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Panama

$509+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$509
(Delta)

Popular in

December

Cheapest in

April

Average price

$617
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
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From Buffalo to Panama
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Highest demand for flights based on searches. 8% potential increase in price ($58 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:14 amBUF - PTY
2 stops28h 58mDelta
Mon 12/83:46 pmPTY - BUF
2 stops23h 29mDelta
Deal found 10/29$509
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:00 pmBUF - PTY
2 stops23h 45mUnited Airlines
Sun 12/214:41 pmPTY - BUF
2 stops24h 13mUnited Airlines
Deal found 10/29$539
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/177:59 pmBUF - PTY
2 stops18h 13mDelta
Mon 12/13:37 pmPTY - BUF
1 stop19h 27mDelta
Deal found 10/29$599
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:34 amBUF - PTY
2 stops10h 08mAmerican Airlines
Wed 12/312:53 pmPTY - BUF
2 stops21h 09mAmerican Airlines
Deal found 10/29$606
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:32 pmBUF - PTY
2 stops22h 10mAmerican Airlines
Sat 12/202:53 pmPTY - BUF
2 stops20h 29mAmerican Airlines
Deal found 10/29$618
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:30 pmBUF - PTY
2 stops19h 15mUnited Airlines
Mon 12/811:55 pmPTY - BUF
2 stops13h 17mUnited Airlines
Deal found 10/30$663
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:32 amBUF - PTY
2 stops31h 17mAmerican Airlines
Mon 12/12:43 pmPTY - BUF
2 stops32h 06mAmerican Airlines
Deal found 10/29$697
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:48 pmBUF - PTY
2 stops21h 19mUnited Airlines
Fri 12/2610:00 amPTY - BUF
1 stop8h 34mUnited Airlines
Deal found 10/29$707
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/133:18 pmBUF - PTY
1 stop19h 15mMultiple Airlines
Sat 12/209:40 amPTY - BUF
1 stop11h 10mMultiple Airlines
Deal found 10/29$779

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Buffalo

Fly to

Panama

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 11/24

9:14 am-2:12 pm

2 stops28h 58m

Panama City Tocumen Intl

Mon 12/8

3:46 pm-3:15 pm

2 stops23h 29m

$509

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 2/6

6:20 pm-5:10 am

1 stop10h 50m

Panama City Tocumen Intl

Wed 2/11

4:41 pm-1:17 pm

2 stops20h 36m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 2/6

6:53 pm-3:52 pm

2 stops20h 59m

Panama City Tocumen Intl

Wed 2/11

2:27 pm-10:59 am

2 stops20h 32m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/17

11:24 am-8:02 pm

1 stop8h 38m

Panama City Tocumen Intl

Fri 1/23

11:55 pm-8:29 pm

2 stops20h 34m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 3/16

6:45 pm-4:10 am

1 stop10h 25m

Panama City Tocumen Intl

Sat 3/21

10:55 pm-7:06 pm

2 stops19h 11m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 12/17

3:00 pm-2:45 pm

2 stops23h 45m

Panama City Tocumen Intl

Sun 12/21

4:41 pm-4:54 pm

2 stops24h 13m

$539

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama

What is the cheapest month to book a flight from Buffalo to Panama?

Currently, May is the cheapest month in which you can book a flight from Buffalo to Panama (average of $240). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to PA?

Find hourly flight availability from Buffalo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s optimal to fly from Buffalo to Panama in the evening. By choosing this option you can save up to 56% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Crew

8.5

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • How long is the flight from Buffalo to Panama?

    For as low as $522, Delta can have you in Panama from Buffalo in 10h 50m. The distance from Buffalo to Panama is about 2339 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama?

    Currently, May is the cheapest month in which you can book a flight from Buffalo to Panama (average of $240). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Buffalo to Panama

Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$486Average$674FlexibilityNo cancel feeOn-timeN/A

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