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$116+ Cheap flights from Knoxville (TYS) to San Francisco Bay Area

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Feb 11 — Feb 181
Wed 2/11
Wed 2/18
1 adult, Economy
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Cheap flight deals from Knoxville to San Francisco Bay Area

Keep the following information in mind while searching for Knoxville to San Francisco Bay Area flight deals. Data was last updated January 12, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$171
(Frontier)

One-way from

$116
(Orbitz)

Popular in

December

Cheapest in

February

Average price

$403
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
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From Knoxville McGhee Tyson to San Francisco Bay Area
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One-way flight from Knoxville McGhee Tyson to San Francisco Bay Area
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Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Knoxville to San Francisco Bay Area

Cheapest flights from Knoxville to San Francisco Bay Area
Explore the most affordable flight options available from Knoxville to San Francisco Bay Area. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 12, 2026.

This Frontier deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:13 pm
TYS
-
SFO
1 stop28h 48m
Frontier
Mon 3/26:15 am
SFO
-
TYS
1 stop10h 03m
Frontier
Deal found 1/12$171
This Frontier deal was found by Cheapflights users on 1/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/24:30 pm
TYS
-
SFO
1 stop10h 58m
Frontier
Fri 2/66:15 am
SFO
-
TYS
1 stop6h 15m
Frontier
Deal found 1/9$190
This Expedia deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:13 pm
TYS
-
SFO
1 stop28h 48m
Frontier
Fri 2/206:15 am
SFO
-
TYS
1 stop10h 12m
Frontier
Deal found 1/10$245
This Kiwi.com deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:30 am
TYS
-
SFO
1 stop12h 28m
Multiple Airlines
Mon 3/28:48 am
SFO
-
TYS
1 stop7h 30m
Multiple Airlines
Deal found 1/10$296
This Kiwi.com deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:12 pm
TYS
-
SFO
1 stop14h 51m
Frontier
Mon 2/166:15 am
SFO
-
TYS
1 stop10h 03m
Frontier
Deal found 1/10$298
This Kiwi.com deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:00 am
TYS
-
SFO
1 stop11h 20m
Multiple Airlines
Sun 3/159:33 pm
SFO
-
TYS
1 stop22h 06m
Multiple Airlines
Deal found 1/10$315
This United Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/67:20 pm
TYS
-
SFO
1 stop9h 10m
United Airlines
Sat 2/75:00 am
SFO
-
TYS
1 stop7h 14m
United Airlines
Deal found 1/11$323
This Kiwi.com deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:12 pm
TYS
-
SFO
1 stop14h 51m
Multiple Airlines
Tue 2/176:55 am
SFO
-
TYS
2 stops29h 07m
Multiple Airlines
Deal found 1/11$327
This American Airlines deal was found by Cheapflights users on 1/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:50 am
TYS
-
SFO
1 stop8h 10m
American Airlines
Wed 3/46:00 am
SFO
-
TYS
1 stop6h 37m
American Airlines
Deal found 1/11$328
This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:40 am
TYS
-
SJC
1 stop10h 37m
American Airlines
Tue 3/36:00 am
SJC
-
TYS
1 stop6h 37m
American Airlines
Deal found 1/10$367
This deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:01 pm
TYS
-
SJC
1 stop7h 32m
Delta
Tue 3/311:18 pm
SJC
-
TYS
1 stop7h 33m
Delta
Deal found 1/10$385
This Delta deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:15 pm
TYS
-
OAK
2 stops8h 34m
Delta
Sat 7/115:05 pm
OAK
-
TYS
2 stops14h 05m
Delta
Deal found 1/10$394

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Francisco Bay Area that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco Bay Area that are best for you.

