HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$486+ Cheap flights from O'Hare Intl (ORD) to Florence, AL (MSL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — MSL
Aug 8 — Aug 151
Sat 8/8
Sat 8/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from O'Hare Intl to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2026.

This Contour deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2211:20 am
ORD
-
MSL
2 stops24h 30m
Contour
Sun 7/261:00 pm
MSL
-
ORD
2 stops21h 40m
Contour
Deal found 7/7$486
This Gotogate deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:15 am
ORD
-
MSL
2 stops29h 10m
Contour
Mon 8/1012:45 pm
MSL
-
ORD
2 stops22h 05m
Contour
Deal found 7/6$573
This Contour deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2311:20 am
ORD
-
MSL
2 stops24h 30m
Contour
Mon 7/277:25 am
MSL
-
ORD
2 stops34h 40m
Contour
Deal found 7/8$615

Find flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 9, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$486
(Contour)
Provider with most accurate pricing for Chicago O'Hare Intl-Florence Muscle Shoals flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Florence Muscle Shoals flights.
Search Deals
From Chicago O'Hare Intl to Florence Muscle Shoals
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Wed 7/22

11:20 am-11:50 am

2 stops24h 30m

Florence Muscle Shoals

Sun 7/26

1:00 pm-10:40 am

2 stops21h 40m

$486

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Tue 8/4

11:15 am-4:25 pm

2 stops29h 10m

Florence Muscle Shoals

Mon 8/10

12:45 pm-10:50 am

2 stops22h 05m

$573

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Thu 7/23

11:20 am-11:50 am

2 stops24h 30m

Florence Muscle Shoals

Mon 7/27

7:25 am-6:05 pm

2 stops34h 40m

$615

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/7

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Chicago O'Hare Intl Airport-Florence, Alabama flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, Alabama flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, Alabama flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Most people fly into Florence Muscle Shoals (MSL) if they book a flight to Florence from Chicago O'Hare Intl. On average, Muscle Shoals has 0 inbound flights from Chicago O'Hare Intl per day from 0 airlines. Florence Muscle Shoals is conveniently located just 5.4 mi from Florence’s city center.

  • How long is the flight from Chicago O'Hare Intl Airport to Florence, Alabama?

    There are many flights that can get you from Chicago O'Hare Intl Airport to Florence, Alabama in 24h 30m. Fly via Contour to get the fastest option. The distance between Chicago O'Hare Intl Airport and Florence, Alabama is about 500 mi.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sheffield
Muscle Shoals

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.