$140+ Cheap flights from Knoxville to Portland, ME (TYS - PWM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PWM
Mar 25 — Apr 11
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to PortlandExplore the most affordable flight options available from Knoxville to Portland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
Explore the most affordable flight options available from Knoxville to Portland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:10 am
TYS
- PWM
1 stop4h 51m
Delta
Sat 9/2611:25 am
PWM
- TYS
1 stop4h 47m
Delta
Deal found 2/22![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:30 pm
TYS
- PWM
1 stop4h 54m
American Airlines
Sat 9/261:02 pm
PWM
- TYS
2 stops6h 02m
American Airlines
Deal found 2/20![American Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:30 pm
TYS
- PWM
2 stops10h 35m
Southwest
Sat 4/45:30 am
PWM
- TYS
2 stops10h 40m
Southwest
Deal found 2/22![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am
TYS
- PWM
1 stop6h 07m
American Airlines
Sat 10/312:39 pm
PWM
- TYS
1 stop4h 07m
American Airlines
Deal found 2/19![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:26 pm
TYS
- PWM
1 stop5h 41m
American Airlines
Mon 6/295:17 pm
PWM
- TYS
1 stop4h 14m
American Airlines
Deal found 2/20![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:40 pm
TYS
- PWM
1 stop7h 00m
American Airlines
Tue 7/287:23 am
PWM
- TYS
1 stop5h 09m
American Airlines
Deal found 2/21![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/512:45 pm
TYS
- PWM
2 stops11h 20m
Southwest
Tue 7/73:45 pm
PWM
- TYS
1 stop5h 30m
Southwest
Deal found 2/20![Southwest logo]()
$323
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:13 pm
TYS
- PWM
1 stop6h 34m
American Airlines
Sun 8/306:00 am
PWM
- TYS
1 stop4h 05m
American Airlines
Deal found 2/20![American Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:30 am
TYS
- PWM
2 stops17h 35m
Southwest
Mon 3/302:50 pm
PWM
- TYS
1 stop7h 20m
Southwest
Deal found 2/22![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:20 pm
TYS
- PWM
2 stops9h 45m
Southwest
Tue 7/283:45 pm
PWM
- TYS
1 stop5h 30m
Southwest
Deal found 2/21![Southwest logo]()
$338
Best flights from Knoxville to PortlandDiscover carefully curated flight deals from Knoxville to Portland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
Discover carefully curated flight deals from Knoxville to Portland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:26 pm
TYS
- PWM
1 stop5h 41m
American Airlines
Mon 6/295:17 pm
PWM
- TYS
1 stop4h 14m
American Airlines
Deal found 2/19![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/512:45 pm
TYS
- PWM
2 stops11h 20m
Southwest
Tue 7/73:45 pm
PWM
- TYS
1 stop5h 30m
Southwest
Deal found 2/20![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:01 am
TYS
- PWM
1 stop5h 17m
Delta
Mon 3/95:23 am
PWM
- TYS
1 stop5h 54m
Delta
Deal found 2/19![Delta logo]()
$384
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:20 pm
TYS
- PWM
2 stops9h 45m
Southwest
Tue 7/285:30 am
PWM
- TYS
2 stops11h 30m
Southwest
Deal found 2/21![Southwest logo]()
$328
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:30 am
TYS
- PWM
2 stops17h 35m
Southwest
Mon 3/302:50 pm
PWM
- TYS
1 stop7h 20m
Southwest
Deal found 2/22![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:35 pm
TYS
- PWM
2 stops11h 30m
Southwest
Wed 7/2210:30 am
PWM
- TYS
2 stops9h 50m
Southwest
Deal found 2/21![Southwest logo]()
$349
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:20 pm
TYS
- PWM
2 stops9h 45m
Southwest
Sun 6/145:30 am
PWM
- TYS
2 stops10h 15m
Southwest
Deal found 2/19![Southwest logo]()
$378
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2512:35 pm
TYS
- PWM
2 stops11h 30m
Southwest
Thu 7/25:35 am
PWM
- TYS
2 stops10h 10m
Southwest
Deal found 2/19![Southwest logo]()
$393
Last-minute flights from Knoxville to PortlandDiscover last-minute flight deals from Knoxville to Portland. Data last updated February 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Portland. Data last updated February 23, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:01 am
TYS
- PWM
1 stop5h 17m
Delta
Mon 3/95:23 am
PWM
- TYS
1 stop5h 54m
Delta
Deal found 2/19![Delta logo]()
$384
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/51:20 pm
TYS
- PWM
2 stops10h 45m
Southwest
Mon 3/95:30 pm
PWM
- TYS
1 stop4h 40m
Southwest
Deal found 2/19![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:50 am
TYS
- PWM
1 stop4h 40m
Southwest
Sat 3/285:20 pm
PWM
- TYS
1 stop4h 50m
Southwest
Deal found 2/21![Southwest logo]()
$423
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:50 am
TYS
- PWM
1 stop4h 40m
Southwest
Mon 3/235:30 am
PWM
- TYS
2 stops13h 15m
Southwest
Deal found 2/21![Southwest logo]()
$434
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:30 am
TYS
- PWM
2 stops17h 35m
Southwest
Mon 3/302:50 pm
PWM
- TYS
1 stop7h 20m
Southwest
Deal found 2/22![Southwest logo]()
$335
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:50 am
TYS
- PWM
1 stop4h 05m
Southwest
Sat 4/45:20 pm
PWM
- TYS
1 stop4h 50m
Southwest
Deal found 2/22![Southwest logo]()
$279
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:00 am
TYS
- PWM
2 stops7h 14m
American Airlines
Sat 4/45:29 am
PWM
- TYS
1 stop5h 42m
American Airlines
Deal found 2/22![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:20 pm
TYS
- PWM
2 stops10h 45m
Southwest
Fri 4/32:50 pm
PWM
- TYS
1 stop7h 20m
Southwest
Deal found 2/19![Southwest logo]()
$375
