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$426+ Cheap flights from O'Hare Intl (ORD) to Florence, AL (MSL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — MSL
ago. 23 — ago. 301
sáb. 8/23
sáb. 8/30
1 adult, Economy
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Cheap flight deals from O'Hare Intl to Florence

Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Florence (MSL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 18, 2025.

Round-trip from

$426
(Contour)
From Chicago O'Hare Intl to Florence Muscle Shoals
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Find flight deals from O'Hare Intl to Florence

Cheapest flights from O'Hare Intl to Florence
Explore the most affordable flight options available from O'Hare Intl to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 18, 2025.

This Contour deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/12:10 pmORD - MSL
2 stops45h 50mContour
lun. 9/82:15 pmMSL - ORD
2 stops28h 30mContour
Deal found 8/18$426
This Contour deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/12:10 pmORD - MSL
2 stops29h 00mContour
vie. 9/51:00 pmMSL - ORD
2 stops29h 45mContour
Deal found 8/17$466
This Booking.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/232:10 pmORD - MSL
2 stops44h 15mContour
lun. 8/252:15 pmMSL - ORD
2 stops28h 30mContour
Deal found 8/15$482
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/237:46 pmORD - MSL
2 stops23h 24mMultiple Airlines
lun. 8/252:15 pmMSL - ORD
1 stop7h 59mMultiple Airlines
Deal found 8/15$506

Cheapflights Fare Finder

 
Customize your flight search to find flights from O'Hare Intl to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence that are best for you.

Fly from

O'Hare Intl

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

lun. 9/1

2:10 pm-12:00 pm

2 stops45h 50m

Florence Muscle Shoals

lun. 9/8

2:15 pm-6:45 pm

2 stops28h 30m

$426

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

lun. 9/1

2:10 pm-7:10 pm

2 stops29h 00m

Florence Muscle Shoals

vie. 9/5

1:00 pm-6:45 pm

2 stops29h 45m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Best time to book a flight from O'Hare Intl to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from O'Hare Intl with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from O'Hare Intl to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Chicago O'Hare Intl?

    Most people fly into Florence Muscle Shoals (MSL) if they book a flight to Florence from Chicago O'Hare Intl. On average, Muscle Shoals has 0 inbound flights from Chicago O'Hare Intl per day from 0 airlines. Florence Muscle Shoals is conveniently located just 5.4 mi from Florence’s city center.

  • How long is the flight from Chicago O'Hare Intl Airport to Florence, Alabama?

    There are many flights that can get you from Chicago O'Hare Intl Airport to Florence, Alabama in 45h 50m. Fly via Contour to get the fastest option. The distance between Chicago O'Hare Intl Airport and Florence, Alabama is about 500 mi.

  • Can I find deals for flights from O'Hare Intl to Florence that include hotel bookings?

    Yes. In addition to deals on O'Hare Intl to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from O'Hare Intl to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from O'Hare Intl to Florence.

  • Can I find deals for business class flights from O'Hare Intl to Florence?

    Yes. Cheapflights offers flight deals from O'Hare Intl to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sheffield
Muscle Shoals

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