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$454+ Cheap flights from Santiago de los Caballeros (STI) to San Francisco (SFO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
STI — SFO
feb. 25 — mar. 41
mié. 2/25
mié. 3/4
1 adult, Economy
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Cheap flight deals from Santiago de los Caballeros to San Francisco

Cheapest flights from Santiago de los Caballeros to San Francisco
Explore the most affordable flight options available from Santiago de los Caballeros to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 26, 2026.

This Trip.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/116:00 am
STI
-
SFO
1 stop17h 49m
JetBlue
mié. 3/187:01 am
SFO
-
STI
1 stop10h 59m
JetBlue
Deal found 1/25$454
This Faresmojo deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/267:05 am
STI
-
SFO
1 stop15h 24m
JetBlue
mié. 4/13:20 pm
SFO
-
STI
1 stop14h 13m
JetBlue
Deal found 1/26$552
This JetBlue deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/123:34 am
STI
-
SFO
1 stop12h 26m
JetBlue
mié. 5/2011:40 am
SFO
-
STI
1 stop11h 27m
JetBlue
Deal found 1/25$582
This JetBlue deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/312:12 pm
STI
-
SFO
1 stop15h 17m
JetBlue
sáb. 2/711:50 am
SFO
-
STI
1 stop10h 57m
JetBlue
Deal found 1/24$609
This JetBlue deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/24:15 am
STI
-
SFO
1 stop12h 45m
JetBlue
mar. 7/146:55 am
SFO
-
STI
1 stop17h 15m
JetBlue
Deal found 1/26$623
This Flighttix deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/127:00 am
STI
-
SFO
1 stop15h 31m
JetBlue
jue. 3/197:01 am
SFO
-
STI
1 stop14h 20m
JetBlue
Deal found 1/26$626

Find flight deals from Santiago de los Caballeros to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santiago de los Caballeros (STI) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$454
(Trip.com)

Popular in

February

Cheapest in

September

Average price

$771
Provider with most accurate pricing for Santiago de los Caballeros-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago de los Caballeros-San Francisco flights.
Search Deals
From Santiago de los Caballeros to San Francisco
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($125 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago de los Caballeros to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 26, 2026.
Use the filters below to find and compare flights from Santiago de los Caballeros to San Francisco that are best for you.

Fly from

Santiago de los Caballeros

Fly to

San Francisco

Route

Depart

Return

Price

Santiago de los CaballerosSan Francisco

STI - SFO

STISFO

Santiago de los Caballeros

mié. 3/11

6:00 am-8:49 pm

1 stop17h 49m

San Francisco

mié. 3/18

7:01 am-9:00 pm

1 stop10h 59m

$454

Santiago de los CaballerosSan Francisco

STI - SFO

STISFO

Santiago de los Caballeros

jue. 3/26

7:05 am-7:29 pm

1 stop15h 24m

San Francisco

mié. 4/1

3:20 pm-8:33 am

1 stop14h 13m

$552

Santiago de los CaballerosSan Francisco

STI - SFO

STISFO

Santiago de los Caballeros

mar. 5/12

3:34 am-1:00 pm

1 stop12h 26m

San Francisco

mié. 5/20

11:40 am-2:07 am

1 stop11h 27m

$582

Santiago de los CaballerosSan Francisco

STI - SFO

STISFO

Santiago de los Caballeros

jue. 7/2

4:15 am-2:00 pm

1 stop12h 45m

San Francisco

mar. 7/14

6:55 am-3:10 am

1 stop17h 15m

$623

Santiago de los CaballerosSan Francisco

STI - SFO

STISFO

Santiago de los Caballeros

mié. 3/25

3:10 am-5:54 pm

1 stop17h 44m

San Francisco

jue. 4/2

6:55 am-3:06 am

1 stop17h 11m

$689

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

  • Most accurate provider: When it comes to deals on Santiago de los Caballeros-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago de los Caballeros-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago de los Caballeros-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago de los Caballeros-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago de los Caballeros-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago de los Caballeros to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago de los Caballeros with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago de los Caballeros to San Francisco

What is the cheapest month to book a flight from Santiago de los Caballeros to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Santiago de los Caballeros to San Francisco (average of $225). Flying from Santiago de los Caballeros to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santiago de los Caballeros to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago de los Caballeros to San Francisco?

    A quick flight from Santiago de los Caballeros to San Francisco can take about 17h 49m. JetBlue provides one of the quickest options available for as low as $454. The distance from Santiago de los Caballeros to San Francisco is about 3336 mi.

  • Can I find deals for flights from Santiago de los Caballeros to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santiago de los Caballeros to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago de los Caballeros to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago de los Caballeros to San Francisco.

  • Can I find deals for business class flights from Santiago de los Caballeros to San Francisco?

    Yes. Cheapflights offers flight deals from Santiago de los Caballeros to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago de los Caballeros to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Santiago de los Caballeros to San Francisco (average of $225). Flying from Santiago de los Caballeros to San Francisco in August is currently the most expensive (average of $714). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

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