What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

What is the most punctual flight time for Guayaquil to Panama City flights?

Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

Which airline has the best punctuality record on Guayaquil to Panama City flights?

Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 4% of flights being delayed.

How often are flights from Guayaquil to Panama City delayed?

About 4% of weekly flights between Guayaquil and Panama City have experienced delays in the past year, with the average delay time being 93 minutes.

How popular is this Guayaquil to Panama City flight route?

This flight path from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl was viewed by 70 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Guayaquil to Panama City?

There are many flights that can get you from Guayaquil to Panama City in 2h 11m. Fly via Copa Airlines to get the fastest option. There are 776 mi between Guayaquil and Panama City. All flights are typically nonstop.

What are the cheapest airlines flying from Guayaquil to Panama City round-trip?

Our cheapest airline available from Guayaquil to Panama City is Copa Airlines. Our recent data shows that you can find tickets from as low as $167 on this airline. An additional option worth looking into is Avianca, starting at $222. Copa Airlines is currently priced 45% below the average price you’ll pay for this route.

Weekly flight availability from Guayaquil to Panama City

The most flights from GYE to PTY are scheduled on a Saturday (16 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most reliable airlines from Guayaquil to Panama City?

No one likes to see their flight delayed. When booking a flight from Guayaquil to Panama City consider choosing Copa Airlines (93%), KLM (90%) or United Airlines (90%) as they are the most reliable in getting you off to your destination on time.

Most accurate provider : When it comes to deals on Guayaquil-Panama City flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Guayaquil-Panama City flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Guayaquil-Panama City flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Guayaquil-Panama City flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Guayaquil to Panama City?

You will need to book a flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl if you want to fly from Guayaquil to Panama City. At least 2 different airlines have flights from Jose Joaquin de Olmedo (GYE) to Tocumen Intl (PTY) on a regular basis. There are 11 flights to Panama City from the Guayaquil airport per day. If you manage to book one that is nonstop, then you can expect the flight time from GYE to PTY to be around 2h 08m.

Can I find deals for flights from Guayaquil to Panama City that include hotel bookings?

Yes. In addition to deals on Guayaquil to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Guayaquil to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Panama City.

Can I find deals for business class flights from Guayaquil to Panama City?

Yes. Cheapflights offers flight deals from Guayaquil to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$184+ Flights from Guayaquil to Panama City

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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl are usually found in May or June, booked 68 days in advance, depart on a Friday or Saturday and return on a Saturday

Cheap flight deals from Guayaquil to Panama City

Cheapest flights from Guayaquil to Panama City
Explore the most affordable flight options available from Guayaquil to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

Sat 12/2010:25 amGYE - PTY

1 stop6h 30mAvianca

Sat 12/272:55 amPTY - GYE

1 stop6h 20mAvianca

Deal found 12/14

$349

Tue 12/163:30 amGYE - PTY

1 stop10h 30mAvianca

Sat 12/202:55 amPTY - GYE

1 stop6h 20mAvianca

Deal found 12/12

$368

Thu 12/189:05 amGYE - PTY

1 stop7h 50mAvianca

Sat 12/202:55 amPTY - GYE

1 stop11h 35mAvianca

Deal found 12/14

$369

Tue 12/164:32 amGYE - PTY

Nonstop2h 09mCopa Airlines

Sun 12/219:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/11

$376

Fri 12/126:34 pmGYE - PTY

Nonstop2h 07mCopa Airlines

Tue 12/163:19 pmPTY - GYE

Nonstop2h 17mCopa Airlines

Deal found 12/12

$388

Fri 12/126:55 pmGYE - PTY

1 stop13h 55mAvianca

Wed 12/172:55 amPTY - GYE

2 stops8h 30mAvianca

Deal found 12/12

$398

Wed 12/246:45 amGYE - PTY

2 stops10h 10mAvianca

Tue 12/302:55 amPTY - GYE

2 stops9h 15mAvianca

Deal found 12/13

$416

Best flights from Guayaquil to Panama City
Discover carefully curated flight deals from Guayaquil to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 14, 2025.

