$201+ Cheap flights from Missouri to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
may. 10 — may. 171
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Panama with Cheapflights
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Cheapest flights from Missouri to PanamaExplore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 10, 2026.
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/66:16 am
MCI
- PTY
1 stop12h 21m
United Airlines
mar. 8/113:30 pm
PTY
- MCI
2 stops18h 51m
United Airlines
Deal found 4/6![United Airlines logo]()
$471
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
mar. 6/210:00 am
PTY
- MCI
1 stop12h 31m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/178:30 am
MCI
- PTY
1 stop10h 07m
United Airlines
jue. 8/2010:55 pm
PTY
- MCI
2 stops19h 47m
United Airlines
Deal found 4/6![United Airlines logo]()
$491
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/78:30 am
MCI
- PTY
1 stop29h 44m
United Airlines
mié. 6/103:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/7![United Airlines logo]()
$496
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/295:08 am
MCI
- PTY
1 stop9h 12m
American Airlines
mar. 9/13:20 pm
PTY
- MCI
1 stop9h 09m
American Airlines
Deal found 4/4![American Airlines logo]()
$501
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/510:14 am
STL
- PTY
1 stop8h 23m
United Airlines
lun. 5/1810:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/16:00 am
MCI
- PTY
2 stops22h 04m
United Airlines
lun. 8/1010:55 pm
PTY
- MCI
2 stops15h 22m
United Airlines
Deal found 4/5![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/136:30 am
STL
- PTY
2 stops12h 07m
United Airlines
mar. 6/23:30 pm
PTY
- STL
2 stops20h 41m
United Airlines
Deal found 4/4![United Airlines logo]()
$509
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/36:50 pm
STL
- PTY
1 stop18h 12m
Delta
mar. 5/192:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$513
This KAYAK deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/16:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
lun. 8/103:30 pm
PTY
- MCI
1 stop18h 35m
Copa Airlines
Deal found 4/4![Copa Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/277:55 pm
MCI
- PTY
2 stops17h 50m
United Airlines
sáb. 10/313:41 pm
PTY
- MCI
1 stop31h 26m
United Airlines
Deal found 4/5![United Airlines logo]()
$515
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:00 am
STL
- PTY
2 stops13h 31m
United Airlines
lun. 6/13:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 4/6![United Airlines logo]()
$518
Best flights from Missouri to PanamaDiscover carefully curated flight deals from Missouri to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 10, 2026.
Discover carefully curated flight deals from Missouri to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/176:23 am
MCI
- PTY
1 stop7h 51m
United Airlines
jue. 8/2010:55 pm
PTY
- MCI
2 stops19h 47m
United Airlines
Deal found 4/5![United Airlines logo]()
$471
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/66:00 am
STL
- PTY
1 stop7h 02m
Delta
mié. 5/132:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/6![Delta logo]()
$505
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/66:12 pm
SGF
- PTY
2 stops18h 02m
American Airlines
sáb. 7/111:14 pm
PTY
- SGF
2 stops20h 43m
American Airlines
Deal found 4/5![American Airlines logo]()
$852
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/78:30 am
MCI
- PTY
1 stop29h 44m
United Airlines
mié. 6/103:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/7![United Airlines logo]()
$496
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/46:00 am
STL
- PTY
1 stop10h 12m
United Airlines
mié. 5/2010:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/176:00 am
STL
- PTY
1 stop6h 50m
Delta
lun. 6/12:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/4![Delta logo]()
$576
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/16:00 am
MCI
- PTY
2 stops22h 04m
United Airlines
