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Panama

$232+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Mar 11 — Mar 181
Wed 3/11
Wed 3/18
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This Expedia deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:39 pm
BUF
-
PTY
2 stops15h 51m
Multiple Airlines
Fri 5/153:50 pm
PTY
-
BUF
2 stops16h 10m
Multiple Airlines
Deal found 2/6$500
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:35 am
BUF
-
PTY
2 stops24h 55m
Multiple Airlines
Wed 3/1811:25 am
PTY
-
BUF
3 stops20h 39m
Multiple Airlines
Deal found 2/8$523
This Travelocity deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:35 pm
BUF
-
PTY
2 stops15h 55m
Multiple Airlines
Sun 3/157:50 pm
PTY
-
BUF
2 stops12h 14m
Multiple Airlines
Deal found 2/8$538
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:31 am
BUF
-
PTY
1 stop10h 00m
United Airlines
Sun 5/310:55 pm
PTY
-
BUF
1 stop9h 55m
United Airlines
Deal found 2/5$539
This Expedia deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:58 pm
BUF
-
PTY
3 stops19h 57m
Multiple Airlines
Wed 3/253:50 pm
PTY
-
BUF
2 stops16h 12m
Multiple Airlines
Deal found 2/5$541
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:50 pm
BUF
-
PTY
2 stops25h 47m
United Airlines
Wed 8/2610:00 am
PTY
-
BUF
2 stops22h 49m
United Airlines
Deal found 2/4$543
This Gurufare deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 am
BUF
-
PTY
1 stop14h 02m
Multiple Airlines
Sat 2/1410:00 am
PTY
-
BUF
1 stop11h 02m
Multiple Airlines
Deal found 2/5$549
This Orbitz deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
BUF
-
PTY
2 stops28h 30m
Multiple Airlines
Sun 3/13:50 pm
PTY
-
BUF
2 stops17h 50m
Multiple Airlines
Deal found 2/5$551
This Gurufare deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/76:00 am
BUF
-
PTY
1 stop14h 02m
Copa Airlines
Sat 2/144:41 pm
PTY
-
BUF
2 stops20h 31m
Copa Airlines
Deal found 2/5$553
This Orbitz deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:29 pm
BUF
-
PTY
2 stops14h 01m
Multiple Airlines
Sat 2/287:50 pm
PTY
-
BUF
2 stops13h 50m
Multiple Airlines
Deal found 2/5$586

Find flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated February 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$500
(Expedia)

One-way from

$232
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$583
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama
Search Deals
One-way flight from Buffalo to Panama
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Buffalo

Fly to

Panama

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 5/9

7:39 pm-10:30 am

2 stops15h 51m

Panama City Tocumen Intl

Fri 5/15

3:50 pm-9:00 am

2 stops16h 10m

$500

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/11

10:35 am-10:30 am

2 stops24h 55m

Panama City Tocumen Intl

Wed 3/18

11:25 am-9:04 am

3 stops20h 39m

$523

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/18

7:58 pm-6:55 pm

2 stops23h 57m

Panama City Tocumen Intl

Wed 3/25

3:50 pm-9:02 am

2 stops16h 12m

$535

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 4/30

10:31 am-7:31 pm

1 stop10h 00m

Panama City Tocumen Intl

Sun 5/3

10:55 pm-9:50 am

1 stop9h 55m

$539

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 5/9

7:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Fri 5/15

10:55 pm-10:04 am

1 stop10h 09m

$543

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/11

10:23 am-7:02 pm

1 stop9h 39m

Panama City Tocumen Intl

Wed 3/18

11:35 am-9:50 am

2 stops21h 15m

$543

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 3/24

7:30 pm-1:45 pm

2 stops19h 15m

Panama City Tocumen Intl

Tue 3/31

3:30 pm-1:13 pm

2 stops20h 43m

$543

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 2/26

6:00 am-10:30 am

2 stops28h 30m

Panama City Tocumen Intl

Sun 3/1

3:50 pm-9:40 am

2 stops17h 50m

$551

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 4/30

7:39 pm-10:30 am

2 stops15h 51m

Panama City Tocumen Intl

Sun 5/3

11:25 am-11:29 am

3 stops23h 04m

$609

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 6/18

5:47 pm-4:12 pm

2 stops23h 25m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/6

Showing 1-10 of 15 results
1
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Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama

What is the cheapest month to book a flight from Buffalo to Panama?

Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama (average of $453). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 9, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,173 reviews
Delta
7.9
Good
8,173 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • How long is the flight from Buffalo to Panama?

    For as low as $539, United Airlines can have you in Panama from Buffalo in 10h. The distance from Buffalo to Panama is about 2339 mi.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama (average of $453). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Buffalo to Panama

Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$497Average$632FlexibilityNo cancel feeOn-timeN/A

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