$421+ Cheap flights from Panama City (PTY) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in March or January, booked 59 days in advance, depart on a Monday or Sunday and return on a Wednesday
Cheap flight deals from Panama City to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to SantiagoExplore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:10 pm -
1 stop9h 35m
Tue 11/107:30 am -
1 stop9h 45m
Deal found 11/2![Avianca logo]()
$606
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:05 am -
1 stop17h 40m
Thu 12/34:15 pm -
1 stop11h 05m
Deal found 10/30![Avianca logo]()
$608
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:30 am -
1 stop10h 40m
Tue 12/84:15 pm -
1 stop11h 05m
Deal found 11/2![Avianca logo]()
$621
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:30 am -
1 stop10h 40m
Sun 12/64:15 pm -
1 stop11h 05m
Deal found 11/2![Avianca logo]()
$627
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:05 am -
1 stop17h 40m
Sun 12/67:30 am -
1 stop9h 45m
Deal found 11/2![Avianca logo]()
$629
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:11 pm -
Nonstop6h 32m
Tue 12/85:07 am -
Nonstop6h 56m
Deal found 11/3![Copa Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:56 pm -
Nonstop6h 28m
Thu 11/191:26 am -
Nonstop6h 57m
Deal found 11/3![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:08 pm -
Nonstop6h 27m
Thu 12/313:53 am -
Nonstop6h 52m
Deal found 11/3![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:11 pm -
Nonstop6h 27m
Sun 12/65:07 am -
Nonstop6h 56m
Deal found 11/2![Copa Airlines logo]()
$706
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/173:56 pm -
Nonstop6h 27m
Thu 12/245:07 am -
Nonstop6h 56m
Deal found 11/2![Copa Airlines logo]()
$715
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:24 pm -
Nonstop6h 22m
Thu 11/1912:15 pm -
Nonstop6h 56m
Deal found 11/3![Copa Airlines logo]()
$719
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:10 pm -
1 stop11h 35m
Thu 11/192:10 am -
1 stop9h 00m
Deal found 11/1![Avianca logo]()
$733
Best flights from Panama City to SantiagoDiscover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:11 pm -
Nonstop6h 32m
Tue 12/85:07 am -
Nonstop6h 56m
Deal found 10/31![Copa Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:11 pm -
Nonstop6h 32m
Sun 12/612:20 pm -
Nonstop6h 51m
Deal found 10/31![Copa Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:25 pm -
Nonstop6h 23m
Mon 12/75:07 am -
Nonstop6h 56m
Deal found 11/2![Copa Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:25 pm -
Nonstop6h 23m
Mon 11/305:07 am -
Nonstop6h 56m
Deal found 11/4![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/263:56 pm -
Nonstop6h 28m
Sun 12/612:20 pm -
Nonstop6h 51m
Deal found 11/1![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/273:56 pm -
Nonstop6h 28m
Sun 12/612:20 pm -
Nonstop6h 51m
Deal found 11/1![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:11 pm -
Nonstop6h 35m
Fri 1/153:53 am -
Nonstop6h 52m
Deal found 10/31![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/63:56 pm -
Nonstop6h 32m
Wed 1/135:13 am -
Nonstop6h 50m
Deal found 11/4![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/17:11 pm -
Nonstop6h 32m
Mon 3/811:58 pm -
Nonstop6h 44m
Deal found 11/2![Copa Airlines logo]()
$695
Last-minute flights from Panama City to SantiagoDiscover last-minute flight deals from Panama City to Santiago. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Santiago. Data last updated November 4, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:10 pm -
1 stop11h 35m
Thu 11/192:10 am -
1 stop9h 00m
Deal found 11/1![Avianca logo]()
$733
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:10 pm -
1 stop9h 35m
Tue 11/107:30 am -
1 stop9h 45m
Deal found 11/2![Avianca logo]()
$606
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:24 pm -
Nonstop6h 22m
Thu 11/1912:15 pm -
Nonstop6h 56m
Deal found 11/3![Copa Airlines logo]()
$719
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:08 pm -
Nonstop6h 28m
Tue 11/243:48 am -
Nonstop6h 57m
Deal found 11/3![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:11 pm -
Nonstop6h 27m
Sun 12/65:07 am -
Nonstop6h 56m
Deal found 11/2![Copa Airlines logo]()
$706
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:05 am -
1 stop17h 40m
Thu 12/34:15 pm -
1 stop11h 05m
Deal found 10/30![Avianca logo]()
$608
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:05 am -
1 stop17h 40m
Sun 12/67:30 am -
1 stop9h 45m
Deal found 11/2![Avianca logo]()
$629
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:30 am -
1 stop10h 40m
Sun 12/64:15 pm -
1 stop11h 05m
Deal found 11/1![Avianca logo]()
$627
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:30 am -
1 stop10h 40m
Tue 12/84:15 pm -
1 stop11h 05m
Deal found 11/2![Avianca logo]()
$621
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:11 pm -
