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$158+ Cheap flights from North Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — PTY
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from North Carolina to Panama

Keep the following information in mind while searching for North Carolina to Panama flight deals. Data was last updated September 16, 2025.

Round-trip from

$246
(Copa Airlines)

One-way from

$158
(Avianca Connect)

Popular in

December

Cheapest in

November

Average price

$367

Good round-trip deal

$322 or less

Good one-way deal

$196 or less
From North Carolina to Panama
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One-way flight from North Carolina to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from North Carolina to Panama.
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Price to beat on a one-way flight from North Carolina to Panama.
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Find flight deals from North Carolina to Panama

Cheapest flights from North Carolina to Panama
Explore the most affordable flight options available from North Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/14:19 pmRDU - PTY
Nonstop4h 27mCopa Airlines
Wed 10/88:57 amPTY - RDU
Nonstop4h 30mCopa Airlines
Deal found 9/14$246
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amRDU - PTY
1 stop13h 37mUnited Airlines
Tue 10/2110:00 amPTY - RDU
1 stop11h 14mUnited Airlines
Deal found 9/15$260
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/78:37 pmRDU - PTY
2 stops18h 26mAmerican Airlines
Tue 10/213:15 pmPTY - RDU
1 stop7h 41mAmerican Airlines
Deal found 9/15$265
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amRDU - PTY
1 stop13h 37mUnited Airlines
Fri 10/243:30 pmPTY - RDU
1 stop29h 44mUnited Airlines
Deal found 9/15$267
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:47 pmRDU - PTY
2 stops19h 16mAmerican Airlines
Mon 10/203:15 pmPTY - RDU
2 stops19h 04mAmerican Airlines
Deal found 9/14$275
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:51 pmRDU - PTY
1 stop19h 12mAmerican Airlines
Tue 10/143:15 pmPTY - RDU
1 stop7h 41mAmerican Airlines
Deal found 9/14$277
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/174:19 pmRDU - PTY
Nonstop4h 27mCopa Airlines
Fri 10/248:57 amPTY - RDU
Nonstop4h 30mCopa Airlines
Deal found 9/15$286
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:16 pmRDU - PTY
2 stops22h 15mAmerican Airlines
Mon 9/293:31 pmPTY - RDU
2 stops18h 47mAmerican Airlines
Deal found 9/15$328
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:04 amRDU - PTY
1 stop7h 45mAmerican Airlines
Mon 11/242:43 pmPTY - RDU
1 stop7h 25mAmerican Airlines
Deal found 9/15$337
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/195:34 pmRDU - PTY
2 stops20h 09mAmerican Airlines
Wed 12/34:37 pmPTY - RDU
1 stop7h 22mAmerican Airlines
Deal found 9/14$342
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:19 pmRDU - PTY
1 stop18h 24mAmerican Airlines
Fri 12/52:50 pmPTY - RDU
1 stop9h 09mAmerican Airlines
Deal found 9/14$345
This Vliegwinkel deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Vliegwinkel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/301:49 pmCLT - PTY
1 stop7h 48mMultiple Airlines
Thu 11/68:25 amPTY - CLT
1 stop7h 36mMultiple Airlines
Deal found 9/15$392

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from North Carolina to Panama that are best for you.

Fly from

North Carolina

Fly to

Panama

Route

Depart

Return

Price

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 10/1

4:19 pm-7:46 pm

Nonstop4h 27m

Panama City Tocumen Intl

Wed 10/8

8:57 am-2:27 pm

Nonstop4h 30m

$246

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 10/3

4:19 pm-7:46 pm

Nonstop4h 27m

Panama City Tocumen Intl

Wed 10/8

8:57 am-2:27 pm

Nonstop4h 30m

$246

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Tue 10/14

6:00 am-2:14 pm

1 stop9h 14m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-11:31 am

1 stop19h 01m

$260

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Fri 10/31

8:37 pm-2:03 pm

2 stops18h 26m

Panama City Tocumen Intl

Mon 11/3

2:49 pm-9:23 am

2 stops18h 34m

$342

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 11/19

4:24 pm-1:43 pm

2 stops21h 19m

Panama City Tocumen Intl

Wed 12/3

4:37 pm-9:55 am

2 stops17h 18m

$342

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Thu 10/16

6:00 am-6:37 pm

1 stop13h 37m

Panama City Tocumen Intl

Thu 10/23

10:00 am-10:14 pm

1 stop11h 14m

$388

RaleighPanama City

RDU - PTY

RDUPTY

Raleigh-Durham

Wed 10/22

6:00 am-6:37 pm

1 stop13h 37m

Panama City Tocumen Intl

Mon 10/27

7:55 am-9:54 pm

1 stop12h 59m

$388

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 10/30

1:49 pm-8:37 pm

1 stop7h 48m

Panama City Tocumen Intl

Thu 11/6

8:25 am-4:01 pm

1 stop7h 36m

$392

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 9/29

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

Thu 10/2

2:10 pm-11:46 pm

1 stop8h 36m

$395

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 10/20

5:30 am-12:56 pm

1 stop8h 26m

Panama City Tocumen Intl

Wed 10/22

2:21 pm-11:50 pm

1 stop8h 29m

$395

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 50 results
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Best time to book a flight from North Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Panama

What is the cheapest month to book a flight from North Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from North Carolina to Panama (average of $478). Flying from North Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to PA?

Find hourly flight availability from North Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Panama as you normally would.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this North Carolina to Panama flight route?

    Flights from North Carolina to Panama have been viewed 29 times in the past calendar month.

  • How long is the flight from North Carolina to Panama?

    There are many flights that can get you from North Carolina to Panama in 4h 27m. Fly via Copa Airlines, United Airlines, or American Airlines to get the fastest option. The distance from North Carolina to Panama is about 1851 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from North Carolina to Panama that include hotel bookings?

    Yes. In addition to deals on North Carolina to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Panama.

  • Can I find deals for business class flights from North Carolina to Panama?

    Yes. Cheapflights offers flight deals from North Carolina to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Panama?

    Currently, October is the cheapest month in which you can book a flight from North Carolina to Panama (average of $478). Flying from North Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from North Carolina to Panama

Discover the top 4 airlines that operate flights from North Carolina to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$249Average$592FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$282Average$416FlexibilityNo cancel feeOn-time70%
DeltaCheapest$302Average$546FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$351Average$509FlexibilityNo cancel feeOn-time69%

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