What are the cheapest airlines to fly from San Francisco to Santiago de los Caballeros one-way?

$236 is the cheapest one-way deal found within the past few days, from JetBlue. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $356 and $466, respectively.

What is the cheapest day to fly from San Francisco to Santiago de los Caballeros?

Travelers seeking maximum savings on their San Francisco to Santiago de los Caballeros flight should consider departing on Monday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

What are the most popular airlines that fly from San Francisco to Santiago de los Caballeros?

When booking a flight from San Francisco to Santiago de los Caballeros, you may want to consider flying on American Airlines, JetBlue or Delta as they are the most popular for this route.

What is the cheapest day to fly round-trip from San Francisco to Santiago de los Caballeros?

Leaving on a Sunday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 77% on the overall cost on flights from San Francisco to Santiago de los Caballeros.

What is the cheapest month to fly from San Francisco to Santiago de los Caballeros?

January can be a great time to fly to Santiago de los Caballeros from San Francisco with a flight ticket averaging about $811. Cheapflights users have found deals in the month of January for as cheap as $480. The most expensive prices can be found in the month of February.

How can I find direct flights from San Francisco to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago de los Caballeros.

Can I find deals for business class flights from San Francisco to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from San Francisco to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$236+ Flights from San Francisco to Santiago de los Caballeros

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from San Francisco to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Francisco to Santiago de los Caballeros

Round-trip from	$495 (JetBlue)
One-way from	$236 (JetBlue)
Popular in	February
Cheapest in	January
Average price	$910

From San Francisco to Santiago de los Caballeros

Search Deals

One-way flight from San Francisco to Santiago de los Caballeros

Search Deals

High demand for flights, 1% potential price rise

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($37 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Find flight deals from San Francisco to Santiago de los Caballeros

Cheapest flights from San Francisco to Santiago de los Caballeros
Explore the most affordable flight options available from San Francisco to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Tue 9/1610:30 pmSFO - STI

1 stop12h 43mJetBlue

Sat 9/2712:48 pmSTI - SFO

1 stop15h 11mJetBlue

Deal found 6/30

$495

Tue 9/1612:30 pmSFO - STI

2 stops20h 57mAmerican Airlines

Fri 9/261:29 pmSTI - SFO

1 stop12h 24mAmerican Airlines

Deal found 6/30

$619

Tue 11/117:00 amSFO - STI

1 stop14h 26mDelta

Sat 11/226:45 amSTI - SFO

1 stop18h 19mDelta

Deal found 7/1

$635

Tue 9/167:10 amSFO - STI

3 stops24h 54mMultiple Airlines

Sat 9/2712:10 pmSTI - SFO

3 stops31h 29mMultiple Airlines

Deal found 6/30

$697

Best flights from San Francisco to Santiago de los Caballeros
Discover carefully curated flight deals from San Francisco to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Tue 9/1610:30 pmSFO - STI

1 stop12h 43mJetBlue

Sat 9/2712:48 pmSTI - SFO

1 stop15h 11mJetBlue

Deal found 6/30

$495

Tue 9/1612:30 pmSFO - STI

2 stops20h 57mAmerican Airlines

Fri 9/261:29 pmSTI - SFO

1 stop12h 24mAmerican Airlines

Deal found 6/30

$619

Thu 9/114:10 pmSFO - STI

1 stop17h 30mDelta

Sun 9/218:40 pmSTI - SFO

1 stop21h 15mDelta

Deal found 7/1

$655

Tue 9/167:10 amSFO - STI

3 stops24h 54mMultiple Airlines

Sat 9/2712:10 pmSTI - SFO

3 stops31h 29mMultiple Airlines

Deal found 6/30

$697

Last-minute flights from San Francisco to Santiago de los Caballeros
Discover last-minute flight deals from San Francisco to Santiago de los Caballeros. Data last updated July 1, 2025 and is based on user searches.

Fri 7/116:00 amSFO - STI

1 stop10h 34mJetBlue

Wed 7/231:13 pmSTI - SFO

1 stop13h 31mJetBlue

Deal found 6/30

$836

Fri 7/118:00 amSFO - STI

1 stop10h 19mAmerican Airlines

Wed 7/237:04 amSTI - SFO

2 stops16h 22mAmerican Airlines

Deal found 6/30

$859

Fri 7/1111:59 pmSFO - STI

3 stops30h 51mMultiple Airlines

Wed 7/2310:55 amSTI - SFO

3 stops24h 10mMultiple Airlines

Deal found 6/30

$934

Sat 7/127:40 amSFO - STI

1 stop16h 18mJetBlue

Mon 7/2110:38 pmSTI - SFO

1 stop14h 07mJetBlue

Deal found 6/30

$725

Sun 7/2011:59 pmSFO - STI

3 stops30h 51mMultiple Airlines

Wed 7/3010:55 amSTI - SFO

3 stops24h 10mMultiple Airlines

Deal found 6/29

$801

Mon 7/287:29 pmSFO - STI

2 stops14h 14mDelta

Mon 8/48:58 pmSTI - SFO

2 stops18h 14mDelta

Deal found 6/30

$879

Sun 8/38:00 amSFO - STI

1 stop10h 19mAmerican Airlines

Mon 8/187:00 amSTI - SFO

2 stops12h 43mAmerican Airlines

Deal found 6/29

$693

One-way flights from San Francisco to Santiago de los Caballeros
Search for one-way flight options from San Francisco to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Tue 8/56:00 amSFO - STI