Thu 12/182:35 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Tue 12/2311:17 amPTY - GYE

Nonstop2h 17mCopa Airlines

Deal found 12/14

$376

Sat 12/2012:20 pmGYE - PTY

Nonstop2h 12mCopa Airlines

Sun 12/2811:17 amPTY - GYE

Nonstop2h 17mCopa Airlines

Deal found 12/14

$376

Wed 12/176:34 pmGYE - PTY

Nonstop2h 07mCopa Airlines

Sun 12/219:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/11

$376

Fri 12/1912:20 pmGYE - PTY

Nonstop2h 12mCopa Airlines

Tue 12/239:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/13

$376

Wed 12/172:35 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Fri 12/2611:17 amPTY - GYE

Nonstop2h 17mCopa Airlines

Deal found 12/13

$376

Wed 1/286:33 pmGYE - PTY

Nonstop2h 08mCopa Airlines

Wed 2/49:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/12

$407

Wed 1/72:35 pmGYE - PTY

Nonstop2h 07mCopa Airlines

Sat 1/1011:17 amPTY - GYE

Nonstop2h 17mCopa Airlines

Deal found 12/11

$407

Sat 3/144:33 amGYE - PTY

Nonstop2h 10mCopa Airlines

Wed 3/189:40 pmPTY - GYE

Nonstop2h 15mCopa Airlines

Deal found 12/14

$407

Thu 1/156:33 pmGYE - PTY

Nonstop2h 08mCopa Airlines

Sun 1/186:27 pmPTY - GYE

Nonstop2h 19mCopa Airlines

Deal found 12/12

$407

Thu 1/226:33 pmGYE - PTY

Nonstop2h 08mCopa Airlines

Sat 1/319:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/12

$407

Last-minute flights from Guayaquil to Panama City
Discover last-minute flight deals from Guayaquil to Panama City. Data last updated December 14, 2025 and is based on user searches.

Wed 12/176:55 pmGYE - PTY

1 stop5h 45mAvianca

Sat 12/202:55 amPTY - GYE

1 stop6h 20mAvianca

Deal found 12/11

$368

Wed 12/172:35 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Sun 12/219:02 amPTY - GYE

Nonstop2h 16mCopa Airlines

Deal found 12/13

$376

Thu 12/189:05 amGYE - PTY

1 stop7h 50mAvianca

Sat 12/202:55 amPTY - GYE

1 stop11h 35mAvianca

Deal found 12/14

$369

Sat 12/2010:25 amGYE - PTY

1 stop6h 30mAvianca

Sat 12/272:55 amPTY - GYE

1 stop6h 20mAvianca

Deal found 12/14

$349

Fri 1/96:55 pmGYE - PTY

1 stop5h 45mAvianca

Mon 1/129:45 amPTY - GYE

1 stop4h 40mAvianca

Deal found 12/12

$339

Fri 1/93:35 pmGYE - PTY

1 stop9h 05mAvianca

Thu 1/152:55 amPTY - GYE

2 stops8h 30mAvianca

Deal found 12/12

$359

Sat 1/105:00 pmGYE - PTY

2 stops8h 00mAvianca

Sat 1/172:55 pmPTY - GYE

1 stop8h 40mAvianca

Deal found 12/12

$388

Sun 1/114:40 amGYE - PTY

1 stop9h 20mAvianca

Tue 1/132:55 amPTY - GYE

2 stops13h 25mAvianca

Deal found 12/13

$373

Tue 1/133:30 amGYE - PTY

1 stop5h 20mAvianca

Sat 1/175:50 pmPTY - GYE

2 stops15h 10mAvianca

Deal found 12/11

$379

One-way flights from Guayaquil to Panama City
Search for one-way flight options from Guayaquil to Panama City. Find affordable one-way fares based on user searches. Data last updated December 14, 2025.

Thu 1/110:25 amGYE - PTY

1 stop6h 30mAvianca

Deal found 12/11

$184

Thu 1/2212:20 pmGYE - PTY

Nonstop2h 08mCopa Airlines

Deal found 12/12

$200

Fri 1/164:40 pmGYE - PTY

2 stops8h 00mAvianca

Deal found 12/11

$226

Mon 12/222:35 pmGYE - PTY

Nonstop2h 11mCopa Airlines

Deal found 12/14

$260

Sat 2/145:29 amGYE - PTY

Nonstop2h 10mCopa Airlines

Deal found 12/14

$279

Tue 1/139:00 pmGYE - PTY

2 stops19h 55mAvianca

Deal found 12/11

$315

Thu 1/16:34 amGYE - PTY

2 stops10h 21mMultiple Airlines

Deal found 12/11

$360

Fri 2/64:33 amGYE - PTY

Nonstop2h 08mCopa Airlines

Deal found 12/14

$483

Sat 2/78:00 pmGYE - PTY

2 stops18h 00mAvianca

Deal found 12/14

$512

Thu 2/198:34 amGYE - PTY

Nonstop2h 07mCopa Airlines

Deal found 12/13

$751

Find flight deals from Guayaquil to Panama City

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$339 (Avianca)
One-way from	$184 (FlightHub)
Popular in	November
Cheapest in	May
Average price	$359
Good round-trip deal	$376 or less
Good one-way deal	$238 or less