Fly from

Knoxville

Fly to

San Francisco Bay Area

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-10:01 pm

1 stop28h 48m

San Francisco

Mon 3/2

6:15 am-7:18 pm

1 stop10h 03m

$171

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 2/2

4:30 pm-12:28 am

1 stop10h 58m

San Francisco

Fri 2/6

6:15 am-3:30 pm

1 stop6h 15m

$190

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 2/16

8:13 pm-10:01 pm

1 stop28h 48m

San Francisco

Fri 2/20

6:15 am-7:27 pm

1 stop10h 12m

$245

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 2/26

8:30 am-5:58 pm

1 stop12h 28m

San Francisco

Mon 3/2

8:48 am-7:18 pm

1 stop7h 30m

$296

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/13

8:12 pm-8:03 am

1 stop14h 51m

San Francisco

Mon 2/16

6:15 am-7:18 pm

1 stop10h 03m

$298

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 3/4

10:00 am-6:20 pm

1 stop11h 20m

San Francisco

Sun 3/15

9:33 pm-10:39 pm

1 stop22h 06m

$315

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/6

7:20 pm-1:30 am

1 stop9h 10m

San Francisco

Sat 2/7

5:00 am-3:14 pm

1 stop7h 14m

$323

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 2/13

8:12 pm-8:03 am

1 stop14h 51m

San Francisco

Tue 2/17

6:55 am-3:02 pm

2 stops29h 07m

$327

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 2/25

8:50 am-2:00 pm

1 stop8h 10m

San Francisco

Wed 3/4

6:00 am-3:37 pm

1 stop6h 37m

$328

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 3/4

1:00 pm-6:36 pm

1 stop8h 36m

San Francisco

Fri 3/13

10:40 pm-10:31 am

1 stop8h 51m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/11

Showing 1-10 of 60 results
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Best time to book a flight from Knoxville to San Francisco Bay Area

Have a flexible travel schedule? Discover the best time to fly to San Francisco Bay Area from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco Bay Area

What is the cheapest month to book a flight from Knoxville to San Francisco Bay Area?

Currently, June is the cheapest month in which you can book a flight from Knoxville to San Francisco Bay Area (average of $194). Flying from Knoxville to San Francisco Bay Area in March is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco Bay Area

Get insights into the airlines that provide service to San Francisco Bay Area. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco Bay Area. Reviews last updated January 12, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to San Francisco Bay Area by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,033 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,033 reviews
Delta
7.9
Good
8,033 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,144 reviews
Delta
7.9
Good
8,033 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,111 reviews
Delta
7.9
Good
8,033 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.7
Fair
3,055 reviews
Delta
7.9
Good
8,033 reviews

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco Bay Area. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to San Francisco Bay Area?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to San Francisco Bay Area from Knoxville.

  • How long is the flight from Knoxville to San Francisco Bay Area?

    A quick flight from Knoxville to San Francisco Bay Area can take about 9h 38m. Frontier provides one of the quickest options available for as low as $385. There are 2092 mi between Knoxville and San Francisco Bay Area. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to San Francisco Bay Area one-way?

    $76 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on American Airlines and Frontier, with prices starting from $121 and $124, respectively.

  • What are the most popular routes from Knoxville to San Francisco Bay Area?

    Most travelers choose Knoxville McGhee Tyson - San Francisco, Knoxville McGhee Tyson - San Jose or Knoxville McGhee Tyson - Oakland when deciding on the best route from Knoxville to San Francisco Bay Area.

  • Can I find deals for flights from Knoxville to San Francisco Bay Area that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco Bay Area flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco Bay Area?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco Bay Area.

  • Can I find deals for business class flights from Knoxville to San Francisco Bay Area?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco Bay Area by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco Bay Area?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to San Francisco Bay Area (average of $194). Flying from Knoxville to San Francisco Bay Area in March is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to San Francisco Bay Area

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Top 4 airlines flying from Knoxville to San Francisco Bay Area

Discover the top 4 airlines that operate flights from Knoxville to San Francisco Bay Area. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$180Average$268FlexibilityNo cancel feeOn-time62%
DeltaCheapest$276Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$279Average$562FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$286Average$562FlexibilityNo cancel feeOn-time69%

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