Missouri

$124+ Cheap flights from Myrtle Beach (MYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Apr 27 — May 41
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Cheap flight deals from Myrtle Beach to Missouri

Cheapest flights from Myrtle Beach to Missouri
Explore the most affordable flight options available from Myrtle Beach to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.

This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:00 am
MYR
-
STL
1 stop5h 40m
Delta
Tue 5/126:57 pm
STL
-
MYR
1 stop4h 01m
Delta
Deal found 3/24$272
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:28 am
MYR
-
MCI
1 stop5h 29m
American Airlines
Tue 5/121:40 pm
MCI
-
MYR
1 stop7h 16m
American Airlines
Deal found 3/25$281
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:35 am
MYR
-
MCI
1 stop5h 15m
Southwest
Tue 5/1212:20 pm
MCI
-
MYR
2 stops7h 10m
Southwest
Deal found 3/25$286
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/912:05 pm
MYR
-
STL
1 stop12h 20m
Multiple Airlines
Mon 4/134:59 pm
STL
-
MYR
1 stop17h 06m
Multiple Airlines
Deal found 3/26$287
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:00 am
MYR
-
STL
1 stop5h 40m
Delta
Tue 5/126:21 am
STL
-
MYR
1 stop7h 09m
Delta
Deal found 3/24$296
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:00 am
MYR
-
STL
1 stop5h 40m
Delta
Mon 5/117:01 pm
STL
-
MYR
1 stop3h 57m
Delta
Deal found 3/24$297
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:04 am
MYR
-
MCI
2 stops7h 56m
American Airlines
Tue 5/121:40 pm
MCI
-
MYR
2 stops8h 22m
American Airlines
Deal found 3/25$307
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:14 pm
MYR
-
MCI
1 stop7h 50m
United Airlines
Tue 5/126:17 am
MCI
-
MYR
1 stop7h 01m
United Airlines
Deal found 3/24$310
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:45 pm
MYR
-
STL
1 stop7h 00m
Southwest
Tue 4/1411:35 am
STL
-
MYR
1 stop5h 00m
Southwest
Deal found 3/26$313
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:11 am
MYR
-
MCI
2 stops7h 15m
American Airlines
Tue 5/123:11 pm
MCI
-
MYR
1 stop6h 51m
American Airlines
Deal found 3/24$315
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:14 pm
MYR
-
STL
1 stop6h 59m
United Airlines
Mon 5/117:45 am
STL
-
MYR
1 stop5h 33m
United Airlines
Deal found 3/24$316
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1712:05 pm
MYR
-
STL
1 stop8h 21m
Delta
Mon 4/206:50 pm
STL
-
MYR
1 stop4h 24m
Delta
Deal found 3/26$321

Find flight deals from Myrtle Beach to Missouri

Keep the following information in mind while searching for Myrtle Beach to Missouri flight deals. Data was last updated March 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$272
(Delta)

One-way from

$124
(Delta)

Popular in

March

Cheapest in

August

Average price

$494
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
From Myrtle Beach Intl to Missouri
One-way flight from Myrtle Beach Intl to Missouri
Highest demand for flights based on searches. 9% potential increase in price ($41 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Average for round-trip flights in March 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 5/7

11:00 am-3:40 pm

1 stop5h 40m

Lambert-St Louis

Tue 5/12

6:57 pm-11:58 pm

1 stop4h 01m

$272

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 4/9

12:05 pm-11:25 pm

1 stop12h 20m

Lambert-St Louis

Mon 4/13

4:59 pm-11:05 am

1 stop17h 06m

$287

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/10

1:45 pm-7:45 pm

1 stop7h 00m

Lambert-St Louis

Tue 4/14

11:35 am-5:35 pm

1 stop5h 00m

$313

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 5/8

3:14 pm-9:13 pm

1 stop6h 59m

Lambert-St Louis

Mon 5/11

7:45 am-2:18 pm

1 stop5h 33m

$316

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/17

6:00 am-11:56 am

1 stop6h 56m

Lambert-St Louis

Mon 4/20

6:48 am-11:55 am

1 stop4h 07m

$321

Myrtle BeachSpringfield

MYR - SGF

MYRSGF

Myrtle Beach Intl

Sat 9/5

6:45 pm-10:29 pm

1 stop4h 44m

Springfield-Branson

Sat 9/12

3:30 pm-11:39 pm

1 stop7h 09m

$323
Quickest round-trip

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 5/9

6:00 am-9:49 am

1 stop4h 49m

Lambert-St Louis

Mon 5/11

7:01 pm-11:58 pm

1 stop3h 57m

$338

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 5/8

11:00 am-3:40 pm

1 stop5h 40m

Lambert-St Louis

Sun 5/10

5:15 pm-11:58 pm

1 stop5h 43m

$348

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 7/8

7:55 am-11:15 am

1 stop4h 20m

Lambert-St Louis

Wed 7/15

1:10 pm-9:10 pm

1 stop7h 00m

$351

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 4/9

6:54 pm-11:58 pm

1 stop6h 04m

Lambert-St Louis

Sat 4/11

6:32 am-12:10 pm

1 stop4h 38m

$351

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Showing 1-10 of 53 resultsSorted by cheapest first
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Best time to book a flight from Myrtle Beach to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Missouri

What is the cheapest month to book a flight from Myrtle Beach to Missouri?

Currently, December is the cheapest month in which you can book a flight from Myrtle Beach to Missouri (average of $118). Flying from Myrtle Beach to Missouri in March is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to MO?

Find hourly flight availability from Myrtle Beach to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2026.

When flying from Myrtle Beach to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Myrtle Beach to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 28, 2026.
Read through reviews of airlines operating flights from Myrtle Beach to Missouri, such as Southwest,Delta, andAmerican Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

8.0

Food

7.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Overall

8.0

Food

7.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Overall

8.0

Food

7.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Overall

8.0

Food

7.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Myrtle Beach to Missouri?

    Most people fly from Myrtle Beach Intl (MYR) if they book a flight from Myrtle Beach to Missouri. Myrtle Beach Intl is conveniently located just 2.1 mi from Myrtle Beach’s city center.

  • How popular is this Myrtle Beach to Missouri flight route?

  • How long is the flight from Myrtle Beach to Missouri?

    Delta, Southwest, and United Airlines can get you from Myrtle Beach to Missouri in just under 5h 40m. Your travel time can differ by up to 1h 20m. Airlines will cover a distance of 727 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Myrtle Beach to Missouri one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $93. However, be on the lookout for offers from Delta and Southwest, as they are both options that can get you from Myrtle Beach to Missouri for a low price.

  • What are the most popular routes from Myrtle Beach to Missouri?

  • Can I find deals for flights from Myrtle Beach to Missouri that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Missouri.

  • Can I find deals for business class flights from Myrtle Beach to Missouri?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Myrtle Beach to Missouri (average of $118). Flying from Myrtle Beach to Missouri in March is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Missouri

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Myrtle Beach to Missouri

Discover the top 3 airlines that operate flights from Myrtle Beach to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$128Average$364FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$177Average$372FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$231Average$421FlexibilityNo cancel feeOn-time63%

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