$503+ Cheap flights from Des Moines (DSM) to Portugal
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LIS
Apr 10 — Apr 171
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Portugal with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to PortugalExplore the most affordable flight options available from Des Moines to Portugal. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
Explore the most affordable flight options available from Des Moines to Portugal. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
This Expedia deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Wed 4/298:20 am
OPO
- DSM
2 stops17h 13m
Iberia
Deal found 3/10![Iberia logo]()
$656
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:00 pm
DSM
- OPO
2 stops17h 45m
American Airlines
Tue 4/218:20 am
OPO
- DSM
2 stops21h 29m
American Airlines
Deal found 3/6![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:05 am
DSM
- OPO
2 stops18h 35m
American Airlines
Wed 4/298:20 am
OPO
- DSM
2 stops17h 13m
American Airlines
Deal found 3/8![American Airlines logo]()
$659
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:00 pm
DSM
- OPO
2 stops17h 45m
American Airlines
Tue 4/2812:25 pm
OPO
- DSM
2 stops29h 01m
American Airlines
Deal found 3/7![American Airlines logo]()
$660
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Tue 4/288:40 pm
OPO
- DSM
2 stops28h 53m
Iberia
Deal found 3/6![Iberia logo]()
$668
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:00 am
DSM
- OPO
2 stops28h 15m
United Airlines
Sat 12/512:30 pm
OPO
- DSM
2 stops16h 31m
United Airlines
Deal found 3/8![United Airlines logo]()
$689
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:16 pm
DSM
- OPO
2 stops15h 29m
Iberia
Mon 4/278:20 am
OPO
- DSM
2 stops17h 13m
Iberia
Deal found 3/6![Iberia logo]()
$707
Best flights from Des Moines to PortugalDiscover carefully curated flight deals from Des Moines to Portugal that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
Discover carefully curated flight deals from Des Moines to Portugal that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:05 am
DSM
- OPO
2 stops18h 35m
American Airlines
Tue 4/218:20 am
OPO
- DSM
2 stops21h 29m
American Airlines
Deal found 3/6![American Airlines logo]()
$658
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Tue 4/288:40 pm
OPO
- DSM
2 stops28h 53m
Iberia
Deal found 3/6![Iberia logo]()
$668
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:01 pm
DSM
- OPO
2 stops24h 09m
Delta
Sat 5/25:00 am
OPO
- DSM
2 stops18h 02m
Delta
Deal found 3/10![Delta logo]()
$814
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:13 pm
DSM
- OPO
2 stops15h 47m
American Airlines
Tue 4/2812:25 pm
OPO
- DSM
2 stops29h 01m
American Airlines
Deal found 3/7![American Airlines logo]()
$662
This Iberia deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:16 pm
DSM
- OPO
2 stops15h 29m
Iberia
Wed 4/298:20 am
OPO
- DSM
2 stops21h 29m
Iberia
Deal found 3/7![Iberia logo]()
$669
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:00 pm
DSM
- OPO
2 stops17h 45m
American Airlines
Thu 4/308:20 am
OPO
- DSM
2 stops17h 13m
American Airlines
Deal found 3/9![American Airlines logo]()
$757
This Expedia deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Thu 4/308:20 am
OPO
- DSM
2 stops17h 13m
Iberia
Deal found 3/11![Iberia logo]()
$872
This Iberia deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:16 pm
DSM
- OPO
2 stops19h 44m
Iberia
Fri 5/18:40 pm
OPO
- DSM
2 stops28h 53m
Iberia
Deal found 3/10![Iberia logo]()
$935
Last-minute flights from Des Moines to PortugalDiscover last-minute flight deals from Des Moines to Portugal. Data last updated March 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Portugal. Data last updated March 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:00 pm
DSM
- OPO
2 stops17h 45m
American Airlines
Tue 4/218:20 am
OPO
- DSM
2 stops21h 29m
American Airlines
Deal found 3/6![American Airlines logo]()
$658
This Iberia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1912:00 pm
DSM
- OPO
2 stops22h 00m
Iberia
Sun 4/264:40 pm
OPO
- DSM
2 stops32h 53m
Iberia
Deal found 3/6![Iberia logo]()
$727
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:16 pm
DSM
- OPO
2 stops15h 29m
Iberia
Mon 4/278:20 am
OPO
- DSM
2 stops17h 13m
Iberia
Deal found 3/6![Iberia logo]()
$707
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:25 am
DSM
- OPO
2 stops18h 15m
American Airlines
Tue 4/2812:25 pm
OPO
- DSM
2 stops29h 01m
American Airlines
Deal found 3/7![American Airlines logo]()
$660
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Tue 4/288:40 pm
OPO
- DSM
2 stops28h 53m
Iberia
Deal found 3/6![Iberia logo]()
$668
