Santiago

$318+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
ago. 19 — ago. 261
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in October or June, booked 80 days in advance, depart on a Thursday or Tuesday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$607
(Mytrip)

One-way from

$318
(Mytrip)

Popular in

January

Cheapest in

October

Average price

$563

Good round-trip deal

$642 or less

Good one-way deal

$1,004 or less
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Highest demand for flights based on searches. 5% potential increase in price ($36 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Average for round-trip flights in August 2025
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
Price to beat on a one-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.

Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/235:25 pmPTY - SCL
2 stops28h 15mMultiple Airlines
mar. 9/307:10 amSCL - PTY
1 stop11h 20mMultiple Airlines
Deal found 8/14$607
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/313:20 amPTY - SCL
2 stops18h 20mMultiple Airlines
lun. 9/87:10 amSCL - PTY
1 stop16h 00mMultiple Airlines
Deal found 8/13$619
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/115:25 pmPTY - SCL
2 stops28h 15mMultiple Airlines
mié. 9/1712:55 amSCL - PTY
1 stop10h 00mMultiple Airlines
Deal found 8/14$628
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/193:20 amPTY - SCL
2 stops16h 50mMultiple Airlines
dom. 11/21:35 amSCL - PTY
1 stop9h 15mMultiple Airlines
Deal found 8/13$640
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/233:20 amPTY - SCL
2 stops34h 10mMultiple Airlines
sáb. 8/302:30 pmSCL - PTY
1 stop20h 40mMultiple Airlines
Deal found 8/14$647
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/111:00 amPTY - SCL
1 stop10h 30mAvianca
lun. 9/87:10 amSCL - PTY
2 stops31h 25mAvianca
Deal found 8/13$648
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/2510:28 pmPTY - SCL
1 stop14h 08mMultiple Airlines
dom. 9/2812:25 amSCL - PTY
1 stop11h 57mMultiple Airlines
Deal found 8/14$652
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/315:55 pmPTY - SCL
1 stop9h 35mAvianca
dom. 11/94:25 pmSCL - PTY
1 stop10h 35mAvianca
Deal found 8/14$658

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

dom. 8/31

3:20 am-10:40 pm

2 stops18h 20m

Santiago Arturo Merino Benitez

lun. 9/8

7:10 am-12:35 pm

2 stops31h 25m

$607

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

lun. 9/22

3:25 am-7:45 am

2 stops26h 20m

Santiago Arturo Merino Benitez

mar. 9/30

7:10 am-12:10 am

1 stop19h 00m

$628

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 9/11

5:25 pm-11:40 pm

2 stops28h 15m

Santiago Arturo Merino Benitez

mié. 9/17

12:55 am-8:55 am

1 stop10h 00m

$628

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

dom. 10/19

3:20 am-10:10 pm

2 stops16h 50m

Santiago Arturo Merino Benitez

dom. 11/2

1:35 am-8:50 am

1 stop9h 15m

$640

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 8/28

9:55 am-2:35 pm

2 stops27h 40m

$318

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 9/18

9:55 am-5:15 am

1 stop17h 20m

$343

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 8/28

5:25 pm-4:15 am

1 stop9h 50m

$343

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 9/18

9:55 am-5:01 am

3 stops17h 06m

$393

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

jue. 9/18

9:28 pm-5:58 am

Nonstop6h 30m

$838

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

vie. 12/12

9:45 am-12:30 am

1 stop12h 45m

$935

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 12 results
1
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Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on August 8, 2025.

Booking 80 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

It’s optimal to fly from Panama City to Santiago at noon. By choosing this option you can save up to 3% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from Panama City to Santiago

Explore weekly flight availability from Panama City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated agosto 14, 2025.

The most flights from PTY to SCL are scheduled on a Monday (8 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated agosto 14, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.5

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.5

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.5

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $354. Another airline that can offer you cheap pricing is Copa Airlines. You may be able to fly from Panama City to Santiago for 37% less than the average price by searching for these airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider KLM (86%), Turkish Airlines (82%) or Copa Airlines (73%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $855 for a flight from Panama City to Santiago. The cheapest flight overall is $563 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $666.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$354Average$495FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$454Average$647FlexibilityNo cancel feeOn-time70%

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