lun. 8/103:30 pm
PTY
- MCI
2 stops17h 37m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/206:00 am
STL
- PTY
1 stop6h 50m
Delta
mar. 5/262:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/5![Delta logo]()
$588
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/306:36 pm
MCI
- PTY
2 stops21h 36m
United Airlines
mar. 6/93:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/76:00 am
STL
- PTY
1 stop7h 09m
Delta
mié. 6/102:24 pm
PTY
- STL
1 stop9h 32m
Delta
Deal found 4/7![Delta logo]()
$588
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/146:00 am
STL
- PTY
1 stop12h 37m
United Airlines
dom. 5/177:55 am
PTY
- STL
1 stop14h 35m
United Airlines
Deal found 4/5![United Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/258:15 pm
STL
- PTY
2 stops23h 16m
United Airlines
jue. 5/2810:00 am
PTY
- STL
1 stop10h 42m
United Airlines
Deal found 4/5![United Airlines logo]()
$552
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/76:00 am
STL
- PTY
2 stops22h 04m
United Airlines
mié. 6/103:30 pm
PTY
- STL
2 stops20h 41m
United Airlines
Deal found 4/7![United Airlines logo]()
$594
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/216:15 am
SGF
- PTY
1 stop12h 22m
United Airlines
jue. 5/2810:00 am
PTY
- SGF
1 stop9h 08m
United Airlines
Deal found 4/6![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/66:15 am
SGF
- PTY
1 stop12h 22m
United Airlines
sáb. 7/117:55 am
PTY
- SGF
1 stop10h 48m
United Airlines
Deal found 4/5![United Airlines logo]()
$688
Last-minute flights from Missouri to PanamaDiscover last-minute flight deals from Missouri to Panama. Data last updated abril 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Panama. Data last updated abril 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/36:50 pm
STL
- PTY
1 stop18h 12m
Delta
jue. 5/212:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$513
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/510:14 am
STL
- PTY
1 stop8h 23m
United Airlines
lun. 5/1810:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/102:59 pm
MCI
- PTY
1 stop23h 15m
United Airlines
mié. 5/207:55 am
PTY
- MCI
1 stop14h 34m
United Airlines
Deal found 4/5![United Airlines logo]()
$526
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/138:30 pm
STL
- PTY
2 stops19h 42m
United Airlines
mié. 5/277:55 am
PTY
- STL
2 stops13h 21m
United Airlines
Deal found 4/4![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/148:30 pm
STL
- PTY
2 stops17h 44m
United Airlines
lun. 6/13:30 pm
PTY
- STL
2 stops17h 11m
United Airlines
Deal found 4/4![United Airlines logo]()
$526
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/156:00 am
STL
- PTY
1 stop6h 50m
Delta
mar. 5/262:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$522
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/196:00 am
STL
- PTY
1 stop6h 50m
Delta
lun. 6/12:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/8![Delta logo]()
$525
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
mar. 6/210:00 am
PTY
- MCI
1 stop12h 31m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$479
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
lun. 6/13:30 pm
PTY
- MCI
2 stops17h 37m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$483
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/287:55 pm
MCI
- PTY
2 stops23h 36m
United Airlines
lun. 6/13:30 pm
PTY
- MCI
2 stops17h 37m
United Airlines
Deal found 4/6![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:00 am
STL
- PTY
2 stops13h 31m
United Airlines
lun. 6/13:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 4/6![United Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/308:30 am
MCI
- PTY
1 stop10h 07m
United Airlines
mar. 6/93:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/4![United Airlines logo]()
$528
One-way flights from Missouri to PanamaSearch for one-way flight options from Missouri to Panama. Find affordable one-way fares based on user searches. Data last updated abril 10, 2026.
