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Missouri

$317+ Cheap flights from Panama to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MCI
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Panama to Missouri

Cheapest flights from Panama to Missouri
Explore the most affordable flight options available from Panama to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:55 amPTY - STL
1 stop14h 00mUnited Airlines
Sat 1/103:11 pmSTL - PTY
2 stops22h 34mUnited Airlines
Deal found 12/15$623
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:22 pmPTY - MCI
1 stop9h 34mDelta
Wed 1/75:50 amMCI - PTY
1 stop7h 05mDelta
Deal found 12/16$649
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:55 amPTY - MCI
1 stop26h 41mUnited Airlines
Thu 1/18:09 amMCI - PTY
1 stop7h 58mUnited Airlines
Deal found 12/16$671
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:35 amPTY - SGF
1 stop11h 24mUnited Airlines
Thu 1/19:00 amSGF - PTY
1 stop7h 07mUnited Airlines
Deal found 12/17$680
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:55 pmPTY - MCI
2 stops19h 31mAmerican Airlines
Thu 1/16:36 pmMCI - PTY
2 stops18h 17mAmerican Airlines
Deal found 12/16$684
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:55 pmPTY - SGF
2 stops18h 06mAmerican Airlines
Thu 1/14:27 pmSGF - PTY
2 stops20h 26mAmerican Airlines
Deal found 12/16$690
This Cheapflightsfares deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:50 pmPTY - MCI
3 stops49h 41mAvianca
Thu 1/15:46 pmMCI - PTY
2 stops39h 44mAvianca
Deal found 12/16$1,114

Find flight deals from Panama to Missouri

Keep the following information in mind while searching for Panama to Missouri flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$458
(United Airlines)

One-way from

$317
(American Airlines)

Popular in

July

Cheapest in

June

Average price

$517
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama to Missouri
Search Deals
One-way flight from Panama to Missouri
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama to Missouri that are best for you.

Fly from

Panama

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Thu 1/22

8:55 am-10:40 pm

1 stop14h 45m

Kansas City

Mon 1/26

10:30 am-7:38 pm

1 stop8h 08m

$458

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Sat 1/17

5:00 pm-10:01 am

2 stops18h 01m

Kansas City

Wed 1/21

5:11 pm-1:27 pm

2 stops19h 16m

$482

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Mon 1/19

2:27 pm-11:04 am

1 stop21h 37m

Kansas City

Fri 1/23

11:44 am-3:52 pm

1 stop27h 08m

$495

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 2/19

3:20 pm-9:06 am

1 stop18h 46m

Lambert-St Louis

Sun 2/22

3:47 pm-1:55 pm

1 stop21h 08m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/17

4:41 pm-12:21 pm

2 stops20h 40m

Lambert-St Louis

Wed 2/25

6:55 pm-5:07 pm

2 stops21h 12m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 2/19

8:55 am-10:14 pm

1 stop14h 19m

Lambert-St Louis

Thu 2/26

6:00 am-5:07 pm

1 stop10h 07m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/17

8:55 am-10:14 pm

1 stop14h 19m

Lambert-St Louis

Mon 2/23

6:00 am-5:07 pm

1 stop10h 07m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/17

8:55 am-10:14 pm

1 stop14h 19m

Lambert-St Louis

Thu 2/26

6:25 am-8:02 pm

2 stops12h 37m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 2/19

8:55 am-10:14 pm

1 stop14h 19m

Lambert-St Louis

Mon 2/23

6:55 pm-2:45 pm

2 stops18h 50m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/17

8:55 am-10:14 pm

1 stop14h 19m

Lambert-St Louis

Tue 2/24

6:00 am-2:45 pm

1 stop7h 45m

$516

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 20 results
1
2

Best time to book a flight from Panama to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Missouri

What is the cheapest month to book a flight from Panama to Missouri?

Currently, December is the cheapest month in which you can book a flight from Panama to Missouri (average of $224). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MO?

Find hourly flight availability from Panama to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

It’s optimal to fly from Panama to Missouri in the evening. By choosing this option you can save up to 28% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown United Airlines and American Airlines from Panama to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,091 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Boarding

7.7

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability
United Airlines
7.4
Good
9,091 reviews
United Airlines
7.4
Good
9,091 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Boarding

7.7

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability
American Airlines
7.2
Good
11,054 reviews
United Airlines
7.4
Good
9,091 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Boarding

7.7

Overall

7.4

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Kevin,Dec 2025

BOS - EWR

Seems like every United flight has a delay and it’s always someone else’s fault. Step up and take some accountability

Related info for your journey

Find useful and relevant information for your journey from Panama to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Missouri?

    A quick flight from Panama to Missouri can take about 14h 45m. United Airlines provides one of the quickest options available for as low as $458. There are 2292 mi between Panama and Missouri.

  • Can I find deals for flights from Panama to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Missouri.

  • Can I find deals for business class flights from Panama to Missouri?

    Yes. Cheapflights offers flight deals from Panama to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Panama to Missouri (average of $224). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama to Missouri

Discover the top 2 airlines that operate flights from Panama to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$418Average$629FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$431Average$733FlexibilityNo cancel feeOn-time71%

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