
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 5, 2026.
Round-trip from | $417 (Booking.com) |
|---|---|
One-way from | $240 (Mytrip) |
Fly from
Fly to
Route
Depart
Return
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Sat 11/21
6:40 am-11:50 am
2 stops29h 10m
Florence Muscle Shoals
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Mon 11/16
7:55 am-11:50 am
2 stops27h 55m
Florence Muscle Shoals
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Thu 11/19
2:55 pm-6:50 pm
2 stops27h 55m
Florence Muscle Shoals
Mon 11/23
12:25 pm-1:44 pm
3 stops25h 19m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Wed 11/18
2:55 pm-6:50 pm
2 stops27h 55m
Florence Muscle Shoals
Sun 11/22
12:25 pm-12:43 am
2 stops12h 18m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Tue 11/17
4:36 pm-6:50 pm
1 stop26h 14m
Florence Muscle Shoals
Sat 11/21
12:25 pm-12:43 am
2 stops12h 18m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Mon 11/16
10:29 am-6:50 pm
1 stop8h 21m
Florence Muscle Shoals
Fri 11/20
7:50 am-7:46 am
1 stop23h 56m
ChicagoFlorence
ORD Chicago O'Hare Intl - MSL Florence Muscle Shoals
ORDMSL
Chicago O'Hare Intl
Thu 12/3
2:55 pm-6:50 pm
2 stops27h 55m
Florence Muscle Shoals
Mon 12/7
7:50 am-2:15 pm
2 stops30h 25m
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