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$284+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in August or May, booked 20 days in advance, depart on a Sunday or Thursday and return on a Tuesday

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$474
(Priceline)

One-way from

$284
(Avianca)

Popular in

January

Cheapest in

August

Average price

$474

Good round-trip deal

$557 or less
Provider with most accurate pricing for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Santiago Arturo Merino Benitez flights.
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From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 10% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.
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Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Priceline deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/233:25 amPTY - SCL
1 stop9h 00mAvianca
Fri 5/305:55 amSCL - PTY
1 stop11h 35mAvianca
Deal found 4/30$474
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/233:25 amPTY - SCL
1 stop9h 00mMultiple Airlines
Tue 7/19:39 pmSCL - PTY
2 stops20h 16mMultiple Airlines
Deal found 4/30$621
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/213:32 pmPTY - SCL
Nonstop6h 36mCopa Airlines
Mon 7/2811:27 amSCL - PTY
Nonstop6h 53mCopa Airlines
Deal found 4/30$632

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 5/23

3:25 am-1:25 pm

1 stop9h 00m

Santiago Arturo Merino Benitez

Fri 5/30

5:55 am-4:30 pm

1 stop11h 35m

$474

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 6/23

3:25 am-1:25 pm

1 stop9h 00m

Santiago Arturo Merino Benitez

Tue 7/1

9:39 pm-4:55 pm

2 stops20h 16m

$621

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 7/21

3:32 pm-11:08 pm

Nonstop6h 36m

Santiago Arturo Merino Benitez

Mon 7/28

11:27 am-5:20 pm

Nonstop6h 53m

$632

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Tue 5/6

9:50 am-4:35 am

1 stop17h 45m

$284

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 5/10

9:28 pm-12:25 pm

2 stops37h 57m

$352

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Wed 6/4

11:48 am-7:24 pm

Nonstop6h 36m

$695

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sat 5/10

1:20 pm-7:20 am

2 stops65h 00m

$8,705

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Compare providers for flights from Panama City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago in May.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on April 25, 2025.

Booking 20 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

It’s optimal to fly from Panama City to Santiago at noon. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight in the afternoon.

Weekly flight availability from Panama City to Santiago

Explore weekly flight availability from Panama City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 1, 2025.

The most flights from PTY to SCL are scheduled on a Monday (7 on average). You will have fewer flight options on Thursday, which is when the least amount of flights are scheduled (6 on average).

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated May 1, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, Iberia and Avianca from Panama City to Santiago to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,415 reviews

Overall

7.5

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Copa Airlines
7.5
Good
1,415 reviews
Copa Airlines
7.5
Good
1,415 reviews

Overall

7.5

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Iberia
7.0
Good
2,701 reviews
Copa Airlines
7.5
Good
1,415 reviews

Overall

7.5

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.
Avianca
6.7
Okay
2,317 reviews
Copa Airlines
7.5
Good
1,415 reviews

Overall

7.5

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Reviews

1 / 20
4.0
Okay

Anonymous,Mar 2025

PTY - JFK

There was no chance for me to choose a seat even if I were willing to pay extra for it when I was doing the check-in on line. My seats were the last row on the plane and they didn't have enough food to give me. I had to eat what was left after everybody else had their choice of food. This is unacceptable. Everyone should have a choice. I paid money just like everybody else. Never had this happened on any other airlines even if my seats were last row on the plane.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 6 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

    This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $474. Another airline that can offer you cheap pricing is Copa Airlines. You may be able to fly from Panama City to Santiago for 8% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City to Santiago one-way?

    One-way options have recently been found by users for as low as $284 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $695 and Iberia from $8,705 one-way.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider Turkish Airlines (93%), KLM (82%) or Copa Airlines (79%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $589 for a flight from Panama City to Santiago. The cheapest flight overall is $522 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $499.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Punta Arenas car rentals
Temuco car rentals
Lastarria car rentals

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$294Average$439FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$370Average$592FlexibilityNo cancel feeOn-time70%

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