HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Missouri

$247+ Cheap flights from Panama to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Missouri with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Missouri

Keep the following information in mind while searching for Panama to Missouri flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$429
(American Airlines)

One-way from

$247
(Delta)

Popular in

September

Cheapest in

April

Average price

$552
Provider with most accurate pricing for Panama City Tocumen Intl-Kansas City flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Kansas City flights.
Search Deals
From Panama to Missouri
Search Deals
One-way flight from Panama to Missouri
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Panama to Missouri

Cheapest flights from Panama to Missouri
Explore the most affordable flight options available from Panama to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/231:50 pmPTY - MCI
2 stops20h 06mAmerican Airlines
Mon 6/305:45 pmMCI - PTY
2 stops19h 15mAmerican Airlines
Deal found 4/28$429
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/12:23 pmPTY - MCI
1 stop9h 36mDelta
Sun 8/316:00 amMCI - PTY
1 stop6h 54mDelta
Deal found 4/30$435
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/273:40 pmPTY - STL
1 stop8h 19mAmerican Airlines
Fri 9/55:31 amSTL - PTY
1 stop6h 54mAmerican Airlines
Deal found 4/29$451
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:00 amPTY - MCI
2 stops23h 09mUnited Airlines
Mon 10/66:32 pmMCI - PTY
2 stops19h 42mUnited Airlines
Deal found 4/29$518
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/143:30 pmPTY - STL
1 stop25h 23mUnited Airlines
Sat 6/218:25 amSTL - PTY
1 stop10h 12mUnited Airlines
Deal found 4/30$558
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/310:55 pmPTY - SGF
2 stops15h 36mUnited Airlines
Wed 6/118:35 amSGF - PTY
1 stop7h 37mUnited Airlines
Deal found 4/30$560
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/133:20 pmPTY - SGF
2 stops18h 30mAmerican Airlines
Fri 6/206:28 pmSGF - PTY
2 stops18h 32mAmerican Airlines
Deal found 4/29$575
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/62:20 pmPTY - STL
1 stop9h 16mDelta
Tue 5/136:00 amSTL - PTY
1 stop6h 48mDelta
Deal found 4/29$607
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/298:10 pmPTY - MCI
3 stops24h 02mMultiple Airlines
Thu 6/59:07 pmMCI - PTY
3 stops35h 48mMultiple Airlines
Deal found 4/30$613
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/223:20 amPTY - STL
2 stops20h 32mMultiple Airlines
Sat 5/2410:10 amSTL - PTY
1 stop10h 09mMultiple Airlines
Deal found 4/29$860
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/123:20 amPTY - SGF
3 stops37h 35mMultiple Airlines
Fri 6/201:15 pmSGF - PTY
2 stops31h 04mMultiple Airlines
Deal found 4/29$877
This Avianca deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/73:20 amPTY - STL
2 stops16h 03mAvianca
Sun 5/119:40 amSTL - PTY
2 stops14h 30mAvianca
Deal found 4/29$3,655

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama to Missouri that are best for you.

Fly from

Panama

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Mon 6/23

1:50 pm-9:56 am

2 stops20h 06m

Kansas City

Mon 6/30

5:45 pm-1:00 pm

2 stops19h 15m

$429

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Fri 8/1

2:23 pm-11:59 pm

1 stop9h 36m

Kansas City

Sun 8/31

6:00 am-12:54 pm

1 stop6h 54m

$435

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 8/27

3:40 pm-11:59 pm

1 stop8h 19m

Lambert-St Louis

Fri 9/5

5:31 am-12:25 pm

1 stop6h 54m

$451

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Fri 8/1

7:55 am-12:03 pm

1 stop28h 08m

Kansas City

Sun 8/31

11:33 am-2:14 pm

2 stops26h 41m

$539

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 6/14

3:30 pm-4:53 pm

1 stop25h 23m

Lambert-St Louis

Sat 6/21

8:25 am-6:37 pm

1 stop10h 12m

$558

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Tue 6/3

10:55 pm-2:31 pm

2 stops15h 36m

Springfield-Branson

Wed 6/11

8:35 am-4:12 pm

1 stop7h 37m

$560

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Fri 6/13

3:20 pm-9:50 am

2 stops18h 30m

Springfield-Branson

Fri 6/20

6:28 pm-1:00 pm

2 stops18h 32m

$575

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Thu 5/29

8:10 pm-8:12 pm

3 stops24h 02m

Kansas City

Thu 6/5

9:07 pm-8:55 am

3 stops35h 48m

$613

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/22

3:20 am-11:52 pm

2 stops20h 32m

Lambert-St Louis

Sat 5/24

10:10 am-8:19 pm

1 stop10h 09m

$860

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Thu 6/12

3:20 am-4:55 pm

3 stops37h 35m

Springfield-Branson

Fri 6/20

1:15 pm-8:19 pm

2 stops31h 04m

$877

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Panama to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Missouri

What is the cheapest month to book a flight from Panama to Missouri?

Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $311). Flying from Panama to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MO?

Find hourly flight availability from Panama to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to Missouri as you normally would.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 1, 2025.
Read through reviews of airlines operating flights from Panama to Missouri, such as Delta, Copa Airlines and United Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.5
Good
1,415 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Panama to Missouri one-way?

    One-way options have recently been found by users for as low as $247 on Delta. Other airlines that offer cheap prices include American Airlines from $284 and United Airlines from $356 one-way.

  • Can I find deals for flights from Panama to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Missouri.

  • Can I find deals for business class flights from Panama to Missouri?

    Yes. Cheapflights offers flight deals from Panama to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $311). Flying from Panama to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
San José to Newark flights
San José to John F Kennedy Intl flights
San José to Orlando flights
Guatemala City to Los Angeles flights
San José to Miami flights
San Salvador to Los Angeles flights
Guatemala City to John F Kennedy Intl flights
San José to Los Angeles flights
San José to Fort Lauderdale flights
Guatemala City to Miami flights
Guatemala City to Newark flights
San José to LaGuardia flights
Panama City to Miami flights
Panama City to John F Kennedy Intl flights
San Salvador to Miami flights
Guatemala City to Fort Lauderdale flights
San Salvador to Dulles Intl flights
Guatemala City to Hobby flights
San Salvador to Dallas/Fort Worth flights
San Salvador to John F Kennedy Intl flights
Panama City to Newark flights
Guatemala City to George Bush Intcntl flights
San Salvador to Hobby flights
Panama City to Orlando flights
San Pedro Sula to Miami flights
Guatemala City to Dulles Intl flights
Guatemala City to Orlando flights
San Salvador to George Bush Intcntl flights
Guatemala City to LaGuardia flights
San José to O'Hare Intl flights
Guatemala City to O'Hare Intl flights
San José to San Francisco flights
San Salvador to Newark flights
San José to Las Vegas flights
San José to Hobby flights
San Pedro Sula to Hobby flights
San Pedro Sula to George Bush Intcntl flights
San José to Atlanta flights
Guatemala City to Ontario flights
San José to George Bush Intcntl flights
San José to Seattle flights
Guatemala City to Boston flights
Panama City to Los Angeles flights
San Pedro Sula to John F Kennedy Intl flights
Panama City to LaGuardia flights
San José to Dallas/Fort Worth flights
San José to Dulles Intl flights
San Salvador to LaGuardia flights
Managua to Miami flights
San Salvador to Atlanta flights

Top 2 airlines flying from Panama to Missouri

Discover the top 2 airlines that operate flights from Panama to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$554FlexibilityNo cancel feeOn-time69%
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.