Provider with most accurate pricing for Guayaquil Jose Joaquin de Olmedo-Panama City Tocumen Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Guayaquil Jose Joaquin de Olmedo-Panama City Tocumen Intl flights.

Search Deals

From Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl

Search Deals

One-way flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 13% potential increase in price ($47 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl.

Search Deals

Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Guayaquil to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Thu 12/18

2:35 pm-4:46 pm

Nonstop2h 11m

Panama City Tocumen Intl

Tue 12/23

11:17 am-1:34 pm

Nonstop2h 17m

$376

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Sat 12/20

12:20 pm-2:32 pm

Nonstop2h 12m

Panama City Tocumen Intl

Sun 12/28

11:17 am-1:34 pm

Nonstop2h 17m

$376

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 12/17

6:34 pm-8:41 pm

Nonstop2h 07m

Panama City Tocumen Intl

Sun 12/21

9:02 am-11:18 am

Nonstop2h 16m

$376

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Fri 12/19

12:20 pm-2:32 pm

Nonstop2h 12m

Panama City Tocumen Intl

Tue 12/23

9:02 am-11:18 am

Nonstop2h 16m

$376

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 12/17

2:35 pm-4:46 pm

Nonstop2h 11m

Panama City Tocumen Intl

Fri 12/26

11:17 am-1:34 pm

Nonstop2h 17m

$376

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 1/28

6:33 pm-8:41 pm

Nonstop2h 08m

Panama City Tocumen Intl

Wed 2/4

9:02 am-11:18 am

Nonstop2h 16m

$407

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Wed 1/7

2:35 pm-4:42 pm

Nonstop2h 07m

Panama City Tocumen Intl

Sat 1/10

11:17 am-1:34 pm

Nonstop2h 17m

$407

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Sat 3/14

4:33 am-6:43 am

Nonstop2h 10m

Panama City Tocumen Intl

Wed 3/18

9:40 pm-11:55 pm

Nonstop2h 15m

$407

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Thu 1/15

6:33 pm-8:41 pm

Nonstop2h 08m

Panama City Tocumen Intl

Sun 1/18

6:27 pm-8:46 pm

Nonstop2h 19m

$407

GuayaquilPanama City

GYE - PTY

GYEPTY

Guayaquil Jose Joaquin de Olmedo

Thu 1/22

6:33 pm-8:41 pm

Nonstop2h 08m

Panama City Tocumen Intl

Sat 1/31

9:02 am-11:18 am

Nonstop2h 16m

$407

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 18 results

Compare providers for flights from Guayaquil to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Panama City in December.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
Kiwi.com	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Guayaquil-Panama City flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Guayaquil-Panama City flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Guayaquil-Panama City flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Guayaquil-Panama City flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guayaquil to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Guayaquil with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Panama City

Prices

Airlines

Delays

How far ahead should I book a flight from Guayaquil to Panama City?

The best time to book flights from Guayaquil to Panama City is 68 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Guayaquil to Panama City?

Currently, May is the cheapest month in which you can book a flight from Guayaquil to Panama City (average of $120). Flying from Guayaquil to Panama City in November is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to PTY?

A simple way to save on the total cost of your ticket is to fly from Guayaquil to Panama City in the afternoon. If you’re flexible enough to do this you can expect to save up to 25% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Guayaquil to Panama City?

Travelers seeking maximum savings on their Guayaquil to Panama City flight should consider departing on Friday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

The best insider tips for Guayaquil to Panama City flights

Cheapflights partnered with top experts to bring you the best recommendations for your Guayaquil to Panama City trip

Airlines

United Airlines

United’s Economy Plus provides extra legroom and priority boarding, enhancing comfort on international flights.

United’s Premium Plus offers upgraded comfort with bigger seats, extra legroom, and priority check-in.

