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$97+ Cheap flights from Myrtle Beach (MYR) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — STL
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Missouri

Cheapest flights from Myrtle Beach to Missouri
Explore the most affordable flight options available from Myrtle Beach to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:54 amMYR - MCI
1 stop8h 16mSpirit Airlines
Sun 12/286:15 pmMCI - MYR
1 stop22h 53mSpirit Airlines
Deal found 12/10$335
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:54 amMYR - MCI
2 stops14h 05mSpirit Airlines
Tue 12/306:15 pmMCI - MYR
1 stop22h 53mSpirit Airlines
Deal found 12/11$432
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:54 amMYR - STL
1 stop26h 02mMultiple Airlines
Mon 1/54:27 pmSTL - MYR
2 stops24h 41mMultiple Airlines
Deal found 12/10$448
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:25 pmMYR - STL
1 stop4h 40mSouthwest
Mon 1/55:10 amSTL - MYR
1 stop4h 25mSouthwest
Deal found 12/10$457
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2912:48 pmMYR - STL
2 stops7h 43mAmerican Airlines
Thu 1/12:04 pmSTL - MYR
1 stop4h 07mAmerican Airlines
Deal found 12/11$462
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 amMYR - STL
2 stops8h 38mAmerican Airlines
Wed 12/316:02 amSTL - MYR
1 stop4h 36mAmerican Airlines
Deal found 12/9$472
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:32 pmMYR - STL
1 stop15h 13mMultiple Airlines
Tue 12/3010:48 amSTL - MYR
2 stops30h 20mMultiple Airlines
Deal found 12/11$477
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 amMYR - STL
2 stops8h 38mAmerican Airlines
Tue 12/302:04 pmSTL - MYR
1 stop4h 07mAmerican Airlines
Deal found 12/10$494
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:29 amMYR - STL
1 stop6h 41mDelta
Sat 1/37:10 amSTL - MYR
1 stop8h 24mDelta
Deal found 12/10$497
This Southwest deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:15 pmMYR - STL
1 stop4h 35mSouthwest
Tue 12/302:15 pmSTL - MYR
1 stop4h 20mSouthwest
Deal found 12/11$517
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amMYR - SGF
2 stops10h 12mAmerican Airlines
Tue 12/306:24 pmSGF - MYR
1 stop4h 31mAmerican Airlines
Deal found 12/11$587
This Southwest deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:00 amMYR - MCI
2 stops8h 00mSouthwest
Tue 12/3010:25 amMCI - MYR
2 stops10h 25mSouthwest
Deal found 12/11$588

Find flight deals from Myrtle Beach to Missouri

Keep the following information in mind while searching for Myrtle Beach to Missouri flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$182
(Super.com)

One-way from

$97
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$529
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From Myrtle Beach Intl to Missouri
Search Deals
One-way flight from Myrtle Beach Intl to Missouri
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Missouri that are best for you.

Fly from

Myrtle Beach

Fly to

Missouri

Route

Depart

Return

Price

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Tue 1/6

9:54 am-5:10 pm

1 stop8h 16m

Kansas City

Fri 1/9

11:26 am-7:20 pm

1 stop6h 54m

$182

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Thu 12/25

9:54 am-5:10 pm

1 stop8h 16m

Kansas City

Sun 12/28

6:15 pm-6:08 pm

1 stop22h 53m

$335

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Thu 1/8

6:00 am-10:16 am

1 stop5h 16m

Kansas City

Mon 1/12

6:23 pm-11:43 pm

1 stop4h 20m

$357

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Thu 1/8

6:23 am-3:08 pm

2 stops9h 45m

Kansas City

Mon 1/12

10:58 am-4:59 pm

1 stop5h 01m

$362

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Tue 1/6

8:15 am-2:20 pm

2 stops7h 05m

Kansas City

Fri 1/9

6:15 am-5:00 pm

2 stops9h 45m

$385

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 4/9

6:58 pm-11:42 pm

1 stop5h 44m

Lambert-St Louis

Mon 4/13

6:45 am-11:56 am

1 stop4h 11m

$417

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 3/27

6:00 am-8:52 am

1 stop3h 52m

Lambert-St Louis

Wed 4/1

6:00 am-1:32 pm

1 stop6h 32m

$417

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 2/27

12:15 pm-4:52 pm

1 stop5h 37m

Lambert-St Louis

Sun 3/1

6:35 am-12:11 pm

1 stop4h 36m

$417

Myrtle BeachKansas City

MYR - MCI

MYRMCI

Myrtle Beach Intl

Fri 6/5

7:50 pm-11:55 pm

1 stop5h 05m

Kansas City

Mon 6/8

7:00 am-12:19 pm

1 stop4h 19m

$417

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 4/9

9:15 am-12:05 pm

1 stop3h 50m

Lambert-St Louis

Mon 4/13

11:14 am-6:56 pm

2 stops6h 42m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 44 results
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Best time to book a flight from Myrtle Beach to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Missouri

What is the cheapest month to book a flight from Myrtle Beach to Missouri?

Currently, December is the cheapest month in which you can book a flight from Myrtle Beach to Missouri (average of $118). Flying from Myrtle Beach to Missouri in July is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to MO?

Find hourly flight availability from Myrtle Beach to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Myrtle Beach to Missouri in the afternoon. If you’re flexible enough to do this you can expect to save up to 31% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from Myrtle Beach to Missouri?

Use this chart to determine the cheapest time to fly round-trip from Myrtle Beach to Missouri. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Myrtle Beach to Missouri flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Myrtle Beach to Missouri?

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated December 12, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Missouri, such as Southwest, Delta, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,252 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,252 reviews
Southwest
7.9
Good
4,252 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,009 reviews
Southwest
7.9
Good
4,252 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,048 reviews
Southwest
7.9
Good
4,252 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,175 reviews
Southwest
7.9
Good
4,252 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

7.9

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Myrtle Beach to Missouri?

    Most people fly from Myrtle Beach Intl (MYR) if they book a flight from Myrtle Beach to Missouri. Myrtle Beach Intl is conveniently located just 2.1 mi from Myrtle Beach’s city center.

  • How popular is this Myrtle Beach to Missouri flight route?

    This flight path from Myrtle Beach Intl to Missouri was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Myrtle Beach to Missouri?

    Spirit Airlines, Delta, and American Airlines can get you from Myrtle Beach to Missouri in just under 5h 16m. Your travel time can differ by up to 4h 29m. Airlines will cover a distance of 957 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Myrtle Beach to Missouri one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $93. However, be on the lookout for offers from Spirit Airlines and Delta, as they are both options that can get you from Myrtle Beach to Missouri for a low price.

  • What are the most popular routes from Myrtle Beach to Missouri?

    The most popular flight routes from Myrtle Beach to Missouri are Myrtle Beach Intl - Lambert-St Louis, Myrtle Beach Intl - Kansas City and Myrtle Beach Intl - Springfield-Branson.

  • Can I find deals for flights from Myrtle Beach to Missouri that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Missouri.

  • Can I find deals for business class flights from Myrtle Beach to Missouri?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Missouri?

    Currently, December is the cheapest month in which you can book a flight from Myrtle Beach to Missouri (average of $118). Flying from Myrtle Beach to Missouri in July is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Myrtle Beach to Missouri

Discover the top 4 airlines that operate flights from Myrtle Beach to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$356FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$199Average$250FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$204Average$383FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$281Average$395FlexibilityNo cancel feeOn-time63%

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