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$249+ Cheap flights from Roanoke (ROA) to Missouri

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Roanoke to Missouri

Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

Popular in

May

Cheapest in

August

Average price

$330
Provider with most accurate pricing for Roanoke-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Roanoke-Lambert-St Louis flights.
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From Roanoke to Missouri
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Highest demand for flights based on searches. 9% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Roanoke to Missouri

Cheapest flights from Roanoke to Missouri
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:00 amROA - MCI
1 stop6h 42mDelta
Sat 12/137:00 amMCI - ROA
1 stop7h 08mDelta
Deal found 11/3$249
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:00 amROA - MCI
1 stop5h 07mDelta
Mon 11/176:38 pmMCI - ROA
1 stop4h 37mDelta
Deal found 11/1$279
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:05 amROA - MCI
2 stops8h 45mAmerican Airlines
Mon 11/174:16 pmMCI - ROA
1 stop4h 20mAmerican Airlines
Deal found 11/1$284
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/153:50 pmROA - MCI
1 stop6h 20mDelta
Mon 11/245:12 pmMCI - ROA
1 stop6h 03mDelta
Deal found 11/3$294
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/151:25 pmROA - MCI
2 stops11h 17mUnited Airlines
Mon 11/246:00 amMCI - ROA
1 stop4h 59mUnited Airlines
Deal found 11/3$299
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:01 amROA - MCI
1 stop7h 22mAmerican Airlines
Sun 11/164:05 pmMCI - ROA
1 stop4h 48mAmerican Airlines
Deal found 11/2$309
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:05 amROA - STL
1 stop6h 35mDelta
Sun 11/167:02 pmSTL - ROA
1 stop4h 13mDelta
Deal found 11/2$309
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:45 amROA - MCI
1 stop4h 55mUnited Airlines
Sun 11/166:00 amMCI - ROA
2 stops7h 12mUnited Airlines
Deal found 11/2$314
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:54 pmROA - MCI
2 stops8h 09mAmerican Airlines
Sun 12/146:39 pmMCI - ROA
1 stop4h 24mAmerican Airlines
Deal found 11/3$340
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:06 pmROA - MCI
1 stop5h 24mAmerican Airlines
Tue 12/212:37 pmMCI - ROA
1 stop6h 58mAmerican Airlines
Deal found 11/3$342
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:00 amROA - MCI
1 stop5h 06mAmerican Airlines
Sat 12/135:13 amMCI - ROA
2 stops8h 11mAmerican Airlines
Deal found 11/3$347
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:59 pmROA - MCI
1 stop4h 40mDelta
Sun 11/95:12 pmMCI - ROA
1 stop6h 03mDelta
Deal found 11/3$354

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.

Fly from

Roanoke

Fly to

Missouri

Route

Depart

Return

Price

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Thu 12/11

6:00 am-11:42 am

1 stop6h 42m

Kansas City

Sun 12/14

5:12 pm-12:11 am

1 stop5h 59m

$249

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Thu 12/11

6:00 am-11:42 am

1 stop6h 42m

Kansas City

Sat 12/13

7:00 am-3:08 pm

1 stop7h 08m

$249

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 2/21

7:59 pm-11:56 pm

1 stop4h 57m

Kansas City

Tue 2/24

7:00 am-2:49 pm

1 stop6h 49m

$249

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 11/15

6:00 am-10:07 am

1 stop5h 07m

Kansas City

Mon 11/17

6:38 pm-12:15 am

1 stop4h 37m

$279

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 11/15

3:50 pm-9:10 pm

1 stop6h 20m

Kansas City

Mon 11/24

5:12 pm-12:15 am

1 stop6h 03m

$294

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Sat 11/15

1:25 pm-11:42 pm

2 stops11h 17m

Kansas City

Mon 11/24

6:00 am-11:59 am

1 stop4h 59m

$299

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Fri 11/14

9:01 am-3:23 pm

1 stop7h 22m

Kansas City

Sun 11/16

4:05 pm-9:53 pm

1 stop4h 48m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 11/14

5:38 pm-10:45 pm

1 stop6h 07m

Lambert-St Louis

Mon 11/17

8:25 am-2:12 pm

1 stop4h 47m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 11/13

7:05 am-12:40 pm

1 stop6h 35m

Lambert-St Louis

Sun 11/16

7:02 pm-12:15 am

1 stop4h 13m

$309

RoanokeKansas City

ROA - MCI

ROAMCI

Roanoke

Fri 11/14

6:45 am-10:40 am

1 stop4h 55m

Kansas City

Sun 11/16

6:00 am-2:12 pm

2 stops7h 12m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/2

Showing 1-10 of 27 results
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2
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Best time to book a flight from Roanoke to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to Missouri

What is the cheapest month to book a flight from Roanoke to Missouri?

Currently, May is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $191). Flying from Roanoke to Missouri in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to MO?

Find hourly flight availability from Roanoke to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 41% on flights from Roanoke to Missouri by exploring options for tickets in the evening.

What is the cheapest day to fly from Roanoke to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Roanoke to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Roanoke to Missouri flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Roanoke to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 3, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,038 reviews
Delta
7.9
Good
8,002 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to Missouri?

    For a flight from Roanoke to Missouri, you will be flying from Roanoke. Roanoke (ROA) is just 4.2 mi from the center of the city.

  • How long is the flight from Roanoke to Missouri?

    Delta, United Airlines, and American Airlines can get you from Roanoke to Missouri in just under 5h 18m. Your travel time can differ by up to 1h 24m. Airlines will cover a distance of 574 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Roanoke to Missouri one-way?

    $332 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $332 and $548, respectively.

  • What are the most popular routes from Roanoke to Missouri?

    The most popular route from Roanoke to Missouri is Roanoke - Kansas City. You may also consider Roanoke - Lambert-St Louis or Roanoke - Springfield-Branson.

  • Can I find deals for flights from Roanoke to Missouri that include hotel bookings?

    Yes. In addition to deals on Roanoke to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to Missouri.

  • Can I find deals for business class flights from Roanoke to Missouri?

    Yes. Cheapflights offers flight deals from Roanoke to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to Missouri?

    Currently, May is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $191). Flying from Roanoke to Missouri in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Roanoke to Missouri

Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$373FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$354FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$383FlexibilityNo cancel feeOn-time71%

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