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$194+ Cheap flights from Roanoke (ROA) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Roanoke to Missouri

Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated September 17, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$194
(Kiwi.com)

Popular in

March

Cheapest in

July

Average price

$427
From Roanoke to Missouri
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One-way flight from Roanoke to Missouri
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Highest demand for flights based on searches. 16% potential increase in price ($81 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Roanoke to Missouri

Cheapest flights from Roanoke to Missouri
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:20 pmROA - MCI
1 stop6h 49mAmerican Airlines
Tue 10/286:02 amMCI - ROA
1 stop7h 11mAmerican Airlines
Deal found 9/15$249
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:55 pmROA - STL
1 stop4h 45mDelta
Sun 11/167:02 pmSTL - ROA
1 stop4h 19mDelta
Deal found 9/17$249
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:00 amROA - STL
1 stop3h 44mDelta
Sat 10/115:25 pmSTL - ROA
1 stop5h 44mDelta
Deal found 9/14$254
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:05 amROA - STL
1 stop6h 14mDelta
Mon 10/65:15 pmSTL - ROA
1 stop5h 54mDelta
Deal found 9/16$259
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:28 pmROA - STL
2 stops7h 21mAmerican Airlines
Mon 10/64:25 pmSTL - ROA
1 stop5h 00mAmerican Airlines
Deal found 9/16$264
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:45 amROA - STL
1 stop5h 04mUnited Airlines
Tue 9/303:23 pmSTL - ROA
1 stop5h 18mUnited Airlines
Deal found 9/15$284
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/96:00 amROA - STL
1 stop4h 56mAmerican Airlines
Sun 10/125:30 amSTL - ROA
1 stop4h 12mAmerican Airlines
Deal found 9/15$309
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:06 pmROA - MCI
1 stop5h 24mAmerican Airlines
Fri 11/289:00 amMCI - ROA
1 stop6h 46mAmerican Airlines
Deal found 9/17$322
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:00 amROA - SGF
1 stop7h 07mAmerican Airlines
Sat 10/116:26 pmSGF - ROA
1 stop4h 33mAmerican Airlines
Deal found 9/15$324
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3010:52 amROA - MCI
1 stop6h 04mUnited Airlines
Sat 10/41:00 pmMCI - ROA
1 stop7h 41mUnited Airlines
Deal found 9/15$329
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/98:18 pmROA - MCI
1 stop4h 51mAmerican Airlines
Tue 10/145:38 pmMCI - ROA
1 stop4h 27mAmerican Airlines
Deal found 9/16$339
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/197:01 amROA - SGF
1 stop7h 32mAmerican Airlines
Sun 9/216:05 pmSGF - ROA
1 stop5h 06mAmerican Airlines
Deal found 9/16$339

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.

Fly from

Roanoke

Fly to

Missouri

Route

Depart

Return

Price

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 10/25

6:20 pm-12:09 am

1 stop6h 49m

Kansas City

Tue 10/28

6:02 am-2:13 pm

1 stop7h 11m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 10/4

6:00 am-8:44 am

1 stop3h 44m

Lambert-St Louis

Sat 10/11

5:25 pm-12:09 am

1 stop5h 44m

$254

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/2

7:05 am-12:19 pm

1 stop6h 14m

Lambert-St Louis

Mon 10/6

5:15 pm-12:09 am

1 stop5h 54m

$259

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/2

5:28 pm-11:49 pm

2 stops7h 21m

Lambert-St Louis

Mon 10/6

4:25 pm-10:25 pm

1 stop5h 00m

$264

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 11/13

6:00 am-10:49 am

1 stop5h 49m

Lambert-St Louis

Sun 11/16

7:02 pm-12:21 am

1 stop4h 19m

$279

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 10/24

5:59 pm-10:55 pm

1 stop5h 56m

Lambert-St Louis

Sun 10/26

5:30 am-10:42 am

1 stop4h 12m

$279

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 9/26

6:45 am-10:49 am

1 stop5h 04m

Lambert-St Louis

Tue 9/30

3:23 pm-9:41 pm

1 stop5h 18m

$284

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/9

6:00 am-9:56 am

1 stop4h 56m

Lambert-St Louis

Sun 10/12

5:30 am-10:42 am

1 stop4h 12m

$309

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 11/22

8:06 pm-12:30 am

1 stop5h 24m

Kansas City

Fri 11/28

9:00 am-4:46 pm

1 stop6h 46m

$322

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Thu 10/2

6:45 am-12:19 pm

1 stop6h 34m

Kansas City

Mon 10/6

1:00 pm-9:41 pm

1 stop7h 41m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 26 results
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Best time to book a flight from Roanoke to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Missouri

What is the cheapest month to book a flight from Roanoke to Missouri?

Currently, August is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $311). Flying from Roanoke to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to MO?

Find hourly flight availability from Roanoke to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Roanoke to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Missouri?

    For a flight from Roanoke to Missouri, you will be flying from Roanoke. Roanoke (ROA) is just 4.2 mi from the center of the city.

  • How long is the flight from Roanoke to Missouri?

    American Airlines, Delta, and United Airlines can get you from Roanoke to Missouri in just under 3h 44m. Your travel time can differ by up to 3h 05m. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Roanoke to Missouri one-way?

    $289 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $322 and $322, respectively.

  • What are the most popular routes from Roanoke to Missouri?

    The most popular route from Roanoke to Missouri is Roanoke - Lambert-St Louis. You may also consider Roanoke - Kansas City or Roanoke - Springfield-Branson.

  • Can I find deals for flights from Roanoke to Missouri that include hotel bookings?

    Yes. In addition to deals on Roanoke to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Missouri.

  • Can I find deals for business class flights from Roanoke to Missouri?

    Yes. Cheapflights offers flight deals from Roanoke to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $311). Flying from Roanoke to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Roanoke to Missouri

Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$218Average$399FlexibilityNo cancel feeOn-time69%
DeltaCheapest$242Average$367FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$403FlexibilityNo cancel feeOn-time71%

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