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$298+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in August or October, booked 67 days in advance, depart on a Thursday or Monday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$552
(Priceline)

One-way from

$298
(Avianca)

Popular in

January

Cheapest in

August

Average price

$542

Good round-trip deal

$636 or less
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 8% potential increase in price ($53 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
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Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Priceline deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/213:20 amPTY - SCL
1 stop9h 05mAvianca
Thu 6/262:30 pmSCL - PTY
1 stop10h 40mAvianca
Deal found 6/11$552
This Copa Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:35 pmPTY - SCL
Nonstop6h 33mCopa Airlines
Sat 11/154:19 amSCL - PTY
Nonstop6h 53mCopa Airlines
Deal found 6/10$604
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:10 pmPTY - SCL
3 stops30h 20mMultiple Airlines
Mon 10/207:10 amSCL - PTY
1 stop19h 35mMultiple Airlines
Deal found 6/11$621
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:35 pmPTY - SCL
2 stops39h 15mUnited Airlines
Tue 12/210:45 pmSCL - PTY
2 stops23h 17mUnited Airlines
Deal found 6/11$1,362
This Iberia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/227:55 amPTY - SCL
2 stops35h 40mIberia
Wed 10/18:00 pmSCL - PTY
2 stops68h 31mIberia
Deal found 6/12$2,999

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 6/22

11:05 am-10:30 pm

1 stop10h 25m

Santiago Arturo Merino Benitez

Thu 6/26

2:30 pm-12:10 am

1 stop10h 40m

$552

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

11:44 am-8:17 pm

Nonstop6h 33m

Santiago Arturo Merino Benitez

Sun 11/9

6:12 am-11:05 am

Nonstop6h 53m

$604

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 10/5

8:10 pm-4:30 am

3 stops30h 20m

Santiago Arturo Merino Benitez

Mon 10/20

7:10 am-12:45 am

1 stop19h 35m

$621

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 11/14

3:35 pm-8:50 am

2 stops39h 15m

Santiago Arturo Merino Benitez

Tue 12/2

10:45 pm-8:02 pm

2 stops23h 17m

$1,362

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 9/22

7:55 am-9:35 pm

2 stops35h 40m

Santiago Arturo Merino Benitez

Wed 10/1

8:00 pm-2:31 pm

2 stops68h 31m

$2,999

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 6/25

5:25 pm-4:15 am

1 stop9h 50m

$298

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 10/26

1:30 pm-1:25 pm

2 stops21h 55m

$331

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 8/3

7:11 pm-2:47 am

Nonstop6h 36m

$687

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on June 9, 2025.

Booking 67 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

It’s optimal to fly from Panama City to Santiago at noon. By choosing this option you can save up to 13% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from Panama City to Santiago

Explore weekly flight availability from Panama City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 12, 2025.

The most flights from PTY to SCL are scheduled on a Monday (7 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (7 on average).

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 12, 2025.
Copa Airlines
7.5
Good
1,451 reviews

Entertainment

6.8

Crew

8.1

Overall

7.5

Comfort

7.4

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,451 reviews
Copa Airlines
7.5
Good
1,451 reviews

Entertainment

6.8

Crew

8.1

Overall

7.5

Comfort

7.4

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,345 reviews
Copa Airlines
7.5
Good
1,451 reviews

Entertainment

6.8

Crew

8.1

Overall

7.5

Comfort

7.4

Boarding

7.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 7 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

    This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $552. Another airline that can offer you cheap pricing is Copa Airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider KLM (90%), Turkish Airlines (88%) or Copa Airlines (75%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $700 for a flight from Panama City to Santiago. The cheapest flight overall is $573 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $542.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Punta Arenas car rentals
Temuco car rentals
Lastarria car rentals

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$294Average$444FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$443Average$636FlexibilityNo cancel feeOn-time70%

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