$393+ Cheap flights from O'Hare Intl (ORD) to Florence, AL (MSL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — MSL
Oct 4 — Oct 111
Round-trip
1 adult, Economy
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Find cheap flights from O'Hare Intl to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Florence
Cheapest
Best
Last-minute
Cheapest flights from O'Hare Intl to FlorenceExplore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This Gotogate deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:30 am -
2 stops7h 20m
Fri 9/1812:45 pm -
2 stops22h 05m
Deal found 8/30![Contour logo]()
$393
This Booking.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:30 am -
2 stops7h 20m
Mon 9/2112:45 pm -
2 stops22h 05m
Deal found 9/2![Contour logo]()
$394
This Mytrip deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:30 am -
2 stops24h 30m
Sun 10/47:25 am -
2 stops27h 25m
Deal found 8/30![Contour logo]()
$405
This Gotogate deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:30 am -
2 stops24h 30m
Thu 10/81:50 pm -
2 stops21h 00m
Deal found 9/2![Contour logo]()
$514
Best flights from O'Hare Intl to FlorenceDiscover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from O'Hare Intl to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This Gotogate deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:30 am -
2 stops7h 20m
Fri 9/1812:45 pm -
2 stops22h 05m
Deal found 8/30![Contour logo]()
$393
This Booking.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:30 am -
2 stops7h 20m
Mon 9/2112:45 pm -
2 stops22h 05m
Deal found 9/2![Contour logo]()
$394
This Gotogate deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:30 am -
2 stops24h 30m
Thu 10/81:50 pm -
2 stops21h 00m
Deal found 9/2![Contour logo]()
$514
Last-minute flights from O'Hare Intl to FlorenceDiscover last-minute flight deals from O'Hare Intl to Florence. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Florence. Data last updated September 4, 2026 and is based on user searches.
This Gotogate deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:30 am -
2 stops7h 20m
Fri 9/1812:45 pm -
2 stops22h 05m
Deal found 8/30![Contour logo]()
$393
This Booking.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:30 am -
2 stops7h 20m
Mon 9/2112:45 pm -
2 stops22h 05m
Deal found 9/2![Contour logo]()
$394
This Gotogate deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:30 am -
2 stops24h 30m
Thu 10/81:50 pm -
2 stops21h 00m
Deal found 9/2![Contour logo]()
$514
This Mytrip deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:30 am -
2 stops24h 30m
Sun 10/47:25 am -
2 stops27h 25m
Deal found 8/30![Contour logo]()
$405
Find flight deals from O'Hare Intl to Florence
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 4, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $393 (Gotogate) |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Mon 9/14
11:30 am-6:50 pm
2 stops7h 20m
Florence Muscle Shoals
Fri 9/18
12:45 pm-10:50 am
2 stops22h 05m
$393
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Thu 9/17
11:30 am-6:50 pm
2 stops7h 20m
Florence Muscle Shoals
Mon 9/21
12:45 pm-10:50 am
2 stops22h 05m
$394
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Thu 10/1
11:30 am-12:00 pm
2 stops24h 30m
Florence Muscle Shoals
Thu 10/8
1:50 pm-10:50 am
2 stops21h 00m
$514
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Chicago O'Hare Intl Airport-Florence, Alabama flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, Alabama flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, Alabama flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
ORD-MSL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSheffield
Muscle Shoals
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