Search for one-way flight options from Missouri to Panama. Find affordable one-way fares based on user searches. Data last updated abril 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/216:16 am
MCI
- PTY
1 stop9h 56m
United Airlines
Deal found 4/5![United Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/63:18 pm
MCI
- PTY
2 stops23h 02m
American Airlines
Deal found 4/9![American Airlines logo]()
$206
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/68:30 am
MCI
- PTY
1 stop7h 42m
United Airlines
Deal found 4/9![United Airlines logo]()
$211
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/186:54 pm
STL
- PTY
2 stops17h 52m
American Airlines
Deal found 4/8![American Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/185:27 pm
STL
- PTY
3 stops39h 48m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$240
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/56:16 am
MCI
- PTY
1 stop12h 21m
United Airlines
Deal found 4/9![United Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/186:28 pm
MCI
- PTY
2 stops18h 18m
American Airlines
Deal found 4/6![American Airlines logo]()
$247
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/197:55 pm
MCI
- PTY
2 stops22h 42m
United Airlines
Deal found 4/7![United Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/186:56 pm
MCI
- PTY
2 stops23h 41m
United Airlines
Deal found 4/9![United Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/176:03 pm
MCI
- PTY
2 stops42h 11m
American Airlines
Deal found 4/7![American Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/56:24 pm
MCI
- PTY
3 stops30h 11m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$321
Find flight deals from Missouri to Panama
Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated abril 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $471 (United Airlines) |
One-way from | $201 (United Airlines) |
Popular in | December |
Cheapest in | April |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 10, 2026.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
lun. 8/17
6:23 am-2:14 pm
1 stop7h 51m
Panama City Tocumen Intl
jue. 8/20
10:55 pm-6:42 pm
2 stops19h 47m
$471
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
dom. 6/7
8:30 am-2:14 pm
1 stop29h 44m
Panama City Tocumen Intl
mié. 6/10
3:30 pm-10:03 am
1 stop18h 33m
$496
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
mié. 5/6
6:00 am-1:02 pm
1 stop7h 02m
Panama City Tocumen Intl
mié. 5/13
2:15 pm-11:59 pm
1 stop9h 44m
$505
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
lun. 5/4
6:00 am-4:12 pm
1 stop10h 12m
Panama City Tocumen Intl
mié. 5/20
10:00 am-10:30 pm
1 stop12h 30m
$505
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
sáb. 8/1
6:00 am-4:04 am
2 stops22h 04m
Panama City Tocumen Intl
lun. 8/10
3:30 pm-9:07 am
2 stops17h 37m
$505
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
sáb. 5/30
6:36 pm-4:12 pm
2 stops21h 36m
Panama City Tocumen Intl
mar. 6/9
3:30 pm-10:03 am
1 stop18h 33m
$505
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
jue. 5/14
6:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
dom. 5/17
7:55 am-10:30 pm
1 stop14h 35m
$522
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
lun. 5/25
8:15 pm-7:31 pm
2 stops23h 16m
Panama City Tocumen Intl
jue. 5/28
10:00 am-8:42 pm
1 stop10h 42m
$552
Quickest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
dom. 5/17
6:00 am-12:50 pm
1 stop6h 50m
Panama City Tocumen Intl
lun. 6/1
2:15 pm-9:38 pm
1 stop7h 23m
$576
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
mié. 5/20
6:00 am-12:50 pm
1 stop6h 50m
Panama City Tocumen Intl
mar. 5/26
2:15 pm-9:38 pm
1 stop7h 23m
$588
Showing 1-10 of 24 resultsSorted by cheapest first
Best time to book a flight from Missouri to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
MCI-PTY
STL-PTY
SGF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Panama
USMO-PA0
MCI-PTY
STL-PTY
SGF-PTY
What is the cheapest month to book a flight from Missouri to Panama?
Currently, June is the cheapest month in which you can book a flight from Missouri to Panama (average of $194). Flying from Missouri to Panama in May is currently the most expensive (average of $451). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Panama by cabin class
Find flights from Missouri to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Panama flights
Browse other Missouri and Panama flight options. Last updated on abril 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Panama
Find the right flight back to Missouri after your stay in Panama
Missouri to Panama flights
Consider these flights traveling from Missouri to Panama.
Top 3 airlines flying from Missouri to Panama
Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$373 | Average$549 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$393 | Average$586 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$393 | Average$601 | FlexibilityNo cancel fee | On-time71% |