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$164+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated June 12, 2025.

Round-trip from

$337
(Delta)

One-way from

$164
(Delta)

Popular in

December

Cheapest in

October

Average price

$601
From Missouri to Panama
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One-way flight from Missouri to Panama
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Highest demand for flights based on searches. 13% potential increase in price ($92 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amMCI - PTY
1 stop6h 47mDelta
Tue 10/212:12 pmPTY - MCI
1 stop9h 45mDelta
Deal found 6/12$337
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:10 amMCI - PTY
1 stop10h 27mUnited Airlines
Tue 10/213:30 pmPTY - MCI
2 stops19h 07mUnited Airlines
Deal found 6/12$342
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/274:19 pmMCI - PTY
2 stops20h 06mAmerican Airlines
Wed 11/54:20 pmPTY - MCI
1 stop8h 17mAmerican Airlines
Deal found 6/11$378
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/258:20 amSTL - PTY
1 stop10h 17mUnited Airlines
Tue 9/23:30 pmPTY - STL
1 stop18h 31mUnited Airlines
Deal found 6/10$393
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/281:29 pmSTL - PTY
1 stop23h 44mDelta
Wed 8/62:28 pmPTY - STL
1 stop17h 54mDelta
Deal found 6/11$401
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/318:01 pmSTL - PTY
2 stops18h 14mAmerican Airlines
Fri 8/83:30 pmPTY - STL
2 stops40h 36mAmerican Airlines
Deal found 6/11$476
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/308:55 amSGF - PTY
1 stop9h 42mUnited Airlines
Sat 9/610:00 amPTY - SGF
1 stop8h 28mUnited Airlines
Deal found 6/9$561
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/3011:24 amSTL - PTY
3 stops36h 46mMultiple Airlines
Wed 8/611:05 amPTY - STL
3 stops29h 26mMultiple Airlines
Deal found 6/11$615
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/46:04 pmMCI - PTY
2 stops30h 06mMultiple Airlines
Fri 8/85:25 pmPTY - MCI
3 stops28h 01mMultiple Airlines
Deal found 6/10$657
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/265:40 pmMCI - PTY
1 stop12h 33mCopa Airlines
Sat 7/59:13 amPTY - MCI
1 stop10h 33mCopa Airlines
Deal found 6/12$3,243

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 10/14

6:00 am-12:47 pm

1 stop6h 47m

Panama City Tocumen Intl

Tue 10/21

2:12 pm-11:57 pm

1 stop9h 45m

$337

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 10/14

8:10 am-6:37 pm

1 stop10h 27m

Panama City Tocumen Intl

Tue 10/21

3:30 pm-10:37 am

2 stops19h 07m

$342

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 10/27

4:19 pm-12:25 pm

2 stops20h 06m

Panama City Tocumen Intl

Wed 11/5

4:20 pm-11:37 pm

1 stop8h 17m

$378

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 9/8

3:30 pm-10:01 am

1 stop18h 31m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/28

1:29 pm-1:13 pm

1 stop23h 44m

Panama City Tocumen Intl

Wed 8/6

2:28 pm-8:22 am

1 stop17h 54m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/31

8:01 pm-2:15 pm

2 stops18h 14m

Panama City Tocumen Intl

Fri 8/8

3:30 pm-8:06 am

2 stops40h 36m

$476

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Sat 8/30

8:55 am-6:37 pm

1 stop9h 42m

Panama City Tocumen Intl

Sat 9/6

10:00 am-6:28 pm

1 stop8h 28m

$561

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 7/30

11:24 am-12:10 am

3 stops36h 46m

Panama City Tocumen Intl

Wed 8/6

11:05 am-4:31 pm

3 stops29h 26m

$615

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 8/4

6:04 pm-12:10 am

2 stops30h 06m

Panama City Tocumen Intl

Fri 8/8

5:25 pm-9:26 pm

3 stops28h 01m

$657

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/11

8:15 am-8:34 pm

1 stop12h 19m

Panama City Tocumen Intl

Fri 7/18

7:30 pm-9:59 am

1 stop14h 29m

$1,554

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 18 results
1
2

Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 12, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines and United Airlines from Missouri to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to Panama one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $164. However, be on the lookout for offers from United Airlines and Copa Airlines, as they are both options that can get you from Missouri to Panama for a low price.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$373Average$557FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$394Average$572FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$397Average$568FlexibilityNo cancel feeOn-time69%

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