One-way flights from Knoxville to PortlandSearch for one-way flight options from Knoxville to Portland. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
Search for one-way flight options from Knoxville to Portland. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:30 am
TYS
- PWM
1 stop7h 56m
United Airlines
Deal found 2/19![United Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2912:45 pm
TYS
- PWM
2 stops10h 10m
Southwest
Deal found 2/19![Southwest logo]()
$145
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
TYS
- PWM
1 stop4h 17m
Delta
Deal found 2/21![Delta logo]()
$155
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:45 am
TYS
- PWM
1 stop8h 15m
Southwest
Deal found 2/21![Southwest logo]()
$175
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:01 am
TYS
- PWM
1 stop5h 17m
Delta
Deal found 2/22![Delta logo]()
$220
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:13 am
TYS
- PWM
2 stops9h 06m
American Airlines
Deal found 2/22![American Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:54 am
TYS
- PWM
2 stops22h 55m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$229
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:21 pm
TYS
- PWM
2 stops8h 59m
United Airlines
Deal found 2/22![United Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:36 pm
TYS
- PWM
3 stops36h 41m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$265
Find flight deals from Knoxville to Portland
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Portland (PWM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (Southwest) |
One-way from | $140 (United Airlines) |
Popular in | November |
Cheapest in | September |
Average price | $434 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Portland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Knoxville to Portland that are best for you.
Fly from
Knoxville
Fly to
Portland
Route
Depart
Return
Price
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Wed 6/24
6:26 pm-12:07 am
1 stop5h 41m
Portland
Mon 6/29
5:17 pm-9:31 pm
1 stop4h 14m
$314
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Sun 7/5
12:45 pm-12:05 am
2 stops11h 20m
Portland
Tue 7/7
3:45 pm-9:15 pm
1 stop5h 30m
$323
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Thu 7/23
2:20 pm-12:05 am
2 stops9h 45m
Portland
Tue 7/28
5:30 am-5:00 pm
2 stops11h 30m
$328
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Mon 3/23
6:30 am-12:05 am
2 stops17h 35m
Portland
Mon 3/30
2:50 pm-10:10 pm
1 stop7h 20m
$335
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Fri 7/17
12:35 pm-12:05 am
2 stops11h 30m
Portland
Wed 7/22
10:30 am-8:20 pm
2 stops9h 50m
$349
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Thu 6/11
2:20 pm-12:05 am
2 stops9h 45m
Portland
Sun 6/14
5:30 am-3:45 pm
2 stops10h 15m
$378
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Thu 3/5
6:01 am-11:18 am
1 stop5h 17m
Portland
Mon 3/9
5:23 am-11:17 am
1 stop5h 54m
$384
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Thu 6/25
12:35 pm-12:05 am
2 stops11h 30m
Portland
Thu 7/2
5:35 am-3:45 pm
2 stops10h 10m
$393
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Wed 7/29
6:30 am-2:26 pm
1 stop7h 56m
$140
KnoxvillePortland
TYS - PWM
TYSPWM
Knoxville McGhee Tyson
Wed 7/29
12:45 pm-10:55 pm
2 stops10h 10m
$145
Showing 1-10 of 17 results
Compare providers for flights from Knoxville to Portland
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Portland in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Portland, Maine flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Portland, Maine flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Portland, Maine flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Portland, Maine flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Portland, Maine flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Portland
Have a flexible travel schedule? Discover the best time to fly to Portland from Knoxville with our price prediction graph.
TYS-PWM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Portland
Reviews of airlines servicing Portland
Get insights into the airlines that provide service to Portland. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Portland. Reviews last updated February 23, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Portland. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.9
Boarding
8.1
Crew
8.5
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Overall
7.9
Boarding
8.1
Crew
8.5
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Overall
7.9
Boarding
8.1
Crew
8.5
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Overall
7.9
Boarding
8.1
Crew
8.5
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Portland. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Portland?
Book flights to Portland if you plan to visit one of these locationsNorth Conway
Brunswick
Auburn
Conway
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Knoxville and Portland flights
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Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on February 23, 2026.
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Explore flights to Portland departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 23, 2026.
Top 3 airlines flying from Knoxville to Portland
Discover the top 3 airlines that operate flights from Knoxville to Portland. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$457 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$258 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$418 | FlexibilityNo cancel fee | On-timeN/A |