How popular is this Key Largo to San Francisco flight route?

The Key Largo to San Francisco flight path was viewed by 75 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Key Largo to San Francisco?

Departing from Key Largo to San Francisco will take you 6h 34m. The distance from Key Largo to San Francisco is about 2579 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines to fly from Key Largo to San Francisco one-way?

The cheapest airlines for a one-way flight from Key Largo to San Francisco are Southwest ($119), United Airlines ($124), and Delta ($129).

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the cheapest flights from Key Largo to San Francisco?

Looking for the cheapest flight from Key Largo to San Francisco? While on average our users pay $831, our data indicates the cheapest price to be $115. The most popular route (Miami - San Francisco), is priced around $157.

What are the most reliable airlines from Key Largo to San Francisco?

No one likes to see their flight delayed. When booking a flight from Key Largo to San Francisco consider choosing GOL (89%), Japan Airlines (86%) or Fiji Airways (85%) as they are the most reliable in getting you off to your destination on time.

What are the most popular airlines that fly from Key Largo to San Francisco?

Consider American Airlines, United Airlines or Frontier when booking your flight. These represent the most popular airlines when flying from Key Largo to San Francisco.

What airport do you fly into for flights to San Francisco from Key Largo?

San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Key Largo to San Francisco. 7 airlines have flights to San Francisco from Key Largo on a regular basis. Booking flights from Key Largo to San Francisco should not be difficult; the airport handles an average of 19 inbound flights from Key Largo per day.

Can I find deals for flights from Key Largo to San Francisco that include hotel bookings?

Yes. In addition to deals on Key Largo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key Largo to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Francisco.

Can I find deals for business class flights from Key Largo to San Francisco?

Yes. Cheapflights offers flight deals from Key Largo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$118+ Cheap Flights from Key Largo to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Key Largo to San Francisco are usually found in January or November, booked 15 days in advance, depart on a Tuesday or Friday and return on a Monday

Cheap flight deals from Key Largo to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$232 (Kiwi.com)
One-way from	$118 (Trip.com)
Popular in	June
Cheapest in	January
Average price	$332

Provider with most accurate pricing for Miami-San Francisco flight deals.

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From Key Largo to San Francisco

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One-way flight from Key Largo to San Francisco

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Highest demand for flights based on searches. 4% potential increase in price ($13 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

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Average for round-trip flights in October 2025

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Find flight deals from Key Largo to San Francisco

Cheapest flights from Key Largo to San Francisco
Explore the most affordable flight options available from Key Largo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

Sat 12/611:35 amMIA - SFO

2 stops47h 18mMultiple Airlines

Sat 12/136:30 amSFO - MIA

1 stop19h 49mMultiple Airlines

Deal found 10/22

$232

Mon 11/248:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Fri 11/287:00 amSFO - MIA

Nonstop5h 36mUnited Airlines

Deal found 10/21

$233

Mon 11/248:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Sat 12/610:45 pmSFO - MIA

1 stop9h 51mUnited Airlines

Deal found 10/22

$234

Sat 11/86:00 amMIA - SFO

2 stops20h 47mFrontier

Mon 11/1010:23 pmSFO - MIA

1 stop12h 05mFrontier

Deal found 10/22

$235

Wed 11/56:00 pmMIA - SFO

Nonstop6h 32mUnited Airlines

Sun 11/95:10 amSFO - MIA

1 stop10h 07mUnited Airlines

Deal found 10/21

$237

Thu 12/117:26 pmMIA - SFO

2 stops25h 09mFrontier

Sat 12/1311:33 pmSFO - MIA

1 stop8h 15mFrontier

Deal found 10/22

$239

Wed 12/35:58 pmMIA - SFO

1 stop22h 20mFrontier

Sat 12/611:33 pmSFO - MIA

1 stop8h 15mFrontier

Deal found 10/21

$241

Sat 12/67:44 amMIA - SFO

Nonstop6h 22mAmerican Airlines

Tue 12/91:17 pmSFO - MIA

Nonstop5h 33mAmerican Airlines

Deal found 10/21

$242

Wed 11/196:00 pmMIA - SFO

Nonstop6h 32mUnited Airlines

Wed 11/265:10 amSFO - MIA

1 stop10h 07mUnited Airlines

Deal found 10/23

$243

Wed 11/191:45 pmMIA - SFO

1 stop7h 50mSouthwest

Wed 11/265:15 amSFO - MIA

1 stop10h 50mSouthwest

Deal found 10/23

$244

Thu 11/208:36 amMIA - SFO

1 stop18h 48mFrontier

Tue 11/256:32 amSFO - MIA

1 stop19h 38mFrontier

Deal found 10/21

$245

Best flights from Key Largo to San Francisco
Discover carefully curated flight deals from Key Largo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2025.

