HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Bruxelles-National

$645+ Cheap flights from Panama City (PTY) to Bruxelles-National (BRU)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BRU
dic. 3 — dic. 101
mié. 12/3
mié. 12/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Bruxelles-National with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Brussels Bruxelles-National are usually found in January or February, booked 42 days in advance, depart on a Monday or Saturday and return on a Tuesday

Find flight deals from Panama City to Bruxelles-National

Cheapest flights from Panama City to Bruxelles-National
Explore the most affordable flight options available from Panama City to Bruxelles-National. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 3, 2025.

This FlightHub deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/109:30 pmPTY - BRU
1 stop30h 20mAir Europa
mié. 2/410:45 amBRU - PTY
1 stop15h 00mAir Europa
Deal found 11/3$789
This FlightHub deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/109:45 pmPTY - BRU
1 stop37h 35mTurkish Airlines
mié. 2/47:50 amBRU - PTY
2 stops39h 15mTurkish Airlines
Deal found 11/3$803
This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/229:45 pmPTY - BRU
1 stop37h 20mTurkish Airlines
vie. 12/511:35 amBRU - PTY
1 stop38h 15mTurkish Airlines
Deal found 11/3$815
This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/229:45 pmPTY - BRU
1 stop18h 25mTurkish Airlines
mar. 12/911:35 amBRU - PTY
1 stop38h 15mTurkish Airlines
Deal found 11/3$922
This Turkish Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/306:45 pmPTY - BRU
1 stop37h 30mTurkish Airlines
dom. 12/711:35 amBRU - PTY
2 stops35h 30mTurkish Airlines
Deal found 11/2$1,026
This KLM deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/276:45 pmPTY - BRU
1 stop13h 30mKLM
sáb. 1/32:45 pmBRU - PTY
1 stop31h 45mKLM
Deal found 11/2$1,036
This Turkish Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/256:45 pmPTY - BRU
1 stop37h 30mTurkish Airlines
vie. 12/511:35 amBRU - PTY
1 stop38h 15mTurkish Airlines
Deal found 11/3$1,073
This KLM deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/286:45 pmPTY - BRU
1 stop13h 30mKLM
sáb. 1/32:45 pmBRU - PTY
1 stop31h 45mKLM
Deal found 11/2$1,111
This Gotogate deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/309:30 pmPTY - BRU
1 stop14h 15mAir Europa
dom. 12/710:45 amBRU - PTY
1 stop15h 00mAir Europa
Deal found 11/2$1,116
This Air Europa deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/239:30 pmPTY - BRU
1 stop14h 15mAir Europa
dom. 12/710:45 amBRU - PTY
1 stop15h 00mAir Europa
Deal found 11/3$1,125
This Air Europa deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/239:30 pmPTY - BRU
1 stop14h 15mAir Europa
sáb. 12/66:55 pmBRU - PTY
1 stop30h 50mAir Europa
Deal found 11/3$1,135

Cheap flight deals from Panama City to Bruxelles-National

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Bruxelles-National (BRU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated noviembre 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$749
(Turkish Airlines)

One-way from

$645
(Mytrip)

Popular in

December

Cheapest in

January

Average price

$904
Provider with most accurate pricing for Panama City Tocumen Intl-Brussels Bruxelles-National flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Brussels Bruxelles-National flights.
Search Deals
From Panama City Tocumen Intl to Brussels Bruxelles-National
Search Deals
One-way flight from Panama City Tocumen Intl to Brussels Bruxelles-National
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Bruxelles-National that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 3, 2025.
Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Panama City

Fly to

Bruxelles-National

Route

Depart

Return

Price

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

sáb. 11/22

9:45 pm-5:05 pm

1 stop37h 20m

Brussels Bruxelles-National

vie. 12/5

11:35 am-7:50 pm

1 stop38h 15m

$815

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

mié. 11/26

9:45 pm-10:10 pm

1 stop18h 25m

Brussels Bruxelles-National

vie. 12/5

6:20 pm-7:50 pm

1 stop31h 30m

$815

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

sáb. 2/14

9:45 pm-10:35 am

1 stop30h 50m

Brussels Bruxelles-National

jue. 2/26

7:50 am-5:05 pm

2 stops39h 15m

$825

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

sáb. 2/14

10:05 pm-10:20 pm

1 stop18h 15m

Brussels Bruxelles-National

jue. 2/26

6:15 am-4:30 pm

1 stop16h 15m

$828

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

jue. 3/19

6:45 pm-10:10 pm

1 stop21h 25m

Brussels Bruxelles-National

mié. 4/1

7:20 am-6:30 pm

2 stops42h 10m

$917

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

dom. 2/8

10:20 pm-10:20 pm

2 stops18h 00m

Brussels Bruxelles-National

jue. 2/12

2:45 pm-4:30 pm

1 stop31h 45m

$937

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

vie. 1/30

6:45 pm-2:15 pm

1 stop13h 30m

Brussels Bruxelles-National

dom. 2/15

2:45 pm-4:30 pm

1 stop31h 45m

$944

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

jue. 3/19

5:50 pm-7:00 pm

2 stops19h 10m

Brussels Bruxelles-National

mié. 4/1

7:45 pm-8:55 am

2 stops20h 10m

$1,011

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

dom. 11/30

6:45 pm-2:15 pm

1 stop37h 30m

Brussels Bruxelles-National

dom. 12/7

11:35 am-5:05 pm

2 stops35h 30m

$1,026

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

lun. 3/30

3:25 am-8:05 pm

3 stops33h 40m

$645

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 12 results
1
2

Compare providers for flights from Panama City to Bruxelles-National

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Bruxelles-National in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
Trip.comPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City-Brussels Bruxelles-National Airport flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Panama City-Brussels Bruxelles-National Airport flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Panama City-Brussels Bruxelles-National Airport flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Brussels Bruxelles-National Airport flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Brussels Bruxelles-National Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Bruxelles-National

Have a flexible travel schedule? Discover the best time to fly to Bruxelles-National from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Brussels Bruxelles-National Airport

How far ahead should I book a flight from Panama City to Brussels Bruxelles-National Airport?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Bruxelles-National. Price data was last updated on October 31, 2025.

