HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$166+ Cheap flights from O'Hare Intl (ORD) to Florence, AL (MSL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — MSL
Apr 29 — May 61
Wed 4/29
Wed 5/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from O'Hare Intl to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:00 pm
ORD
-
MSL
1 stop20h 50m
Multiple Airlines
Wed 4/157:25 am
MSL
-
ORD
2 stops16h 59m
Multiple Airlines
Deal found 3/27$356
This Mytrip deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:17 am
ORD
-
MSL
3 stops35h 53m
Multiple Airlines
Mon 4/137:25 am
MSL
-
ORD
2 stops32h 50m
Multiple Airlines
Deal found 3/28$514
This Contour deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:20 am
ORD
-
MSL
2 stops7h 50m
Contour
Sun 4/191:00 pm
MSL
-
ORD
2 stops21h 40m
Contour
Deal found 3/26$602
This Booking.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:10 pm
ORD
-
MSL
2 stops28h 15m
Contour
Fri 6/51:00 pm
MSL
-
ORD
2 stops21h 40m
Contour
Deal found 3/29$614
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:55 pm
ORD
-
MSL
1 stop24h 15m
Multiple Airlines
Wed 4/17:25 am
MSL
-
ORD
2 stops16h 11m
Multiple Airlines
Deal found 3/27$636
This Contour deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:20 am
ORD
-
MSL
2 stops24h 30m
Contour
Thu 5/141:00 pm
MSL
-
ORD
2 stops21h 40m
Contour
Deal found 3/29$662
This Gotogate deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2911:20 am
ORD
-
MSL
2 stops24h 30m
Contour
Wed 4/17:25 am
MSL
-
ORD
2 stops27h 15m
Contour
Deal found 3/27$750

Find flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$356
(Kiwi.com)

One-way from

$166
(Kiwi.com)
Provider with most accurate pricing for Chicago O'Hare Intl-Florence Muscle Shoals flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago O'Hare Intl-Florence Muscle Shoals flights.
Search Deals
From Chicago O'Hare Intl to Florence Muscle Shoals
Search Deals
One-way flight from Chicago O'Hare Intl to Florence Muscle Shoals
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sat 4/11

3:00 pm-11:50 am

1 stop20h 50m

Florence Muscle Shoals

Wed 4/15

7:25 am-12:24 am

2 stops16h 59m

$356

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sat 4/11

7:17 am-7:10 pm

3 stops35h 53m

Florence Muscle Shoals

Mon 4/13

7:25 am-4:15 pm

2 stops32h 50m

$514
Quickest round-trip

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 4/12

11:20 am-7:10 pm

2 stops7h 50m

Florence Muscle Shoals

Sun 4/19

1:00 pm-10:40 am

2 stops21h 40m

$602

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Tue 6/2

12:10 pm-4:25 pm

2 stops28h 15m

Florence Muscle Shoals

Fri 6/5

1:00 pm-10:40 am

2 stops21h 40m

$614

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Mon 5/11

11:20 am-11:50 am

2 stops24h 30m

Florence Muscle Shoals

Thu 5/14

1:00 pm-10:40 am

2 stops21h 40m

$662
Cheapest one-way
Quickest one-way

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Tue 4/28

7:15 pm-7:10 pm

2 stops23h 55m

$166

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Sorted by cheapest first

Compare providers for flights from O'Hare Intl to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Florence in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Florence, Alabama flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Florence, Alabama flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Florence, Alabama flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Florence, Alabama flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago O'Hare Intl Airport to Florence

What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Florence, Alabama?

Currently, January is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Florence, Alabama (average of $209). Flying from Chicago O'Hare Intl Airport to Florence, Alabama in December is currently the most expensive (average of $249). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Most people fly into Florence Muscle Shoals (MSL) if they book a flight to Florence from Chicago O'Hare Intl. On average, Muscle Shoals has 0 inbound flights from Chicago O'Hare Intl per day from 0 airlines. Florence Muscle Shoals is conveniently located just 5.4 mi from Florence’s city center.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Florence, Alabama?

    Currently, January is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Florence, Alabama (average of $209). Flying from Chicago O'Hare Intl Airport to Florence, Alabama in December is currently the most expensive (average of $249). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sheffield
Muscle Shoals

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.