Thu 11/277:10 amMIA - SFO

1 stop9h 30mSouthwest

Wed 12/35:50 amSFO - MIA

1 stop7h 10mSouthwest

Deal found 10/21

$244

Fri 11/148:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Sun 11/1612:43 amSFO - MIA

1 stop7h 10mUnited Airlines

Deal found 10/20

$247

Sat 11/157:00 amMIA - SFO

1 stop10h 43mDelta

Tue 11/1810:30 pmSFO - MIA

1 stop9h 51mDelta

Deal found 10/22

$257

Tue 11/1111:55 amMIA - SFO

1 stop8h 52mUnited Airlines

Sat 11/155:15 amSFO - MIA

1 stop7h 29mUnited Airlines

Deal found 10/22

$247

Wed 11/56:00 amMIA - SFO

1 stop8h 45mDelta

Sat 11/81:45 pmSFO - MIA

1 stop7h 44mDelta

Deal found 10/23

$257

Wed 12/248:42 amMIA - SFO

Nonstop6h 38mUnited Airlines

Sun 12/2811:05 pmSFO - MIA

1 stop8h 25mUnited Airlines

Deal found 10/22

$248

Sat 12/67:00 amMIA - SFO

1 stop10h 47mDelta

Mon 12/812:30 amSFO - MIA

1 stop10h 02mDelta

Deal found 10/21

$257

Thu 11/132:10 pmMIA - SFO

1 stop9h 46mDelta

Sat 11/1512:30 amSFO - MIA

1 stop10h 02mDelta

Deal found 10/21

$262

Fri 11/1412:36 pmMIA - SFO

1 stop11h 20mDelta

Sat 11/1512:30 amSFO - MIA

1 stop10h 02mDelta

Deal found 10/23

$267

Wed 1/77:00 amMIA - SFO

1 stop8h 55mDelta

Fri 1/96:00 amSFO - MIA

1 stop8h 14mDelta

Deal found 10/22

$268

Last-minute flights from Key Largo to San Francisco
Discover last-minute flight deals from Key Largo to San Francisco. Data last updated October 23, 2025 and is based on user searches.

Wed 11/56:00 pmMIA - SFO

Nonstop6h 32mUnited Airlines

Sun 11/95:10 amSFO - MIA

1 stop10h 07mUnited Airlines

Deal found 10/21

$237

Thu 11/612:17 pmMIA - SFO

2 stops14h 54mMultiple Airlines

Mon 11/1010:23 pmSFO - MIA

1 stop12h 05mMultiple Airlines

Deal found 10/21

$251

Fri 11/78:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Mon 11/1012:43 amSFO - MIA

1 stop7h 10mUnited Airlines

Deal found 10/21

$247

Sat 11/86:00 amMIA - SFO

2 stops20h 47mFrontier

Mon 11/1010:23 pmSFO - MIA

1 stop12h 05mFrontier

Deal found 10/22

$235

Fri 11/147:07 pmMIA - SFO

2 stops24h 36mFrontier

Sun 11/1610:23 pmSFO - MIA

1 stop8h 48mFrontier

Deal found 10/22

$246

Sat 11/157:44 amMIA - SFO

Nonstop6h 23mAmerican Airlines

Tue 11/181:15 pmSFO - MIA

Nonstop5h 30mAmerican Airlines

Deal found 10/22

$248

Wed 11/196:00 pmMIA - SFO

Nonstop6h 32mUnited Airlines

Wed 11/265:10 amSFO - MIA

1 stop10h 07mUnited Airlines

Deal found 10/23

$243

Wed 11/191:45 pmMIA - SFO

1 stop7h 50mSouthwest

Wed 11/265:15 amSFO - MIA

1 stop10h 50mSouthwest

Deal found 10/23

$244

Thu 11/208:36 amMIA - SFO

1 stop18h 48mFrontier

Tue 11/256:32 amSFO - MIA

1 stop19h 38mFrontier

Deal found 10/21

$245

Mon 11/248:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Fri 11/287:00 amSFO - MIA

Nonstop5h 36mUnited Airlines

Deal found 10/21

$233

Mon 11/248:45 amMIA - SFO

Nonstop6h 34mUnited Airlines

Sat 12/610:45 pmSFO - MIA

1 stop9h 51mUnited Airlines

Deal found 10/22

$234

One-way flights from Key Largo to San Francisco
Search for one-way flight options from Key Largo to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 23, 2025.

