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$170+ Cheap flights from North Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Apr 30 — May 71
Thu 4/30
Thu 5/7
1 adult, Economy
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Cheap flight deals from North Carolina to Panama

Cheapest flights from North Carolina to Panama
Explore the most affordable flight options available from North Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2026.

This Trip.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:09 am
RDU
-
PTY
2 stops17h 26m
Multiple Airlines
Sat 5/165:30 am
PTY
-
RDU
3 stops24h 54m
Multiple Airlines
Deal found 3/27$380
This Trip.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:23 am
RDU
-
PTY
2 stops26h 07m
Multiple Airlines
Thu 4/164:25 am
PTY
-
RDU
2 stops26h 53m
Multiple Airlines
Deal found 3/30$387
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:09 am
RDU
-
PTY
1 stop12h 11m
Multiple Airlines
Fri 5/159:33 pm
PTY
-
RDU
1 stop8h 51m
Multiple Airlines
Deal found 3/28$400
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:09 am
RDU
-
PTY
1 stop12h 11m
Multiple Airlines
Thu 5/146:34 pm
PTY
-
RDU
1 stop11h 50m
Multiple Airlines
Deal found 3/28$403
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:09 am
RDU
-
PTY
1 stop12h 11m
Multiple Airlines
Sun 5/179:33 pm
PTY
-
RDU
1 stop8h 51m
Multiple Airlines
Deal found 3/27$428
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:09 am
RDU
-
PTY
1 stop12h 11m
Multiple Airlines
Sun 5/316:34 pm
PTY
-
RDU
1 stop11h 50m
Multiple Airlines
Deal found 3/26$434
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:30 am
CLT
-
PTY
1 stop8h 26m
Delta
Thu 10/222:21 pm
PTY
-
CLT
1 stop17h 19m
Delta
Deal found 3/29$439
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:09 am
RDU
-
PTY
1 stop8h 45m
Multiple Airlines
Wed 5/139:33 pm
PTY
-
RDU
1 stop8h 51m
Multiple Airlines
Deal found 3/28$440
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
-
PTY
2 stops19h 05m
Multiple Airlines
Thu 5/73:10 pm
PTY
-
CLT
2 stops19h 33m
Multiple Airlines
Deal found 3/31$447
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
CLT
-
PTY
1 stop6h 13m
Delta
Thu 9/32:28 pm
PTY
-
CLT
1 stop8h 29m
Delta
Deal found 3/27$449
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:55 am
CLT
-
PTY
1 stop6h 25m
American Airlines
Thu 9/33:20 pm
PTY
-
CLT
2 stops14h 09m
American Airlines
Deal found 3/27$453
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:48 pm
CLT
-
PTY
1 stop7h 32m
Multiple Airlines
Thu 5/288:10 am
PTY
-
CLT
1 stop8h 03m
Multiple Airlines
Deal found 3/30$458

Find flight deals from North Carolina to Panama

Keep the following information in mind while searching for North Carolina to Panama flight deals. Data was last updated March 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$380
(Trip.com)

One-way from

$170
(Trip.com)

Popular in

December

Cheapest in

October

Average price

$619

Good round-trip deal

$370 or less

Good one-way deal

$179 or less
Provider with most accurate pricing for Raleigh-Durham-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Panama City Tocumen Intl flights.
Search Deals
From North Carolina to Panama
Search Deals
One-way flight from North Carolina to Panama
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from North Carolina to Panama.
Search Deals
Price to beat on a one-way flight from North Carolina to Panama.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 9/1

8:00 am-1:13 pm

1 stop6h 13m

Panama City Tocumen Intl

Thu 9/3

2:28 pm-11:57 pm

1 stop8h 29m

$449

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 8/12

6:07 pm-4:04 am

1 stop10h 57m

Panama City Tocumen Intl

Wed 8/26

10:55 pm-10:08 am

1 stop10h 13m

$467

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 8/12

5:30 am-1:13 pm

1 stop8h 43m

Panama City Tocumen Intl

Wed 8/26

2:28 pm-12:06 am

1 stop8h 38m

$467

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 9/2

10:49 am-7:31 pm

1 stop9h 42m

Panama City Tocumen Intl

Tue 9/8

9:45 am-11:43 pm

2 stops12h 58m

$467

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Mon 6/15

10:47 am-7:31 pm

1 stop9h 44m

Panama City Tocumen Intl

Mon 6/22

3:30 pm-3:43 pm

2 stops23h 13m

$471

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Wed 7/8

11:30 am-4:04 am

2 stops17h 34m

Panama City Tocumen Intl

Mon 7/13

10:55 pm-3:14 pm

2 stops15h 19m

$471

NorfolkPanama City

ORF - PTY

ORFPTY

Norfolk

Tue 8/25

6:10 am-2:14 pm

1 stop9h 04m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-2:51 pm

2 stops22h 21m

$471

AshevillePanama City

AVL - PTY

AVLPTY

Asheville Regional

Wed 5/27

6:40 am-7:31 pm

2 stops13h 51m

Panama City Tocumen Intl

Tue 6/9

3:30 pm-1:29 pm

2 stops20h 59m

$471

AshevillePanama City

AVL - PTY

AVLPTY

Asheville Regional

Wed 5/13

5:45 am-12:50 pm

1 stop8h 05m

Panama City Tocumen Intl

Wed 5/20

2:15 pm-11:39 pm

1 stop8h 24m

$486

AshevillePanama City

AVL - PTY

AVLPTY

Asheville Regional

Thu 5/14

5:45 am-12:50 pm

1 stop8h 05m

Panama City Tocumen Intl

Thu 5/21

2:15 pm-11:39 pm

1 stop8h 24m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/29

Showing 1-10 of 58 resultsSorted by cheapest first
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Best time to book a flight from North Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Panama

What is the cheapest month to book a flight from North Carolina to Panama?

Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to PA?

Find hourly flight availability from North Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Panama as you normally would.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this North Carolina to Panama flight route?

    Flights from North Carolina to Panama have been viewed 23 times in the past calendar month.

  • How long is the flight from North Carolina to Panama?

    There are many flights that can get you from North Carolina to Panama in 6h 13m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. The distance from North Carolina to Panama is about 1808 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from North Carolina to Panama one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $199. Users have also found prices from $212 and $446 on Delta and Copa Airlines, respectively.

  • Can I find deals for flights from North Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on North Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Panama.

  • Can I find deals for business class flights from North Carolina to Panama?

    Yes. Cheapflights offers flight deals from North Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Panama?

    Currently, August is the cheapest month in which you can book a flight from North Carolina to Panama (average of $234). Flying from North Carolina to Panama in December is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from North Carolina to Panama

Discover the top 4 airlines that operate flights from North Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$255Average$599FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$352Average$539FlexibilityNo cancel feeOn-time70%
DeltaCheapest$385Average$595FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$409Average$512FlexibilityNo cancel feeOn-time69%

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