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$186+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated September 15, 2025.

Round-trip from

$386
(Delta)

One-way from

$186
(Delta)

Popular in

December

Cheapest in

July

Average price

$661
From Missouri to Panama
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One-way flight from Missouri to Panama
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Highest demand for flights based on searches. 11% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:00 amSTL - PTY
1 stop6h 56mDelta
Thu 10/232:21 pmPTY - STL
1 stop9h 20mDelta
Deal found 9/15$386
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Wed 10/2210:00 amPTY - STL
1 stop8h 57mUnited Airlines
Deal found 9/15$393
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Wed 10/223:30 pmPTY - STL
2 stops22h 57mUnited Airlines
Deal found 9/15$398
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/143:03 pmSTL - PTY
2 stops23h 00mAmerican Airlines
Thu 10/233:15 pmPTY - STL
2 stops18h 20mAmerican Airlines
Deal found 9/14$399
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:15 amSTL - PTY
1 stop12h 22mUnited Airlines
Mon 10/273:41 pmPTY - STL
1 stop27h 06mUnited Airlines
Deal found 9/15$401
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/136:00 amSTL - PTY
1 stop6h 56mDelta
Fri 10/242:21 pmPTY - STL
1 stop9h 20mDelta
Deal found 9/15$403
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Tue 10/2110:00 amPTY - STL
1 stop12h 00mUnited Airlines
Deal found 9/15$410
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Thu 10/233:30 pmPTY - STL
2 stops19h 19mUnited Airlines
Deal found 9/15$415
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/213:03 pmMCI - PTY
1 stop27h 34mUnited Airlines
Tue 10/283:41 pmPTY - MCI
1 stop22h 32mUnited Airlines
Deal found 9/15$419
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/298:10 amMCI - PTY
1 stop10h 28mUnited Airlines
Wed 11/54:41 pmPTY - MCI
1 stop17h 48mUnited Airlines
Deal found 9/14$423
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:25 amSTL - PTY
1 stop10h 12mUnited Airlines
Fri 10/2410:00 amPTY - STL
1 stop8h 57mUnited Airlines
Deal found 9/15$427
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:47 pmMCI - PTY
1 stop18h 09mDelta
Wed 10/292:21 pmPTY - MCI
1 stop25h 13mDelta
Deal found 9/15$429

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-11:41 pm

1 stop9h 20m

$386

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Wed 10/22

2:21 pm-10:26 am

1 stop20h 05m

$386

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Wed 10/22

10:00 am-6:57 pm

1 stop8h 57m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/15

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 10/22

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Wed 10/22

3:30 pm-10:49 am

2 stops19h 19m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 40 results
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Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Panama?

    For as low as $386, Delta can have you in Panama from Missouri in 6h 56m. Airlines will cover a distance of 2159 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Panama one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $186. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Missouri to Panama for a low price.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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O'Hare Intl to Panama City flights
Boston to San José flights
Dulles Intl to Guatemala City flights
Miami to Managua flights
O'Hare Intl to Guatemala City flights
Denver to San José flights
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Baltimore to San Salvador flights
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Baltimore to San José flights
San Francisco to San José flights
Reagan-National to San José flights
LaGuardia to Guatemala City flights
Reagan-National to San Salvador flights
Atlanta to San Salvador flights
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Miami to San Salvador flights
O'Hare Intl to Liberia flights
Miami to San José flights
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Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$571FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$401Average$603FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$410Average$587FlexibilityNo cancel feeOn-time71%

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