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San Francisco Bay Area

$130+ Cheap flights from Knoxville (TYS) to San Francisco Bay Area

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Dec 4 — Dec 111
Thu 12/4
Thu 12/11
1 adult, Economy
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Cheap flight deals from Knoxville to San Francisco Bay Area

Keep the following information in mind while searching for Knoxville to San Francisco Bay Area flight deals. Data was last updated November 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$130
(Frontier)

Popular in

March

Cheapest in

January

Average price

$504
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
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From Knoxville McGhee Tyson to San Francisco Bay Area
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Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Knoxville to San Francisco Bay Area

Cheapest flights from Knoxville to San Francisco Bay Area
Explore the most affordable flight options available from Knoxville to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2025.

This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - SFO
1 stop10h 32mFrontier
Mon 12/156:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$130
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - SFO
1 stop10h 32mFrontier
Sun 12/146:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$134
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - SFO
1 stop10h 32mFrontier
Mon 12/156:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$206
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - SFO
1 stop10h 32mFrontier
Sun 12/146:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$210
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:52 pmTYS - SFO
1 stop10h 32mFrontier
Mon 12/156:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$216
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:52 pmTYS - SFO
1 stop10h 32mFrontier
Sun 12/146:30 amSFO - TYS
1 stop6h 27mFrontier
Deal found 11/4$220
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:52 pmTYS - SFO
1 stop18h 01mMultiple Airlines
Sat 12/136:30 amSFO - TYS
1 stop27h 41mMultiple Airlines
Deal found 11/4$246
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/84:52 pmTYS - SFO
1 stop10h 32mFrontier
Thu 12/186:24 amSFO - TYS
1 stop6h 07mFrontier
Deal found 11/4$266
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:53 pmTYS - SFO
2 stops35h 18mMultiple Airlines
Wed 12/106:30 amSFO - TYS
1 stop27h 41mMultiple Airlines
Deal found 11/3$291
This Trip.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:17 pmTYS - SFO
1 stop22h 23mFrontier
Thu 11/202:54 pmSFO - TYS
1 stop21h 59mFrontier
Deal found 11/1$299
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/52:37 pmTYS - SFO
1 stop9h 22mDelta
Mon 12/1512:37 pmSFO - TYS
1 stop7h 51mDelta
Deal found 11/4$329
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:30 amTYS - SJC
2 stops35h 02mMultiple Airlines
Thu 12/183:27 pmSJC - TYS
1 stop22h 35mMultiple Airlines
Deal found 11/4$335

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco Bay Area that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco Bay Area that are best for you.

Fly from

Knoxville

Fly to

San Francisco Bay Area

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-9:11 pm

2 stops35h 18m

San Francisco

Wed 12/10

6:30 am-1:11 pm

1 stop27h 41m

$291

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 11/13

7:17 pm-2:40 pm

1 stop22h 23m

San Francisco

Thu 11/20

2:54 pm-3:53 pm

1 stop21h 59m

$299

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 12/6

3:50 pm-9:16 pm

1 stop8h 26m

San Francisco

Sat 12/13

8:15 am-8:10 pm

1 stop8h 55m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 12/7

7:59 pm-12:20 am

1 stop7h 21m

San Francisco

Tue 12/16

10:45 pm-11:47 am

1 stop10h 02m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sat 12/6

1:27 pm-6:16 pm

1 stop7h 49m

San Francisco

Sun 12/14

2:00 pm-11:28 pm

1 stop6h 28m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 12/11

12:50 pm-5:58 pm

1 stop8h 08m

San Francisco

Tue 12/16

10:30 pm-9:38 am

1 stop8h 08m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 12/8

5:40 am-10:30 am

1 stop7h 50m

San Francisco

Sat 12/13

6:00 am-4:49 pm

1 stop7h 49m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 12/5

3:57 pm-8:59 pm

1 stop8h 02m

San Francisco

Sun 12/14

10:30 pm-9:38 am

1 stop8h 08m

$329

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 11/13

7:17 pm-2:40 pm

1 stop22h 23m

San Francisco

Wed 11/19

8:55 pm-10:37 pm

1 stop22h 42m

$347

KnoxvilleSan Jose

TYS - SJC

TYSSJC

Knoxville McGhee Tyson

Wed 12/10

3:57 pm-8:41 pm

1 stop7h 44m

San Jose

Sat 12/13

6:20 am-7:03 pm

1 stop9h 43m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 51 results
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Best time to book a flight from Knoxville to San Francisco Bay Area

Have a flexible travel schedule? Discover the best time to fly to San Francisco Bay Area from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco Bay Area

What is the cheapest month to book a flight from Knoxville to San Francisco Bay Area?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco Bay Area (average of $168). Flying from Knoxville to San Francisco Bay Area in December is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to XIH?

Find hourly flight availability from Knoxville to San Francisco Bay Area. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2025.

When flying from Knoxville to San Francisco Bay Area, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 34% versus a flight in the morning.

What is the cheapest day to fly from Knoxville to San Francisco Bay Area?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco Bay Area. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco Bay Area flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco Bay Area

Get insights into the airlines that provide service to San Francisco Bay Area. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco Bay Area. Reviews last updated November 4, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to San Francisco Bay Area by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,003 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,003 reviews
Delta
7.9
Good
8,003 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,002 reviews
Delta
7.9
Good
8,003 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,040 reviews
Delta
7.9
Good
8,003 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,117 reviews
Delta
7.9
Good
8,003 reviews

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco Bay Area. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to San Francisco Bay Area?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to San Francisco Bay Area from Knoxville.

  • How long is the flight from Knoxville to San Francisco Bay Area?

    A quick flight from Knoxville to San Francisco Bay Area can take about 8h 26m. Frontier provides one of the quickest options available for as low as $329. There are 2114 mi between Knoxville and San Francisco Bay Area. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to San Francisco Bay Area?

    Most travelers choose Knoxville McGhee Tyson - San Francisco, Knoxville McGhee Tyson - San Jose or Knoxville McGhee Tyson - Oakland when deciding on the best route from Knoxville to San Francisco Bay Area.

  • Can I find deals for flights from Knoxville to San Francisco Bay Area that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco Bay Area flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco Bay Area?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco Bay Area.

  • Can I find deals for business class flights from Knoxville to San Francisco Bay Area?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco Bay Area by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco Bay Area?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco Bay Area (average of $168). Flying from Knoxville to San Francisco Bay Area in December is currently the most expensive (average of $339). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to San Francisco Bay Area

Discover the top 4 airlines that operate flights from Knoxville to San Francisco Bay Area. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$157Average$210FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$243Average$527FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$399FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$561FlexibilityNo cancel feeOn-time71%

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