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$187+ Cheap flights from Myrtle Beach to Santa Ana (MYR - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SNA
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$339
(CheapOair)

One-way from

$187
(CheapOair)

Popular in

January

Cheapest in

August

Average price

$350
From Myrtle Beach Intl to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Myrtle Beach Intl to Santa Ana J. Wayne/Orange Cnty
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Highest demand for flights based on searches. 12% potential increase in price ($80 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Myrtle Beach to Santa Ana

Cheapest flights from Myrtle Beach to Santa Ana
Explore the most affordable flight options available from Myrtle Beach to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/111:54 pmMYR - SNA
1 stop9h 03mAmerican Airlines
Wed 12/38:55 amSNA - MYR
1 stop8h 55mAmerican Airlines
Deal found 9/15$337
This CheapOair deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:59 amMYR - SNA
2 stops14h 00mSpirit Airlines
Mon 11/175:46 pmSNA - MYR
2 stops13h 55mSpirit Airlines
Deal found 9/15$339
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/295:57 pmMYR - SNA
2 stops18h 20mUnited Airlines
Sat 10/44:15 pmSNA - MYR
2 stops15h 24mUnited Airlines
Deal found 9/15$606
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/295:57 pmMYR - SNA
2 stops18h 20mUnited Airlines
Fri 10/36:40 pmSNA - MYR
1 stop17h 45mUnited Airlines
Deal found 9/14$620
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/811:20 amMYR - SNA
1 stop9h 18mUnited Airlines
Tue 10/146:40 pmSNA - MYR
2 stops12h 59mUnited Airlines
Deal found 9/15$652
This KAYAK deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:59 amMYR - SNA
2 stops14h 00mSpirit Airlines
Tue 12/25:46 pmSNA - MYR
2 stops13h 55mSpirit Airlines
Deal found 9/15$695
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/224:45 pmMYR - SNA
2 stops19h 31mUnited Airlines
Sat 9/279:05 pmSNA - MYR
1 stop11h 00mUnited Airlines
Deal found 9/15$791

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santa Ana that are best for you.

Fly from

Myrtle Beach

Fly to

Santa Ana

Route

Depart

Return

Price

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 11/11

1:54 pm-7:57 pm

1 stop9h 03m

Santa Ana J. Wayne/Orange Cnty

Wed 12/3

8:55 am-8:50 pm

1 stop8h 55m

$337

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sat 11/15

9:59 am-8:59 pm

2 stops14h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 11/17

5:46 pm-10:41 am

2 stops13h 55m

$339

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Tue 3/3

2:28 pm-8:24 pm

1 stop8h 56m

Santa Ana J. Wayne/Orange Cnty

Wed 3/4

8:28 am-5:27 pm

1 stop5h 59m

$459

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Mon 9/29

5:57 pm-9:17 am

2 stops18h 20m

Santa Ana J. Wayne/Orange Cnty

Sat 10/4

4:15 pm-10:39 am

2 stops15h 24m

$606

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Mon 9/29

5:57 pm-9:17 am

2 stops18h 20m

Santa Ana J. Wayne/Orange Cnty

Fri 10/3

6:40 pm-3:25 pm

1 stop17h 45m

$620

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 10/9

1:43 pm-10:03 pm

2 stops11h 20m

$187

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sun 10/12

3:59 pm-7:14 pm

2 stops30h 15m

$190

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Thu 11/27

8:00 am-4:40 pm

2 stops11h 40m

$245

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sun 10/12

9:05 pm-10:03 pm

3 stops27h 58m

$260

Myrtle BeachSanta Ana

MYR - SNA

MYRSNA

Myrtle Beach Intl

Sun 10/26

1:43 pm-10:03 pm

2 stops11h 20m

$288

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 15 results
1
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Best time to book a flight from Myrtle Beach to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Santa Ana

What is the cheapest month to book a flight from Myrtle Beach to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santa Ana (average of $298). Flying from Myrtle Beach to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SNA?

Find hourly flight availability from Myrtle Beach to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Santa Ana is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 18% on airfare.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Boarding

7.5

Comfort

7.2

Crew

8.0

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Food

6.4

Boarding

7.5

Comfort

7.2

Crew

8.0

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santa Ana?

    For as low as $337, American Airlines can have you in Santa Ana from Myrtle Beach in 9h 03m. The distance from Myrtle Beach to Santa Ana is about 2224 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Myrtle Beach to Santa Ana round-trip?

    Flying on American Airlines is currently your cheapest option to Santa Ana, with prices starting at $319. This flight start at 40% lower than the current average price 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santa Ana.

  • Can I find deals for business class flights from Myrtle Beach to Santa Ana?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santa Ana (average of $298). Flying from Myrtle Beach to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Alternative routes for Myrtle Beach to Santa Ana

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Top airline flying from Myrtle Beach to Santa Ana

Discover the top airline that operate flights from Myrtle Beach to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$319Average$542FlexibilityNo cancel feeOn-time71%

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