Copa Airlines

Copa’s punctuality is impressive, ranking third globally with 89.46% on-time arrivals in 2023.

Copa’s Economy Classic offers one checked bag and advance seat selection, ideal for value-conscious travelers.

Our travel experts

Harriet Baskas

Expert on United Airlines

Paul Rubio

Expert on Copa Airlines

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Guayaquil to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.6

Good

1,557 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Copa Airlines

7.6

Good

1,557 reviews

Copa Airlines

7.6

Good

1,557 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Avianca

6.6

Okay

2,485 reviews

Copa Airlines

7.6

Good

1,557 reviews

Reviews

1 / 20

10.0

Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

What airports do I use to fly from Guayaquil to Panama City?
You will need to book a flight from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl if you want to fly from Guayaquil to Panama City. At least 2 different airlines have flights from Jose Joaquin de Olmedo (GYE) to Tocumen Intl (PTY) on a regular basis. There are 11 flights to Panama City from the Guayaquil airport per day. If you manage to book one that is nonstop, then you can expect the flight time from GYE to PTY to be around 2h 08m.
How popular is this Guayaquil to Panama City flight route?
This flight path from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl was viewed by 70 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Guayaquil to Panama City?
There are many flights that can get you from Guayaquil to Panama City in 2h 11m. Fly via Copa Airlines to get the fastest option. There are 776 mi between Guayaquil and Panama City. All flights are typically nonstop.
What are the cheapest airlines flying from Guayaquil to Panama City round-trip?
Our cheapest airline available from Guayaquil to Panama City is Copa Airlines. Our recent data shows that you can find tickets from as low as $167 on this airline. An additional option worth looking into is Avianca, starting at $222. Copa Airlines is currently priced 45% below the average price you’ll pay for this route.
What are the most reliable airlines from Guayaquil to Panama City?
No one likes to see their flight delayed. When booking a flight from Guayaquil to Panama City consider choosing Copa Airlines (93%), KLM (90%) or United Airlines (90%) as they are the most reliable in getting you off to your destination on time.
What are the cheapest flights from Guayaquil to Panama City?
Looking at all options, your cheapest flight can be booked for $185. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Panama City Tocumen Intl) can be booked for $374 on average, our data indicates $770 when flying from Guayaquil to Panama City.
Can I find deals for flights from Guayaquil to Panama City that include hotel bookings?
Yes. In addition to deals on Guayaquil to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Guayaquil to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Panama City.
Can I find deals for business class flights from Guayaquil to Panama City?
Yes. Cheapflights offers flight deals from Guayaquil to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Guayaquil to Panama City?
Currently, May is the cheapest month in which you can book a flight from Guayaquil to Panama City (average of $120). Flying from Guayaquil to Panama City in November is currently the most expensive (average of $188). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Guayaquil to Panama City

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Complete your trip

Panama City car rentals

Panama City Tocumen Intl Airport car rentals

Casco Viejo car rentals

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Ancón car rentals

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Bethania car rentals

Parque Lefevre car rentals

Juan Diaz car rentals

Pueblo Nuevo car rentals

Other flights to Panama City

Top 2 airlines flying from Guayaquil to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$222	Average$382	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$236	Average$339	FlexibilityNo cancel fee	On-time71%

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$184+ Cheap flights from Guayaquil (GYE) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Guayaquil to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Panama City Tocumen Intl are usually found in May or June, booked 68 days in advance, depart on a Friday or Saturday and return on a Saturday

Cheap flight deals from Guayaquil to Panama City

Cheapest flights from Guayaquil to Panama CityExplore the most affordable flight options available from Guayaquil to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

Explore the most affordable flight options available from Guayaquil to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

Find flight deals from Guayaquil to Panama City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Cheapflights Fare Finder

Use the filters below to find and compare flights from Guayaquil to Panama City that are best for you.

Compare providers for flights from Guayaquil to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guayaquil to Panama City in December.

Best time to book a flight from Guayaquil to Panama City

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Everything you need to know about your flight from Guayaquil to Panama City

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Weekly flight availability from Guayaquil to Panama City

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The best insider tips for Guayaquil to Panama City flights

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Airlines

United Airlines

Copa Airlines

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Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Guayaquil to Panama City, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

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Top 2 airlines flying from Guayaquil to Panama City

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Cheapest flights from Guayaquil to Panama City
Explore the most affordable flight options available from Guayaquil to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.