$183+ Cheap flights from Buffalo to Panama City, FL (BUF - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — ECP
Apr 16 — Apr 231
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:28 pm
BUF
- ECP
1 stop5h 18m
American Airlines
Tue 5/124:40 pm
ECP
- BUF
1 stop5h 00m
American Airlines
Deal found 3/13![American Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
BUF
- ECP
1 stop5h 03m
American Airlines
Sat 5/212:52 pm
ECP
- BUF
1 stop7h 42m
American Airlines
Deal found 3/12![American Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:04 am
BUF
- ECP
2 stops8h 08m
United Airlines
Wed 5/62:14 pm
ECP
- BUF
1 stop5h 47m
United Airlines
Deal found 3/12![United Airlines logo]()
$394
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 17, 2026.
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
BUF
- ECP
1 stop7h 12m
United Airlines
Wed 5/62:14 pm
ECP
- BUF
1 stop5h 47m
United Airlines
Deal found 3/12![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:40 pm
BUF
- ECP
1 stop4h 32m
Delta
Mon 5/45:49 am
ECP
- BUF
1 stop4h 12m
Delta
Deal found 3/12![Delta logo]()
$411
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:50 am
BUF
- ECP
2 stops8h 25m
Southwest
Fri 5/19:55 am
ECP
- BUF
1 stop7h 15m
Southwest
Deal found 3/15![Southwest logo]()
$412
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:13 pm
BUF
- ECP
2 stops8h 24m
American Airlines
Thu 7/91:17 pm
ECP
- BUF
2 stops7h 38m
American Airlines
Deal found 3/17![American Airlines logo]()
$437
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:31 pm
BUF
- ECP
1 stop7h 05m
Delta
Mon 5/116:00 am
ECP
- BUF
1 stop4h 13m
Delta
Deal found 3/13![Delta logo]()
$421
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated March 17, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated March 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:40 pm
BUF
- ECP
1 stop5h 09m
American Airlines
Wed 4/810:48 am
ECP
- BUF
2 stops9h 32m
American Airlines
Deal found 3/15![American Airlines logo]()
$432
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/54:47 pm
BUF
- ECP
1 stop7h 17m
Delta
Wed 4/86:00 am
ECP
- BUF
1 stop4h 01m
Delta
Deal found 3/16![Delta logo]()
$514
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
BUF
- ECP
1 stop5h 03m
American Airlines
Sat 5/212:52 pm
ECP
- BUF
1 stop7h 42m
American Airlines
Deal found 3/12![American Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:50 am
BUF
- ECP
1 stop4h 50m
Southwest
Fri 5/19:55 am
ECP
- BUF
1 stop7h 15m
Southwest
Deal found 3/15![Southwest logo]()
$407
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated March 17, 2026.
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:59 pm
BUF
- ECP
1 stop4h 53m
American Airlines
Deal found 3/13![American Airlines logo]()
$183
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:00 am
BUF
- ECP
1 stop7h 21m
United Airlines
Deal found 3/12![United Airlines logo]()
$204
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:57 pm
BUF
- ECP
1 stop7h 07m
Delta
Deal found 3/15![Delta logo]()
$211
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:19 pm
BUF
- ECP
2 stops8h 21m
American Airlines
Deal found 3/12![American Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:40 pm
BUF
- ECP
1 stop4h 32m
Delta
Deal found 3/16![Delta logo]()
$260
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:28 pm
BUF
- ECP
1 stop5h 18m
American Airlines
Deal found 3/15![American Airlines logo]()
$265
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:40 pm
BUF
- ECP
1 stop4h 32m
Delta
Deal found 3/12![Delta logo]()
$268
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
BUF
- ECP
1 stop7h 23m
United Airlines
Deal found 3/15![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:35 pm
BUF
- ECP
1 stop19h 09m
American Airlines
Deal found 3/12![American Airlines logo]()
$329
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $365 (American Airlines) |
One-way from | $160 (American Airlines) |
Popular in | April |
Cheapest in | November |
Average price | $455 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 5/5
7:00 am-1:12 pm
1 stop7h 12m
Panama City NW Florida Beaches
Wed 5/6
2:14 pm-9:01 pm
1 stop5h 47m
$389
Quickest round-trip
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Fri 5/1
7:40 pm-11:12 pm
1 stop4h 32m
Panama City NW Florida Beaches
Mon 5/4
5:49 am-11:01 am
1 stop4h 12m
$411
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Sun 4/26
5:50 am-1:15 pm
2 stops8h 25m
Panama City NW Florida Beaches
Fri 5/1
9:55 am-6:10 pm
1 stop7h 15m
$412
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Sat 5/9
12:31 pm-6:36 pm
1 stop7h 05m
Panama City NW Florida Beaches
Mon 5/11
6:00 am-11:13 am
1 stop4h 13m
$421
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Fri 7/3
4:13 pm-11:37 pm
2 stops8h 24m
Panama City NW Florida Beaches
Thu 7/9
1:17 pm-9:55 pm
2 stops7h 38m
$437
Cheapest one-way
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 4/7
3:55 pm-10:52 pm
2 stops7h 57m
$188
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 6/16
7:00 am-1:21 pm
1 stop7h 21m
$204
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Tue 6/16
1:45 pm-6:26 pm
1 stop5h 41m
$204
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Wed 4/22
7:28 pm-11:46 pm
1 stop5h 18m
$265
Quickest one-way
BuffaloPanama City
BUF - ECP
BUFECP
Buffalo
Thu 4/23
7:40 pm-11:12 pm
1 stop4h 32m
$268
Sorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 17, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Buffalo to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Complete your trip
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Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on March 17, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Panama City
Discover the top 3 airlines that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$406 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$292 | Average$480 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$302 | Average$663 | FlexibilityNo cancel fee | On-time63% |