Wed 11/510:15 pmMIA - SFO

2 stops17h 45mFrontier

Deal found 10/20

$118

Fri 10/319:35 amMIA - SFO

1 stop7h 45mSouthwest

Deal found 10/22

$119

Tue 11/257:12 amMIA - SFO

1 stop10h 05mFrontier

Deal found 10/22

$120

Wed 11/1912:17 pmMIA - SFO

2 stops30h 46mMultiple Airlines

Deal found 10/23

$121

Sat 11/227:24 pmMIA - SFO

2 stops38h 47mFrontier

Deal found 10/23

$122

Mon 11/310:15 pmMIA - SFO

2 stops26h 07mFrontier

Deal found 10/21

$123

Sat 1/249:05 amMIA - SFO

1 stop10h 45mUnited Airlines

Deal found 10/23

$124

Sun 12/215:30 amMIA - SFO

2 stops18h 00mFrontier

Deal found 10/23

$125

Sat 11/225:35 pmMIA - SFO

1 stop9h 55mSouthwest

Deal found 10/21

$126

Sun 12/145:30 amMIA - SFO

1 stop10h 48mFrontier

Deal found 10/23

$127

Fri 1/232:00 pmMIA - SFO

1 stop11h 20mSouthwest

Deal found 10/23

$128

Tue 11/1811:27 amMIA - SFO

1 stop10h 02mDelta

Deal found 10/23

$129

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key Largo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 11/27

7:10 am-1:40 pm

1 stop9h 30m

San Francisco

Wed 12/3

5:50 am-4:00 pm

1 stop7h 10m

$244

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 11/14

8:45 am-12:19 pm

Nonstop6h 34m

San Francisco

Sun 11/16

12:43 am-10:53 am

1 stop7h 10m

$247

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 11/11

11:55 am-5:47 pm

1 stop8h 52m

San Francisco

Sat 11/15

5:15 am-3:44 pm

1 stop7h 29m

$247

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 12/24

8:42 am-12:20 pm

Nonstop6h 38m

San Francisco

Sun 12/28

11:05 pm-10:30 am

1 stop8h 25m

$248

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 11/15

7:00 am-2:43 pm

1 stop10h 43m

San Francisco

Tue 11/18

10:30 pm-11:21 am

1 stop9h 51m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 11/5

6:00 am-11:45 am

1 stop8h 45m

San Francisco

Sat 11/8

1:45 pm-12:29 am

1 stop7h 44m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 12/6

7:00 am-2:47 pm

1 stop10h 47m

San Francisco

Mon 12/8

12:30 am-1:32 pm

1 stop10h 02m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 11/13

2:10 pm-8:56 pm

1 stop9h 46m

San Francisco

Sat 11/15

12:30 am-1:32 pm

1 stop10h 02m

$262

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 11/14

12:36 pm-8:56 pm

1 stop11h 20m

San Francisco

Sat 11/15

12:30 am-1:32 pm

1 stop10h 02m

$267

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 1/7

7:00 am-12:55 pm

1 stop8h 55m

San Francisco

Fri 1/9

6:00 am-5:14 pm

1 stop8h 14m

$268

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/21

Showing 1-10 of 22 results

Best time to book a flight from Key Largo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key Largo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Francisco

How far ahead should I book a flight from Key Largo to San Francisco?

The price you pay for your flight from Key Largo to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 15 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Key Largo to San Francisco?

Currently, June is the cheapest month in which you can book a flight from Key Largo to San Francisco (average of $89). Flying from Key Largo to San Francisco in August is currently the most expensive (average of $201). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SFO?

One of the essential ways to save on airfare from Key Largo to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 62% on airfare.

What is the cheapest day to fly from Key Largo to San Francisco?

Travelers seeking maximum savings on their Key Largo to San Francisco flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Francisco

The most flights from KE9 to SFO are scheduled on a Tuesday (22 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (10 on average).

