$269+ Cheap flights from Roanoke (ROA) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Mar 14 — Mar 211
1 adult, Economy
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Find cheap flights from Roanoke to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to MissouriExplore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
ROA
- MCI
1 stop4h 31m
Delta
Sat 7/185:26 pm
MCI
- ROA
1 stop5h 23m
Delta
Deal found 2/9![Delta logo]()
$269
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:51 pm
ROA
- STL
1 stop5h 07m
Delta
Tue 3/317:03 am
STL
- ROA
1 stop6h 30m
Delta
Deal found 2/9![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:00 am
ROA
- STL
1 stop4h 35m
American Airlines
Tue 3/318:00 am
STL
- ROA
2 stops7h 33m
American Airlines
Deal found 2/10![American Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:00 am
ROA
- STL
1 stop5h 54m
Delta
Thu 7/235:30 pm
STL
- ROA
1 stop5h 19m
Delta
Deal found 2/10![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:04 pm
ROA
- STL
1 stop5h 48m
American Airlines
Fri 3/206:40 pm
STL
- ROA
1 stop4h 19m
American Airlines
Deal found 2/11![American Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:39 pm
ROA
- MCI
1 stop5h 10m
Delta
Sat 6/65:12 pm
MCI
- ROA
1 stop6h 22m
Delta
Deal found 2/11![Delta logo]()
$294
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:50 pm
ROA
- MCI
1 stop5h 05m
Delta
Sat 6/133:36 pm
MCI
- ROA
1 stop7h 13m
Delta
Deal found 2/11![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:00 am
ROA
- STL
1 stop4h 35m
American Airlines
Mon 3/306:33 pm
STL
- ROA
1 stop4h 26m
American Airlines
Deal found 2/11![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:19 pm
ROA
- MCI
1 stop6h 28m
Delta
Sun 5/316:38 pm
MCI
- ROA
1 stop4h 56m
Delta
Deal found 2/10![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:47 am
ROA
- MCI
1 stop4h 42m
United Airlines
Mon 6/17:08 pm
MCI
- ROA
2 stops13h 38m
United Airlines
Deal found 2/10![United Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:33 pm
ROA
- MCI
1 stop5h 26m
United Airlines
Sat 2/283:22 pm
MCI
- ROA
1 stop4h 27m
United Airlines
Deal found 2/10![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:00 am
ROA
- MCI
1 stop4h 33m
Delta
Sun 2/155:06 pm
MCI
- ROA
1 stop6h 00m
Delta
Deal found 2/9![Delta logo]()
$379
Best flights from Roanoke to MissouriDiscover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
ROA
- MCI
1 stop4h 31m
Delta
Sat 7/185:26 pm
MCI
- ROA
1 stop5h 23m
Delta
Deal found 2/9![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:04 pm
ROA
- STL
1 stop5h 58m
American Airlines
Tue 3/312:00 pm
STL
- ROA
1 stop5h 30m
American Airlines
Deal found 2/10![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:47 am
ROA
- MCI
1 stop4h 42m
United Airlines
Mon 6/17:08 pm
MCI
- ROA
2 stops13h 38m
United Airlines
Deal found 2/10![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:00 am
ROA
- STL
1 stop5h 54m
Delta
Thu 7/235:30 pm
STL
- ROA
1 stop5h 19m
Delta
Deal found 2/9![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
ROA
- STL
1 stop4h 40m
American Airlines
Sat 2/281:30 pm
STL
- ROA
1 stop6h 00m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:51 pm
ROA
- STL
1 stop5h 07m
Delta
Tue 3/317:03 am
STL
- ROA
1 stop6h 30m
Delta
Deal found 2/9![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:04 pm
ROA
- STL
1 stop6h 00m
American Airlines
Sat 2/286:36 pm
STL
- ROA
1 stop4h 16m
American Airlines
Deal found 2/10![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:59 pm
ROA
- STL
1 stop4h 37m
Delta
Fri 3/136:59 pm
STL
- ROA
1 stop4h 05m
Delta
Deal found 2/9![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:33 pm
ROA
- MCI
1 stop5h 26m
United Airlines
Sat 2/283:22 pm
MCI
- ROA
1 stop4h 27m
United Airlines
Deal found 2/10![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:04 pm
ROA
- STL
1 stop5h 48m
American Airlines
Fri 3/206:40 pm
STL
- ROA
1 stop4h 19m
