$186+ Cheap flights from Missouri to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Aug 5 — Aug 121
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Panama
Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated July 31, 2025.
Round-trip from | $393 (American Airlines) |
|---|---|
One-way from | $164 (United Airlines) |
Popular in | December |
Cheapest in | July |
Average price | $473 |
Find flight deals from Missouri to Panama
Cheapest flights from Missouri to PanamaExplore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - PTY
1 stop6h 56mDelta
Thu 11/133:17 pmPTY - STL
1 stop9h 22mDelta
Deal found 7/31![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:15 amSTL - PTY
1 stop7h 30mUnited Airlines
Thu 11/134:41 pmPTY - STL
2 stops19h 10mUnited Airlines
Deal found 7/31![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:05 amMCI - PTY
1 stop8h 09mUnited Airlines
Mon 9/2910:00 amPTY - MCI
1 stop12h 27mUnited Airlines
Deal found 7/29![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/35:28 amSTL - PTY
1 stop7h 27mAmerican Airlines
Sun 9/73:31 pmPTY - STL
2 stops20h 52mAmerican Airlines
Deal found 7/30![American Airlines logo]()
$420
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amMCI - PTY
1 stop6h 52mDelta
Sun 11/168:05 amPTY - MCI
1 stop15h 16mDelta
Deal found 7/31![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:06 amMCI - PTY
1 stop9h 25mAmerican Airlines
Fri 9/193:31 pmPTY - MCI
1 stop8h 28mAmerican Airlines
Deal found 7/29![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 pmSGF - PTY
2 stops18h 36mAmerican Airlines
Thu 11/132:43 pmPTY - SGF
2 stops22h 40mAmerican Airlines
Deal found 7/30![American Airlines logo]()
$526
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSGF - PTY
1 stop6h 56mDelta
Thu 11/133:17 pmPTY - SGF
1 stop8h 15mDelta
Deal found 7/30![Delta logo]()
$531
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:00 amSGF - PTY
1 stop9h 38mUnited Airlines
Tue 11/188:55 amPTY - SGF
1 stop11h 59mUnited Airlines
Deal found 7/30![United Airlines logo]()
$541
This Avianca Connect deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/85:15 amMCI - PTY
2 stops19h 30mMultiple Airlines
Fri 9/123:25 amPTY - MCI
2 stops19h 42mMultiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$549
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1410:35 amSTL - PTY
1 stop9h 44mMultiple Airlines
Sat 9/203:20 amPTY - STL
2 stops33h 42mMultiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$824
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.
Fly from
Missouri
Fly to
Panama
Route
Depart
Return
Price
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Mon 9/22
6:05 am-2:14 pm
1 stop8h 09m
Panama City Tocumen Intl
Mon 9/29
10:00 am-10:27 pm
1 stop12h 27m
$408
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 10/22
5:23 am-2:00 pm
1 stop8h 37m
Panama City Tocumen Intl
Sun 10/26
3:15 pm-11:56 pm
1 stop8h 41m
$415
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 9/3
11:05 am-6:37 pm
1 stop7h 32m
Panama City Tocumen Intl
Sun 9/7
3:30 pm-6:58 pm
1 stop27h 28m
$419
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Wed 11/12
6:00 am-1:52 pm
1 stop6h 52m
Panama City Tocumen Intl
Sun 11/16
8:05 am-10:21 pm
1 stop15h 16m
$428
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Mon 9/15
5:06 am-2:31 pm
1 stop9h 25m
Panama City Tocumen Intl
Fri 9/19
3:31 pm-11:59 pm
1 stop8h 28m
$443
SpringfieldPanama City
SGF - PTY
SGFPTY
Springfield-Branson
Thu 11/6
6:00 pm-1:36 pm
2 stops18h 36m
Panama City Tocumen Intl
Thu 11/13
2:43 pm-12:23 pm
2 stops22h 40m
$526
SpringfieldPanama City
SGF - PTY
SGFPTY
Springfield-Branson
Thu 11/6
6:00 am-1:56 pm
1 stop6h 56m
Panama City Tocumen Intl
Thu 11/13
3:17 pm-10:32 pm
1 stop8h 15m
$531
SpringfieldPanama City
SGF - PTY
SGFPTY
Springfield-Branson
Sat 11/15
9:00 am-7:38 pm
1 stop9h 38m
Panama City Tocumen Intl
Tue 11/18
8:55 am-7:54 pm
1 stop11h 59m
$541
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Mon 9/8
5:15 am-12:45 am
2 stops19h 30m
Panama City Tocumen Intl
Fri 9/12
3:25 am-11:07 pm
2 stops19h 42m
$549
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 9/14
10:35 am-8:19 pm
1 stop9h 44m
Panama City Tocumen Intl
Sat 9/20
3:20 am-1:02 pm
2 stops33h 42m
$824
Showing 1-10 of 13 results
Best time to book a flight from Missouri to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Panama
What is the cheapest month to book a flight from Missouri to Panama?
Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to PA?
Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.
When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 31, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Missouri to Panama by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Boarding
8.2
Food
7.3
Crew
8.5
Overall
8.0
Entertainment
7.9
Reviews
1 / 20
10.0
ExcellentKim,May 2025
PIH - SLC
Comfort
7.9
Boarding
8.2
Food
7.3
Crew
8.5
Overall
8.0
Entertainment
7.9
Reviews
1 / 20
10.0
ExcellentKim,May 2025
PIH - SLC
Comfort
7.9
Boarding
8.2
Food
7.3
Crew
8.5
Overall
8.0
Entertainment
7.9
Reviews
1 / 20
10.0
ExcellentKim,May 2025
PIH - SLC
Comfort
7.9
Boarding
8.2
Food
7.3
Crew
8.5
Overall
8.0
Entertainment
7.9
Reviews
1 / 20
10.0
ExcellentKim,May 2025
PIH - SLC
Related info for your journey
Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Missouri to Panama
Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$373 | Average$571 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$397 | Average$595 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$410 | Average$581 | FlexibilityNo cancel fee | On-time71% |