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$179+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
STL
-
PTY
1 stop10h 07m
United Airlines
Wed 3/113:41 pm
PTY
-
STL
1 stop17h 40m
United Airlines
Deal found 2/3$415
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:30 am
STL
-
PTY
2 stops13h 01m
United Airlines
Sat 4/2510:55 pm
PTY
-
STL
2 stops13h 27m
United Airlines
Deal found 2/1$423
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:40 am
MCI
-
PTY
1 stop7h 22m
Delta
Tue 5/122:20 pm
PTY
-
MCI
1 stop9h 29m
Delta
Deal found 2/3$430
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Fri 6/123:30 pm
PTY
-
STL
1 stop18h 23m
United Airlines
Deal found 2/1$432
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:10 am
MCI
-
PTY
1 stop10h 27m
United Airlines
Tue 5/123:30 pm
PTY
-
MCI
2 stops22h 56m
United Airlines
Deal found 2/3$434
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:30 am
STL
-
PTY
2 stops12h 07m
United Airlines
Fri 6/123:30 pm
PTY
-
STL
1 stop18h 23m
United Airlines
Deal found 2/1$436
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:42 pm
STL
-
PTY
2 stops21h 04m
American Airlines
Sun 5/171:49 pm
PTY
-
STL
2 stops21h 20m
American Airlines
Deal found 2/3$441
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:15 am
MCI
-
PTY
1 stop12h 23m
United Airlines
Wed 3/253:41 pm
PTY
-
MCI
1 stop17h 49m
United Airlines
Deal found 2/1$445
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:20 pm
STL
-
PTY
1 stop20h 41m
American Airlines
Fri 4/31:50 pm
PTY
-
STL
2 stops18h 45m
American Airlines
Deal found 2/2$447
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Fri 4/243:30 pm
PTY
-
STL
1 stop17h 55m
United Airlines
Deal found 2/3$449
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:20 pm
MCI
-
PTY
2 stops19h 00m
American Airlines
Mon 8/313:20 pm
PTY
-
MCI
1 stop9h 09m
American Airlines
Deal found 2/1$454
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:15 am
MCI
-
PTY
1 stop9h 52m
United Airlines
Tue 3/173:41 pm
PTY
-
MCI
1 stop17h 49m
United Airlines
Deal found 2/3$459

Find flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$415
(United Airlines)

One-way from

$179
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$616
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Missouri to Panama
Search Deals
One-way flight from Missouri to Panama
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/11

6:00 am-6:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Tue 3/24

3:41 pm-9:21 am

1 stop17h 40m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/4

6:00 am-1:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Wed 3/11

2:28 pm-11:58 pm

1 stop9h 30m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Wed 5/6

2:27 pm-11:34 pm

1 stop9h 07m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/4

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Wed 3/11

3:41 pm-9:21 am

1 stop17h 40m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Wed 5/6

3:30 pm-8:18 am

2 stops16h 48m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

6:30 am-7:31 pm

2 stops13h 01m

Panama City Tocumen Intl

Sat 4/25

7:55 am-10:28 pm

1 stop14h 33m

$423

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 3/29

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Thu 4/2

3:30 pm-9:25 am

1 stop17h 55m

$432

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 4/11

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Tue 4/14

7:55 am-10:28 pm

1 stop14h 33m

$432

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 3/18

8:00 am-6:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Wed 3/25

3:41 pm-10:36 am

2 stops18h 55m

$449

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 3/9

5:54 am-1:03 pm

1 stop7h 09m

Panama City Tocumen Intl

Thu 3/12

2:28 pm-12:12 am

1 stop9h 44m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/31

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, June is the cheapest month in which you can book a flight from Missouri to Panama (average of $201). Flying from Missouri to Panama in May is currently the most expensive (average of $453). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Panama?

    For as low as $415, United Airlines can have you in Panama from Missouri in 6h 50m. Airlines will cover a distance of 2159 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, June is the cheapest month in which you can book a flight from Missouri to Panama (average of $201). Flying from Missouri to Panama in May is currently the most expensive (average of $453). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Panama City flights
John F Kennedy Intl to San José flights
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Dulles Intl to San José flights
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LaGuardia to Panama City flights
O'Hare Intl to San José flights
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San Francisco to San José flights
Atlanta to San José flights
Los Angeles to Panama City flights
Hobby to San José flights
George Bush Intcntl to Guatemala City flights
Dallas/Fort Worth to San José flights
Atlanta to San Salvador flights
Boston to San José flights
Reagan-National to San José flights
Fort Lauderdale to San José flights
Baltimore to San José flights
Hobby to San Pedro Sula flights
Los Angeles to Liberia flights
George Bush Intcntl to San José flights
Boston to Panama City flights
Miami to San José flights
George Bush Intcntl to San Pedro Sula flights
LaGuardia to Liberia flights
Dulles Intl to Guatemala City flights
Orlando to Panama City flights
Baltimore to Panama City flights
Miami to Managua flights
Miami to San Salvador flights
Denver to San José flights
Dallas/Fort Worth to Panama City flights
Reagan-National to San Salvador flights

Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$227Average$552FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$393Average$585FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$591FlexibilityNo cancel feeOn-time71%

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