Nonstop6h 32m
Tue 12/85:07 am -
Nonstop6h 56m
Deal found 11/3![Copa Airlines logo]()
$679
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/173:56 pm -
Nonstop6h 27m
Thu 12/245:07 am -
Nonstop6h 56m
Deal found 11/2![Copa Airlines logo]()
$715
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:08 pm -
Nonstop6h 27m
Thu 12/313:53 am -
Nonstop6h 52m
Deal found 11/4![Copa Airlines logo]()
$695
One-way flights from Panama City to SantiagoSearch for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/128:45 am -
1 stop10h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:47 am -
1 stop24h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/94:10 pm -
3 stops31h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$439
This Mytrip deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2310:05 am -
2 stops17h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:45 am -
1 stop24h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$520
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/159:44 pm -
2 stops22h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$525
Find flight deals from Panama City to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $606 (Avianca) |
One-way from | $421 (Kiwi.com) |
Popular in | October |
Cheapest in | March |
Average price | $622 |
Good round-trip deal | $679 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Tue 1/12
8:45 am-8:58 pm
1 stop10h 13m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$421
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Wed 12/9
10:05 am-5:00 am
2 stops16h 55m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$459
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Tue 12/22
2:30 am-5:05 am
3 stops24h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$517
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Mon 1/4
10:05 am-1:13 am
2 stops13h 08m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$534
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Tue 12/29
2:30 am-3:10 pm
1 stop10h 40m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$659
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Thu 12/3
7:11 pm-3:43 am
Nonstop6h 32m
Santiago Arturo Merino Benitez
Tue 12/8
5:07 am-10:03 am
Nonstop6h 56m
$679
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Wed 12/2
7:11 pm-3:43 am
Nonstop6h 32m
Santiago Arturo Merino Benitez
Sun 12/6
12:20 pm-5:11 pm
Nonstop6h 51m
$679
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Mon 11/30
6:25 pm-2:48 am
Nonstop6h 23m
Santiago Arturo Merino Benitez
Mon 12/7
5:07 am-10:03 am
Nonstop6h 56m
$679
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Thu 11/19
6:25 pm-2:48 am
Nonstop6h 23m
Santiago Arturo Merino Benitez
Mon 11/30
5:07 am-10:03 am
Nonstop6h 56m
$694
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Thu 11/26
3:56 pm-12:24 am
Nonstop6h 28m
Santiago Arturo Merino Benitez
Sun 12/6
12:20 pm-5:11 pm
Nonstop6h 51m
$694
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Panama City to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
PTY-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Santiago
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Santiago?
Booking 58 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Panama City to Santiago?
Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of $561). Flying from Panama City to Santiago in October is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SCL?
Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2026.
When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Panama City to Santiago delayed?
About 10% of weekly flights between Panama City and Santiago have experienced delays in the past year, with the average delay time being 116 minutes.
What is the most punctual flight time for Panama City to Santiago flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Friday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Santiago flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 10% of flights being delayed.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 4, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Boarding
7.8
Food
7.0
Overall
7.6
Comfort
7.4
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Boarding
7.8
Food
7.0
Overall
7.6
Comfort
7.4
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Entertainment
6.9
Boarding
7.8
Food
7.0
Overall
7.6
Comfort
7.4
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
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Panama City and Santiago flights
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Top 2 airlines flying from Panama City to Santiago
Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$295 | Average$612 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$353 | Average$657 | FlexibilityNo cancel fee | On-time70% |