The price you pay for your flight from Panama City to Brussels Bruxelles-National Airport may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

Currently, January is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of $685). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to BRU?

Find hourly flight availability from Panama City to Bruxelles-National. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 3, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City to Brussels Bruxelles-National Airport in the evening. If you’re flexible enough to do this you can expect to save up to 16% on your trip compared to booking a flight in the afternoon.

How much does it cost to fly round-trip from Panama City to Brussels Bruxelles-National Airport?

Reviews of airlines servicing Bruxelles-National

Get insights into the airlines that provide service to Bruxelles-National. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Bruxelles-National. Reviews last updated noviembre 3, 2025.
Read reviews from past customers who have flown Air France and Air Europa from Panama City to Brussels Bruxelles-National Airport. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,482 reviews

Entertainment

7.0

Food

7.0

Crew

8.2

Overall

7.4

Boarding

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air France
7.4
Good
1,482 reviews
Air France
7.4
Good
1,482 reviews

Entertainment

7.0

Food

7.0

Crew

8.2

Overall

7.4

Boarding

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.
Air Europa
7.0
Good
568 reviews
Air France
7.4
Good
1,482 reviews

Entertainment

7.0

Food

7.0

Crew

8.2

Overall

7.4

Boarding

7.4

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

SYLVIA,Apr 2025

TLV - CDG

A newer plane. The flight from TelAviv to Paris was on a new aircraft, wider seat. ,more privacy. Nice toilets. The flight from Paris to Santiago Chile was on a very old aircraft. Awful toilets, outmoded sits etc.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Bruxelles-National. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Brussels Bruxelles-National?

    If you book a flight to Brussels Bruxelles-National from Panama City, you will be flying from Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City. There are 0 flights from Tocumen Intl to Brussels Bruxelles-National per day from 2 different airlines.

  • How long is the flight from Panama City to Brussels Bruxelles-National Airport?

    Departing from Panama City to Brussels Bruxelles-National Airport will take you 33h 50m. The distance from Panama City to Brussels Bruxelles-National Airport is about 5462 mi.

  • What are the cheapest airlines flying from Panama City to Brussels Bruxelles-National Airport round-trip?

    Flying on Air France is currently your cheapest option to Brussels Bruxelles-National Airport, with prices starting at $785. Another option worth looking into is Air Europa, starting at $797 round trip. Air France is 9% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Panama City to Bruxelles-National that include hotel bookings?

    Yes. In addition to deals on Panama City to Bruxelles-National flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Bruxelles-National?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Bruxelles-National.

  • Can I find deals for business class flights from Panama City to Bruxelles-National?

    Yes. Cheapflights offers flight deals from Panama City to Bruxelles-National by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Brussels Bruxelles-National Airport?

    Currently, January is the cheapest month in which you can book a flight from Panama City to Brussels Bruxelles-National Airport (average of $685). Flying from Panama City to Brussels Bruxelles-National Airport in December is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Brussels Bruxelles-National Airport?

Book flights to Brussels Bruxelles-National Airport if you plan to visit one of these locations
Charleroi
Mons
Hasselt
Mechelen
Zaventem

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Other flights to Bruxelles-National

Explore flights to Bruxelles-National departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on noviembre 3, 2025.
Newark to Bruxelles-National flights
John F Kennedy Intl to Bruxelles-National flights
Dulles Intl to Bruxelles-National flights
O'Hare Intl to Bruxelles-National flights
Boston to Bruxelles-National flights
Brussels Bruxelles-National Airport to Dublin flights
Brussels Bruxelles-National Airport to Barcelona-El Prat Airport flights
Brussels Bruxelles-National Airport to Marrakech flights
Brussels Bruxelles-National Airport to Dublin flights
Brussels Bruxelles-National Airport to Bucharest Otopeni Intl Airport flights
Brussels Bruxelles-National Airport to Nice flights
Brussels Bruxelles-National Airport to Barcelona-El Prat Airport flights
Brussels Bruxelles-National Airport to Geneva flights
Brussels Bruxelles-National Airport to Bilbao flights
Brussels Bruxelles-National Airport to Madrid flights
Brussels Bruxelles-National Airport to Milan Linate Airport flights
Brussels Bruxelles-National Airport to Geneva flights
Brussels Bruxelles-National Airport to Alicante flights
Brussels Bruxelles-National Airport to Bucharest Otopeni Intl Airport flights
Brussels Bruxelles-National Airport to Rome Fiumicino Airport flights
Brussels Bruxelles-National Airport to Istanbul Sabiha Gokcen Airport flights
Brussels Bruxelles-National Airport to Málaga flights
Brussels Bruxelles-National Airport to Heraklion flights

Top 2 airlines flying from Panama City to Bruxelles-National

Discover the top 2 airlines that operate flights from Panama City to Bruxelles-National. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
Air FranceCheapest$785Average$1,039FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$797Average$903FlexibilityNo cancel feeOn-time83%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.