American Airlines
Deal found 2/11![American Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
ROA
- MCI
1 stop6h 11m
Delta
Thu 5/285:12 pm
MCI
- ROA
1 stop6h 22m
Delta
Deal found 2/10![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
ROA
- MCI
1 stop6h 11m
Delta
Mon 6/16:38 pm
MCI
- ROA
1 stop4h 56m
Delta
Deal found 2/10![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:39 pm
ROA
- MCI
1 stop5h 10m
Delta
Sat 6/65:12 pm
MCI
- ROA
1 stop6h 22m
Delta
Deal found 2/11![Delta logo]()
$294
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:40 am
ROA
- SGF
1 stop5h 06m
United Airlines
Sun 3/296:30 pm
SGF
- ROA
2 stops18h 43m
United Airlines
Deal found 2/11![United Airlines logo]()
$464
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:50 pm
ROA
- MCI
1 stop5h 05m
Delta
Sat 6/133:36 pm
MCI
- ROA
1 stop7h 13m
Delta
Deal found 2/11![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/287:50 am
ROA
- SGF
1 stop10h 40m
American Airlines
Sun 3/297:36 am
SGF
- ROA
1 stop15h 23m
American Airlines
Deal found 2/11![American Airlines logo]()
$462
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:19 pm
ROA
- MCI
1 stop6h 28m
Delta
Sun 5/316:38 pm
MCI
- ROA
1 stop4h 56m
Delta
Deal found 2/10![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:59 pm
ROA
- SGF
2 stops15h 40m
United Airlines
Sun 4/196:30 pm
SGF
- ROA
1 stop14h 43m
United Airlines
Deal found 2/11![United Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:28 am
ROA
- SGF
1 stop11h 07m
American Airlines
Sun 4/197:29 am
SGF
- ROA
1 stop15h 41m
American Airlines
Deal found 2/11![American Airlines logo]()
$490
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1011:08 am
ROA
- SGF
1 stop5h 02m
Delta
Sun 4/126:55 pm
SGF
- ROA
1 stop4h 09m
Delta
Deal found 2/9![Delta logo]()
$414
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:00 am
ROA
- SGF
1 stop6h 08m
Delta
Sun 3/296:55 pm
SGF
- ROA
1 stop4h 09m
Delta
Deal found 2/11![Delta logo]()
$427
Last-minute flights from Roanoke to MissouriDiscover last-minute flight deals from Roanoke to Missouri. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Missouri. Data last updated February 12, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:00 am
ROA
- MCI
1 stop4h 33m
Delta
Sun 2/155:06 pm
MCI
- ROA
1 stop6h 00m
Delta
Deal found 2/9![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:04 pm
ROA
- MCI
1 stop6h 04m
American Airlines
Sun 2/1512:11 pm
MCI
- ROA
1 stop6h 18m
American Airlines
Deal found 2/9![American Airlines logo]()
$457
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
ROA
- STL
1 stop4h 40m
American Airlines
Sat 2/281:30 pm
STL
- ROA
1 stop6h 00m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:33 pm
ROA
- MCI
1 stop5h 26m
United Airlines
Sat 2/283:22 pm
MCI
- ROA
1 stop4h 27m
United Airlines
Deal found 2/10![United Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:47 pm
ROA
- MCI
1 stop6h 19m
United Airlines
Sun 3/18:00 am
MCI
- ROA
2 stops11h 07m
United Airlines
Deal found 2/10![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:40 am
ROA
- MCI
1 stop4h 56m
United Airlines
Mon 3/28:00 am
MCI
- ROA
2 stops11h 07m
United Airlines
Deal found 2/11![United Airlines logo]()
$450
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:51 pm
ROA
- MCI
1 stop5h 21m
Delta
Mon 3/166:41 pm
MCI
- ROA
1 stop4h 23m
Delta
Deal found 2/9![Delta logo]()
$454
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:04 pm
ROA
- STL
1 stop5h 48m
American Airlines
Fri 3/206:40 pm
STL
- ROA
1 stop4h 19m
American Airlines
Deal found 2/11![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:00 am
ROA
- STL
1 stop4h 35m
American Airlines
Mon 3/306:33 pm
STL
- ROA
1 stop4h 26m
American Airlines
Deal found 2/11![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:51 pm
ROA
- STL
1 stop5h 07m
Delta
Tue 3/317:03 am
STL
- ROA
1 stop6h 30m
Delta
Deal found 2/9![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:00 am
