$199+ Cheap flights from Panama City, FL to San Diego (ECP - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SAN
May 30 — Jun 61
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San DiegoExplore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from Panama City to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:16 pm
ECP
- SAN
1 stop7h 32m
American Airlines
Tue 6/96:15 am
SAN
- ECP
1 stop6h 17m
American Airlines
Deal found 4/25![American Airlines logo]()
$375
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:55 pm
ECP
- SAN
1 stop6h 15m
Southwest
Wed 6/107:45 am
SAN
- ECP
2 stops9h 55m
Southwest
Deal found 4/27![Southwest logo]()
$380
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:05 pm
ECP
- SAN
1 stop11h 15m
Southwest
Tue 6/97:45 am
SAN
- ECP
2 stops9h 55m
Southwest
Deal found 4/25![Southwest logo]()
$386
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
ECP
- SAN
1 stop7h 16m
Delta
Sat 6/61:50 pm
SAN
- ECP
1 stop7h 01m
Delta
Deal found 4/25![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:55 pm
ECP
- SAN
2 stops8h 55m
Southwest
Sat 7/46:20 am
SAN
- ECP
1 stop8h 40m
Southwest
Deal found 4/26![Southwest logo]()
$391
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:05 pm
ECP
- SAN
1 stop11h 15m
Southwest
Sat 6/611:40 am
SAN
- ECP
2 stops9h 15m
Southwest
Deal found 4/25![Southwest logo]()
$398
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:30 pm
ECP
- SAN
2 stops8h 40m
Southwest
Wed 5/2710:40 pm
SAN
- ECP
1 stop8h 25m
Southwest
Deal found 4/25![Southwest logo]()
$412
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 am
ECP
- SAN
1 stop6h 55m
Southwest
Sat 6/1310:25 am
SAN
- ECP
1 stop7h 55m
Southwest
Deal found 4/29![Southwest logo]()
$416
Best flights from Panama City to San DiegoDiscover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from Panama City to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:55 pm
ECP
- SAN
1 stop6h 15m
Southwest
Wed 6/107:45 am
SAN
- ECP
2 stops9h 55m
Southwest
Deal found 4/27![Southwest logo]()
$380
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:38 am
ECP
- SAN
2 stops10h 17m
United Airlines
Wed 9/28:00 am
SAN
- ECP
1 stop6h 23m
United Airlines
Deal found 4/29![United Airlines logo]()
$480
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:05 pm
ECP
- SAN
1 stop11h 15m
Southwest
Tue 6/97:45 am
SAN
- ECP
2 stops9h 55m
Southwest
Deal found 4/25![Southwest logo]()
$386
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:50 pm
ECP
- SAN
1 stop7h 50m
Southwest
Sun 6/2110:40 pm
SAN
- ECP
1 stop10h 10m
Southwest
Deal found 4/28![Southwest logo]()
$416
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:05 pm
ECP
- SAN
2 stops9h 20m
Southwest
Sat 6/611:30 am
SAN
- ECP
2 stops9h 25m
Southwest
Deal found 4/25![Southwest logo]()
$418
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:55 pm
ECP
- SAN
2 stops7h 30m
Southwest
Sat 6/66:30 am
SAN
- ECP
1 stop8h 55m
Southwest
Deal found 4/26![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:35 am
ECP
- SAN
1 stop9h 30m
Southwest
Sat 6/610:40 pm
SAN
- ECP
1 stop8h 50m
Southwest
Deal found 4/26![Southwest logo]()
$458
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:20 pm
ECP
- SAN
2 stops10h 05m
Southwest
Sun 10/256:40 am
SAN
- ECP
1 stop5h 50m
Southwest
Deal found 4/27![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:55 am
ECP
- SAN
2 stops8h 30m
Southwest
Sun 6/710:40 pm
SAN
- ECP
1 stop8h 55m
Southwest
Deal found 4/26![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:55 pm
ECP
- SAN
2 stops7h 30m
Southwest
Wed 6/1710:25 am
SAN
- ECP
2 stops9h 40m
Southwest
Deal found 4/29![Southwest logo]()
$477
Last-minute flights from Panama City to San DiegoDiscover last-minute flight deals from Panama City to San Diego. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Diego. Data last updated April 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:14 pm
ECP
- SAN
1 stop10h 25m
United Airlines
Mon 5/1112:10 pm
SAN
- ECP
1 stop7h 55m
United Airlines
Deal found 4/27![United Airlines logo]()
$832
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:25 pm
ECP
- SAN
1 stop7h 30m
Southwest
Fri 5/156:30 am
SAN
- ECP
1 stop7h 05m
Southwest
Deal found 4/26![Southwest logo]()
$577
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:05 pm
ECP
- SAN
1 stop6h 19m
United Airlines
Wed 5/2710:40 pm
SAN
- ECP
1 stop9h 04m
United Airlines
Deal found 4/25![United Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:30 pm
ECP
- SAN
2 stops8h 40m
Southwest
Wed 5/2710:40 pm
SAN
- ECP
1 stop8h 25m
Southwest
Deal found 4/25![Southwest logo]()
$412
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:00 am
ECP
- SAN
1 stop9h 47m
American Airlines
Sat 6/610:28 pm
SAN
- ECP
1 stop10h 00m
American Airlines
Deal found 4/25![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:00 pm
ECP
- SAN
1 stop8h 10m
Southwest
Sat 6/611:40 am
SAN
- ECP
2 stops9h 15m
Southwest
Deal found 4/25![Southwest logo]()
