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$154+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$398
(United Airlines)

One-way from

$154
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$615
Provider with most accurate pricing for Kansas City-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Panama City Tocumen Intl flights.
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From Missouri to Panama
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One-way flight from Missouri to Panama
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Highest demand for flights based on searches. 14% potential increase in price ($107 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/243:17 pmMCI - PTY
2 stops21h 43mAmerican Airlines
Tue 7/11:50 pmPTY - MCI
2 stops23h 13mAmerican Airlines
Deal found 4/29$393
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2610:15 amSTL - PTY
1 stop27h 59mUnited Airlines
Mon 6/303:30 pmPTY - STL
1 stop18h 01mUnited Airlines
Deal found 4/29$398
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1410:05 amSTL - PTY
1 stop8h 57mDelta
Sat 6/218:10 amPTY - STL
1 stop8h 15mDelta
Deal found 4/30$407
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:05 amMCI - PTY
2 stops12h 32mUnited Airlines
Sat 8/2310:00 amPTY - MCI
2 stops24h 37mUnited Airlines
Deal found 4/30$433
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/265:47 pmSTL - PTY
2 stops19h 13mAmerican Airlines
Mon 6/301:50 pmPTY - STL
2 stops18h 56mAmerican Airlines
Deal found 4/29$443
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/175:45 amMCI - PTY
1 stop7h 03mDelta
Tue 5/202:13 pmPTY - MCI
1 stop9h 46mDelta
Deal found 4/30$517
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:43 pmSGF - PTY
2 stops19h 37mAmerican Airlines
Thu 1/84:40 pmPTY - SGF
2 stops19h 43mAmerican Airlines
Deal found 4/30$542
This Avianca Connect deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:00 amMCI - PTY
2 stops18h 45mMultiple Airlines
Thu 6/193:20 amPTY - MCI
2 stops18h 41mMultiple Airlines
Deal found 4/29$649
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:48 pmSGF - PTY
1 stop23h 19mUnited Airlines
Thu 1/84:40 pmPTY - SGF
2 stops22h 39mUnited Airlines
Deal found 4/30$820
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2410:10 amSTL - PTY
1 stop10h 09mMultiple Airlines
Sun 5/253:20 amPTY - STL
2 stops20h 32mMultiple Airlines
Deal found 4/30$830
This Ovago deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/68:25 amSTL - PTY
2 stops15h 45mAvianca
Wed 7/93:20 amPTY - STL
2 stops30h 39mAvianca
Deal found 4/30$1,060

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 6/24

3:17 pm-1:00 pm

2 stops21h 43m

Panama City Tocumen Intl

Tue 7/1

1:50 pm-1:03 pm

2 stops23h 13m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/26

10:15 am-2:14 pm

1 stop27h 59m

Panama City Tocumen Intl

Mon 6/30

3:30 pm-9:31 am

1 stop18h 01m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 6/14

10:05 am-7:02 pm

1 stop8h 57m

Panama City Tocumen Intl

Sat 6/21

8:10 am-4:25 pm

1 stop8h 15m

$407

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Fri 8/15

6:05 am-6:37 pm

2 stops12h 32m

Panama City Tocumen Intl

Sat 8/23

10:00 am-10:37 am

2 stops24h 37m

$433

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/26

5:47 pm-1:00 pm

2 stops19h 13m

Panama City Tocumen Intl

Mon 6/30

1:50 pm-8:46 am

2 stops18h 56m

$443

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sat 5/17

5:45 am-12:48 pm

1 stop7h 03m

Panama City Tocumen Intl

Tue 5/20

2:13 pm-11:59 pm

1 stop9h 46m

$517

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Fri 6/13

6:00 am-12:45 am

2 stops18h 45m

Panama City Tocumen Intl

Thu 6/19

3:20 am-10:01 pm

2 stops18h 41m

$649

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 5/24

10:10 am-8:19 pm

1 stop10h 09m

Panama City Tocumen Intl

Sun 5/25

3:20 am-11:52 pm

2 stops20h 32m

$830

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 5/6

8:25 am-12:10 am

2 stops15h 45m

Panama City Tocumen Intl

Wed 7/9

3:20 am-9:59 am

2 stops30h 39m

$1,060

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 6/3

5:00 am-6:37 pm

2 stops13h 37m

$154

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 16 results
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Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated May 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to Panama one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $154. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Missouri to Panama for a low price.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$379Average$568FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$397Average$567FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$440Average$573FlexibilityNo cancel feeOn-time71%

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