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$166+ Cheap flights from North Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from North Carolina to Panama

Cheapest flights from North Carolina to Panama
Explore the most affordable flight options available from North Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:45 pm
CLT
-
PTY
1 stop17h 01m
American Airlines
Tue 5/191:49 pm
PTY
-
CLT
1 stop8h 08m
American Airlines
Deal found 2/9$409
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:05 am
CLT
-
PTY
1 stop8h 41m
American Airlines
Tue 5/191:49 pm
PTY
-
CLT
1 stop8h 08m
American Airlines
Deal found 2/10$419
This Trip.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:18 am
RDU
-
PTY
2 stops17h 47m
Multiple Airlines
Wed 4/223:10 pm
PTY
-
RDU
2 stops15h 23m
Multiple Airlines
Deal found 2/9$421
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:35 pm
ORF
-
PTY
1 stop7h 56m
United Airlines
Tue 4/147:55 am
PTY
-
ORF
1 stop13h 28m
United Airlines
Deal found 2/9$425
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:29 am
ORF
-
PTY
1 stop8h 51m
American Airlines
Wed 8/263:20 pm
PTY
-
ORF
1 stop7h 22m
American Airlines
Deal found 2/10$427
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:20 am
ORF
-
PTY
2 stops10h 47m
United Airlines
Tue 2/244:41 pm
PTY
-
ORF
2 stops21h 22m
United Airlines
Deal found 2/9$429
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:05 am
CLT
-
PTY
1 stop8h 41m
American Airlines
Fri 5/151:49 pm
PTY
-
CLT
1 stop8h 08m
American Airlines
Deal found 2/10$429
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:05 am
CLT
-
PTY
1 stop8h 15m
American Airlines
Mon 8/313:20 pm
PTY
-
CLT
2 stops14h 09m
American Airlines
Deal found 2/10$433
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:15 am
CLT
-
PTY
1 stop7h 25m
American Airlines
Wed 4/151:49 pm
PTY
-
CLT
1 stop8h 08m
American Airlines
Deal found 2/11$434
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
ORF
-
PTY
2 stops13h 37m
United Airlines
Mon 5/119:45 am
PTY
-
ORF
2 stops12h 59m
United Airlines
Deal found 2/10$435
This Trip.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:00 am
CLT
-
PTY
3 stops28h 30m
Multiple Airlines
Wed 3/252:55 pm
PTY
-
CLT
2 stops20h 12m
Multiple Airlines
Deal found 2/10$438
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/256:00 am
ORF
-
PTY
1 stop8h 45m
United Airlines
Tue 3/34:41 pm
PTY
-
ORF
2 stops21h 41m
United Airlines
Deal found 2/11$439

Find flight deals from North Carolina to Panama

Keep the following information in mind while searching for North Carolina to Panama flight deals. Data was last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$409
(American Airlines)

One-way from

$166
(Mytrip)

Popular in

December

Cheapest in

October

Average price

$597

Good round-trip deal

$294 or less

Good one-way deal

$150 or less
Provider with most accurate pricing for Raleigh-Durham-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Panama City Tocumen Intl flights.
Search Deals
From North Carolina to Panama
Search Deals
One-way flight from North Carolina to Panama
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from North Carolina to Panama.
Search Deals
Price to beat on a one-way flight from North Carolina to Panama.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

North Carolina

Fly to

Panama

Route

Depart

Return

Price

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Tue 4/7

12:35 pm-7:31 pm

1 stop7h 56m

Panama City Tocumen Intl

Tue 4/14

7:55 am-10:23 pm

1 stop13h 28m

$425

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 5/7

6:00 am-6:37 pm

2 stops13h 37m

Panama City Tocumen Intl

Mon 5/11

9:45 am-11:44 pm

2 stops12h 59m

$425

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 5/16

5:05 am-12:46 pm

1 stop8h 41m

Panama City Tocumen Intl

Fri 5/29

1:14 pm-9:24 pm

1 stop7h 10m

$429

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Tue 4/7

12:35 pm-7:31 pm

1 stop7h 56m

Panama City Tocumen Intl

Mon 4/13

3:30 pm-2:20 pm

2 stops21h 50m

$439

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Tue 3/24

5:00 pm-4:07 pm

2 stops24h 07m

Panama City Tocumen Intl

Tue 3/31

3:30 pm-2:20 pm

2 stops21h 50m

$439

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 2/26

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-2:22 pm

2 stops21h 41m

$439

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Thu 4/9

12:35 pm-7:31 pm

1 stop7h 56m

Panama City Tocumen Intl

Mon 4/13

3:30 pm-2:20 pm

2 stops21h 50m

$439

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 2/25

6:00 am-2:45 pm

1 stop8h 45m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-2:22 pm

2 stops21h 41m

$439

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 5/21

10:39 pm-12:14 pm

1 stop14h 35m

Panama City Tocumen Intl

Sun 5/24

1:14 pm-9:54 am

1 stop19h 40m

$443

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sat 4/18

6:10 am-12:46 pm

1 stop7h 36m

Panama City Tocumen Intl

Tue 4/21

1:49 pm-6:26 am

2 stops15h 37m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 57 results
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Best time to book a flight from North Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Panama

What is the cheapest month to book a flight from North Carolina to Panama?

Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to PA?

Find hourly flight availability from North Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 12, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Panama as you normally would.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this North Carolina to Panama flight route?

    Flights from North Carolina to Panama have been viewed 21 times in the past calendar month.

  • How long is the flight from North Carolina to Panama?

    There are many flights that can get you from North Carolina to Panama in 7h 28m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance from North Carolina to Panama is about 1867 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from North Carolina to Panama one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $212. Users have also found prices from $221 and $445 on American Airlines and Copa Airlines, respectively.

  • Can I find deals for flights from North Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on North Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Panama.

  • Can I find deals for business class flights from North Carolina to Panama?

    Yes. Cheapflights offers flight deals from North Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Panama?

    Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for North Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from North Carolina to Panama

Discover the top 4 airlines that operate flights from North Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$588FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$352Average$504FlexibilityNo cancel feeOn-time70%
DeltaCheapest$367Average$555FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$409Average$533FlexibilityNo cancel feeOn-time69%

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