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Missouri

$343+ Cheap flights from Panama to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Panama to Missouri

Cheapest flights from Panama to Missouri
Explore the most affordable flight options available from Panama to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:40 pm
PTY
-
MCI
1 stop7h 58m
American Airlines
Thu 10/85:11 am
MCI
-
PTY
1 stop8h 49m
American Airlines
Deal found 2/3$528
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:15 pm
PTY
-
MCI
1 stop9h 25m
Delta
Mon 3/25:35 am
MCI
-
PTY
1 stop7h 15m
Delta
Deal found 2/2$559
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:41 pm
PTY
-
MCI
1 stop17h 51m
United Airlines
Mon 3/28:00 am
MCI
-
PTY
1 stop10h 38m
United Airlines
Deal found 2/1$568
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:55 pm
PTY
-
STL
2 stops16h 51m
United Airlines
Tue 6/26:20 am
STL
-
PTY
1 stop12h 17m
United Airlines
Deal found 2/2$573
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:00 am
PTY
-
SGF
2 stops14h 45m
United Airlines
Sun 9/276:15 pm
SGF
-
PTY
2 stops19h 59m
United Airlines
Deal found 1/31$575
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:30 pm
PTY
-
MCI
2 stops17h 32m
United Airlines
Sat 7/187:45 am
MCI
-
PTY
2 stops20h 19m
United Airlines
Deal found 2/2$627
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:20 pm
PTY
-
STL
1 stop8h 39m
American Airlines
Thu 9/105:33 am
STL
-
PTY
1 stop8h 37m
American Airlines
Deal found 2/1$640
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/244:41 pm
PTY
-
MCI
1 stop17h 51m
United Airlines
Thu 2/2610:15 am
MCI
-
PTY
1 stop8h 23m
United Airlines
Deal found 2/2$656
This Faresmojo deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:20 pm
PTY
-
MCI
1 stop8h 05m
JetBlue
Wed 7/85:40 am
MCI
-
PTY
1 stop7h 27m
JetBlue
Deal found 2/1$661
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:10 pm
PTY
-
MCI
1 stop10h 47m
American Airlines
Tue 7/145:01 am
MCI
-
PTY
1 stop7h 09m
American Airlines
Deal found 2/1$664
This Faresmojo deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:20 pm
PTY
-
MCI
1 stop8h 05m
JetBlue
Wed 7/85:40 am
MCI
-
PTY
1 stop7h 27m
JetBlue
Deal found 2/1$680
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:55 am
PTY
-
MCI
1 stop14h 45m
United Airlines
Sat 2/283:22 pm
MCI
-
PTY
2 stops22h 23m
United Airlines
Deal found 2/1$682

Find flight deals from Panama to Missouri

Keep the following information in mind while searching for Panama to Missouri flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$457
(United Airlines)

One-way from

$343
(Avianca)

Popular in

January

Cheapest in

June

Average price

$559
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama to Missouri
Search Deals
One-way flight from Panama to Missouri
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Panama to Missouri that are best for you.

Fly from

Panama

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:32 am

1 stop17h 51m

Kansas City

Mon 3/2

8:00 am-7:38 pm

1 stop10h 38m

$568

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Wed 2/25

2:40 pm-10:42 am

2 stops21h 02m

Kansas City

Mon 3/2

6:33 pm-1:40 pm

2 stops18h 07m

$573

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/30

10:55 pm-12:11 pm

2 stops13h 16m

Lambert-St Louis

Tue 6/2

8:15 pm-4:12 pm

2 stops19h 57m

$573

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Sat 6/27

3:30 pm-9:02 am

2 stops17h 32m

Kansas City

Sat 7/18

7:45 am-4:04 am

2 stops20h 19m

$627

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 2/24

4:41 pm-9:32 am

1 stop17h 51m

Kansas City

Thu 2/26

10:15 am-7:38 pm

1 stop8h 23m

$656

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Wed 6/17

2:20 pm-10:25 pm

1 stop8h 05m

Kansas City

Wed 7/8

5:40 am-1:07 pm

1 stop7h 27m

$661

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 7/7

1:10 pm-11:57 pm

1 stop10h 47m

Kansas City

Tue 7/14

5:01 am-12:10 pm

1 stop7h 09m

$664

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Wed 6/17

3:30 pm-6:28 pm

1 stop26h 58m

Springfield-Branson

Tue 7/7

6:00 am-4:04 am

2 stops22h 04m

$928

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Wed 6/17

1:10 pm-9:00 am

2 stops19h 50m

Springfield-Branson

Tue 7/7

5:26 pm-12:10 pm

2 stops18h 44m

$982

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 4/18

5:30 am-10:28 pm

2 stops16h 58m

$343

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 14 results
1
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Best time to book a flight from Panama to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Missouri

What is the cheapest month to book a flight from Panama to Missouri?

Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $230). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 3, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Panama to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,229 reviews

Food

6.6

Comfort

7.3

Crew

8.1

Boarding

7.7

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
United Airlines
7.4
Good
9,229 reviews
United Airlines
7.4
Good
9,229 reviews

Food

6.6

Comfort

7.3

Crew

8.1

Boarding

7.7

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
American Airlines
7.2
Good
11,212 reviews
United Airlines
7.4
Good
9,229 reviews

Food

6.6

Comfort

7.3

Crew

8.1

Boarding

7.7

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats

Related info for your journey

Find useful and relevant information for your journey from Panama to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Missouri?

    A quick flight from Panama to Missouri can take about 17h 51m. United Airlines provides one of the quickest options available for as low as $568. There are 2292 mi between Panama and Missouri. This flight may include one or multiple stops.

  • Can I find deals for flights from Panama to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Missouri.

  • Can I find deals for business class flights from Panama to Missouri?

    Yes. Cheapflights offers flight deals from Panama to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $230). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama to Missouri

Discover the top 2 airlines that operate flights from Panama to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$629FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$431Average$733FlexibilityNo cancel feeOn-time71%

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