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$517+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated September 11, 2025.

Round-trip from

$517
(Delta)

Popular in

March

Cheapest in

April

Average price

$558
From Buffalo to Panama
Search Deals
High demand for flights, 4% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
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Find flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/287:30 pmBUF - PTY
2 stops19h 15mUnited Airlines
Sat 11/13:41 pmPTY - BUF
2 stops18h 22mUnited Airlines
Deal found 9/10$522
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:00 amBUF - PTY
1 stop7h 55mUnited Airlines
Sun 11/164:41 pmPTY - BUF
2 stops17h 22mUnited Airlines
Deal found 9/11$568
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:00 amBUF - PTY
1 stop7h 56mDelta
Sat 11/12:21 pmPTY - BUF
1 stop8h 18mDelta
Deal found 9/10$606
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:30 amBUF - PTY
1 stop8h 20mUnited Airlines
Sun 9/283:30 pmPTY - BUF
2 stops17h 23mUnited Airlines
Deal found 9/10$829
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:12 pmBUF - PTY
1 stop15h 21mMultiple Airlines
Sun 11/168:16 amPTY - BUF
1 stop9h 48mMultiple Airlines
Deal found 9/11$950
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/248:00 pmBUF - PTY
2 stops15h 25mMultiple Airlines
Sat 9/273:20 amPTY - BUF
2 stops14h 44mMultiple Airlines
Deal found 9/10$1,104
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2410:40 amBUF - PTY
1 stop10h 54mCopa Airlines
Sun 9/2810:29 pmPTY - BUF
1 stop10h 14mCopa Airlines
Deal found 9/10$1,295
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/287:30 pmBUF - PTY
2 stops15h 50mAvianca
Fri 10/312:55 amPTY - BUF
2 stops14h 51mAvianca
Deal found 9/10$1,526
This Gotogate deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:30 pmBUF - PTY
3 stops23h 55mAvianca
Sun 11/165:55 pmPTY - BUF
2 stops24h 49mAvianca
Deal found 9/11$3,740

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Buffalo

Fly to

Panama

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 2/1

6:00 am-2:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Thu 2/5

3:27 pm-11:57 pm

1 stop8h 30m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/31

6:00 am-8:04 pm

1 stop14h 04m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:57 pm

1 stop8h 30m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 1/29

6:00 am-2:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Tue 2/3

3:27 pm-11:57 pm

1 stop8h 30m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 1/30

6:00 am-8:04 pm

1 stop14h 04m

Panama City Tocumen Intl

Tue 2/3

3:27 pm-11:57 pm

1 stop8h 30m

$517

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 11/8

7:30 pm-1:55 pm

2 stops18h 25m

Panama City Tocumen Intl

Sun 11/16

4:41 pm-10:03 am

2 stops17h 22m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 9/24

5:54 pm-2:14 pm

2 stops21h 20m

Panama City Tocumen Intl

Sun 9/28

3:30 pm-9:53 am

2 stops17h 23m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 1/29

5:23 pm-5:07 pm

2 stops23h 44m

Panama City Tocumen Intl

Tue 2/3

4:41 pm-2:14 pm

2 stops21h 33m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 10/28

6:00 am-1:55 pm

1 stop8h 55m

Panama City Tocumen Intl

Sat 11/1

3:41 pm-11:03 am

2 stops18h 22m

$522

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 1/31

5:23 pm-5:07 pm

2 stops23h 44m

Panama City Tocumen Intl

Wed 2/4

4:41 pm-1:24 pm

2 stops20h 43m

$522

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama

What is the cheapest month to book a flight from Buffalo to Panama?

Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama (average of $478). Flying from Buffalo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to PA?

Find hourly flight availability from Buffalo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Buffalo to Panama as you normally would.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • How long is the flight from Buffalo to Panama?

    For as low as $517, Delta can have you in Panama from Buffalo in 8h 02m. The distance from Buffalo to Panama is about 2339 mi.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama?

    Currently, October is the cheapest month in which you can book a flight from Buffalo to Panama (average of $478). Flying from Buffalo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Buffalo to Panama

Discover the top 2 airlines that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$441Average$497FlexibilityNo cancel feeOn-time69%
DeltaCheapest$445Average$650FlexibilityNo cancel feeOn-timeN/A

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