HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$319+ Cheap flights from Buffalo to Panama City, FL (BUF - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — ECP
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Buffalo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Buffalo to Panama City NW Florida Beaches are usually found in November or February, booked 90 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Buffalo to Panama City

Cheapest flights from Buffalo to Panama City
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:01 pmBUF - ECP
2 stops12h 01mDelta
Wed 12/318:02 amECP - BUF
1 stop3h 59mDelta
Deal found 12/13$512
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:00 amBUF - ECP
1 stop5h 37mAmerican Airlines
Thu 1/17:15 amECP - BUF
1 stop4h 42mAmerican Airlines
Deal found 12/13$598
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amBUF - ECP
1 stop14h 56mDelta
Wed 12/318:02 amECP - BUF
1 stop3h 59mDelta
Deal found 12/13$747
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:15 pmBUF - ECP
1 stop5h 38mAmerican Airlines
Thu 1/17:15 amECP - BUF
1 stop4h 42mAmerican Airlines
Deal found 12/13$797
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:20 pmBUF - ECP
1 stop5h 35mAmerican Airlines
Sat 12/204:09 pmECP - BUF
1 stop7h 03mAmerican Airlines
Deal found 12/13$817
This Southwest deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amBUF - ECP
2 stops7h 55mSouthwest
Sat 12/206:00 pmECP - BUF
1 stop4h 45mSouthwest
Deal found 12/13$822
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:15 pmBUF - ECP
1 stop5h 43mAmerican Airlines
Thu 1/17:15 amECP - BUF
1 stop4h 42mAmerican Airlines
Deal found 12/13$857
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amBUF - ECP
1 stop18h 53mAmerican Airlines
Thu 1/17:15 amECP - BUF
1 stop4h 42mAmerican Airlines
Deal found 12/13$881

Find flight deals from Buffalo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$319
(American Airlines)

One-way from

$160
(American Airlines)

Popular in

April

Cheapest in

November

Average price

$488
Provider with most accurate pricing for Buffalo-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City NW Florida Beaches flights.
Search Deals
From Buffalo to Panama City NW Florida Beaches
Search Deals
One-way flight from Buffalo to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Buffalo

Fly to

Panama City

Route

Depart

Return

Price

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/30

12:58 pm-5:33 pm

1 stop5h 35m

Panama City NW Florida Beaches

Thu 2/5

12:03 pm-6:13 pm

1 stop5h 10m

$319

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/16

6:26 pm-10:51 pm

1 stop5h 25m

Panama City NW Florida Beaches

Tue 1/20

6:00 am-11:19 am

1 stop4h 19m

$328

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 1/7

7:00 am-11:33 am

1 stop5h 33m

Panama City NW Florida Beaches

Sun 1/11

6:03 pm-11:41 pm

1 stop4h 38m

$336

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Tue 2/24

1:20 pm-6:10 pm

1 stop5h 50m

Panama City NW Florida Beaches

Mon 3/2

7:35 am-1:55 pm

1 stop5h 20m

$341

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Tue 2/24

11:51 am-6:52 pm

2 stops8h 01m

Panama City NW Florida Beaches

Mon 3/2

6:06 pm-11:31 pm

1 stop4h 25m

$346

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Tue 2/24

11:19 am-10:37 pm

2 stops12h 18m

Panama City NW Florida Beaches

Mon 3/2

7:19 am-1:03 pm

1 stop4h 44m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Compare providers for flights from Buffalo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

How far ahead should I book a flight from Buffalo to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Buffalo to Panama City. Price data was last updated on December 12, 2025.

The best time to book flights from Buffalo to Panama City, Florida is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

Currently, December is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of $82). Flying from Buffalo to Panama City, Florida in July is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to ECP?

Find hourly flight availability from Buffalo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 14, 2025.

It’s typically best to fly out from Buffalo to Panama City, Florida in the evening. Doing so could potentially save you 15% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 14, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from Buffalo to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,007 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,052 reviews
Southwest
7.9
Good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Overall

7.9

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Panama City, Florida?

    American Airlines can get you from Buffalo to Panama City, Florida in just under 5h 35m. Your travel time can differ by up to . Airlines will cover a distance of 952 mi.

  • What are the cheapest airlines flying from Buffalo to Panama City, Florida round-trip?

    Our cheapest airline available from Buffalo to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $222 on this airline. Additional options worth looking into are American Airlines and Southwest, starting at $292 and $381 round-trip. Delta is priced at 48% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City, Florida?

    Currently, December is the cheapest month in which you can book a flight from Buffalo to Panama City, Florida (average of $82). Flying from Buffalo to Panama City, Florida in July is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Miami flights
Newark to Miami flights
Newark to Fort Lauderdale flights
LaGuardia to Miami flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
Newark to West Palm Beach flights
Newark to Orlando flights
John F Kennedy Intl to West Palm Beach flights
John F Kennedy Intl to Tampa flights
LaGuardia to Orlando flights
LaGuardia to West Palm Beach flights
Newark to Tampa flights
LaGuardia to Tampa flights
Newark to Fort Myers flights
John F Kennedy Intl to Fort Myers flights
LaGuardia to Fort Myers flights
White Plains to Orlando flights
Buffalo to Orlando flights
John F Kennedy Intl to Sarasota flights
Newark to Sarasota flights
Newark to Jacksonville flights
Islip to Orlando flights
Islip to West Palm Beach flights
Newark to Key West flights
Syracuse to Orlando flights
John F Kennedy Intl to Jacksonville flights
Islip to Fort Lauderdale flights
LaGuardia to Jacksonville flights
White Plains to West Palm Beach flights
Albany to Orlando flights
LaGuardia to Sarasota flights
White Plains to Fort Lauderdale flights
Buffalo to Fort Lauderdale flights
White Plains to Miami flights
LaGuardia to Key West flights
Rochester to Orlando flights
John F Kennedy Intl to Key West flights
Stewart to Orlando flights
Islip to Tampa flights
White Plains to Tampa flights
Albany to Fort Lauderdale flights
Buffalo to Tampa flights
Stewart to Fort Lauderdale flights
White Plains to Fort Myers flights
Albany to Tampa flights
John F Kennedy Intl to Daytona Beach flights
Newark to St Petersburg flights
Newark to Orlando Sanford Intl flights

Top 3 airlines flying from Buffalo to Panama City

Discover the top 3 airlines that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$270Average$406FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$555FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$381Average$629FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.