. By choosing this option you can save up to 8% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Panama City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,533 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,533 reviews

Boarding

7.8

Overall

7.6

Comfort

7.4

Crew

8.1

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 30m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

    This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Santiago?

    Copa Airlines can get you from Panama City to Santiago in just under 6h 32m. Your travel time will be generally consistent. Panama City and Santiago are separated by a distance of 2986 mi. Generally, flights for this route are nonstop.

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $325. Another airline that can offer you cheap pricing is Copa Airlines. You may be able to fly from Panama City to Santiago for 43% less than the average price by searching for these airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider Turkish Airlines (88%), KLM (87%) or Copa Airlines (81%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $855 for a flight from Panama City to Santiago. The cheapest flight overall is $481 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $470.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Temuco car rentals
Lastarria car rentals

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$325Average$530FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$490Average$664FlexibilityNo cancel feeOn-time70%

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