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$164+ Cheap flights from North Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from North Carolina to Panama

Cheapest flights from North Carolina to Panama
Explore the most affordable flight options available from North Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:10 amRDU - PTY
1 stop10h 57mUnited Airlines
Wed 1/2110:00 amPTY - RDU
1 stop11h 05mUnited Airlines
Deal found 12/14$509
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:05 amRDU - PTY
1 stop10h 49mAmerican Airlines
Wed 1/212:27 pmPTY - RDU
2 stops19h 28mAmerican Airlines
Deal found 12/14$513
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:17 pmRDU - PTY
2 stops19h 37mAmerican Airlines
Mon 1/194:50 pmPTY - RDU
2 stops19h 31mAmerican Airlines
Deal found 12/14$543
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:10 amRDU - PTY
1 stop13h 28mUnited Airlines
Mon 1/194:41 pmPTY - RDU
1 stop29h 49mUnited Airlines
Deal found 12/14$558
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:09 pmORF - PTY
2 stops19h 45mAmerican Airlines
Mon 12/292:53 pmPTY - ORF
2 stops17h 33mAmerican Airlines
Deal found 12/16$578
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Thu 12/2511:35 amPTY - CLT
1 stop10h 07mUnited Airlines
Deal found 12/17$586
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:44 amRDU - PTY
2 stops26h 09mAmerican Airlines
Wed 12/312:53 pmPTY - RDU
1 stop7h 52mAmerican Airlines
Deal found 12/17$603
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:20 amORF - PTY
2 stops10h 47mUnited Airlines
Thu 1/84:41 pmPTY - ORF
2 stops21h 26mUnited Airlines
Deal found 12/16$619
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:31 amRDU - PTY
2 stops13h 07mUnited Airlines
Wed 12/314:41 pmPTY - RDU
1 stop18h 40mUnited Airlines
Deal found 12/16$626
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:11 pmRDU - PTY
Nonstop4h 35mCopa Airlines
Mon 1/198:57 amPTY - RDU
Nonstop4h 18mCopa Airlines
Deal found 12/14$634
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:00 amMYR - PTY
1 stop7h 57mDelta
Tue 12/308:00 amPTY - MYR
1 stop12h 30mDelta
Deal found 12/17$640
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Tue 1/610:00 amPTY - CLT
1 stop11h 16mUnited Airlines
Deal found 12/17$678

Find flight deals from North Carolina to Panama

Keep the following information in mind while searching for North Carolina to Panama flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$404
(United Airlines)

One-way from

$164
(United Airlines)

Popular in

December

Cheapest in

October

Average price

$809

Good round-trip deal

$334 or less

Good one-way deal

$301 or less
Provider with most accurate pricing for Raleigh-Durham-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Panama City Tocumen Intl flights.
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From North Carolina to Panama
Search Deals
One-way flight from North Carolina to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from North Carolina to Panama.
Search Deals
Price to beat on a one-way flight from North Carolina to Panama.
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Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

North Carolina

Fly to

Panama

Route

Depart

Return

Price

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 1/29

7:26 pm-3:38 pm

2 stops20h 12m

Panama City Tocumen Intl

Tue 2/3

2:27 pm-10:37 am

2 stops20h 10m

$408

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 1/28

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Wed 2/4

4:41 pm-2:25 pm

2 stops21h 44m

$408

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Mon 1/19

4:12 pm-2:45 pm

2 stops22h 33m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-2:07 pm

2 stops21h 26m

$408

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Sat 5/9

6:08 am-4:12 pm

2 stops11h 04m

Panama City Tocumen Intl

Tue 5/12

9:45 am-11:39 pm

2 stops12h 54m

$422

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Fri 2/20

6:36 pm-1:50 pm

2 stops19h 14m

Panama City Tocumen Intl

Fri 2/27

4:05 pm-11:54 pm

1 stop7h 49m

$426

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Fri 2/13

4:55 pm-2:45 pm

2 stops21h 50m

Panama City Tocumen Intl

Tue 2/24

4:41 pm-2:22 pm

2 stops21h 41m

$426

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Fri 2/13

4:55 pm-5:07 pm

2 stops24h 12m

Panama City Tocumen Intl

Wed 2/18

4:41 pm-2:22 pm

2 stops21h 41m

$426

GreensboroPanama City

GSO - PTY

GSOPTY

Greensboro/H. Point

Wed 3/18

7:01 am-2:22 pm

1 stop8h 21m

Panama City Tocumen Intl

Wed 3/25

1:44 pm-10:58 pm

1 stop8h 14m

$436

GreensboroPanama City

GSO - PTY

GSOPTY

Greensboro/H. Point

Wed 3/18

7:01 am-2:22 pm

1 stop8h 21m

Panama City Tocumen Intl

Wed 4/1

1:44 pm-10:58 pm

1 stop8h 14m

$436

WilmingtonPanama City

ILM - PTY

ILMPTY

Wilmington New Hanover County

Tue 4/28

6:00 am-12:15 pm

1 stop7h 15m

Panama City Tocumen Intl

Tue 5/5

1:55 pm-11:00 pm

1 stop8h 05m

$436

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 60 results
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Best time to book a flight from North Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Panama

What is the cheapest month to book a flight from North Carolina to Panama?

Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in November is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to PA?

Find hourly flight availability from North Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s optimal to fly from North Carolina to Panama at noon. By choosing this option you can save up to 42% on the cost of your flight, compared to a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this North Carolina to Panama flight route?

    Flights from North Carolina to Panama have been viewed 16 times in the past calendar month.

  • How long is the flight from North Carolina to Panama?

    There are many flights that can get you from North Carolina to Panama in 4h 34m. Fly via American Airlines, United Airlines, or Copa Airlines to get the fastest option. The distance from North Carolina to Panama is about 1851 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from North Carolina to Panama one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $212. Users have also found prices from $216 and $412 on American Airlines and Copa Airlines, respectively.

  • Can I find deals for flights from North Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on North Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Panama.

  • Can I find deals for business class flights from North Carolina to Panama?

    Yes. Cheapflights offers flight deals from North Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Panama?

    Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in November is currently the most expensive (average of $403). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for North Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from North Carolina to Panama

Discover the top 4 airlines that operate flights from North Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$590FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$352Average$470FlexibilityNo cancel feeOn-time70%
DeltaCheapest$367Average$538FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$409Average$517FlexibilityNo cancel feeOn-time69%

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