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$186+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:43 pmSTL - PTY
2 stops19h 02mUnited Airlines
Fri 12/54:41 pmPTY - STL
2 stops20h 34mUnited Airlines
Deal found 11/1$415
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:27 pmMCI - PTY
2 stops19h 18mUnited Airlines
Tue 12/238:55 amPTY - MCI
1 stop14h 35mUnited Airlines
Deal found 10/31$428
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/305:15 amSTL - PTY
1 stop7h 28mAmerican Airlines
Sun 12/74:43 pmPTY - STL
2 stops20h 49mAmerican Airlines
Deal found 11/2$437
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:15 amMCI - PTY
1 stop9h 52mUnited Airlines
Wed 12/108:55 amPTY - MCI
1 stop14h 35mUnited Airlines
Deal found 10/31$438
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/24:16 pmMCI - PTY
2 stops20h 31mAmerican Airlines
Wed 12/102:50 pmPTY - MCI
2 stops18h 51mAmerican Airlines
Deal found 10/31$442
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:05 amMCI - PTY
1 stop9h 37mAmerican Airlines
Mon 1/124:50 pmPTY - MCI
2 stops19h 51mAmerican Airlines
Deal found 11/2$468
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/295:50 amMCI - PTY
1 stop13h 09mDelta
Sat 12/68:05 amPTY - MCI
1 stop16h 42mDelta
Deal found 11/1$478
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:15 amMCI - PTY
1 stop12h 23mUnited Airlines
Sat 12/64:41 pmPTY - MCI
2 stops18h 58mUnited Airlines
Deal found 11/1$482
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/305:04 amMCI - PTY
1 stop7h 39mAmerican Airlines
Sun 12/74:43 pmPTY - MCI
1 stop8h 42mAmerican Airlines
Deal found 11/1$483
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:24 pmSTL - PTY
2 stops20h 21mUnited Airlines
Wed 12/311:35 amPTY - STL
1 stop11h 23mUnited Airlines
Deal found 11/2$486
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:15 amSTL - PTY
1 stop7h 28mAmerican Airlines
Fri 12/54:43 pmPTY - STL
1 stop8h 16mAmerican Airlines
Deal found 11/1$502
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:15 amSTL - PTY
1 stop7h 30mUnited Airlines
Sun 12/78:55 amPTY - STL
1 stop14h 03mUnited Airlines
Deal found 11/2$510

Cheap flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$394
(United Airlines)

One-way from

$164
(United Airlines)

Popular in

February

Cheapest in

April

Average price

$528
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Missouri to Panama
Search Deals
One-way flight from Missouri to Panama
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Wed 2/25

8:55 am-10:14 pm

1 stop14h 19m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/25

5:05 am-1:40 pm

1 stop7h 35m

Panama City Tocumen Intl

Wed 3/11

1:50 pm-11:37 pm

1 stop9h 47m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/24

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Tue 3/10

7:55 am-3:54 pm

1 stop7h 59m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/3

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Thu 2/12

8:55 am-10:14 pm

1 stop14h 19m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/25

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Thu 3/12

11:35 am-10:13 pm

1 stop10h 38m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 2/23

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Tue 3/10

9:30 am-10:49 pm

2 stops13h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/24

7:41 am-7:38 pm

2 stops10h 57m

Panama City Tocumen Intl

Mon 3/9

7:55 am-10:13 pm

1 stop14h 18m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 2/26

6:30 am-8:02 pm

2 stops12h 32m

Panama City Tocumen Intl

Tue 3/10

9:30 am-10:49 pm

2 stops13h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/25

7:41 am-7:38 pm

2 stops10h 57m

Panama City Tocumen Intl

Wed 3/11

7:55 am-10:49 pm

2 stops14h 54m

$398

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 4/13

6:42 pm-12:55 pm

1 stop18h 13m

Panama City Tocumen Intl

Thu 4/16

2:20 pm-11:55 pm

1 stop9h 35m

$409

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, June is the cheapest month in which you can book a flight from Missouri to Panama (average of $208). Flying from Missouri to Panama in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s optimal to fly from Missouri to Panama at noon. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Panama?

    For as low as $394, United Airlines can have you in Panama from Missouri in 7h 35m. Airlines will cover a distance of 2159 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, June is the cheapest month in which you can book a flight from Missouri to Panama (average of $208). Flying from Missouri to Panama in February is currently the most expensive (average of $500). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$574FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$394Average$578FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$401Average$602FlexibilityNo cancel feeOn-time69%

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