1 stop15h 52mJetBlue

Deal found 6/29

$236

Wed 8/68:53 pmSFO - STI

2 stops33h 57mMultiple Airlines

Deal found 6/29

$254

Tue 7/2911:59 pmSFO - STI

2 stops21h 48mDelta

Deal found 6/29

$356

Fri 8/112:55 amSFO - STI

2 stops17h 24mAmerican Airlines

Deal found 6/29

$466

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 9/16

8:40 pm-11:33 am

1 stop11h 53m

Santiago de los Caballeros

Fri 9/26

9:55 am-12:59 am

1 stop18h 04m

$495

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 9/16

12:30 pm-12:27 pm

2 stops20h 57m

Santiago de los Caballeros

Fri 9/26

1:29 pm-10:53 pm

1 stop12h 24m

$619

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Thu 9/11

4:10 pm-12:40 pm

1 stop17h 30m

Santiago de los Caballeros

Sun 9/21

8:40 pm-2:55 pm

1 stop21h 15m

$655

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 9/16

7:10 am-11:04 am

3 stops24h 54m

Santiago de los Caballeros

Sat 9/27

12:10 pm-4:39 pm

3 stops31h 29m

$697

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 8/5

6:00 am-12:52 am

1 stop15h 52m

$236

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Wed 8/6

8:53 pm-9:50 am

2 stops33h 57m

$254

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Tue 7/29

11:59 pm-12:47 am

2 stops21h 48m

$356

San FranciscoSantiago de los Caballeros

SFO - STI

SFOSTI

San Francisco

Fri 8/1

12:55 am-9:19 pm

2 stops17h 24m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Best time to book a flight from San Francisco to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago de los Caballeros

What is the cheapest month to book a flight from San Francisco to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from San Francisco to Santiago de los Caballeros (average of $347). Flying from San Francisco to Santiago de los Caballeros in July is currently the most expensive (average of $629). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to STI?

It’s typically best to fly out from San Francisco to Santiago de los Caballeros in the afternoon. Doing so could potentially save you 33% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta, JetBlue, and American Airlines from San Francisco to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,974 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

JetBlue

7.3

Good

2,919 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,974 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What are the cheapest airlines flying from San Francisco to Santiago de los Caballeros round-trip?
JetBlue, at $495, was found to be the cheapest airline from San Francisco to Santiago de los Caballeros.Alternate airlines to your destination round-trip include American Airlines and Delta. These flights start at 38% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from San Francisco to Santiago de los Caballeros one-way?
$236 is the cheapest one-way deal found within the past few days, from JetBlue. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $356 and $466, respectively.
Can I find deals for flights from San Francisco to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on San Francisco to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago de los Caballeros.
Can I find deals for business class flights from San Francisco to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from San Francisco to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from San Francisco to Santiago de los Caballeros (average of $347). Flying from San Francisco to Santiago de los Caballeros in July is currently the most expensive (average of $629). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from San Francisco to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	Cheapest$463	Average$604	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$543	Average$643	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$624	Average$828	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$236+ Cheap flights from San Francisco (SFO) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from San Francisco to Santiago de los Caballeros

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Santiago de los Caballeros

Cheapest flights from San Francisco to Santiago de los CaballerosExplore the most affordable flight options available from San Francisco to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from San Francisco to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago de los Caballeros that are best for you.

Best time to book a flight from San Francisco to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago de los Caballeros

What is the cheapest month to book a flight from San Francisco to Santiago de los Caballeros?

What is the cheapest time of day to fly from SFO to STI?

Find hourly flight availability from San Francisco to Santiago de los Caballeros. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta, JetBlue, and American Airlines from San Francisco to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Francisco to Santiago de los Caballeros round-trip?

What are the cheapest airlines to fly from San Francisco to Santiago de los Caballeros one-way?

Can I find deals for flights from San Francisco to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from San Francisco to Santiago de los Caballeros?

Can I find deals for business class flights from San Francisco to Santiago de los Caballeros?

What is the cheapest month to book a flight from San Francisco to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Francisco to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from San Francisco to Santiago de los Caballeros

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from San Francisco to Santiago de los Caballeros
Explore the most affordable flight options available from San Francisco to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.