$423
One-way flights from Panama City to San DiegoSearch for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from Panama City to San Diego. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:56 pm
ECP
- SAN
1 stop7h 03m
American Airlines
Deal found 4/25![American Airlines logo]()
$199
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:29 pm
ECP
- SAN
1 stop7h 59m
Delta
Deal found 4/29![Delta logo]()
$200
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:10 am
ECP
- SAN
2 stops10h 25m
Southwest
Deal found 4/29![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:00 am
ECP
- SAN
1 stop7h 10m
Southwest
Deal found 4/29![Southwest logo]()
$229
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:35 am
ECP
- SAN
2 stops9h 15m
Southwest
Deal found 4/26![Southwest logo]()
$234
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2412:10 pm
ECP
- SAN
2 stops9h 25m
Southwest
Deal found 4/25![Southwest logo]()
$245
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:19 am
ECP
- SAN
1 stop9h 11m
Delta
Deal found 4/26![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/184:10 pm
ECP
- SAN
2 stops8h 55m
Southwest
Deal found 4/28![Southwest logo]()
$294
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:16 pm
ECP
- SAN
2 stops9h 43m
American Airlines
Deal found 4/29![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:00 am
ECP
- SAN
1 stop7h 14m
American Airlines
Deal found 4/29![American Airlines logo]()
$494
Find flight deals from Panama City to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (American Airlines) |
One-way from | $199 (American Airlines) |
Popular in | March |
Cheapest in | September |
Average price | $506 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Panama City to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 6/9
3:55 pm-8:10 pm
1 stop6h 15m
San Diego
Wed 6/10
7:45 am-7:40 pm
2 stops9h 55m
$380
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 6/2
12:05 pm-9:20 pm
1 stop11h 15m
San Diego
Tue 6/9
7:45 am-7:40 pm
2 stops9h 55m
$386
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 6/16
12:50 pm-6:40 pm
1 stop7h 50m
San Diego
Sun 6/21
10:40 pm-10:50 am
1 stop10h 10m
$416
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 6/2
12:05 pm-7:25 pm
2 stops9h 20m
San Diego
Sat 6/6
11:30 am-10:55 pm
2 stops9h 25m
$418
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Fri 6/5
5:55 pm-11:25 pm
2 stops7h 30m
San Diego
Sat 6/6
6:30 am-5:25 pm
1 stop8h 55m
$433
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Sat 6/6
11:35 am-7:05 pm
1 stop9h 30m
San Diego
Sat 6/6
10:40 pm-9:30 am
1 stop8h 50m
$458
Quickest round-trip
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Fri 10/16
2:20 pm-10:25 pm
2 stops10h 05m
San Diego
Sun 10/25
6:40 am-2:30 pm
1 stop5h 50m
$462
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Sat 6/6
10:55 am-5:25 pm
2 stops8h 30m
San Diego
Sun 6/7
10:40 pm-9:35 am
1 stop8h 55m
$462
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Mon 6/15
5:55 pm-11:25 pm
2 stops7h 30m
San Diego
Wed 6/17
10:25 am-10:05 pm
2 stops9h 40m
$477
Panama CitySan Diego
ECP - SAN
ECPSAN
Panama City NW Florida Beaches
Tue 9/1
11:38 am-7:55 pm
2 stops10h 17m
San Diego
Wed 9/2
8:00 am-4:23 pm
1 stop6h 23m
$480
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Panama City to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Diego in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Panama City with our price prediction graph.
ECP-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Diego
What is the cheapest month to book a flight from Panama City, Florida to San Diego?
Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to San Diego (average of $336). Flying from Panama City, Florida to San Diego in March is currently the most expensive (average of $575). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City, Florida to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 30, 2026.
Read through reviews of airlines operating flights from Panama City to San Diego, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Panama City
Popular flights
San Diego flight routes
Alternative routes for Panama City to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to San Diego by cabin class
Find flights from Panama City to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and San Diego flights
Browse other Panama City and San Diego flight options. Last updated on April 30, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
Top 4 airlines flying from Panama City to San Diego
Discover the top 4 airlines that operate flights from Panama City to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$256 | Average$500 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$260 | Average$376 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$260 | Average$482 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$326 | Average$487 | FlexibilityNo cancel fee | On-time71% |