ROA
- STL
1 stop4h 35m
American Airlines
Tue 3/318:00 am
STL
- ROA
2 stops7h 33m
American Airlines
Deal found 2/10![American Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:00 am
ROA
- SGF
1 stop6h 08m
Delta
Sun 3/296:55 pm
SGF
- ROA
1 stop4h 09m
Delta
Deal found 2/11![Delta logo]()
$427
One-way flights from Roanoke to MissouriSearch for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:28 am
ROA
- STL
1 stop5h 17m
American Airlines
Deal found 2/11![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:38 pm
ROA
- STL
3 stops27h 41m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:59 pm
ROA
- STL
2 stops27h 31m
United Airlines
Deal found 2/11![United Airlines logo]()
$510
Find flight deals from Roanoke to Missouri
Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (Delta) |
One-way from | $269 (American Airlines) |
Popular in | November |
Cheapest in | February |
Average price | $269 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.
Fly from
Roanoke
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Missouri
Route
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RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Wed 7/15
6:00 am-9:31 am
1 stop4h 31m
Kansas City
Sat 7/18
5:26 pm-11:49 pm
1 stop5h 23m
$269
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Mon 3/16
6:04 pm-11:02 pm
1 stop5h 58m
Lambert-St Louis
Tue 3/31
2:00 pm-8:30 pm
1 stop5h 30m
$269
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Thu 7/9
7:00 am-11:54 am
1 stop5h 54m
Lambert-St Louis
Thu 7/23
5:30 pm-11:49 pm
1 stop5h 19m
$269
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Mon 3/16
7:51 pm-11:58 pm
1 stop5h 07m
Lambert-St Louis
Tue 3/31
7:03 am-2:33 pm
1 stop6h 30m
$269
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Sat 3/7
7:59 pm-11:36 pm
1 stop4h 37m
Lambert-St Louis
Fri 3/13
6:59 pm-12:04 am
1 stop4h 05m
$269
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Tue 2/24
6:00 am-9:40 am
1 stop4h 40m
Lambert-St Louis
Sat 2/28
1:30 pm-8:30 pm
1 stop6h 00m
$279
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Thu 2/26
6:04 pm-11:04 pm
1 stop6h 00m
Lambert-St Louis
Sat 2/28
6:36 pm-11:52 pm
1 stop4h 16m
$279
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Sat 5/23
6:00 am-11:11 am
1 stop6h 11m
Kansas City
Thu 5/28
5:12 pm-12:34 am
1 stop6h 22m
$279
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Thu 5/28
6:00 am-11:11 am
1 stop6h 11m
Kansas City
Mon 6/1
6:38 pm-12:34 am
1 stop4h 56m
$279
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Fri 3/13
6:04 pm-10:52 pm
1 stop5h 48m
Lambert-St Louis
Fri 3/20
6:40 pm-11:59 pm
1 stop4h 19m
$289
Showing 1-10 of 24 results
Best time to book a flight from Roanoke to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
ROA-STL
ROA-MCI
ROA-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Missouri
ROA-USMO
ROA-STL
ROA-MCI
ROA-SGF
What is the cheapest month to book a flight from Roanoke to Missouri?
Currently, November is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $183). Flying from Roanoke to Missouri in March is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 12, 2026.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to Missouri
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Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Roanoke to Missouri by cabin class
Find flights from Roanoke to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and Missouri flights
Browse other Roanoke and Missouri flight options. Last updated on February 12, 2026.
Popular flight searches
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Roanoke to Missouri flights
Consider these flights traveling from Roanoke to Missouri.
Top 3 airlines flying from Roanoke to Missouri
Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$354 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$361 | FlexibilityNo cancel fee | On-timeN/A |