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Key Largo to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

7.9

Good

7,981 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,991 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

11,028 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

JetBlue

7.2

Good

2,908 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Frontier

5.8

Fair

3,128 reviews

Delta

7.9

Good

7,981 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What airport do you fly into for flights to San Francisco from Key Largo?
San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Key Largo to San Francisco. 7 airlines have flights to San Francisco from Key Largo on a regular basis. Booking flights from Key Largo to San Francisco should not be difficult; the airport handles an average of 19 inbound flights from Key Largo per day.
How popular is this Key Largo to San Francisco flight route?
The Key Largo to San Francisco flight path was viewed by 75 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Key Largo to San Francisco?
Departing from Key Largo to San Francisco will take you 6h 34m. The distance from Key Largo to San Francisco is about 2579 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines to fly from Key Largo to San Francisco one-way?
The cheapest airlines for a one-way flight from Key Largo to San Francisco are Southwest ($119), United Airlines ($124), and Delta ($129).
What are the most reliable airlines from Key Largo to San Francisco?
No one likes to see their flight delayed. When booking a flight from Key Largo to San Francisco consider choosing GOL (89%), Japan Airlines (86%) or Fiji Airways (85%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Key Largo to San Francisco?
Looking for the cheapest flight from Key Largo to San Francisco? While on average our users pay $831, our data indicates the cheapest price to be $115. The most popular route (Miami - San Francisco), is priced around $157.
Can I find deals for flights from Key Largo to San Francisco that include hotel bookings?
Yes. In addition to deals on Key Largo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key Largo to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Francisco.
Can I find deals for business class flights from Key Largo to San Francisco?
Yes. Cheapflights offers flight deals from Key Largo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Key Largo to San Francisco?
Currently, June is the cheapest month in which you can book a flight from Key Largo to San Francisco (average of $89). Flying from Key Largo to San Francisco in August is currently the most expensive (average of $201). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Vacaville

Vallejo

Hollister

Foster City

Union City

Fairfield

Burlingame

Redwood City

Lodi

San Mateo

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from Key Largo to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$116	Average$179	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$128	Average$271	FlexibilityNo cancel fee	On-timeN/A
JetBlue	Cheapest$178	Average$299	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$181	Average$340	FlexibilityNo cancel fee	On-time69%
Alaska Airlines	Cheapest$188	Average$310	FlexibilityNo cancel fee	On-time75%
American Airlines	Cheapest$198	Average$365	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$250	Average$323	FlexibilityNo cancel fee	On-time63%

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$118+ Cheap flights from Key Largo, FL to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key Largo to San Francisco with Cheapflights

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3. Compare prices and book

Cheapflights Tip: The best prices from Key Largo to San Francisco are usually found in January or November, booked 15 days in advance, depart on a Tuesday or Friday and return on a Monday

Cheap flight deals from Key Largo to San Francisco

Keep the following information in mind while searching for Key Largo to San Francisco flight deals. Data was last updated October 23, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Key Largo to San Francisco

Cheapest flights from Key Largo to San FranciscoExplore the most affordable flight options available from Key Largo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

Explore the most affordable flight options available from Key Largo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key Largo to San Francisco that are best for you.

Best time to book a flight from Key Largo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key Largo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Francisco

How far ahead should I book a flight from Key Largo to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Francisco. Price data was last updated on October 17, 2025.

What is the cheapest month to book a flight from Key Largo to San Francisco?

What is the cheapest time of day to fly from KE9 to SFO?

Find hourly flight availability from Key Largo to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

What is the cheapest day to fly from Key Largo to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Francisco. Price data was last updated on December 16, 2024.

Weekly flight availability from Key Largo to San Francisco

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Key Largo to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to San Francisco from Key Largo?

How popular is this Key Largo to San Francisco flight route?

How long is the flight from Key Largo to San Francisco?

What are the cheapest airlines to fly from Key Largo to San Francisco one-way?

What are the most reliable airlines from Key Largo to San Francisco?

What are the cheapest flights from Key Largo to San Francisco?

Can I find deals for flights from Key Largo to San Francisco that include hotel bookings?

How can I find direct flights from Key Largo to San Francisco?

Can I find deals for business class flights from Key Largo to San Francisco?

What is the cheapest month to book a flight from Key Largo to San Francisco?

Traveling to a place near San Francisco?

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Alternative routes for Key Largo to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Key Largo to San Francisco

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Cheapest flights from Key Largo to San Francisco
Explore the most affordable flight options available from Key Largo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.