$551+ Cheap flights from O'Hare Intl (ORD) to Florence, AL (MSL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — MSL
Nov 5 — Nov 121
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Florence
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Best
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Cheapest flights from O'Hare Intl to FlorenceExplore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 6, 2026.
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 6, 2026.
This Mytrip deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:11 pm -
2 stops15h 49m
Fri 10/307:25 am -
2 stops12h 34m
Deal found 10/4![Multiple Airlines logo]()
$551
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/192:10 pm -
1 stop28h 40m
Thu 12/317:50 am -
1 stop16h 40m
Deal found 10/4![Multiple Airlines logo]()
$595
This Mytrip deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:26 am -
3 stops25h 34m
Mon 10/127:25 am -
2 stops16h 59m
Deal found 10/2![Multiple Airlines logo]()
$761
Best flights from O'Hare Intl to FlorenceDiscover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 6, 2026.
Discover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 6, 2026.
This Mytrip deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:11 pm -
2 stops15h 49m
Fri 10/307:25 am -
2 stops12h 34m
Deal found 10/4![Multiple Airlines logo]()
$551
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/191:40 pm -
2 stops46h 10m
Thu 12/317:50 am -
1 stop16h 40m
Deal found 10/4![Multiple Airlines logo]()
$615
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/159:40 am -
1 stop9h 10m
Sun 1/1712:25 pm -
2 stops20h 10m
Deal found 10/2![Multiple Airlines logo]()
$655
Last-minute flights from O'Hare Intl to FlorenceDiscover last-minute flight deals from O'Hare Intl to Florence. Data last updated October 6, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Florence. Data last updated October 6, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:26 am -
3 stops25h 34m
Mon 10/127:25 am -
2 stops16h 59m
Deal found 10/2![Multiple Airlines logo]()
$761
This Mytrip deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:11 pm -
2 stops15h 49m
Fri 10/307:25 am -
2 stops12h 34m
Deal found 10/4![Multiple Airlines logo]()
$551
Find flight deals from O'Hare Intl to Florence
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 6, 2026.
Round-trip from | $551 (Mytrip) |
|---|
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 6, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Mon 10/26
8:11 pm-12:00 pm
2 stops15h 49m
Florence Muscle Shoals
Fri 10/30
7:25 am-7:59 pm
2 stops12h 34m
$551
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Sat 12/19
1:40 pm-11:50 am
2 stops46h 10m
Florence Muscle Shoals
Thu 12/31
7:50 am-12:30 am
1 stop16h 40m
$615
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Fri 1/15
9:40 am-6:50 pm
1 stop9h 10m
Florence Muscle Shoals
Sun 1/17
12:25 pm-8:35 am
2 stops20h 10m
$655
Sorted by cheapest first
Best time to book a flight from O'Hare Intl to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
ORD-MSL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSheffield
Muscle Shoals
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