This Expedia deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:00 pm
DSM
- OPO
2 stops17h 45m
Iberia
Wed 4/298:20 am
OPO
- DSM
2 stops17h 13m
Iberia
Deal found 3/10![Iberia logo]()
$656
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:05 am
DSM
- OPO
2 stops18h 35m
American Airlines
Wed 4/298:20 am
OPO
- DSM
2 stops17h 13m
American Airlines
Deal found 3/8![American Airlines logo]()
$659
One-way flights from Des Moines to PortugalSearch for one-way flight options from Des Moines to Portugal. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
Search for one-way flight options from Des Moines to Portugal. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
This Air France deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:45 pm
DSM
- OPO
2 stops15h 40m
Air France
Deal found 3/8![Air France logo]()
$503
This EaseMyTrip deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure EaseMyTrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:16 pm
DSM
- OPO
2 stops22h 09m
Lufthansa
Deal found 3/9![Lufthansa logo]()
$582
Find flight deals from Des Moines to Portugal
Keep the following information in mind while searching for Des Moines to Portugal flight deals. Data was last updated March 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $656 (Expedia) |
One-way from | $503 (Air France) |
Popular in | June |
Cheapest in | April |
Average price | $864 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Portugal that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Des Moines to Portugal that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Mon 4/13
7:05 am-7:40 am
2 stops18h 35m
Porto
Tue 4/21
8:20 am-11:49 pm
2 stops21h 29m
$658
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Tue 4/21
6:13 pm-4:00 pm
2 stops15h 47m
Porto
Tue 4/28
12:25 pm-11:26 am
2 stops29h 01m
$662
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Tue 4/21
12:00 pm-11:45 am
2 stops17h 45m
Porto
Tue 4/28
8:40 pm-7:33 pm
2 stops28h 53m
$668
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Wed 4/22
2:16 pm-11:45 am
2 stops15h 29m
Porto
Wed 4/29
8:20 am-11:49 pm
2 stops21h 29m
$669
Quickest round-trip
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Thu 4/23
12:00 pm-11:45 am
2 stops17h 45m
Porto
Thu 4/30
8:20 am-7:33 pm
2 stops17h 13m
$757
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Sat 4/25
12:01 pm-6:10 pm
2 stops24h 09m
Porto
Sat 5/2
5:00 am-5:02 pm
2 stops18h 02m
$814
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Thu 4/23
12:00 pm-11:45 am
2 stops17h 45m
Porto
Thu 4/30
8:20 am-7:33 pm
2 stops17h 13m
$872
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Fri 4/24
2:16 pm-4:00 pm
2 stops19h 44m
Porto
Fri 5/1
8:40 pm-7:33 pm
2 stops28h 53m
$935
Cheapest one-way
Quickest one-way
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Wed 4/22
5:45 pm-3:25 pm
2 stops15h 40m
$503
Des MoinesPorto
DSM - OPO
DSMOPO
Des Moines
Thu 4/23
7:16 pm-11:25 pm
2 stops22h 09m
$582
Sorted by cheapest first
Best time to book a flight from Des Moines to Portugal
Have a flexible travel schedule? Discover the best time to fly to Portugal from Des Moines with our price prediction graph.
DSM-OPO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Portugal
DSM-PT0
DSM-OPO
What is the cheapest month to book a flight from Des Moines to Portugal?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Portugal (average of $528). Flying from Des Moines to Portugal in June is currently the most expensive (average of $1,121). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Portugal
Get insights into the airlines that provide service to Portugal. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Portugal. Reviews last updated March 11, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Des Moines to Portugal. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Portugal. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Portugal
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Portugal by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Portugal by cabin class
Find flights from Des Moines to Portugal, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Portugal flights
Browse other Des Moines and Portugal flight options. Last updated on March 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Portugal regions
Consider these flights traveling to Portugal regions.
Top 2 airlines flying from Des Moines to Portugal
Discover the top 2 airlines that operate flights from Des Moines to Portugal. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$559 | Average$831 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$806 | Average$1,045 | FlexibilityNo cancel fee | On-time71% |